{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T17:04:25Z","timestamp":1791133465870,"version":"4.1.0"},"reference-count":9,"publisher":"American Chemical Society (ACS)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Org. Lett."],"published-print":{"date-parts":[[1999,7,1]]},"DOI":"10.1021\/ol990623l","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T01:45:00Z","timestamp":1027647900000},"page":"157-160","source":"Crossref","is-referenced-by-count":476,"title":["Enantioselective Synthesis of \u03b1-Amino Nitriles from\n                    <i>N<\/i>\n                    -Benzhydryl Imines and HCN with a Chiral Bicyclic Guanidine as Catalyst"],"prefix":"10.1021","volume":"1","author":[{"given":"E. J.","family":"Corey","sequence":"first","affiliation":[{"name":"Department of Chemistry and Chemical Biology, 12 Oxford Street, Harvard University, Cambridge, Massachusetts 02138"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Grogan","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Chemical Biology, 12 Oxford Street, Harvard University, Cambridge, Massachusetts 02138"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[1999,5,24]]},"reference":[{"key":"ol990623lb00001\/ol990623lb00001_1","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1002\/jlac.18500750103","volume":"75","author":"Strecker A.","year":"1850","journal-title":"Ann. Chem. Pharm."},{"key":"ol990623lb00001\/ol990623lb00001_2","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1016\/S0040-4020(01)80840-1","volume":"50","author":"Duthaler R. O.","year":"1994","journal-title":"Tetrahedron"},{"key":"ol990623lb00002\/ol990623lb00002_1","doi-asserted-by":"crossref","first-page":"5315","DOI":"10.1021\/ja980299+","volume":"120","author":"Sigman M. S.","year":"1998","journal-title":"J. Am. Chem. Soc."},{"key":"ol990623lb00002\/ol990623lb00002_2","doi-asserted-by":"crossref","first-page":"4901","DOI":"10.1021\/ja980139y","volume":"120","author":"Sigman M. S.","year":"1998","journal-title":"J. Am. Chem. Soc."},{"key":"ol990623lb00002\/ol990623lb00002_3","doi-asserted-by":"crossref","first-page":"3186","DOI":"10.1002\/(SICI)1521-3773(19981204)37:22<3186::AID-ANIE3186>3.0.CO;2-E","volume":"37","author":"Ishitani H.","year":"1998","journal-title":"Angew. Chem., Int. Ed. Engl."},{"key":"ol990623lb00002\/ol990623lb00002_4","doi-asserted-by":"crossref","first-page":"4910","DOI":"10.1021\/ja952686e","volume":"118","author":"Iyer M. S.","year":"1996","journal-title":"J. Am. Chem. Soc."},{"key":"ol990623lb00004\/ol990623lb00004_1","unstructured":"(3\n                      R\n                      ,7\n                      R\n                      )-3,7-Diphenyl-1,4,6-triazabicyclo[3.3.0]oct-4-ene (\n                      1\n                      ):\u2009 colorless solid, mp 159\u2212160 \u00b0C; R\n                      \n                        f\n                      \n                      0.28 (1:10:90 NH\n                      4\n                      OH\/MeOH\/CH\n                      2\n                      Cl\n                      2\n                      ); [\u03b1]\n                      23\n                      D\n                      +23.8 (\n                      c\n                      0.58, CHCl\n                      3\n                      ); IR (thin film) 1452, 1492, 1674, 2829, 2926, 3027, 3058, 3106, 3156, 3205 cm\n                      -\n                      1\n                      ;\n                      1\n                      H NMR (400 MHz, CDCl\n                      3\n                      ) \u03b4 7.37 (d, 4 H,\n                      J\n                      = 7.0 Hz), 7.32 (t, 4 H,\n                      J\n                      = 7.1 Hz), 7.25 (t, 2 H,\n                      J\n                      = 2.5 Hz), 6.37 (bs, 1 H), 5.17 (t, 2 H,\n                      J\n                      = 6.5 Hz), 3.50 (t, 2 H,\n                      J\n                      = 7.8 Hz), 3.03 (dd, 2 H,\n                      J\n                      = 6.3, 7.8 Hz) ppm;\n                      13\n                      C NMR (100 MHz, CDCl\n                      3\n                      ) \u03b4 169.3, 143.0, 128.5, 127.4, 126.4, 68.0, 57.2 ppm; CIMS 278(30) [M + NH\n                      4\n                      +\n                      ], 264(100) [M + H\n                      +\n                      ]."},{"key":"ol990623lb00006\/ol990623lb00006_1","doi-asserted-by":"crossref","first-page":"5227","DOI":"10.1016\/S0040-4039(01)93748-7","volume":"30","author":"Corey E. 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