{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T21:23:24Z","timestamp":1785533004153,"version":"3.56.0"},"reference-count":70,"publisher":"American Chemical Society (ACS)","issue":"7","license":[{"start":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T00:00:00Z","timestamp":1771804800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100031478","name":"NextGenerationEU","doi-asserted-by":"publisher","award":["ECS 0000024 ,CUP B83C22002820006"],"award-info":[{"award-number":["ECS 0000024 ,CUP B83C22002820006"]}],"id":[{"id":"10.13039\/100031478","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,7,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The mTOR inhibitor everolimus improved progression-free survival in patients with hormone receptor-positive breast cancer resistant to hormone therapy. Despite initial success, everolimus has not yet realized its full therapeutic potential due to its associated toxicities and the development of resistance. Here, we exploited biocompatible lignin nanoparticles to enhance everolimus delivery and the mechanism of action in hormone receptor-positive breast cancer cells. Everolimus was released from the lignin nanoparticles in a concentration-dependent manner, following a Fickian diffusion-like model. The nanoparticles protected the drug from potential pH-induced degradation. Confocal microscopy confirmed the diffusion and cytoplasmic localization of lignin nanoparticles, as well as the efficient release of the drug. Everolimus release effectively inhibits the proliferation in breast cancer MCF7 cells. EVE\/LNPs showed an improved in vitro antitumor effect compared to EVE against the MCF7 cell line (63 vs 81% survival rate at 10 nM). Under acidic pH conditions, the lignin nanoparticles underwent partial degradation, probably generating oligomers with potential modulating effects on mTOR and FOXM1. Molecular docking simulations showed that lignin oligomers could selectively interact with the ATP-binding cavity of mTOR. The affinity of these interactions was modulated by the redox state of the lignin oligomers, with the strongest bond being observed for quinone derivatives. This dual-action mechanism, which combines drug delivery and modulation of cellular signaling, offers a promising \u201con\/off\u201d switch approach to enhance everolimus-based cancer therapies. Further in vivo studies are warranted to validate these findings.<\/jats:p>","DOI":"10.1021\/prechem.5c00290","type":"journal-article","created":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T12:40:01Z","timestamp":1771850401000},"page":"950-963","source":"Crossref","is-referenced-by-count":1,"title":["Everolimus Delivery\nvia Lignin Nanoparticles Enhances\nAntitumor Activity in Hormone Receptor-Positive Breast Cancer"],"prefix":"10.1021","volume":"4","author":[{"given":"Sofia","family":"Gabellone","sequence":"first","affiliation":[{"name":"IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) \u201cDino Amadori\u201d , , ,","place":["Meldola, Italy, 47014"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Spadazzi","sequence":"additional","affiliation":[{"name":"IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) \u201cDino Amadori\u201d , , ,","place":["Meldola, Italy, 47014"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davide","family":"Piccinino","sequence":"additional","affiliation":[{"name":"Universita\u0300 degli Studi della Tuscia, Largo dell\u2019Universita\u0300 s.n.c. , , ,","place":["Viterbo, Italy, 01100"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0689-6720","authenticated-orcid":true,"given":"Tiziana","family":"Castrignano\u0300","sequence":"additional","affiliation":[{"name":"Universita\u0300 degli Studi della Tuscia , , ,","place":["Viterbo, Italy, 01100"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Cocchi","sequence":"additional","affiliation":[{"name":"IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) \u201cDino Amadori\u201d , , ,","place":["Meldola, Italy, 47014"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Calabrese","sequence":"additional","affiliation":[{"name":"IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) \u201cDino Amadori\u201d , , ,","place":["Meldola, Italy, 47014"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Carotenuto","sequence":"additional","affiliation":[{"name":"Universita\u0300 degli Studi della Tuscia , , ,","place":["Viterbo, Italy, 