{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T22:25:42Z","timestamp":1786573542234,"version":"build-2736575974"},"reference-count":62,"publisher":"American Chemical Society (ACS)","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Proteome Res."],"published-print":{"date-parts":[[2011,11,4]]},"DOI":"10.1021\/pr200452j","type":"journal-article","created":{"date-parts":[[2011,9,8]],"date-time":"2011-09-08T17:00:36Z","timestamp":1315501236000},"page":"4983-4992","source":"Crossref","is-referenced-by-count":75,"title":["The Cardiovascular Risk of Healthy Individuals Studied by NMR Metabonomics of Plasma Samples"],"prefix":"10.1021","volume":"10","author":[{"given":"Patrizia","family":"Bernini","sequence":"first","affiliation":[{"name":"Magnetic Resonance Center (CERM), University of Florence, Via L. Sacconi 6, 50019 Sesto Fiorentino, Italy"},{"name":"FiorGen Foundation, Via L. Sacconi 6, 50019 Sesto Fiorentino, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivano","family":"Bertini","sequence":"additional","affiliation":[{"name":"Magnetic Resonance Center (CERM), University of Florence, Via L. Sacconi 6, 50019 Sesto Fiorentino, Italy"},{"name":"Department of Chemistry, University of Florence, Via della Lastruccia 3, 50019 Sesto Fiorentino, Italy"},{"name":"FiorGen Foundation, Via L. Sacconi 6, 50019 Sesto Fiorentino, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Luchinat","sequence":"additional","affiliation":[{"name":"Magnetic Resonance Center (CERM), University of Florence, Via L. Sacconi 6, 50019 Sesto Fiorentino, Italy"},{"name":"Department of Chemistry, University of Florence, Via della Lastruccia 3, 50019 Sesto Fiorentino, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonardo","family":"Tenori","sequence":"additional","affiliation":[{"name":"FiorGen Foundation, Via L. Sacconi 6, 50019 Sesto Fiorentino, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana","family":"Tognaccini","sequence":"additional","affiliation":[{"name":"Immunohaematology and Transfusion Service of Pistoia Hospital, Piazza Giovanni XXIII, 51100 Pistoia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2011,10,3]]},"reference":[{"issue":"2","key":"ref1\/cit1","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/S0002-8703(00)90236-9","volume":"139","author":"D\u2019Agostino R. B.","year":"2000","journal-title":"Am. Heart J."},{"issue":"7","key":"ref2\/cit2","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1016\/j.amjcard.2007.05.035","volume":"100","author":"McMahan C. A.","year":"2007","journal-title":"Am. J. Cardiol."},{"issue":"21","key":"ref3\/cit3","doi-asserted-by":"crossref","first-page":"2341","DOI":"10.1001\/archinte.166.21.2341","volume":"166","author":"Gidding S. S.","year":"2006","journal-title":"Arch. Intern. Med."},{"issue":"4","key":"ref4\/cit4","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1542\/peds.2006-0970","volume":"118","author":"McMahan C. A.","year":"2006","journal-title":"Pediatrics"},{"issue":"4","key":"ref5\/cit5","doi-asserted-by":"crossref","first-page":"414","DOI":"10.7326\/0003-4819-124-4-199602150-00005","volume":"124","author":"Friedmann P. D.","year":"1996","journal-title":"Ann. Intern. Med."},{"issue":"6985","key":"ref6\/cit6","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1136\/bmj.310.6985.975","volume":"310","author":"Grover S. A.","year":"1995","journal-title":"BMJ [Br. Med. J.]"},{"issue":"7335","key":"ref7\/cit7","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1136\/bmj.324.7335.459","volume":"324","author":"McManus R. J.","year":"2002","journal-title":"BMJ [Br. Med. J.]"},{"issue":"451","key":"ref8\/cit8","first-page":"127","volume":"50","author":"Montgomery A. A.","year":"2000","journal-title":"Br. J. Gen. Pract."},{"issue":"2","key":"ref9\/cit9","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1001\/jama.286.2.180","volume":"286","author":"D\u2019Agostino R. B.","year":"2001","journal-title":"JAMA, J. Am. Med. Assoc."},{"issue":"1","key":"ref10\/cit10","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1161\/01.CIR.83.1.356","volume":"83","author":"Anderson K. M.","year":"1991","journal-title":"Circulation"},{"issue":"19","key":"ref11\/cit11","doi-asserted-by":"crossref","first-page":"2486","DOI":"10.1001\/jama.285.19.2486","volume":"285","author":"Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults","year":"2001","journal-title":"JAMA, J. Am. Med. Assoc."},{"issue":"18","key":"ref12\/cit12","doi-asserted-by":"crossref","first-page":"1837","DOI":"10.1161\/01.CIR.97.18.1837","volume":"97","author":"Wilson P. W.","year":"1998","journal-title":"Circulation"},{"issue":"9398","key":"ref13\/cit13","doi-asserted-by":"crossref","first-page":"1776","DOI":"10.1016\/S0140-6736(03)14941-0","volume":"362","author":"Topol E. J.","year":"2003","journal-title":"Lancet."},{"issue":"19","key":"ref14\/cit14","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1056\/NEJMcp012672","volume":"346","author":"Lauer M. S.","year":"2002","journal-title":"N. Engl. J. Med."