{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T23:17:02Z","timestamp":1788218222809,"version":"build-2803163510"},"reference-count":37,"publisher":"American Chemical Society (ACS)","issue":"8","license":[{"start":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T00:00:00Z","timestamp":1776297600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22405147"],"award-info":[{"award-number":["22405147"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22531006"],"award-info":[{"award-number":["22531006"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["92356305"],"award-info":[{"award-number":["92356305"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003995","name":"Natural Science Foundation of Anhui Province","doi-asserted-by":"publisher","award":["2308085J15"],"award-info":[{"award-number":["2308085J15"]}],"id":[{"id":"10.13039\/501100003995","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005046","name":"Natural Science Foundation of Heilongjiang Province","doi-asserted-by":"publisher","award":["PL2025E107"],"award-info":[{"award-number":["PL2025E107"]}],"id":[{"id":"10.13039\/501100005046","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/na","name":"Natural Science Foundation of Anhui Provincial Higher Education Institutions","doi-asserted-by":"publisher","award":["2023AH010012"],"award-info":[{"award-number":["2023AH010012"]}],"id":[{"id":"10.13039\/na","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/na","name":"Program for Young Talents of Basic Research in Universities of Heilongjiang Province","doi-asserted-by":"publisher","award":["YQJH2025270"],"award-info":[{"award-number":["YQJH2025270"]}],"id":[{"id":"10.13039\/na","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Traditional chiral separation membranes, such as those composed of linear chiral polymers, often struggle to simultaneously achieve high enantioselectivity and high permeability due to issues like low density of recognition sites and poor structural stability, facing the significant \u201cselectivity-permeability\u201d trade-off. In this study, a three-dimensional cross-linked chiral composite membrane (P-SiO2) was constructed on a porous silica (SiO2) support via surface-initiated polymerization, employing a thiol\u2013ene click chemistry strategy. This 3D cross-linked network not only enhanced the spatial regularity and interfacial stability of the chiral recognition sites but also endowed the membrane with a network flexibility intermediate between that of linear polymers and rigid porous materials, effectively improving the membrane\u2019s separation performance and mechanical strength. The effects of key parameters, including the type of cross-linker, the pore size of the SiO2 support, reaction concentration, and the content of the chiral monomer, on the membrane structure and separation performance were systematically investigated. The results demonstrated that the P-SiO2 composite membrane with cross-linked network exhibited excellent chiral resolution performance for the d,l-phenylalanine racemate, with a permeability coefficient of 1.97 \u00d7 10\u201310 m2\/h and an enantiomeric excess (ee%) as high as 98.3%. Mechanistic studies revealed that the chiral recognition process follows a delayed transport mechanism, in which the composite membrane exhibited stronger adsorption for l-phenylalanine, thereby delaying its transport and allowing the d-enantiomer to permeate preferentially. This study provides an innovative design strategy and a feasible preparation pathway for developing chiral separation membrane materials that combine excellent film-forming ability, high enantioselectivity, superior stability, and good mechanical properties, showing broad application prospects in the efficient separation and purification of chiral pharmaceuticals.