01100"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1677-5797","authenticated-orcid":true,"given":"Alessandro","family":"De Vita","sequence":"additional","affiliation":[{"name":"IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) \u201cDino Amadori\u201d , , ,","place":["Meldola, Italy, 47014"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Ceccotti Vlas","sequence":"additional","affiliation":[{"name":"Universita\u0300 degli Studi della Tuscia , , ,","place":["Viterbo, Italy, 01100"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giacomo","family":"Miserocchi","sequence":"additional","affiliation":[{"name":"IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) \u201cDino Amadori\u201d , , ,","place":["Meldola, Italy, 47014"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1192-7322","authenticated-orcid":true,"given":"Silvia","family":"Vanni","sequence":"additional","affiliation":[{"name":"IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) \u201cDino Amadori\u201d , , ,","place":["Meldola, Italy, 47014"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofia","family":"Dellavalle","sequence":"additional","affiliation":[{"name":"IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) \u201cDino Amadori\u201d , , ,","place":["Meldola, Italy, 47014"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oneda","family":"Cani","sequence":"additional","affiliation":[{"name":"IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) \u201cDino Amadori\u201d , , ,","place":["Meldola, Italy, 47014"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Sbanchi","sequence":"additional","affiliation":[{"name":"IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) \u201cDino Amadori\u201d , , ,","place":["Meldola, Italy, 47014"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniele","family":"Avitabile","sequence":"additional","affiliation":[{"name":"IDI Farmaceutici , ,","place":["Pomezia, Italy, 00071"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Liverani","sequence":"additional","affiliation":[{"name":"IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) \u201cDino Amadori\u201d , , ,","place":["Meldola, Italy, 47014"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raffaele","family":"Saladino","sequence":"additional","affiliation":[{"name":"Universita\u0300 degli Studi della Tuscia , , ,","place":["Viterbo, Italy, 01100"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,2,23]]},"reference":[{"issue":"1","key":"2026073101042723400_cit1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-023-01827-6","article-title":"PI3K\/AKT\/mTOR signaling transduction pathway\nand targeted therapies in cancer","volume":"22","author":"Glaviano","year":"2023","journal-title":"Mol. Cancer"},{"issue":"3","key":"2026073101042723400_cit2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24032652","article-title":"The Role of\nPI3K\/AKT\/mTOR Signaling\nin Hepatocellular Carcinoma Metabolism","volume":"24","author":"Tian","year":"2023","journal-title":"Int.\nJ. Mol. Sci."},{"issue":"2","key":"2026073101042723400_cit3","doi-asserted-by":"publisher","DOI":"10.3390\/cancers11020254","article-title":"Casticin-Induced\nInhibition of Cell Growth and Survival Are Mediated through the Dual\nModulation of Akt\/mTOR Signaling Cascade","volume":"11","author":"Lee","year":"2019","journal-title":"Cancers"},{"issue":"6","key":"2026073101042723400_cit4","doi-asserted-by":"publisher","first-page":"372","DOI":"10.3109\/07853890.2014.912836","article-title":"PI3K\/AKT signaling\npathway and cancer: an updated review","volume":"46","author":"Martini","year":"2014","journal-title":"Ann.\nMed."},{"issue":"5","key":"2026073101042723400_cit5","doi-asserted-by":"publisher","first-page":"1121","DOI":"10.1002\/ijc.24831","article-title":"(2010).\nPI3K pathway activation in breast cancer is associated with the basal-like\nphenotype and cancer-specific mortality","volume":"126","author":"Lo\u0301pez-Knowles","year":"2010","journal-title":"Int.\nJ. Cancer"},{"issue":"1","key":"2026073101042723400_cit6","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-023-01608-z","article-title":"Multifaceted\nrole of mTOR (mammalian target of rapamycin) signaling pathway in\nhuman health and disease","volume":"8","author":"Panwar","year":"2023","journal-title":"Signal Transduction\nTargeted Ther."},{"key":"2026073101042723400_cit7","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/j.jbior.2019.03.003","article-title":"Diverse signaling mechanisms of mTOR\ncomplexes: mTORC1 and mTORC2 in forming a formidable relationship","volume":"72","author":"Jhanwar-Uniyal","year":"2019","journal-title":"Adv. Biol. Regul."