{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T02:34:25Z","timestamp":1776306865941,"version":"3.50.1"},"reference-count":71,"publisher":"American Chemical Society (ACS)","issue":"22","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Org. Lett."],"published-print":{"date-parts":[[2009,11,19]]},"DOI":"10.1021\/ol9021832","type":"journal-article","created":{"date-parts":[[2009,10,23]],"date-time":"2009-10-23T18:42:20Z","timestamp":1256323340000},"page":"5246-5249","source":"Crossref","is-referenced-by-count":56,"title":["Organocatalytic Enantioselective Cascade Michael\u2212Michael\u2212Wittig Reactions of Phosphorus Ylides: One-Pot Synthesis of the <i>all<\/i>-<i>cis<\/i> Trisubstituted Cyclohexenecarboxylates via the [1 + 2 + 3] Annulation"],"prefix":"10.1021","volume":"11","author":[{"given":"Bor-Cherng","family":"Hong","sequence":"first","affiliation":[{"name":"Department of Chemistry and Biochemistry, National Chung Cheng University, Chia-Yi, 621, Taiwan, R.O.C., and Instrumentation Center, National Taiwan University, Taipei, 106, Taiwan, R.O.C."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rei-Hau","family":"Jan","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry, National Chung Cheng University, Chia-Yi, 621, Taiwan, R.O.C., and Instrumentation Center, National Taiwan University, Taipei, 106, Taiwan, R.O.C."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chih-Wei","family":"Tsai","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry, National Chung Cheng University, Chia-Yi, 621, Taiwan, R.O.C., and Instrumentation Center, National Taiwan University, Taipei, 106, Taiwan, R.O.C."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roshan Y.","family":"Nimje","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry, National Chung Cheng University, Chia-Yi, 621, Taiwan, R.O.C., and Instrumentation Center, National Taiwan University, Taipei, 106, Taiwan, R.O.C."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ju-Hsiou","family":"Liao","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry, National Chung Cheng University, Chia-Yi, 621, Taiwan, R.O.C., and Instrumentation Center, National Taiwan University, Taipei, 106, Taiwan, R.O.C."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gene-Hsiang","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry, National Chung Cheng University, Chia-Yi, 621, Taiwan, R.O.C., and Instrumentation Center, National Taiwan University, Taipei, 106, Taiwan, R.O.C."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"316","published-online":{"date-parts":[[2009,10,23]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"crossref","DOI":"10.1002\/0471224480","volume-title":"The Nitro Group in Organic Synthesis","author":"Ono N.","year":"2001"},{"key":"ref2\/cit2","unstructured":"For reviews, see:"},{"key":"ref2\/cit2a","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.1002\/1099-0690(200206)2002:12<1877::AID-EJOC1877>3.0.CO;2-U","author":"Berner B. J.","year":"2002","journal-title":"Eur. J. Org. Chem."},{"key":"ref2\/cit2b","doi-asserted-by":"crossref","first-page":"3123","DOI":"10.1039\/b701216k","author":"Sulzer-Moss\u00e9 S.","year":"2007","journal-title":"Chem. Commun."},{"key":"ref3\/cit3","unstructured":"For recent examples, see:"},{"key":"ref3\/cit3a","doi-asserted-by":"crossref","first-page":"1871","DOI":"10.1002\/anie.200704972","volume":"47","author":"Wiesner M.","year":"2008","journal-title":"Angew. Chem., Int. Ed."},{"key":"ref3\/cit3b","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1002\/chem.200701129","volume":"4","author":"Luo S.","year":"2008","journal-title":"Chem.\u2014Eur. J."},{"key":"ref3\/cit3c","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1002\/anie.200704161","volume":"47","author":"Zhu S.","year":"2008","journal-title":"Angew. Chem., Int. Ed."