{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T06:15:27Z","timestamp":1788329727222,"version":"build-2803163510"},"reference-count":58,"publisher":"American Chemical Society (ACS)","issue":"2","license":[{"start":{"date-parts":[[2015,12,8]],"date-time":"2015-12-08T00:00:00Z","timestamp":1449532800000},"content-version":"vor","delay-in-days":365,"URL":"https:\/\/pubs.acs.org\/page\/policy\/authorchoice_termsofuse.html"}],"funder":[{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["5P41 GM 103391-03"],"award-info":[{"award-number":["5P41 GM 103391-03"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["AR056138-01A2"],"award-info":[{"award-number":["AR056138-01A2"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/na","name":"European Social Funds","doi-asserted-by":"publisher","award":["NA"],"award-info":[{"award-number":["NA"]}],"id":[{"id":"10.13039\/na","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,2,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Imaging mass spectrometry (IMS) was employed for the analysis of frozen skin biopsies to investigate the differences between stage IV pressure ulcers that remain stalled, stagnant, and unhealed versus those exhibiting clinical and histological signs of improvement. Our data reveal a rich diversity of proteins that are dynamically modulated, and we selectively highlight a family of calcium binding proteins (S-100 molecules) including calcyclin (S100-A6), calgranulins A (S100-A8) and B (S100-A9), and calgizzarin (S100-A11). IMS allowed us to target three discrete regions of interest: the wound bed, adjacent dermis, and hypertrophic epidermis. Plots derived using unsupervised principal component analysis of the global protein signatures within these three spatial niches indicate that these data from wound signatures have potential as a prognostic tool since they appear to delineate wounds that are favorably responding to therapeutic interventions versus those that remain stagnant or intractable in their healing status. Our discovery-based approach with IMS augments current knowledge of the molecular signatures within pressure ulcers while providing a rationale for a focused examination of the role of calcium modulators within the context of impaired wound healing.<\/jats:p>","DOI":"10.1021\/pr5010218","type":"journal-article","created":{"date-parts":[[2014,12,8]],"date-time":"2014-12-08T19:21:19Z","timestamp":1418066479000},"page":"986-996","source":"Crossref","is-referenced-by-count":37,"title":["Imaging Mass Spectrometry\nfor Assessing Cutaneous\nWound Healing: Analysis of Pressure Ulcers"],"prefix":"10.1021","volume":"14","author":[{"given":"Domenico","family":"Taverna","sequence":"first","affiliation":[{"name":"Universita\u0300 della Calabria , , Via P. Bucci, cubo 12\/D , , ,","place":["Arcavacata di Rende, CS, Italy, 87036"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alonda C.","family":"Pollins","sequence":"additional","affiliation":[{"name":"Vanderbilt University Medical Center , 1161 21st Avenue South, MCN S2221 , , ,","place":["Nashville, Tennessee, United States, 37232-2631"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Sindona","sequence":"additional","affiliation":[{"name":"Universita\u0300 della Calabria , , Via P. Bucci, cubo 12\/C , , , ,","place":["Arcavacata di Rende, CS, Italy, 87036"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard M.","family":"Caprioli","sequence":"additional","affiliation":[{"name":"Vanderbilt University School of Medicine , , 465 21st Avenue South, Medical Research Building 3, Room 9160 , , ,","place":["Nashville, Tennessee, United States, 37232-8575"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lillian B.","family":"Nanney","sequence":"additional","affiliation":[{"name":"Vanderbilt University School of Medicine , 1161 21st Avenue South, MCN S2221 , , ,","place":["Nashville, Tennessee, United States, 37232-2631"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2014,12,8]]},"reference":[{"key":"2026090201461152800_cit1","doi-asserted-by":"crossref","first-page":"2328","DOI":"10.1016\/j.foodchem.2013.05.034","article-title":"Comprehensive assay\nof flavanones in citrus juices and beverages by UHPLC-ESI-MS\/MS and\nderivatization chemistry","volume":"141","author":"Di Donna","year":"2013","journal-title":"Food Chem."},{"key":"2026090201461152800_cit2","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1002\/pca.2493","article-title":"Structural\ncharacterisation of malonyl flavonols in leek (Allium porrum L.) using high-performance liquid chromatography and mass spectrometry","volume":"25","author":"Donna","year":"2014","journal-title":"Phytochem. Anal."