},{"issue":"11","key":"2026073101042723400_cit8","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25116141","article-title":"mTOR: Its Critical\nRole in Metabolic\nDiseases, Cancer, and the Aging Process","volume":"25","author":"Marafie","year":"2024","journal-title":"Int.\nJ. Mol. Sci."},{"issue":"6","key":"2026073101042723400_cit9","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2023.e17052","article-title":"Emodin attenuates\nhigh lipid-induced liver metastasis through the AKT and ERK pathways in vitro in breast cancer cells and in a mouse xenograft\nmodel","volume":"9","author":"Li","year":"2023","journal-title":"Heliyon"},{"issue":"6","key":"2026073101042723400_cit10","doi-asserted-by":"publisher","first-page":"1037","DOI":"10.2174\/1871520621666210720121403","article-title":"Structural\nAspects of mTOR Inhibitors:\nSearch for Potential Compounds","volume":"22","author":"Kaur","year":"2022","journal-title":"Anti-Cancer\nAgents Med. Chem."},{"key":"2026073101042723400_cit11","doi-asserted-by":"publisher","first-page":"73","DOI":"10.4137\/BCBCR.S29268","article-title":"Everolimus in the Treatment\nof Metastatic Breast Cancer","volume":"9","author":"Royce","year":"2015","journal-title":"Breast Cancer:Basic\nClin. Res."},{"issue":"1","key":"2026073101042723400_cit12","doi-asserted-by":"publisher","DOI":"10.1186\/s12935-022-02706-8","article-title":"Recent advances\nand limitations of\nmTOR inhibitors in the treatment of cancer","volume":"22","author":"Ali","year":"2022","journal-title":"Cancer Cell Int."},{"key":"2026073101042723400_cit13","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/686984","article-title":"mTOR Signaling in Protein Translation\nRegulation: Implications in Cancer Genesis and Therapeutic Interventions","volume":"2014","author":"Showkat","year":"2014","journal-title":"Mol. Biol. Int."},{"issue":"1\u20132","key":"2026073101042723400_cit14","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1016\/j.ijpharm.2014.06.006","article-title":"Improved oral absorption\nand chemical stability of\neverolimus via preparation of solid dispersion using solvent wetting\ntechnique","volume":"473","author":"Jang","year":"2014","journal-title":"Int. J. Pharm."},{"key":"2026073101042723400_cit15","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2020.102886","article-title":"Mechanisms of resistance\nto mTOR\ninhibitors","volume":"147","author":"Formisano","year":"2020","journal-title":"Crit. Rev. Oncol. Hematol."},{"issue":"4","key":"2026073101042723400_cit16","doi-asserted-by":"publisher","first-page":"808","DOI":"10.1093\/annonc\/mdu009","article-title":"Incidence and time course of everolimus-related adverse\nevents in postmenopausal women with hormone receptor-positive advanced\nbreast cancer: insights from BOLERO-2","volume":"25","author":"Rugo","year":"2014","journal-title":"Ann.\nOncol."},{"key":"2026073101042723400_cit17","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.618411","article-title":"Advances in Oral\nDrug Delivery","volume":"12","author":"Alqahtani","year":"2021","journal-title":"Front. Pharmacol."},{"key":"2026073101042723400_cit18","doi-asserted-by":"publisher","first-page":"4357","DOI":"10.2147\/IJN.S46900","article-title":"Nanopharmaceuticals (part 1): products\non the market","volume":"9","author":"Weissig","year":"2014","journal-title":"Int. J. Nanomed."},{"issue":"10","key":"2026073101042723400_cit19","doi-asserted-by":"publisher","first-page":"1499","DOI":"10.1080\/17425247.2020.1828342","article-title":"Designing\norodispersible films containing\neverolimus for enhanced compliance and bioavailability","volume":"17","author":"Ma","year":"2020","journal-title":"Expert Opin. Drug. Delivery"},{"key":"2026073101042723400_cit20","doi-asserted-by":"publisher","DOI":"10.1016\/j.jddst.2023.104204","article-title":"Novel polyvinyl-alcohol\nmicrosphere\nfor everolimus delivery for subependymal giant cell astrocytom","volume":"81","author":"Louis","year":"2023","journal-title":"J. Drug Delivery Sci. Technol."},{"key":"2026073101042723400_cit21","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1016\/j.jconrel.2021.10.008","article-title":"Novel\npolymer-based system for intrauterine delivery\nof everolimus for anti-cancer applications","volume":"339","author":"Melendez","year":"2021","journal-title":"J. Controlled Release"},{"key":"2026073101042723400_cit22","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpx.2024.100230","article-title":"Everolimus-encapsulation\nin Pluronic P123 self-assembled micelles as drug delivery systems\nfor drug-coated balloons","volume":"7","author":"Akrami-Hasan-Kohal","year":"2024","journal-title":"Int. J. Pharm.: X."