{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T16:40:59Z","timestamp":1792514459864,"version":"4.5.0"},"reference-count":100,"publisher":"American Chemical Society (ACS)","issue":"3","license":[{"start":{"date-parts":[[2025,7,7]],"date-time":"2025-07-07T00:00:00Z","timestamp":1751846400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009076","name":"University of Science and Technology of China","doi-asserted-by":"publisher","award":["YD2060006006"],"award-info":[{"award-number":["YD2060006006"]}],"id":[{"id":"10.13039\/501100009076","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22305239"],"award-info":[{"award-number":["22305239"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52425306"],"award-info":[{"award-number":["52425306"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002367","name":"Chinese Academy of Sciences","doi-asserted-by":"publisher","award":["XDB0450102"],"award-info":[{"award-number":["XDB0450102"]}],"id":[{"id":"10.13039\/501100002367","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002367","name":"Chinese Academy of Sciences","doi-asserted-by":"publisher","award":["YSBR-094"],"award-info":[{"award-number":["YSBR-094"]}],"id":[{"id":"10.13039\/501100002367","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Polymer Science & Technology"],"published-print":{"date-parts":[[2026,3,24]]},"DOI":"10.1021\/polymscitech.5c00068","type":"journal-article","created":{"date-parts":[[2025,7,7]],"date-time":"2025-07-07T11:43:51Z","timestamp":1751888631000},"page":"114-135","source":"Crossref","is-referenced-by-count":7,"title":["Oral Delivery Systems for Gasotransmitters in Therapeutic Applications"],"prefix":"10.1021","volume":"2","author":[{"given":"Yongwu","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Pharmacy, The First Affiliated Hospital of the University of Science and Technology of China","place":["Hefei, China"]},{"name":"Hefei National Research Center for Physical Sciences at the Microscale, Department of Polymer Science and Engineering","place":["Hefei, China"]},{"name":"University of Science and Technology of China","place":["Hefei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiahui","family":"Sheng","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, The First Affiliated Hospital of the University of Science and Technology of China","place":["Hefei, China"]},{"name":"Hefei National Research Center for Physical Sciences at the Microscale, Department of Polymer Science and Engineering","place":["Hefei, China"]},{"name":"University of Science and Technology of China","place":["Hefei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, The First Affiliated Hospital of the University of Science and Technology of China","place":["Hefei, China"]},{"name":"Hefei National Research Center for Physical Sciences at the Microscale, Department of Polymer Science and Engineering","place":["Hefei, China"]},{"name":"University of Science and Technology of China","place":["Hefei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liqin","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, The First Affiliated Hospital of the University of Science and Technology of China","place":["Hefei, China"]},{"name":"Hefei National Research Center for Physical Sciences at the Microscale, Department of Polymer Science and Engineering","place":["Hefei, China"]},{"name":"University of Science and Technology of China","place":["Hefei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6969-1343","authenticated-orcid":true,"given":"Jinming","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, The First Affiliated Hospital of the University of Science and Technology of China","place":["Hefei, China"]},{"name":"Hefei National Research Center for Physical Sciences at the Microscale, Department of Polymer Science and Engineering","place":["Hefei, China"]},{"name":"University of Science and Technology of China","place":["Hefei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2025,7,7]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2009.05.005"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp0808891"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1038\/ni1001-907"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2014.04.041"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1812704115"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-200161010-00004"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2024.58843"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-43415-8"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202421405"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202314563"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2014.03.054"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2021.12.030"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2022.09.024"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2013.04.020"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2020.07.040"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2015.08.074"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-06373-0"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2022.12.059"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1039\/D0TB01761B"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202309972"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2022.121650"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1016\/j.niox.2020.08.001"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1126\/science.1470903"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.98.22.2365"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1126\/science.355.6324.491-c"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2022.06.010"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)60664-2"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1038\/nrd2466"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2013.04.004"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2015.06.009"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1021\/jacsau.1c00160"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.3390\/ijms221810101"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