{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T07:39:25Z","timestamp":1792136365845,"version":"4.4.0"},"reference-count":55,"publisher":"American Chemical Society (ACS)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Proteome Res."],"published-print":{"date-parts":[[2012,1,1]]},"DOI":"10.1021\/pr2006439","type":"journal-article","created":{"date-parts":[[2011,10,27]],"date-time":"2011-10-27T13:03:43Z","timestamp":1319720623000},"page":"279-291","source":"Crossref","is-referenced-by-count":51,"title":["Hemorrhagic Activity of HF3, a Snake Venom Metalloproteinase: Insights from the Proteomic Analysis of Mouse Skin and Blood Plasma"],"prefix":"10.1021","volume":"11","author":[{"given":"Adriana F.","family":"Paes Leme","sequence":"first","affiliation":[{"name":"Laborat\u00f3rio Especial de Toxinologia Aplicada-CAT\/cepid, Instituto Butantan, S\u00e3o Paulo, Brazil"},{"name":"Laborat\u00f3rio Nacional de Bioci\u00eancias (LNBio), Campinas, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas E.","family":"Sherman","sequence":"additional","affiliation":[{"name":"Department of Microbiology, University of Virginia, Charlottesville, Virginia, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David M.","family":"Smalley","sequence":"additional","affiliation":[{"name":"Department of Microbiology, University of Virginia, Charlottesville, Virginia, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Let\u00edcia O.","family":"Sizukusa","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio Especial de Toxinologia Aplicada-CAT\/cepid, Instituto Butantan, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana K.","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio Especial de Toxinologia Aplicada-CAT\/cepid, Instituto Butantan, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milene C.","family":"Menezes","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio Especial de Toxinologia Aplicada-CAT\/cepid, Instituto Butantan, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jay W.","family":"Fox","sequence":"additional","affiliation":[{"name":"Department of Microbiology, University of Virginia, Charlottesville, Virginia, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Solange M. T.","family":"Serrano","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio Especial de Toxinologia Aplicada-CAT\/cepid, Instituto Butantan, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2011,10,27]]},"reference":[{"key":"ref1\/cit1","first-page":"201","volume":"93","author":"Ownby C. L.","year":"1978","journal-title":"Am. J. Pathol."},{"key":"ref2\/cit2","first-page":"478","volume":"41","author":"Ohsaka A.","year":"1960","journal-title":"Br. J. Exp. Pathol."},{"key":"ref3\/cit3","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/0163-7258(94)90049-3","volume":"62","author":"Bjarnason J. B.","year":"1994","journal-title":"Pharmacol. Ther."},{"key":"ref4\/cit4","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1016\/j.toxicon.2005.02.030","volume":"45","author":"White J.","year":"2005","journal-title":"Toxicon"},{"key":"ref5\/cit5","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1016\/j.toxicon.2005.02.029","volume":"45","author":"Guti\u00e9rrez J. M.","year":"2005","journal-title":"Toxicon"},{"key":"ref6\/cit6","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/0076-6879(95)48023-4","volume":"248","author":"Bjarnason J. B.","year":"1995","journal-title":"Methods Enzymol."},{"key":"ref7\/cit7","doi-asserted-by":"crossref","first-page":"3016","DOI":"10.1111\/j.1742-4658.2008.06466.x","volume":"275","author":"Fox J. W.","year":"2008","journal-title":"FEBS J."},{"key":"ref8\/cit8","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1016\/j.ceb.2003.08.001","volume":"15","author":"White J. M.","year":"2003","journal-title":"Curr. Opin. Cell Biol."},{"key":"ref9\/cit9","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/S0014-5793(99)00119-2","volume":"445","author":"Tang B. L.","year":"1999","journal-title":"FEBS Lett."},{"key":"ref10\/cit10","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/0003-9861(89)90350-0","volume":"275","author":"Baramova E. N.","year":"1989","journal-title":"Arch. Biochem. Biophys."},{"key":"ref11\/cit11","doi-asserted-by":"crossref","first-page":"11575","DOI":"10.1016\/S0021-9258(18)80102-8","volume":"264","author":"Shannon J. D.","year":"1989","journal-title":"J. Biol. Chem."