},{"key":"2026090201461152800_cit3","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.ijms.2013.07.012","article-title":"Evaluation of dialdehydic\nanti-inflammatory active principles in extra-virgin olive oil by reactive\npaper spray mass spectrometry","volume":"352","author":"Mazzotti","year":"2013","journal-title":"Int. J. Mass\nSpectrom."},{"key":"2026090201461152800_cit4","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1002\/jms.3181","article-title":"High-throughput determination of\nSudan Azo-dyes within\npowdered chili pepper by paper spray mass spectrometry","volume":"48","author":"Taverna","year":"2013","journal-title":"J. Mass Spectrom."},{"key":"2026090201461152800_cit5","doi-asserted-by":"crossref","first-page":"4751","DOI":"10.1021\/ac970888i","article-title":"Molecular imaging of biological samples:\nlocalization of peptides and proteins using MALDI-TOF MS","volume":"69","author":"Caprioli","year":"1997","journal-title":"Anal. 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Cancer Res."},{"key":"2026090201461152800_cit14","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1002\/jms.1177","article-title":"Identification\nof\nproteins directly from tissue: in situ tryptic digestions coupled\nwith imaging mass spectrometry","volume":"42","author":"Groseclose","year":"2007","journal-title":"J. Mass Spectrom."},{"key":"2026090201461152800_cit15","doi-asserted-by":"crossref","first-page":"3715","DOI":"10.1002\/pmic.200800495","article-title":"High-throughput\nproteomic analysis of formalin-fixed paraffin-embedded tissue microarrays\nusing MALDI imaging mass spectrometry","volume":"8","author":"Groseclose","year":"2008","journal-title":"Proteomics."},{"key":"2026090201461152800_cit16","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1021\/pr060549i","article-title":"Direct analysis and MALDI imaging\nof formalin-fixed,\nparaffin-embedded tissue sections","volume":"6","author":"Lemaire","year":"2007","journal-title":"J. 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Proteomics."},{"key":"2026090201461152800_cit20","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1016\/j.jasms.2008.02.013","article-title":"Solvent-free matrix\ndry-coating for MALDI imaging of phospholipids","volume":"19","author":"Puolitaival","year":"2008","journal-title":"J. Am. Soc. Mass Spectrom."},{"key":"2026090201461152800_cit21","doi-asserted-by":"crossref","first-page":"6448","DOI":"10.1021\/ac060788p","article-title":"Direct molecular analysis of whole-body animal tissue\nsections by imaging MALDI mass spectrometry","volume":"78","author":"Khatib-Shahidi","year":"2006","journal-title":"Anal. Chem."},{"key":"2026090201461152800_cit22","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1002\/jms.525","article-title":"Direct analysis\nof drug candidates in tissue by matrix-assisted\nlaser desorption\/ionization mass spectrometry","volume":"38","author":"Reyzer","year":"2003","journal-title":"J. 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Nurs."},{"key":"2026090201461152800_cit26","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1111\/j.1524-475X.2009.00522.x","article-title":"African Americans\nshow increased risk for pressure ulcers: a retrospective analysis\nof acute care hospitals in America","volume":"17","author":"Fogerty","year":"2009","journal-title":"Wound Repair\nRegener."},{"key":"2026090201461152800_cit27","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/j.1524-475X.2007.00327.x","article-title":"Risk factors\nfor pressure ulcers in acute care hospitals","volume":"16","author":"Fogerty","year":"2008","journal-title":"Wound Repair Regener."},{"key":"2026090201461152800_cit28","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1111\/j.1524-475X.2009.00543.x","article-title":"Human skin wounds: a major and snowballing\nthreat to public health and the economy","volume":"17","author":"Sen","year":"2009","journal-title":"Wound\nRepair Regener."},{"key":"2026090201461152800_cit29","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1111\/j.1524-475X.2012.00791.x","article-title":"Analysis of the\nproteomic profile of chronic pressure ulcers","volume":"20","author":"Edsberg","year":"2012","journal-title":"Wound Repair Regener."},{"key":"2026090201461152800_cit30","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1111\/j.1524-475X.2011.00738.x","article-title":"Multiplexed\nmolecular descriptors of pressure ulcers defined by imaging mass spectrometry","volume":"19","author":"Taverna","year":"2011","journal-title":"Wound Repair Regener."