<\/jats:p>","DOI":"10.1021\/polymscitech.6c00030","type":"journal-article","created":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T15:36:09Z","timestamp":1776353769000},"page":"568-578","source":"Crossref","is-referenced-by-count":0,"title":["Surface-Initiated\nThiol\u2013Ene Click Polymerization\nfor Fabricating 3D Cross-Linked Chiral Composite Membranes with Enhanced\nEnantioselectivity and Permeability"],"prefix":"10.1021","volume":"2","author":[{"given":"Yu","family":"Zang","sequence":"first","affiliation":[{"name":"Qiqihar University , , Wenhua Street 42 , , ,","place":["Qiqihar, Heilongjiang, China, 161006"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingwen","family":"Zhang","sequence":"additional","affiliation":[{"name":"Qiqihar University , , Wenhua Street 42 , , ,","place":["Qiqihar, Heilongjiang, China, 161006"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang","family":"Xia","sequence":"additional","affiliation":[{"name":"Qiqihar University , , Wenhua Street 42 , , ,","place":["Qiqihar, Heilongjiang, China, 161006"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2630-4905","authenticated-orcid":true,"given":"Jianjun","family":"Wang","sequence":"additional","affiliation":[{"name":"Qiqihar University , , Wenhua Street 42 , , ,","place":["Qiqihar, Heilongjiang, China, 161006"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0996-380X","authenticated-orcid":true,"given":"Liang","family":"Xu","sequence":"additional","affiliation":[{"name":"Qiqihar University , , Wenhua Street 42 , , ,","place":["Qiqihar, Heilongjiang, China, 161006"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1554-3740","authenticated-orcid":true,"given":"Jiao","family":"Liu","sequence":"additional","affiliation":[{"name":"Qiqihar University , , Wenhua Street 42 , , ,","place":["Qiqihar, Heilongjiang, China, 161006"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangming","family":"Fu","sequence":"additional","affiliation":[{"name":"Qiqihar University , , Wenhua Street 42 , , ,","place":["Qiqihar, Heilongjiang, China, 161006"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruyan","family":"Xie","sequence":"additional","affiliation":[{"name":"Qiqihar University , , Wenhua Street 42 , , ,","place":["Qiqihar, Heilongjiang, China, 161006"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3494-9591","authenticated-orcid":true,"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Zhengzhou University , , No. 100, Science Avenue , , ,","place":["Zhengzhou, Henan, China, 450001"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,4,16]]},"reference":[{"key":"2026083118585502900_cit1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.2174\/1570163820666230503141234","article-title":"Chirality: A Key Factor in Pharmaceutical Industry","volume":"20","author":"Kalkar","year":"2023","journal-title":"Curr. Drug Discovery Technol."},{"key":"2026083118585502900_cit2","doi-asserted-by":"publisher","first-page":"115180","DOI":"10.1016\/j.addr.2025.115180","article-title":"Chirality\nin Drug Discovery and Development:\nRecent Advances in Safety and Efficacy Profiling","volume":"205","author":"Kaur","year":"2025","journal-title":"Adv. Drug Delivery Rev."},{"key":"2026083118585502900_cit3","doi-asserted-by":"publisher","DOI":"10.1002\/bmc.5800","article-title":"Enantioselective\nMembranes for Pharmaceutical Applications:\nA Comprehensive Review","volume":"38","author":"Gogoi","year":"2024","journal-title":"Biomed. Chromatogr."},{"key":"2026083118585502900_cit4","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1038\/s41570-023-00567-x","article-title":"The Thalidomide Tragedy: Lessons Learned and the Imperative\nof Chirality in Modern Drug Design","volume":"8","author":"Smith","year":"2024","journal-title":"Nat. Rev.\nChem."