},{"issue":"11","key":"ref15\/cit15","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1080\/004982599238047","volume":"29","author":"Nicholson J. K.","year":"1999","journal-title":"Xenobiotica"},{"key":"ref16\/cit16","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1038\/msb4100095","volume":"2","author":"Nicholson J. K.","year":"2006","journal-title":"Mol. Syst. Biol."},{"issue":"1","key":"ref17\/cit17","doi-asserted-by":"crossref","first-page":"35","DOI":"10.2174\/1568026023394498","volume":"2","author":"Shockcor J. P.","year":"2002","journal-title":"Curr. Top. Med. Chem."},{"issue":"7216","key":"ref18\/cit18","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1038\/4551054a","volume":"455","author":"Nicholson J. K.","year":"2008","journal-title":"Nature"},{"issue":"5","key":"ref19\/cit19","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1586\/14737159.6.5.717","volume":"6","author":"Serkova N. J.","year":"2006","journal-title":"Expert Rev. Mol. Diagn."},{"key":"ref20\/cit20","doi-asserted-by":"crossref","first-page":"D521","DOI":"10.1093\/nar\/gkl923","volume":"35","author":"Wishart D. S.","year":"2007","journal-title":"Nucleic Acids Res."},{"issue":"1","key":"ref21\/cit21","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.ab.2006.04.014","volume":"355","author":"Aranjbar N.","year":"2006","journal-title":"Anal. Biochem."},{"issue":"1","key":"ref22\/cit22","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/83496","volume":"19","author":"Raamsdonk L. M.","year":"2001","journal-title":"Nat. Biotechnol."},{"issue":"10","key":"ref23\/cit23","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1038\/sj.embor.embor944","volume":"4","author":"Urbanczyk-Wochniak E.","year":"2003","journal-title":"EMBO Rep."},{"issue":"2","key":"ref24\/cit24","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/0304-4165(95)00152-2","volume":"1289","author":"Mendes P.","year":"1996","journal-title":"Biochim. Biophys. Acta"},{"issue":"7231","key":"ref25\/cit25","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1038\/nature07762","volume":"457","author":"Sreekumar A.","year":"2009","journal-title":"Nature"},{"issue":"7","key":"ref26\/cit26","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1016\/j.biocel.2010.05.001","volume":"43","author":"Oakman C.","year":"2011","journal-title":"Int. J. Biochem. Cell Biol."},{"issue":"5","key":"ref27\/cit27","doi-asserted-by":"crossref","first-page":"e10538","DOI":"10.1371\/journal.pone.0010538","volume":"5","author":"Lanza I. R.","year":"2010","journal-title":"PLoS One"},{"key":"ref28\/cit28","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1021\/pr800548z","volume":"1","author":"Bertini I.","year":"2009","journal-title":"J. Proteome Res."},{"issue":"2","key":"ref29\/cit29","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1161\/CIRCGENETICS.108.815605","volume":"1","author":"Wilson P. W.","year":"2008","journal-title":"Circ. Cardiovasc. Genet."},{"issue":"1","key":"ref30\/cit30","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1161\/CIRCGENETICS.108.808329","volume":"1","author":"Mayr M.","year":"2008","journal-title":"Circ. Cardiovasc. Genet."},{"issue":"7193","key":"ref31\/cit31","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1038\/nature06882","volume":"453","author":"Holmes E.","year":"2008","journal-title":"Nature"},{"issue":"18","key":"ref32\/cit32","first-page":"S466","volume":"120","author":"Shah S. H.","year":"2009","journal-title":"Circulation"},{"issue":"2","key":"ref33\/cit33","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1161\/CIRCGENETICS.109.852814","volume":"3","author":"Shah S. H.","year":"2010","journal-title":"Circ. Cardiovasc. Genet."},{"issue":"25","key":"ref34\/cit34","doi-asserted-by":"crossref","first-page":"3868","DOI":"10.1161\/CIRCULATIONAHA.105.569137","volume":"112","author":"Sabatine M. S.","year":"2005","journal-title":"Circulation"},{"issue":"12","key":"ref35\/cit35","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1038\/nm1202-802","volume":"8","author":"Brindle J. T.","year":"2002","journal-title":"Nat. Med."},{"issue":"6","key":"ref36\/cit36","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1038\/nm1432","volume":"12","author":"Kirschenlohr H. L.","year":"2006","journal-title":"Nat. Med."},{"issue":"1","key":"ref37\/cit37","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1039\/b907021d","volume":"6","author":"Barton R. H.","year":"2010","journal-title":"Mol. BioSyst."},{"issue":"4","key":"ref38\/cit38","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1093\/clinchem\/20.4.470","volume":"20","author":"Allain C. C.","year":"1974","journal-title":"Clin. Chem."},{"issue":"5","key":"ref39\/cit39","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1093\/clinchem\/19.5.476","volume":"19","author":"Bucolo G.","year":"1973","journal-title":"Clin Chem."