},{"issue":"8","key":"2026073101042723400_cit23","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics11080384","article-title":"Everolimus\nNanoformulation in Biological Nanoparticles\nIncreases Drug Responsiveness in Resistant and Low-Responsive Breast\nCancer Cell Lines","volume":"11","author":"Bonizzi","year":"2019","journal-title":"Pharmaceutics"},{"key":"2026073101042723400_cit24","doi-asserted-by":"publisher","DOI":"10.1016\/j.jddst.2024.106209","article-title":"Freeze-thawed\nelectrosprayed everolimus loaded nanoparticles as a potential drug\ndelivery system in brain tumours: Design and characterisation","volume":"101","author":"Lynn","year":"2024","journal-title":"J. Drug Delivery Sci. Technol."},{"issue":"15","key":"2026073101042723400_cit25","doi-asserted-by":"publisher","DOI":"10.3390\/polym15153177","article-title":"Lignins as Promising Renewable Biopolymers\nand Bioactive\nCompounds for High-Performance Materials","volume":"15","author":"Vasile","year":"2023","journal-title":"Polymers"},{"issue":"2","key":"2026073101042723400_cit26","doi-asserted-by":"publisher","DOI":"10.3390\/antiox10020274","article-title":"Nano-Structured Lignin\nas Green Antioxidant and UV Shielding Ingredient for Sunscreen Applications","volume":"10","author":"Piccinino","year":"2021","journal-title":"Antioxidants"},{"key":"2026073101042723400_cit27","doi-asserted-by":"publisher","DOI":"10.1016\/j.eurpolymj.2023.112206","article-title":"Lignin-based carriers for drug delivery applications:\nFrom an industrial waste to a pharmaceutical aid","volume":"195","author":"Chaudhary","year":"2023","journal-title":"Eur. Polym. J."},{"key":"2026073101042723400_cit28","doi-asserted-by":"publisher","first-page":"934","DOI":"10.1016\/j.ijbiomac.2022.09.007","article-title":"Role of lignin-based\nnanoparticles in anticancer drug\ndelivery and bioimaging: An up-to-date review","volume":"221","author":"Ali","year":"2022","journal-title":"Int. J. Biol. Macromol."},{"issue":"18","key":"2026073101042723400_cit29","doi-asserted-by":"publisher","first-page":"5792","DOI":"10.1021\/acssuschemeng.1c08529","article-title":"In Vitro and In Vivo\nEvaluation of Drug-Encapsulated Lignin Nanoparticles for Release Control","volume":"10","author":"Lee","year":"2022","journal-title":"ACS Sustainable Chem. Eng."},{"key":"2026073101042723400_cit30","doi-asserted-by":"publisher","DOI":"10.1016\/j.indcrop.2023.117012","article-title":"Preparation of pH-sensitive\nlignin nanoparticles and\nits application in hydrophobic drug delivery","volume":"202","author":"Lu","year":"2023","journal-title":"Ind. Crops Prod."},{"key":"2026073101042723400_cit31","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2023.124601","article-title":"Recent advances\nin pharmaceutical\nand biotechnological applications of lignin-based materials","volume":"241","author":"Mukheja","year":"2023","journal-title":"Int. J. Biol. Macromol."},{"issue":"10","key":"2026073101042723400_cit32","doi-asserted-by":"publisher","DOI":"10.3390\/ma12101694","article-title":"Effects of Lignin-Based Hollow Nanoparticle\nStructure on the Loading and Release Behavior of Doxorubicin","volume":"12","author":"Zhou","year":"2019","journal-title":"Materials"},{"issue":"17","key":"2026073101042723400_cit33","doi-asserted-by":"publisher","first-page":"4266","DOI":"10.1002\/cssc.202000783","article-title":"Lignin-Based\nMicro- and Nanomaterials and their Composites in Biomedical Applications","volume":"13","author":"Liu","year":"2020","journal-title":"ChemSusChem"},{"key":"2026073101042723400_cit34","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/136590","article-title":"In vitro release kinetics of antituberculosis\ndrugs from nanoparticles assessed using a modified dissolution apparatus","volume":"2013","author":"Gao","year":"2013","journal-title":"Biomed. Res. Int."},{"key":"2026073101042723400_cit35","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfa.2023.131287","article-title":"Development of colloidal lignin particles\nthrough particle design strategies and screening of their Pickering\nstabilizing potential","volume":"666","author":"Colucci","year":"2023","journal-title":"Coll. Surf. A. Physicochem.