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Asymmetric Synthesis of Unsymmetrical Diarylmethanols"],"prefix":"10.1021","volume":"2","author":[{"given":"Takeshi","family":"Ohkuma","sequence":"first","affiliation":[{"name":"Department of Chemistry and Research Center for Materials Science, Nagoya University, Chikusa, Nagoya 464-8602, Japan, and ERATO Molecular Catalysis Project, Japan Science and Technology Corporation, 1247 Yachigusa, Yakusa-cho, Toyota 470-0392, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masatoshi","family":"Koizumi","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Research Center for Materials Science, Nagoya University, Chikusa, Nagoya 464-8602, Japan, and ERATO Molecular Catalysis Project, Japan Science and Technology Corporation, 1247 Yachigusa, Yakusa-cho, Toyota 470-0392, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideyuki","family":"Ikehira","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Research Center for Materials Science, Nagoya University, Chikusa, Nagoya 464-8602, Japan, and ERATO Molecular Catalysis Project, Japan Science and Technology Corporation, 1247 Yachigusa, Yakusa-cho, Toyota 470-0392, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tohru","family":"Yokozawa","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Research Center for Materials Science, Nagoya University, Chikusa, Nagoya 464-8602, Japan, and ERATO Molecular Catalysis Project, Japan Science and Technology Corporation, 1247 Yachigusa, Yakusa-cho, Toyota 470-0392, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryoji","family":"Noyori","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Research Center for Materials Science, Nagoya University, Chikusa, Nagoya 464-8602, Japan, and ERATO Molecular Catalysis Project, Japan Science and Technology Corporation, 1247 Yachigusa, Yakusa-cho, Toyota 470-0392, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2000,2,3]]},"reference":[{"key":"ol9904139b00001\/ol9904139b00001_1","volume":"13","author":"Examples","year":"1969","journal-title":"Indian J. 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Miniprint"},{"key":"ol9904139b00016\/ol9904139b00016_1","first-page":"7484","volume":"50","author":"For","year":"1994","journal-title":"Tetrahedron"},{"key":"ol9904139b00017\/ol9904139b00017_1","first-page":"2078","volume":"10","author":"Watanabe M.","year":"1999","journal-title":"Tetrahedron: Asymmetry"},{"key":"ol9904139b00017\/ol9904139b00017_2","volume-title":"press. See also:\u2009 Harada, N.; Fujita, K.; Watanabe, M. Enantiomer 1997","author":"Kuwahara S.","year":"1998"},{"key":"ol9904139b00018\/ol9904139b00018_1","unstructured":"A typical procedure of the 100-g scale reaction ofo-chlorobenzophenone (1d) with an S\/C ratio of 20000 follows (see also the Supporting Information):\u2009 The ketone1d(101.8 g, 0.47 mol), 2-propanol (150 mL), 1.0 Mt-C4H9OK intert-butyl alcohol (4.7 mL, 4.7 mmol), and solid (S,S)-4a(28.7 mg, 0.0235 mmol) were placed in a 1.5-L stainless steel autoclave. The mixture was degassed, and hydrogen was introduced to a pressure of 8 atm. This mixture was then stirred vigorously at 30 \u00b0C for 55 h. The yield and ee of (S)-2ddetermined by GC and chiral HPLC analysis were 99 and 97%, respectively. After the solvent was removed under reduced pressure, the residue was distilled to give pure (S)-2d(97.5 g, 95% yield):\u2009 bp 138\u2212139 \u00b0C\/0.3 mmHg; [\u03b1]20D\u221221.51\u00b0 (c1.13, CHCl3).17"},{"key":"ol9904139b00019\/ol9904139b00019_1","first-page":"2012","volume":"19","author":"van der Stelt C.","year":"1969","journal-title":"Arzneim.-Forsch."},{"key":"ol9904139b00019\/ol9904139b00019_2","first-page":"691","volume":"21","author":"Rekker R. F.","year":"1971","journal-title":"Arzneim.-Forsch."},{"key":"ol9904139b00020\/ol9904139b00020_1","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1002\/(SICI)1521-3773(19990517)38:10<1460::AID-ANIE1460>3.0.CO;2-Z","volume":"38","author":"Ireland T.","year":"1999","journal-title":"Angew. Chem., Int. 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