},{"key":"ref3\/cit3d","doi-asserted-by":"crossref","first-page":"4722","DOI":"10.1002\/anie.200801130","volume":"47","author":"Hayashi Y.","year":"2008","journal-title":"Angew. Chem., Int. Ed."},{"key":"ref3\/cit3e","doi-asserted-by":"crossref","first-page":"4719","DOI":"10.1002\/anie.200800847","volume":"47","author":"Garcia-Garcia P.","year":"2008","journal-title":"Angew. Chem., Int. Ed."},{"key":"ref3\/cit3f","doi-asserted-by":"crossref","first-page":"7539","DOI":"10.1002\/anie.200802532","volume":"47","author":"Enders D.","year":"2008","journal-title":"Angew. Chem., Int. Ed."},{"key":"ref3\/cit3g","doi-asserted-by":"crossref","first-page":"7714","DOI":"10.1002\/anie.200803236","volume":"47","author":"Mandal T.","year":"2008","journal-title":"Angew. Chem., Int. Ed."},{"key":"ref3\/cit3h","doi-asserted-by":"crossref","first-page":"4660","DOI":"10.1021\/ol901939b","volume":"11","author":"Han B.","year":"2009","journal-title":"Org. Lett."},{"key":"ref4\/cit4a","doi-asserted-by":"crossref","first-page":"2335","DOI":"10.1016\/j.tetasy.2008.10.010","volume":"19","author":"Rai V.","year":"2008","journal-title":"Tetrahedron: Asymmtery"},{"key":"ref4\/cit4b","doi-asserted-by":"crossref","first-page":"5058","DOI":"10.1039\/b713151h","author":"Fu X.","year":"2007","journal-title":"Chem. Commun."},{"key":"ref4\/cit4c","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1039\/B613477G","author":"Bartoli G.","year":"2007","journal-title":"Chem. Commun."},{"key":"ref4\/cit4d","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1002\/adsc.200600429","volume":"349","author":"Wang J.","year":"2007","journal-title":"Adv. Synth. Catal."},{"key":"ref5\/cit5","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1002\/anie.200804883","volume":"48","author":"Ishikawa H.","year":"2009","journal-title":"Angew. Chem., Int. Ed."},{"key":"ref6\/cit6","doi-asserted-by":"crossref","first-page":"6946","DOI":"10.1021\/ja800746q","volume":"130","author":"Lu L.-Q.","year":"2008","journal-title":"J. Am. Chem. Soc."},{"key":"ref7\/cit7","unstructured":"For other reactions, see:"},{"key":"ref7\/cit7a","doi-asserted-by":"crossref","first-page":"2456","DOI":"10.1021\/ja7114844","volume":"130","author":"Zhang Y.","year":"2008","journal-title":"J. Am. Chem. Soc."},{"key":"ref7\/cit7b","doi-asserted-by":"crossref","first-page":"2848","DOI":"10.1021\/ol9010568","volume":"11","author":"Liu Y.-K.","year":"2009","journal-title":"Org. Lett."},{"key":"ref8\/cit8","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1021\/cr040602r","volume":"105","author":"Ballini R.","year":"2005","journal-title":"Chem. Rev."},{"key":"ref9\/cit9a","doi-asserted-by":"crossref","first-page":"4787","DOI":"10.1021\/ol0618407","volume":"8","author":"Hanessian S.","year":"2006","journal-title":"Org. Lett."},{"key":"ref9\/cit9b","doi-asserted-by":"crossref","first-page":"2039","DOI":"10.1039\/B601877G","volume":"4","author":"Mitchell C. E. T.","year":"2006","journal-title":"Org. Biomol. Chem."},{"key":"ref9\/cit9c","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1016\/j.tetasy.2006.03.012","volume":"17","author":"Tsogoeva S. B.","year":"2006","journal-title":"Tetrahedron: Asymmetry"},{"key":"ref9\/cit9d","doi-asserted-by":"crossref","first-page":"1967","DOI":"10.1021\/ol050431s","volume":"7","author":"Vakulya B.","year":"2005","journal-title":"Org. Lett."},{"key":"ref9\/cit9e","doi-asserted-by":"crossref","first-page":"3897","DOI":"10.1021\/ol051301m","volume":"7","author":"Prieto A.","year":"2005","journal-title":"Org. Lett."},{"key":"ref9\/cit9f","doi-asserted-by":"crossref","first-page":"5346","DOI":"10.1039\/b511441a","author":"Mitchell C. E. T.","year":"2005","journal-title":"Chem. Commun."