},{"key":"2026090201461152800_cit31","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1111\/j.1600-0625.2011.01289.x","article-title":"Spatial mapping\nby imaging mass spectrometry offers advancements for rapid definition\nof human skin proteomic signatures","volume":"20","author":"Taverna","year":"2011","journal-title":"Exp. Dermatol."},{"key":"2026090201461152800_cit32","doi-asserted-by":"crossref","first-page":"2717","DOI":"10.1021\/ac3031493","article-title":"Localized\nin situ hydrogel-mediated\nprotein digestion and extraction technique for on-tissue analysis","volume":"85","author":"Harris","year":"2013","journal-title":"Anal. Chem."},{"key":"2026090201461152800_cit33","doi-asserted-by":"crossref","first-page":"7191","DOI":"10.1021\/ac400902h","article-title":"MALDI Imaging and\nin situ identification of integral membrane proteins from rat brain\ntissue sections","volume":"85","author":"Nicklay","year":"2013","journal-title":"Anal. Chem."},{"key":"2026090201461152800_cit34","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.1021\/ac00104a020","article-title":"Method to correlate\ntandem mass spectra of modified peptides to amino acid sequences in\nthe protein database","volume":"67","author":"Yates","year":"1995","journal-title":"Anal. Chem."},{"key":"2026090201461152800_cit35","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/978-1-4020-6191-2_5","article-title":"Pathologies involving the S100 proteins\nand RAGE","volume":"45","author":"Heizmann","year":"2007","journal-title":"Subcell. Biochem."},{"key":"2026090201461152800_cit36","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1111\/j.0022-202X.2004.22719.x","article-title":"S100 proteins in the epidermis","volume":"123","author":"Eckert","year":"2004","journal-title":"J. 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Proteomics"},{"key":"2026090201461152800_cit39","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1111\/j.1440-1827.2011.02783.x","article-title":"Matrix-assisted laser desorption\/ionization\nmass spectrometry reveals decreased calcylcin expression in small\ncell lung cancer","volume":"62","author":"Lee","year":"2012","journal-title":"Pathol. Int."},{"key":"2026090201461152800_cit40","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00432-011-1062-5","article-title":"Calcium-binding\nprotein S100P and cancer: mechanisms and clinical relevance","volume":"138","author":"Jiang","year":"2012","journal-title":"J. Cancer Res. Clin. 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Immunol."},{"key":"2026090201461152800_cit56","doi-asserted-by":"crossref","first-page":"2453","DOI":"10.1182\/blood-2006-08-040444","article-title":"MRP8\/MRP14 impairs endothelial integrity\nand induces a caspase-dependent and -independent cell death program","volume":"109","author":"Viemann","year":"2007","journal-title":"Blood"},{"key":"2026090201461152800_cit57","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1016\/j.jmb.2007.04.065","article-title":"The crystal structure of the human\n(S100A8\/S100A9)2 heterotetramer, calprotectin, illustrates how conformational\nchanges of interacting alpha-helices can determine specific association\nof two EF-hand proteins","volume":"370","author":"Korndorfer","year":"2007","journal-title":"J. Mol. Biol."},{"key":"2026090201461152800_cit58","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1016\/0140-6736(90)93237-J","article-title":"Antimicrobial actions of calcium binding leucocyte\nL1 protein, calprotectin","volume":"336","author":"Steinbakk","year":"1990","journal-title":"Lancet"}],"container-title":["Journal of Proteome Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/pr5010218","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/jprobs\/article-pdf\/14\/2\/986\/15506759\/pr5010218.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/jprobs\/article-pdf\/14\/2\/986\/15506759\/pr5010218.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T05:46:28Z","timestamp":1788327988000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/jprobs\/article\/14\/2\/986\/1464174\/Imaging-Mass-Spectrometry-for-Assessing-Cutaneous"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12,8]]},"references-count":58,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2014,12,8]]},"published-print":{"date-parts":[[2015,2,6]]}},"URL":"https:\/\/doi.org\/10.1021\/pr5010218","relation":{},"ISSN":["1535-3893","1535-3907"],"issn-type":[{"value":"1535-3893","type":"print"},{"value":"1535-3907","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,12,8]]}}}