},{"key":"2026083118585502900_cit5","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1039\/D4CS90023K","article-title":"Chirality\nin Drug Discovery: Navigating\nthe Landscape of Enantioselective Synthesis and Safety Profiling","volume":"54","author":"Chen","year":"2025","journal-title":"Chem. Soc. Rev."},{"key":"2026083118585502900_cit6","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1016\/j.jpha.2023.01.003","article-title":"Recent applications\nand chiral separation development based on stationary phases in open\ntubular capillary electrochromatography (2019\u20132022)","volume":"13","author":"Li","year":"2023","journal-title":"J. Pharm. Anal."},{"key":"2026083118585502900_cit7","doi-asserted-by":"publisher","first-page":"139499","DOI":"10.1016\/j.cej.2022.139499","article-title":"Fabrication\nand Challenges of Homochiral Metal-Organic Framework Membranes for\nEnantioselective Separation","volume":"452","author":"Cheng","year":"2023","journal-title":"Chem. Eng. J."},{"key":"2026083118585502900_cit8","doi-asserted-by":"publisher","first-page":"122234","DOI":"10.1016\/j.memsci.2024.122234","article-title":"Ti3C2Tx MXene-Based\nLaminar Membranes for Enantioselective Separation","volume":"691","author":"Li","year":"2024","journal-title":"J. Membr. Sci."},{"key":"2026083118585502900_cit9","doi-asserted-by":"publisher","first-page":"215392","DOI":"10.1016\/j.ccr.2023.215392","article-title":"Advances in\nMembrane-Based Chiral Separation. Coord","volume":"495","author":"Yu","year":"2023","journal-title":"Chem.\nRev."},{"key":"2026083118585502900_cit10","doi-asserted-by":"publisher","first-page":"122567","DOI":"10.1016\/j.memsci.2023.122567","article-title":"Advances in\nChiral Separation Membranes:\nFrom Materials Design to Applications","volume":"689","author":"Zhang","year":"2024","journal-title":"J. Membr.\nSci."},{"key":"2026083118585502900_cit11","doi-asserted-by":"publisher","first-page":"4872","DOI":"10.1039\/D3CS01052F","article-title":"Overcoming\nthe Trade-Off in Chiral\nSeparation Membranes: Materials Design and Transport Mechanisms","volume":"53","author":"Wang","year":"2024","journal-title":"Chem. Soc. Rev."},{"key":"2026083118585502900_cit12","doi-asserted-by":"publisher","first-page":"123077","DOI":"10.1016\/j.seppur.2022.123077","article-title":"Chiral Separation Membranes:\nRecent Advances and Perspectives","volume":"309","author":"Zhu","year":"2023","journal-title":"Sep. Purif.\nTechnol."},{"key":"2026083118585502900_cit13","doi-asserted-by":"publisher","first-page":"6543","DOI":"10.1021\/acsapm.3c00851","article-title":"Scalable Fabrication\nof Chiral Polymer\nMembranes for Enantiomer Separation","volume":"5","author":"Wang","year":"2023","journal-title":"ACS Appl.\nPolym. Mater."},{"key":"2026083118585502900_cit14","doi-asserted-by":"publisher","first-page":"101789","DOI":"10.1016\/j.progpolymsci.2023.101789","article-title":"Evolution\nof Chiral Polymeric Membranes: From Helical\nPolyacetylenes to Advanced Nanostructures","volume":"148","author":"Zhang","year":"2024","journal-title":"Prog.\nPolym. Sci."},{"key":"2026083118585502900_cit15","doi-asserted-by":"publisher","first-page":"2891","DOI":"10.1021\/acsapm.4c00231","article-title":"Synthesis and Enantioseparation\nPerformance of Axially Chiral Poly(phenylacetylene) Membranes with\nTunable Helical Pitches","volume":"6","author":"Chen","year":"2024","journal-title":"ACS Appl. Polym. Mater."},{"key":"2026083118585502900_cit16","doi-asserted-by":"publisher","first-page":"122801","DOI":"10.1016\/j.memsci.2025.122801","article-title":"High-Flux Chiral Polyamide\nThin-Film\nComposite Membranes for Efficient Separation of Pharmaceutical Enantiomers","volume":"703","author":"Patel","year":"2025","journal-title":"J. Membr. Sci."