},{"key":"ref10\/cit10","doi-asserted-by":"crossref","first-page":"11790","DOI":"10.1021\/ja047047v","volume":"126","author":"Ooi T.","year":"2004","journal-title":"J. Am. Chem. Soc."},{"key":"ref11\/cit11a","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1002\/ejoc.200600653","author":"Tsogoeva S. B.","year":"2007","journal-title":"Eur. J. Org. Chem."},{"key":"ref11\/cit11b","doi-asserted-by":"crossref","first-page":"2065","DOI":"10.1055\/s-2007-983747","author":"Vicario J. L.","year":"2007","journal-title":"Synthesis"},{"key":"ref11\/cit11c","doi-asserted-by":"crossref","first-page":"9202","DOI":"10.1002\/anie.200704454","volume":"46","author":"Reyes E.","year":"2007","journal-title":"Angew. Chem., Int. Ed."},{"key":"ref12\/cit12a","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1002\/adsc.200600316","volume":"349","author":"Hojabri L.","year":"2007","journal-title":"Adv. Synth. Catal."},{"key":"ref12\/cit12b","doi-asserted-by":"crossref","first-page":"5307","DOI":"10.1021\/ol702545z","volume":"9","author":"Gotoh H.","year":"2007","journal-title":"Org. Lett."},{"key":"ref12\/cit12c","doi-asserted-by":"crossref","first-page":"2660","DOI":"10.1002\/adsc.200700353","volume":"349","author":"Zu L.","year":"2007","journal-title":"Adv. Synth. Catal."},{"key":"ref12\/cit12d","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1039\/b717000a","author":"Wang Y.","year":"2008","journal-title":"Chem. Commun."},{"key":"ref13\/cit13a","doi-asserted-by":"crossref","first-page":"10007","DOI":"10.1002\/chem.200801082","volume":"14","author":"Zhao G.-L.","year":"2008","journal-title":"Chem.\u2014Eur. J."},{"key":"ref13\/cit13b","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.1055\/s-2007-984517","author":"Enders D.","year":"2007","journal-title":"Synlett"},{"key":"ref13\/cit13c","doi-asserted-by":"crossref","first-page":"8431","DOI":"10.1002\/anie.200703261","volume":"46","author":"Palomo C.","year":"2007","journal-title":"Angew. Chem., Int. Ed."},{"key":"ref13\/cit13d","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1038\/nature04820","volume":"441","author":"Enders D.","year":"2006","journal-title":"Nature"},{"key":"ref13\/cit13e","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1055\/s-2007-983710","author":"Kraus G. A.","year":"2007","journal-title":"Synthesis"},{"key":"ref14\/cit14","unstructured":"For a review, see:"},{"key":"ref14\/cit14a","doi-asserted-by":"crossref","first-page":"1570","DOI":"10.1002\/anie.200603129","volume":"46","author":"Enders D.","year":"2007","journal-title":"Angew. Chem., Int. Ed."},{"key":"ref15\/cit15","unstructured":"For our previous efforts in exploring new organocatalytic annulations, see:"},{"key":"ref15\/cit15a","doi-asserted-by":"crossref","first-page":"3095","DOI":"10.1039\/b906205j","volume":"7","author":"Hong B.-C.","year":"2009","journal-title":"Org. Biomol. Chem."},{"key":"ref15\/cit15b","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1016\/j.tetlet.2008.11.106","volume":"50","author":"Kotame P.","year":"2009","journal-title":"Tetrahedron Lett."},{"key":"ref15\/cit15c","doi-asserted-by":"crossref","first-page":"2345","DOI":"10.1021\/ol8005369","volume":"10","author":"Hong B.-C.","year":"2008","journal-title":"Org. Lett."},{"key":"ref15\/cit15d","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1002\/ejoc.200701122","author":"Hong B.-C.","year":"2008","journal-title":"Eur. J. Org. Chem."},{"key":"ref16\/cit16","unstructured":"For reviews, see:"},{"key":"ref16\/cit16a","doi-asserted-by":"crossref","first-page":"8060","DOI":"10.1002\/chem.200701643","volume":"14","author":"Steinreiber J.","year":"2008","journal-title":"Chem.\u2014Eur. J."