{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T07:12:42Z","timestamp":1790493162088,"version":"4.1.0"},"reference-count":60,"publisher":"American Chemical Society (ACS)","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Proteome Res."],"published-print":{"date-parts":[[2013,10,4]]},"DOI":"10.1021\/pr400403p","type":"journal-article","created":{"date-parts":[[2013,9,2]],"date-time":"2013-09-02T09:46:28Z","timestamp":1378115188000},"page":"4393-4401","source":"Crossref","is-referenced-by-count":92,"title":["Rapid Diagnosis and Prognosis of\n                    <i>de novo<\/i>\n                    Acute Myeloid Leukemia by Serum Metabonomic Analysis"],"prefix":"10.1021","volume":"12","author":[{"given":"Yihuang","family":"Wang","sequence":"first","affiliation":[{"name":"State\rKey Laboratory of Medical Genomics, Institute of Health Sciences,\rShanghai Institutes for Biological Sciences and Graduate School, Chinese Academy of Sciences and Shanghai Institute of Hematology, Rui Jin Hospital, affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China"},{"name":"Key\rLaboratory of Systems Biomedicine (Ministry of Education), Shanghai\rCenter for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Limin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key\rLaboratory of Magnetic Resonance in Biological Systems, State Key\rLaboratory of Magnetic Resonance and Atomic and Molecular Physics,\rCentre for Biospectroscopy and Metabonomics, Wuhan Institute of Physics\rand Mathematics, Chinese Academy of Sciences, Wuhan 430071, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Lian","family":"Chen","sequence":"additional","affiliation":[{"name":"State\rKey Laboratory of Medical Genomics, Institute of Health Sciences,\rShanghai Institutes for Biological Sciences and Graduate School, Chinese Academy of Sciences and Shanghai Institute of Hematology, Rui Jin Hospital, affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing-Han","family":"Wang","sequence":"additional","affiliation":[{"name":"State\rKey Laboratory of Medical Genomics, Institute of Health Sciences,\rShanghai Institutes for Biological Sciences and Graduate School, Chinese Academy of Sciences and Shanghai Institute of Hematology, Rui Jin Hospital, affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Li","sequence":"additional","affiliation":[{"name":"Key\rLaboratory of Magnetic Resonance in Biological Systems, State Key\rLaboratory of Magnetic Resonance and Atomic and Molecular Physics,\rCentre for Biospectroscopy and Metabonomics, Wuhan Institute of Physics\rand Mathematics, Chinese Academy of Sciences, Wuhan 430071, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun-Min","family":"Li","sequence":"additional","affiliation":[{"name":"State\rKey Laboratory of Medical Genomics, Institute of Health Sciences,\rShanghai Institutes for Biological Sciences and Graduate School, Chinese Academy of Sciences and Shanghai Institute of Hematology, Rui Jin Hospital, affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian-Qing","family":"Mi","sequence":"additional","affiliation":[{"name":"State\rKey Laboratory of Medical Genomics, Institute of Health Sciences,\rShanghai Institutes for Biological Sciences and Graduate School, Chinese Academy of Sciences and Shanghai Institute of Hematology, Rui Jin Hospital, affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Na","family":"Zhang","sequence":"additional","affiliation":[{"name":"State\rKey Laboratory of Medical Genomics, Institute of Health Sciences,\rShanghai Institutes for Biological Sciences and Graduate School, Chinese Academy of Sciences and Shanghai Institute of Hematology, Rui Jin Hospital, affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Li","sequence":"additional","affiliation":[{"name":"State\rKey Laboratory of Medical Genomics, Institute of Health Sciences,\rShanghai Institutes for Biological Sciences and Graduate School, Chinese Academy of Sciences and Shanghai Institute of Hematology, Rui Jin Hospital, affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Song-Fang","family":"Wu","sequence":"additional","affiliation":[{"name":"State\rKey Laboratory of Medical Genomics, Institute of Health Sciences,\rShanghai Institutes for Biological Sciences and Graduate School, Chinese Academy of Sciences and Shanghai Institute of Hematology, Rui Jin Hospital, affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China"},{"name":"Key\rLaboratory of Systems Biomedicine (Ministry of Education), Shanghai\rCenter