.1c21409"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2018.06.018"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.9b08587"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.3c02303"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2021.114005"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1016\/j.biotechadv.2015.01.005"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1517\/17425247.2015.1028916"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1016\/j.nano.2016.05.006"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1016\/j.xphs.2015.10.011"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1039\/D1TB01455B"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.5b00317"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2020.127277"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1002\/bmc.3777"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2021.111248"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrep.2021.101149"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1086\/689289"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/1592328"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2019.01.036"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2013.1388"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.116.003531"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.b19-00540"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.3390\/md20060354"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1124\/pharmrev.121.000564"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2020.120193"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.4c00823"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcis.2025.02.126"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000004242"},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2021.08.059"},{"key":"ref61\/cit61","doi-asserted-by":"publisher","DOI":"10.1080\/10715762.2016.1189546"},{"key":"ref62\/cit62","doi-asserted-by":"publisher","DOI":"10.1039\/C2DT32174B"},{"key":"ref63\/cit63","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2014.05.018"},{"key":"ref64\/cit64","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2014.06.025"},{"key":"ref65\/cit65","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2016.08.030"},{"key":"ref66\/cit66","doi-asserted-by":"publisher","DOI":"10.1021\/acsbiomaterials.2c00464"},{"key":"ref67\/cit67","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.123485"},{"key":"ref68\/cit68","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2024.103153"},{"key":"ref69\/cit69","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2023.106770"},{"key":"ref70\/cit70","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2018.10.020"},{"key":"ref71\/cit71","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2020.101521"},{"key":"ref72\/cit72","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.3c09342"},{"key":"ref73\/cit73","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.3c04819"},{"key":"ref74\/cit74","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2016.06.029"},{"key":"ref75\/cit75","doi-asserted-by":"publisher","DOI":"10.3390\/antiox10060915"},{"key":"ref76\/cit76","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.8b00019"},{"key":"ref77\/cit77","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2024.03.001"},{"key":"ref78\/cit78","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2014.196"},{"key":"ref79\/cit79","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2020.08.005"},{"key":"ref80\/cit80","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.9b00073"},{"key":"ref81\/cit81","doi-asserted-by":"publisher","DOI":"10.1039\/D1SC02711E"},{"key":"ref82\/cit82","doi-asserted-by":"publisher","DOI":"10.1021\/acs.molpharmaceut.2c01104"},{"key":"ref83\/cit83","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2022.02.002"},{"key":"ref84\/cit84","doi-asserted-by":"publisher","DOI":"10.1016\/j.biotechadv.2023.108202"},{"key":"ref85\/cit85","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202502588"},{"key":"ref86\/cit86","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202423527"},{"key":"ref87\/cit87","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2015.04.004"},{"key":"ref88\/cit88","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202410380"},{"key":"ref89\/cit89","doi-asserted-by":"publisher","DOI":"10.1111\/cpr.13374"},{"key":"ref90\/cit90","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvu026"},{"key":"ref91\/cit91","doi-asserted-by":"publisher","DOI":"10.1002\/ejp.798"},{"key":"ref92\/cit92","doi-asserted-by":"publisher","DOI":"10.1111\/1755-5922.12128"},{"key":"ref93\/cit93","doi-asserted-by":"publisher","DOI":"10.1111\/bph.14641"},{"key":"ref94\/cit94","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.5b01962"},{"key":"ref95\/cit95","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2024.152849"},{"key":"ref96\/cit96","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.4c18099"},{"key":"ref97\/cit97","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202419939"},{"key":"ref98\/cit98","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2025.101540"},{"key":"ref99\/cit99","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2015.09.014"},{"key":"ref100\/cit100","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2015.08.012"}],"container-title":["Polymer Science & Technology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/polymscitech.5c00068","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/polymscitech.5c00068","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T08:10:23Z","timestamp":1774339823000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/polymscitech.5c00068"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,7]]},"references-count":100,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3,24]]}},"alternative-id":["10.1021\/polymscitech.5c00068"],"URL":"https:\/\/doi.org\/10.1021\/polymscitech.5c00068","relation":{},"ISSN":["2997-3279","2997-3279"],"issn-type":[{"value":"2997-3279","type":"print"},{"value":"2997-3279","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,7]]}}}