},{"key":"ref16\/cit16b","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1016\/j.tet.2007.10.080","volume":"64","author":"Pellissier H.","year":"2008","journal-title":"Tetrahedron"},{"key":"ref17\/cit17","unstructured":"For recent examples, see:"},{"key":"ref17\/cit17a","doi-asserted-by":"crossref","first-page":"8082","DOI":"10.1002\/chem.200801244","volume":"14","author":"Malkov A. V.","year":"2008","journal-title":"Chem.\u2014Eur. J."},{"key":"ref17\/cit17b","doi-asserted-by":"crossref","first-page":"6180","DOI":"10.1002\/anie.200800641","volume":"47","author":"M\u00fcller C. E.","year":"2008","journal-title":"Angew. Chem., Int. Ed."},{"key":"ref17\/cit17c","doi-asserted-by":"crossref","first-page":"6409","DOI":"10.1021\/jo801158g","volume":"73","author":"Peschiulli A.","year":"2008","journal-title":"J. Org. Chem."},{"key":"ref17\/cit17d","doi-asserted-by":"crossref","first-page":"4177","DOI":"10.1002\/anie.200800381","volume":"47","author":"Wang J.","year":"2008","journal-title":"Angew. Chem., Int. Ed."},{"key":"ref17\/cit17e","doi-asserted-by":"crossref","first-page":"2208","DOI":"10.1039\/b822127h","volume":"7","author":"Yang J.","year":"2009","journal-title":"Org. Biomol. Chem."},{"key":"ref18\/cit18a","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1021\/jo01267a600","volume":"33","author":"Asunskis J.","year":"1968","journal-title":"J. Org. Chem."},{"key":"ref18\/cit18b","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1021\/jo00945a040","volume":"38","author":"Connor D. T.","year":"1973","journal-title":"J. Org. Chem."},{"key":"ref19\/cit19","unstructured":"For a review of chiral diarylprolinol silyl ether catalyzed reactions, see:"},{"key":"ref19\/cit19b","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1002\/asia.200700417","volume":"3","author":"Mielgo A.","year":"2008","journal-title":"Chem. Asian J."},{"key":"ref19\/cit19bb","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1039\/b900098d","author":"Lattanzi A.","year":"2009","journal-title":"Chem. Commun."},{"key":"ref20\/cit20","unstructured":"The reaction at 0.1 M of2took nearly 30 days for completion."},{"key":"ref21\/cit21","unstructured":"99% ee for5b, and 96% for7b."},{"key":"ref22\/cit22","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1039\/B708453F","volume":"38","author":"Palomo C","year":"2009","journal-title":"Chem. Soc. Rev."},{"key":"ref23\/cit23","unstructured":"For reviews, see:"},{"key":"ref23\/cit23a","first-page":"354.","author":"Connon S. J.","year":"2009","journal-title":"Synlett"},{"key":"ref23\/cit23b","doi-asserted-by":"crossref","first-page":"2499.","DOI":"10.1039\/b719249e","author":"Connon S. J.","year":"2008","journal-title":"Chem. Commun."},{"key":"ref23\/cit23c","doi-asserted-by":"crossref","first-page":"1187.","DOI":"10.1039\/b801793j","volume":"38","author":"Zhang Z.","year":"2009","journal-title":"Chem. Soc. Rev."},{"key":"ref25\/cit25","unstructured":"The reaction with \u03b2-alkyl-substituted enals was stopped at the second-step conjugate addition. Attempts at activating the reaction are underway. The reaction of \u03b2-alkyl-substituted nitroolefins with compound2is feasible and actively being investigated."}],"container-title":["Organic Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/ol9021832","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,13]],"date-time":"2023-03-13T14:21:30Z","timestamp":1678717290000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/ol9021832"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,10,23]]},"references-count":71,"journal-issue":{"issue":"22","published-print":{"date-parts":[[2009,11,19]]}},"alternative-id":["10.1021\/ol9021832"],"URL":"https:\/\/doi.org\/10.1021\/ol9021832","relation":{},"ISSN":["1523-7060","1523-7052"],"issn-type":[{"value":"1523-7060","type":"print"},{"value":"1523-7052","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,10,23]]}}}