for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Jin","sequence":"additional","affiliation":[{"name":"Zhejiang\rInstitute of Hematology, First Hospital affiliated to Zhejiang University School of Medicine, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun-Gui","family":"Wang","sequence":"additional","affiliation":[{"name":"Zhejiang\rInstitute of Hematology, First Hospital affiliated to Zhejiang University School of Medicine, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"He","family":"Huang","sequence":"additional","affiliation":[{"name":"Zhejiang\rInstitute of Hematology, First Hospital affiliated to Zhejiang University School of Medicine, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhu","family":"Chen","sequence":"additional","affiliation":[{"name":"State\rKey Laboratory of Medical Genomics, Institute of Health Sciences,\rShanghai Institutes for Biological Sciences and Graduate School, Chinese Academy of Sciences and Shanghai Institute of Hematology, Rui Jin Hospital, affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China"},{"name":"Key\rLaboratory of Systems Biomedicine (Ministry of Education), Shanghai\rCenter for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sai-Juan","family":"Chen","sequence":"additional","affiliation":[{"name":"State\rKey Laboratory of Medical Genomics, Institute of Health Sciences,\rShanghai Institutes for Biological Sciences and Graduate School, Chinese Academy of Sciences and Shanghai Institute of Hematology, Rui Jin Hospital, affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China"},{"name":"Key\rLaboratory of Systems Biomedicine (Ministry of Education), Shanghai\rCenter for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiru","family":"Tang","sequence":"additional","affiliation":[{"name":"Key\rLaboratory of Magnetic Resonance in Biological Systems, State Key\rLaboratory of Magnetic Resonance and Atomic and Molecular Physics,\rCentre for Biospectroscopy and Metabonomics, Wuhan Institute of Physics\rand Mathematics, Chinese Academy of Sciences, Wuhan 430071, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2013,9,18]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"crossref","first-page":"69","DOI":"10.3322\/caac.20107","volume":"61","author":"Jemal A.","year":"2011","journal-title":"CA-Cancer J. Clin."},{"key":"ref2\/cit2","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1111\/j.1365-2141.1976.tb03563.x","volume":"33","author":"Bennett J. M.","year":"1976","journal-title":"Br. J. Hamaetol."},{"key":"ref3\/cit3","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.1038\/leu.2012.57","volume":"26","author":"Mi J. Q.","year":"2012","journal-title":"Leukemia"},{"key":"ref4\/cit4","first-page":"1110","volume":"27","author":"Zou P.","year":"2007","journal-title":"Chin. J. Pract. Intern. Med."},{"key":"ref5\/cit5","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1182\/asheducation-2011.1.43","author":"Roboz G. J.","year":"2011","journal-title":"Hematol. Am. Soc. Hematol. Educ. Program"},{"key":"ref6\/cit6","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1182\/blood-2009-03-209262","volume":"114","author":"Vardiman J. W.","year":"2009","journal-title":"Blood"},{"key":"ref7\/cit7","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1182\/asheducation-2009.1.385","author":"Grimwade D.","year":"2009","journal-title":"Hematol. Am. Soc. Hematol. Educ. Program"},{"key":"ref8\/cit8","doi-asserted-by":"crossref","first-page":"984","DOI":"10.6004\/jnccn.2012.0103","volume":"10","author":"O\u2019Donnell M. R.","year":"2012","journal-title":"J. Natl. Compr. Cancer Network"},{"key":"ref9\/cit9","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1182\/blood-2009-11-254441","volume":"116","author":"Grimwade D.","year":"2010","journal-title":"Blood"},{"key":"ref10\/cit10","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1182\/blood-2002-02-0492","volume":"100","author":"Gilliland D. G.","year":"2002","journal-title":"Blood"},{"key":"ref11\/cit11","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1056\/NEJMoa041974","volume":"352","author":"Falini B.","year":"2005","journal-title":"N. Engl. J. Med."},{"key":"ref12\/cit12","doi-asserted-by":"crossref","first-page":"3024","DOI":"10.1182\/blood-2009-01-197871","volume":"114","author":"Haferlach C.","year":"2009","journal-title":"Blood"},{"key":"ref13\/cit13","doi-asserted-by":"crossref","first-page":"2403","DOI":"10.1056\/NEJMoa041331","volume":"351","author":"Smith M. L.","year":"2004","journal-title":"N. Engl. J. Med."