},{"key":"ref12\/cit12","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1006\/abbi.1999.1517","volume":"373","author":"Jia L. G.","year":"2000","journal-title":"Arch. Biochem. Biophys."},{"key":"ref13\/cit13","doi-asserted-by":"crossref","first-page":"40528","DOI":"10.1074\/jbc.M202049200","volume":"277","author":"Zigrino P.","year":"2002","journal-title":"J. Biol. Chem."},{"key":"ref14\/cit14","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S0014-5793(03)00799-3","volume":"549","author":"Kamiguti A. S.","year":"2003","journal-title":"FEBS Lett."},{"key":"ref15\/cit15","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1042\/bj3200635","volume":"320","author":"Kamiguti A. S.","year":"1996","journal-title":"Biochem. J."},{"key":"ref16\/cit16","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.1111\/j.1538-7836.2005.01358.x","volume":"3","author":"Lu Q.","year":"2005","journal-title":"J. Thromb. Haemost."},{"key":"ref17\/cit17","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1160\/TH09-12-0855","volume":"104","author":"Oliveira A. K.","year":"2010","journal-title":"Thromb. Haemost."},{"key":"ref18\/cit18","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1055\/s-0038-1648847","volume":"72","author":"Kamiguti A. S.","year":"1994","journal-title":"Thromb. Haemost."},{"key":"ref19\/cit19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.abb.2005.06.007","volume":"441","author":"Gallagher P.","year":"2005","journal-title":"Arch. Biochem. Biophys."},{"key":"ref20\/cit20","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1042\/BJ20050483","volume":"391","author":"Serrano S. M.","year":"2005","journal-title":"Biochem. J."},{"key":"ref21\/cit21","doi-asserted-by":"crossref","first-page":"39746","DOI":"10.1074\/jbc.M604855200","volume":"281","author":"Serrano S. M.","year":"2006","journal-title":"J. Biol. Chem."},{"key":"ref22\/cit22","doi-asserted-by":"crossref","first-page":"3611","DOI":"10.1111\/j.1742-4658.2007.05895.x","volume":"274","author":"Serrano S. M.","year":"2007","journal-title":"FEBS J."},{"key":"ref23\/cit23","doi-asserted-by":"crossref","first-page":"e727","DOI":"10.1371\/journal.pntd.0000727","volume":"4","author":"Baldo C.","year":"2010","journal-title":"PLoS Neglected Trop. Dis."},{"key":"ref24\/cit24","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1074\/mcp.R200007-MCP200","volume":"1","author":"Anderson N. L.","year":"2002","journal-title":"Mol. Cell. Proteomics"},{"key":"ref25\/cit25","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1002\/mas.20037","volume":"24","author":"Huang C. M.","year":"2005","journal-title":"Mass Spectrom. Rev."},{"key":"ref26\/cit26","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1016\/0041-0101(86)90094-2","volume":"24","author":"Assakura M. T.","year":"1986","journal-title":"Toxicon"},{"key":"ref27\/cit27","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1016\/j.bbrc.2004.08.012","volume":"322","author":"Silva C. A.","year":"2004","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref28\/cit28","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/j.toxicon.2009.02.019","volume":"53","author":"Oliveira A. K.","year":"2009","journal-title":"Toxicon"},{"key":"ref29\/cit29","doi-asserted-by":"crossref","first-page":"3915","DOI":"10.1016\/j.febslet.2008.10.034","volume":"582","author":"Menezes M. C.","year":"2008","journal-title":"FEBS Lett."},{"key":"ref30\/cit30","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1002\/1615-9861(200111)1:11<1359::AID-PROT1359>3.0.CO;2-Q","volume":"1","author":"Mortz E.","year":"2001","journal-title":"Proteomics"},{"key":"ref31\/cit31","doi-asserted-by":"crossref","first-page":"2495","DOI":"10.1099\/00221287-146-10-2495","volume":"146","author":"Hanna S. L.","year":"2000","journal-title":"Microbiology"},{"key":"ref32\/cit32","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1021\/pr0602996","volume":"6","author":"Aristoteli L. P.","year":"2007","journal-title":"J. Proteome Res."},{"key":"ref33\/cit33","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1002\/pmic.200400931","volume":"5","author":"Serrano S. M.","year":"2005","journal-title":"Proteomics"},{"key":"ref34\/cit34","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1038\/227680a0","volume":"227","author":"Laemmli U. K.","year":"1970","journal-title":"Nature"},{"key":"ref35\/cit35","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.abb.2006.09.018","volume":"455","author":"Escalante T.","year":"2006","journal-title":"Arch. Biochem. Biophys."