},{"issue":"6","key":"ref40\/cit40","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1093\/clinchem\/18.6.499","volume":"18","author":"Friedewald W. T.","year":"1972","journal-title":"Clin. Chem."},{"issue":"1","key":"ref41\/cit41","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1007\/s11306-007-0099-6","volume":"4","author":"Westerhuis J.","year":"2008","journal-title":"Metabolomics"},{"key":"ref42\/cit42","first-page":"1","author":"Szymanska E.","year":"2011","journal-title":"Metabolomics"},{"key":"ref43\/cit43","volume-title":"Studi in Onore del Professore Salvatore Ortu Carboni","author":"Bonferroni C. E.","year":"1935"},{"issue":"4","key":"ref44\/cit44","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1007\/s11306-006-0037-z","volume":"2","author":"Broadhurst D.","year":"2006","journal-title":"Metabolomics"},{"issue":"3","key":"ref45\/cit45","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1080\/10618600.1996.10474713","volume":"5","author":"Ihaka R.","year":"1996","journal-title":"J. Comput. Stat. Graph."},{"issue":"3","key":"ref46\/cit46","first-page":"73","volume":"42","author":"Bellodi G.","year":"1994","journal-title":"Minerva Cardioangiol."},{"issue":"7","key":"ref47\/cit47","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1039\/b302360p","volume":"128","author":"Beckwith-Hall B. M.","year":"2003","journal-title":"Analyst"},{"issue":"9","key":"ref48\/cit48","doi-asserted-by":"crossref","first-page":"e3259","DOI":"10.1371\/journal.pone.0003259","volume":"3","author":"Hageman J. A.","year":"2008","journal-title":"PLoS One"},{"issue":"10","key":"ref49\/cit49","doi-asserted-by":"crossref","first-page":"5440","DOI":"10.1073\/pnas.97.10.5440","volume":"97","author":"Kashiwaya Y.","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"11","key":"ref50\/cit50","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1016\/0024-3205(84)90188-7","volume":"35","author":"Tani T.","year":"1984","journal-title":"Life Sci."},{"issue":"5","key":"ref51\/cit51","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/S0168-8278(05)80349-6","volume":"20","author":"Saibara T.","year":"1994","journal-title":"J. Hepatol."},{"issue":"3","key":"ref52\/cit52","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1038\/nm824","volume":"9","author":"Tunaru S.","year":"2003","journal-title":"Nat. Med."},{"issue":"3","key":"ref53\/cit53","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1002\/med.20102","volume":"27","author":"Soudijn W.","year":"2007","journal-title":"Med. Res. Rev."},{"issue":"1","key":"ref54\/cit54","doi-asserted-by":"crossref","first-page":"36","DOI":"10.3181\/00379727-140-36390","volume":"140","author":"Bazzano G.","year":"1972","journal-title":"Proc. Soc. Exp. Biol. Med."},{"issue":"6988","key":"ref55\/cit55","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1038\/nature02488","volume":"429","author":"He W.","year":"2004","journal-title":"Nature"},{"issue":"1","key":"ref56\/cit56","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S0304-4165(01)00197-0","volume":"1568","author":"Guerranti R.","year":"2001","journal-title":"Biochim. Biophys. Acta"},{"issue":"12","key":"ref57\/cit57","doi-asserted-by":"crossref","first-page":"2641","DOI":"10.1093\/jn\/137.12.2641","volume":"137","author":"Friesen R. W.","year":"2007","journal-title":"J. Nutr."},{"issue":"1","key":"ref58\/cit58","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/S0021-9258(18)70407-9","volume":"232","author":"MacKenzie C. G.","year":"1958","journal-title":"J. Biol. Chem."},{"issue":"11","key":"ref59\/cit59","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1016\/j.clinbiochem.2004.07.005","volume":"37","author":"Slow S.","year":"2004","journal-title":"Clin. Biochem."},{"issue":"2","key":"ref60\/cit60","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1111\/j.1439-0396.2010.01034.x","volume":"95","author":"Kalmar I. D.","year":"2011","journal-title":"J. Anim. Physiol. Anim. Nutr."},{"issue":"5","key":"ref61\/cit61","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.2337\/db06-0783","volume":"56","author":"Befroy D. E.","year":"2007","journal-title":"Diabetes"},{"key":"ref263\/cit263","unstructured":"Fiorgen Foundation. AVIS Project Datasets. http:\/\/www.fiorgen.net\/Downloads.html (accessed September 30, 2011)."}],"container-title":["Journal of Proteome Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/pr200452j","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,10]],"date-time":"2025-03-10T05:29:26Z","timestamp":1741584566000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/pr200452j"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,10,3]]},"references-count":62,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2011,11,4]]}},"alternative-id":["10.1021\/pr200452j"],"URL":"https:\/\/doi.org\/10.1021\/pr200452j","relation":{},"ISSN":["1535-3893","1535-3907"],"issn-type":[{"value":"1535-3893","type":"print"},{"value":"1535-3907","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,10,3]]}}}