},{"key":"ref14\/cit14","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1182\/asheducation-2010.1.47","author":"Foran J. M.","year":"2010","journal-title":"Hematology Am Soc Hematol Educ Program"},{"key":"ref15\/cit15","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1038\/4551054a","volume":"455","author":"Nicholson J. K.","year":"2008","journal-title":"Nature"},{"key":"ref16\/cit16","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1038\/nrd1157","volume":"2","author":"Nicholson J. K.","year":"2003","journal-title":"Nat. Rev. Drug Discovery"},{"key":"ref17\/cit17","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1038\/nm1202-802","volume":"8","author":"Brindle J. T.","year":"2002","journal-title":"Nat. Med."},{"key":"ref18\/cit18","doi-asserted-by":"crossref","first-page":"3423","DOI":"10.1021\/pr300280t","volume":"11","author":"Xu W.","year":"2012","journal-title":"J. Proteome Res."},{"key":"ref19\/cit19","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1021\/pr060470d","volume":"6","author":"Marchesi J. R.","year":"2007","journal-title":"J. Proteome Res."},{"key":"ref20\/cit20","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1021\/pr9008223","volume":"9","author":"Bjerrum J. T.","year":"2010","journal-title":"J. Proteome Res."},{"key":"ref21\/cit21","doi-asserted-by":"crossref","first-page":"6408","DOI":"10.1073\/pnas.94.12.6408","volume":"94","author":"Cheng L. L.","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"ref22\/cit22","first-page":"1142","volume":"35","author":"Chen W.","year":"2008","journal-title":"Prog. Biochem. Biophys."},{"key":"ref23\/cit23","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1038\/nature07762","volume":"457","author":"Sreekumar A.","year":"2009","journal-title":"Nature"},{"key":"ref24\/cit24","doi-asserted-by":"crossref","first-page":"2605","DOI":"10.1021\/pr070063h","volume":"6","author":"Yang Y.","year":"2007","journal-title":"J. Proteome Res."},{"key":"ref25\/cit25","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1038\/leu.2009.295","volume":"24","author":"MacIntyre D. A.","year":"2010","journal-title":"Leukemia"},{"key":"ref26\/cit26","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1002\/ijc.20651","volume":"113","author":"Odunsi K.","year":"2005","journal-title":"Int. J. Cancer"},{"key":"ref27\/cit27","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1593\/neo.81396","volume":"11","author":"Tiziani S.","year":"2009","journal-title":"Neoplasia"},{"key":"ref28\/cit28","doi-asserted-by":"crossref","first-page":"e4251","DOI":"10.1371\/journal.pone.0004251","volume":"4","author":"Tiziani S.","year":"2009","journal-title":"PLoS One"},{"key":"ref29\/cit29","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1021\/cb900300j","volume":"6","author":"Lodi A.","year":"2011","journal-title":"ACS Chem. Biol."},{"key":"ref30\/cit30","doi-asserted-by":"crossref","first-page":"5593","DOI":"10.1182\/blood-2011-03-343988","volume":"118","author":"Shen Y.","year":"2011","journal-title":"Blood"},{"key":"ref31\/cit31","doi-asserted-by":"crossref","first-page":"5188","DOI":"10.1021\/pr900524z","volume":"8","author":"Zhang X.","year":"2009","journal-title":"J. Proteome Res."},{"key":"ref32\/cit32","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1021\/pr900995m","volume":"9","author":"Dai H.","year":"2010","journal-title":"J. Proteome Res."},{"key":"ref33\/cit33","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1021\/pr901045c","volume":"9","author":"Dai H.","year":"2010","journal-title":"J. Proteome Res."},{"key":"ref34\/cit34","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1021\/ac048803i","volume":"77","author":"Cloarec O.","year":"2005","journal-title":"Anal. Chem."},{"key":"ref35\/cit35","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1002\/cem.1187","volume":"22","author":"Eriksson L.","year":"2008","journal-title":"J. Chemom."},{"key":"ref36\/cit36","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1021\/ac00101a004","volume":"67","author":"Nicholson J. K.","year":"1995","journal-title":"Anal. Chem."},{"key":"ref37\/cit37","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.ab.2003.10.033","volume":"325","author":"Tang H.","year":"2004","journal-title":"Anal. Biochem."},{"key":"ref38\/cit38","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1085\/jgp.8.6.519","volume":"8","author":"Warburg O.","year":"1927","journal-title":"J. Gen. Physiol."},{"key":"ref39\/cit39","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1126\/science.123.3191.309","volume":"123","author":"Warburg O.","year":"1956","journal-title":"Science"},{"key":"ref40\/cit40","doi-asserted-by":"crossref","first-page":"1805","DOI":"10.1093\/jnci\/96.24.1805","volume":"96","author":"Garber K.","year":"2004","journal-title":"J. Natl. Cancer Inst."