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In the present study, a bio-based polyesteramide, P(PDC-BiOx), was successfully synthesized via the atom-economical ring-opening polyaddition of PDC and 2,2\u2032-bis(2-oxazoline). The thermal, crystalline, and mechanical properties of the resulting polymer were fully characterized, revealing a completely amorphous backbone with a fracture stress of 10.34 MPa. The marine biodegradability behavior was investigated under both surface and deep seawater conditions, demonstrating a clear correlation between material morphology and biodegradation rate. The experimental results demonstrated that, in surface seawater, the electrosprayed microparticles degraded more rapidly than the hot-pressed film, although both eventually reached a comparable extent of degradation. In comparison, in deep seawater, the electrosprayed microparticles achieved approximately 30% biodegradation within 45 days, which was higher than that of the hot-pressed film. Overall, PDC polyesteramides are promising biomass-derived polymers with straightforward accessibility and potential marine biodegradability.<\/jats:p>","DOI":"10.1021\/polymscitech.6c00037","type":"journal-article","created":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T19:22:13Z","timestamp":1778613733000},"page":"587-596","source":"Crossref","is-referenced-by-count":0,"title":["Atom-Economic\nSynthesis and Morphology-Dependent Marine\nBiodegradation Behavior of 2-Pyrone-4,6-Dicarboxylic Acid\u2013Based\nPolyesteramide"],"prefix":"10.1021","volume":"2","author":[{"given":"Yijie","family":"Jin","sequence":"first","affiliation":[{"name":"Institute of Science Tokyo , , 2-12-1 Ookayama , , , ,","place":["Meguro-ku, Tokyo, Japan, 152-8552"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei Xin","family":"Tan","sequence":"additional","affiliation":[{"name":"Institute of Science Tokyo , , 2-12-1 Ookayama , , , ,","place":["Meguro-ku, Tokyo, Japan, 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