},{"key":"ref36\/cit36","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1006\/exmp.1995.1042","volume":"63","author":"Rucavado A.","year":"1995","journal-title":"Exp. Mol. Pathol."},{"key":"ref37\/cit37","doi-asserted-by":"crossref","first-page":"5120","DOI":"10.1021\/pr900489m","volume":"8","author":"Escalante T.","year":"2009","journal-title":"J. Proteome Res."},{"key":"ref38\/cit38","doi-asserted-by":"crossref","first-page":"5846","DOI":"10.1074\/jbc.273.10.5846","volume":"273","author":"Tortorella M. D.","year":"1998","journal-title":"J. Biol. Chem."},{"key":"ref39\/cit39","first-page":"283","volume":"43","author":"Yanagishita M.","year":"1993","journal-title":"Acta Pathol. Jpn."},{"key":"ref40\/cit40","first-page":"21","volume":"51","author":"Formigli L.","year":"2007","journal-title":"Eur. J. Histochem."},{"key":"ref41\/cit41","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1016\/j.toxicon.2003.11.005","volume":"42","author":"Guti\u00e9rrez J. M.","year":"2003","journal-title":"Toxicon"},{"key":"ref42\/cit42","doi-asserted-by":"crossref","first-page":"2050","DOI":"10.1016\/j.yexcr.2007.03.040","volume":"313","author":"Ivaska J.","year":"2007","journal-title":"Exp. Cell Res."},{"key":"ref43\/cit43","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1038\/ncb898","volume":"5","author":"Mor-Vaknin N.","year":"2003","journal-title":"Nat. Cell Biol."},{"key":"ref44\/cit44","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1007\/s10495-005-2945-1","volume":"10","author":"Tanjoni I.","year":"2005","journal-title":"Apoptosis"},{"key":"ref45\/cit45","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1083\/jcb.200307098","volume":"164","author":"Benaud C.","year":"2004","journal-title":"Cell Biol."},{"key":"ref46\/cit46","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1160\/TH06-08-0436","volume":"97","author":"Kuypers F. A.","year":"2007","journal-title":"Thromb. Haemost."},{"key":"ref47\/cit47","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.abb.2007.04.037","volume":"465","author":"Pinto A. F.","year":"2007","journal-title":"Arch. Biochem. Biophys."},{"key":"ref48\/cit48","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1038\/nature05935","volume":"448","author":"Ousman S. S.","year":"2007","journal-title":"Nature"},{"key":"ref49\/cit49","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1016\/S0021-9258(19)75843-8","volume":"262","author":"Carson S. D.","year":"1987","journal-title":"J. Biol. Chem."},{"key":"ref50\/cit50","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1016\/j.orthres.2005.01.003","volume":"23","author":"Tajima T.","year":"2005","journal-title":"J. Orthop. Res."},{"key":"ref51\/cit51","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1021\/bi00456a032","volume":"29","author":"Baramova E. N.","year":"1990","journal-title":"Biochemistry"},{"key":"ref52\/cit52","doi-asserted-by":"crossref","first-page":"7907","DOI":"10.1021\/bi025770x","volume":"41","author":"Makogonenko E.","year":"2002","journal-title":"Biochemistry"},{"key":"ref53\/cit53","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1089\/104454902753759717","volume":"21","author":"Tolosano E.","year":"2002","journal-title":"DNA Cell Biol."},{"key":"ref54\/cit54","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1111\/j.1471-4159.2008.05796.x","volume":"108","author":"Kratzer I.","year":"2009","journal-title":"J. Neurochem."},{"key":"ref55\/cit55","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1021\/bi00117a015","volume":"31","author":"Catanese J. J.","year":"1992","journal-title":"Biochemistry"}],"container-title":["Journal of Proteome Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/pr2006439","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,7]],"date-time":"2023-04-07T01:58:41Z","timestamp":1680832721000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/pr2006439"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,10,27]]},"references-count":55,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012,1,1]]}},"alternative-id":["10.1021\/pr2006439"],"URL":"https:\/\/doi.org\/10.1021\/pr2006439","relation":{},"ISSN":["1535-3893","1535-3907"],"issn-type":[{"value":"1535-3893","type":"print"},{"value":"1535-3907","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,10,27]]}}}