},{"key":"ref41\/cit41","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1126\/science.1160809","volume":"324","author":"Vander Heiden M. G.","year":"2009","journal-title":"Science"},{"key":"ref42\/cit42","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1097\/CCO.0b013e32834deb9e","volume":"24","author":"Bayley J. P.","year":"2012","journal-title":"Curr. Opin. Oncol."},{"key":"ref43\/cit43","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.cell.2011.02.013","volume":"144","author":"Hanahan D.","year":"2011","journal-title":"Cell"},{"key":"ref44\/cit44","first-page":"285","volume":"131","author":"Parker C. E.","year":"1979","journal-title":"West. J. Med."},{"key":"ref45\/cit45","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/S0950-351X(97)80942-1","volume":"11","author":"Soeters P. B.","year":"1997","journal-title":"Baillieres Clin. Endocrinol. Metab."},{"key":"ref46\/cit46","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1097\/00000658-199312000-00004","volume":"218","author":"Souba W. W.","year":"1993","journal-title":"Ann. Surg."},{"key":"ref47\/cit47","doi-asserted-by":"crossref","first-page":"13","DOI":"10.4103\/0971-5851.96962","volume":"33","author":"Gaurav K.","year":"2012","journal-title":"Indian J. Med. Paediatr. Oncol."},{"key":"ref48\/cit48","doi-asserted-by":"crossref","first-page":"4038","DOI":"10.1021\/pr100226m","volume":"9","author":"Zira A. N.","year":"2010","journal-title":"J. Proteome Res."},{"key":"ref49\/cit49","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.semcancer.2005.04.003","volume":"15","author":"Lai H. S.","year":"2005","journal-title":"Semin. Cancer Biol."},{"key":"ref50\/cit50","first-page":"298","volume":"93","author":"Musolino C.","year":"2002","journal-title":"Recenti Prog. Med."},{"key":"ref51\/cit51","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1007\/s005990070013","volume":"30","author":"Fiorenza A. M.","year":"2000","journal-title":"Int. J. Clin. Lab. Res."},{"key":"ref52\/cit52","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1002\/(SICI)1097-0142(19980715)83:2<379::AID-CNCR24>3.0.CO;2-P","volume":"83","author":"Halton J. M.","year":"1998","journal-title":"Cancer"},{"key":"ref53\/cit53","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1002\/(SICI)1099-1492(199911)12:7<413::AID-NBM587>3.0.CO;2-U","volume":"12","author":"Podo F.","year":"1999","journal-title":"NMR Biomed."},{"key":"ref54\/cit54","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1016\/S0145-2126(02)00035-8","volume":"26","author":"Franks S. E.","year":"2002","journal-title":"Leuk. Res."},{"key":"ref55\/cit55","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.2217\/14622416.7.7.1109","volume":"7","author":"Glunde K.","year":"2006","journal-title":"Pharmacogenomics"},{"key":"ref56\/cit56","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1111\/j.1349-7006.2009.01086.x","volume":"100","author":"Gao H.","year":"2009","journal-title":"Cancer Sci."},{"key":"ref57\/cit57","doi-asserted-by":"crossref","first-page":"2873","DOI":"10.1021\/pr200200y","volume":"10","author":"Cano K. E.","year":"2011","journal-title":"J. Proteome Res."},{"key":"ref58\/cit58","doi-asserted-by":"crossref","first-page":"e248","DOI":"10.1038\/cddis.2011.123","volume":"3","author":"Munoz-Pinedo C.","year":"2012","journal-title":"Cell Death Dis."},{"key":"ref59\/cit59","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1136\/bmj.38415.708634.F7","volume":"330","author":"Evans J. M.","year":"2005","journal-title":"Br. Med. J."},{"key":"ref60\/cit60","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1042\/CS20110386","volume":"122","author":"Viollet B.","year":"2012","journal-title":"Clin. Sci. (London)"}],"container-title":["Journal of Proteome Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/pr400403p","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,2]],"date-time":"2023-04-02T05:18:06Z","timestamp":1680412686000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/pr400403p"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,9,18]]},"references-count":60,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2013,10,4]]}},"alternative-id":["10.1021\/pr400403p"],"URL":"https:\/\/doi.org\/10.1021\/pr400403p","relation":{},"ISSN":["1535-3893","1535-3907"],"issn-type":[{"value":"1535-3893","type":"print"},{"value":"1535-3907","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,9,18]]}}}