},{"key":"2026083118585502900_cit17","doi-asserted-by":"publisher","first-page":"2401234","DOI":"10.1002\/adfm.202401234","article-title":"Biomimetic\nPolypeptide-Based Membranes\nwith Precisely Arranged Chiral Sites for Ultrafast Enantiomer Recognition","volume":"36","author":"Gupta","year":"2026","journal-title":"Adv. Funct. Mater."},{"key":"2026083118585502900_cit18","doi-asserted-by":"publisher","first-page":"1779","DOI":"10.1007\/s11426-024-2443-0","article-title":"Chiral polymer\nmicro\/nano-objects: Evolving preparation strategies in heterogeneous\npolymerization","volume":"68","author":"Liu","year":"2025","journal-title":"Sci. China Chem."},{"key":"2026083118585502900_cit19","doi-asserted-by":"publisher","DOI":"10.1007\/s40843-025-3821-2","article-title":"Chiral supramolecular\nmaterials based on azobenzene self-assembly systems: from regulated\nhelix structures to chiral functions","author":"He","year":"2026","journal-title":"Sci. China\nMater."},{"key":"2026083118585502900_cit20","doi-asserted-by":"publisher","first-page":"568","DOI":"10.1016\/j.jiec.2022.02.046","article-title":"Fabrication\nof PVDF-blended ultrafiltration membranes incorporated by chiral mesoporous\nsilica for enantioseparation","volume":"109","author":"Wang","year":"2022","journal-title":"J. Ind. Eng. Chem."},{"key":"2026083118585502900_cit21","doi-asserted-by":"publisher","first-page":"121198","DOI":"10.1016\/j.memsci.2022.121198","article-title":"Chiral Separation Performance\nof Graphene Oxide-Based Membranes","volume":"668","author":"Liu","year":"2023","journal-title":"J. Membr.\nSci."},{"key":"2026083118585502900_cit22","doi-asserted-by":"publisher","first-page":"125678","DOI":"10.1016\/j.memsci.2025.125678","article-title":"Two-Dimensional\nMaterial Membranes for Critical Separations:\nRecent Progress and Future Perspectives","volume":"999","author":"Chen","year":"2026","journal-title":"J.\nMembr. Sci."},{"key":"2026083118585502900_cit23","doi-asserted-by":"publisher","first-page":"19256","DOI":"10.1021\/acsami.3c19845","article-title":"High-Performance\nChiral Conjugated\nMicroporous Polymer Membranes via Interfacial Engineering for Efficient\nEnantioseparation","volume":"16","author":"Zhang","year":"2024","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"2026083118585502900_cit24","doi-asserted-by":"publisher","first-page":"126833","DOI":"10.1016\/j.seppur.2024.126833","article-title":"Novel Chiral Composite Membranes\nCoated by Microporous Hyper-cross-linked\nPolymer for Efficiently Enantioselective Separation","volume":"340","author":"Wang","year":"2024","journal-title":"Sep. Purif. Technol."},{"key":"2026083118585502900_cit25","doi-asserted-by":"publisher","first-page":"124885","DOI":"10.1016\/j.memsci.2025.124885","article-title":"Supramolecular Chiral\nAmplification in Two-Dimensional Membranes by Incorporation of Cyclodextrins\nfor Enhancing Enantioseparations","volume":"738","author":"Zhang","year":"2026","journal-title":"J. Membr.\nSci."},{"key":"2026083118585502900_cit26","doi-asserted-by":"publisher","first-page":"8558","DOI":"10.1039\/D3NJ00869J","article-title":"An Electrochemical\nSensor Based on Metal-Organic Framework-Chiral Ionic Liquid Composites\nfor the Enantiorecognition of Tryptophan Enantiomers","volume":"47","author":"Hou","year":"2023","journal-title":"New J. Chem."},{"key":"2026083118585502900_cit27","doi-asserted-by":"publisher","DOI":"10.1007\/s40843-025-3936-8","article-title":"Cascade-controlled\nporous composite membranes: pore-supporting\nsynergy enabling high-flux enantioseparation of amino acids and pharmaceuticals","author":"Zang","year":"2026","journal-title":"Sci. China Mater."},{"key":"2026083118585502900_cit28","doi-asserted-by":"publisher","first-page":"124892","DOI":"10.1016\/j.memsci.2025.124892","article-title":"Controllable Oriented Growth of Heteroepitaxial\nMOF-on-MOF Bilayer Chiral Membrane Improved Enantioseparation","volume":"738","author":"Fan","year":"2026","journal-title":"J. Membr. Sci."},{"key":"2026083118585502900_cit29","doi-asserted-by":"publisher","first-page":"216844","DOI":"10.1016\/j.ccr.2025.216844","article-title":"Recent Advances of\nChiral Covalent Organic Frameworks\nfor Enantiomer Separation","volume":"542","author":"Mao","year":"2025","journal-title":"Coord. Chem. Rev."},{"key":"2026083118585502900_cit30","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202506677","article-title":"Dual-Mechanism Synergy\nin Chiral Conjugated Microporous Polymer Membranes for Enhanced Enantioselective\nPermeability","volume":"21","author":"Zang","year":"2025","journal-title":"Small"},{"key":"2026083118585502900_cit31","doi-asserted-by":"publisher","first-page":"2100","DOI":"10.1021\/acs.chemrev.3c00456","article-title":"Click Chemistry\nin Chiral Science:\nFrom Asymmetric Synthesis to Functional Materials","volume":"124","author":"Smith","year":"2024","journal-title":"Chem. Rev."},{"key":"2026083118585502900_cit32","doi-asserted-by":"publisher","first-page":"10245","DOI":"10.1021\/jacs.4c01234","article-title":"Synthesis and Enantioseparation\nPerformance of Axially Chiral Poly(phenylacetylene) Membranes with\nTunable Helical Pitches","volume":"146","author":"Chen","year":"2024","journal-title":"J. Am. Chem. Soc."},{"key":"2026083118585502900_cit33","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202414567","article-title":"High-Flux Chiral Polyamide\nThin-Film\nComposite Membranes for Efficient Separation of Pharmaceutical Enantiomers","volume":"64","author":"Patel","year":"2025","journal-title":"Angew. Chem. Int. Ed."},{"key":"2026083118585502900_cit34","doi-asserted-by":"publisher","first-page":"2401234","DOI":"10.1002\/adma.202401234","article-title":"Biomimetic Polypeptide-Based Membranes\nwith Precisely Arranged Chiral Sites for Ultrafast Enantiomer Recognition","volume":"38","author":"Gupta","year":"2026","journal-title":"Adv. Mater."},{"key":"2026083118585502900_cit35","doi-asserted-by":"publisher","first-page":"7890","DOI":"10.1021\/acsnano.5c01234","article-title":"Interfacial\nEngineering of Chiral\nConjugated Microporous Polymer Membranes for High-Efficiency Enantioseparation","volume":"19","author":"Zhang","year":"2025","journal-title":"ACS Nano"},{"key":"2026083118585502900_cit36","doi-asserted-by":"publisher","first-page":"1485","DOI":"10.1002\/pol.20230025","article-title":"Rational Design\nof Hyper-Cross-Linked Polymers for Biomedical Applications","volume":"61","author":"Liao","year":"2023","journal-title":"J. Polym. Sci."},{"key":"2026083118585502900_cit37","doi-asserted-by":"publisher","first-page":"465652","DOI":"10.1016\/j.chroma.2025.465652","article-title":"Recent Developments\nand Applications of Solid Membrane in Chiral\nSeparation","volume":"1743","author":"Ge","year":"2025","journal-title":"J. Chromatogr. A"}],"container-title":["Polymer Science &amp; Technology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/polymscitech.6c00030","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/pstoco\/article-pdf\/2\/8\/568\/66263669\/polymscitech.6c00030.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/pstoco\/article-pdf\/2\/8\/568\/66263669\/polymscitech.6c00030.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T22:59:04Z","timestamp":1788217144000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/pstoco\/article\/2\/8\/568\/5232983\/Surface-Initiated-Thiol-Ene-Click-Polymerization"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,16]]},"references-count":37,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2026,4,16]]},"published-print":{"date-parts":[[2026,8,25]]}},"URL":"https:\/\/doi.org\/10.1021\/polymscitech.6c00030","relation":{},"ISSN":["2997-3279"],"issn-type":[{"value":"2997-3279","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,16]]}}}