\nEng. Asp."},{"issue":"2","key":"2026073101042723400_cit36","doi-asserted-by":"publisher","first-page":"265","DOI":"10.4314\/tjpr.v12i2.19","article-title":"Effect of Zeta Potential on the Properties of Nano-Drug Delivery\nSystems - A Review (Part 2)","volume":"12","author":"Honary","year":"2013","journal-title":"Trop. J. Pharm.\nRes."},{"issue":"28","key":"2026073101042723400_cit37","doi-asserted-by":"publisher","first-page":"45759","DOI":"10.18632\/oncotarget.17404","article-title":"Extracellular pH is\na biomarker enabling detection of breast cancer and liver cancer using\nCEST MRI","volume":"8","author":"Chen","year":"2017","journal-title":"Oncotarget"},{"issue":"28","key":"2026073101042723400_cit38","doi-asserted-by":"publisher","first-page":"10364","DOI":"10.1021\/acssuschemeng.3c01414","article-title":"Cationic Lignin\nas an Efficient and Biorenewable Antimicrobial Material","volume":"11","author":"Cerda","year":"2023","journal-title":"ACS Sustainable Chem. Eng."},{"issue":"8","key":"2026073101042723400_cit39","doi-asserted-by":"publisher","first-page":"1207","DOI":"10.1021\/acs.bioconjchem.4c00261","article-title":"Lignin-Based Nanoparticles\nfor Combination of Tumor\nOxidative Stress Amplification and Reactive Oxygen Species Responsive\nDrug Release","volume":"35","author":"Zhou","year":"2024","journal-title":"Bioconjugate Chem."},{"issue":"18","key":"2026073101042723400_cit40","doi-asserted-by":"publisher","DOI":"10.3390\/ijms221810096","article-title":"Hydrogen\nPeroxide Generation as an Underlying Response to High Extracellular\nInorganic Phosphate (Pi) in Breast Cancer Cells","volume":"22","author":"Lacerda-Abreu","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"2","key":"2026073101042723400_cit41","doi-asserted-by":"publisher","DOI":"10.3390\/molecules29020346","article-title":"Aromatase Inhibitors\nas a Promising Direction for the Search for New Anticancer Drugs","volume":"29","author":"Janowska","year":"2024","journal-title":"Molecules"},{"issue":"24","key":"2026073101042723400_cit42","doi-asserted-by":"publisher","DOI":"10.3390\/molecules30244778","article-title":"Stereoselective\nCytotoxicity of Enantiopure\n3,3-Dichloro-\u03b3-lactams: Correlating In Vitro Activity with In\nVivo Tolerability","volume":"30","author":"Diaba","year":"2025","journal-title":"Molecules"},{"key":"2026073101042723400_cit43","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.984002","article-title":"Everolimus pharmacokinetics\nand exposure-response relationship in Japanese patients with advanced\nbreast cancer","volume":"13","author":"Hirabatake","year":"2022","journal-title":"Front. Pharmacol."},{"issue":"1","key":"2026073101042723400_cit44","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1136\/jim-2018-000780","article-title":"Everolimus\nshows synergistic antimyeloma effects with bortezomib via the AKT\/mTOR\npathway","volume":"67","author":"Li","year":"2019","journal-title":"J. Invest. Med."},{"issue":"3","key":"2026073101042723400_cit45","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1007\/s12079-019-00510-0","article-title":"mTOR inhibitor Everolimus-induced\napoptosis in melanoma cells","volume":"13","author":"Cio\u0142czyk-Wierzbicka","year":"2019","journal-title":"J. Cell. Commun.\nSignaling"},{"issue":"1","key":"2026073101042723400_cit46","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.bbrc.2020.08.039","article-title":"Everolimus\nreduces postoperative arthrofibrosis in rabbits by inducing autophagy-mediated\nfibroblast apoptosis by PI3K\/Akt\/mTOR signaling pathway","volume":"533","author":"Liu","year":"2020","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"2026073101042723400_cit47","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/5381692","article-title":"Understanding\nof ROS-Inducing Strategy\nin Anticancer Therapy","volume":"2019","author":"Kim","year":"2019","journal-title":"Oxid. Med. Cell. Longevity"},{"issue":"6","key":"2026073101042723400_cit48","doi-asserted-by":"publisher","first-page":"862","DOI":"10.1002\/cam4.150","article-title":"Therapeutic potential\nand adverse\nevents of everolimus for treatment of hepatocellular carcinoma - systematic\nreview and meta-analysis","volume":"2","author":"Yamanaka","year":"2013","journal-title":"Cancer Med."},{"issue":"1","key":"2026073101042723400_cit49","doi-asserted-by":"publisher","DOI":"10.1186\/s13068-021-01934-w","article-title":"Depolymerization\nand conversion of\nlignin to value-added bioproducts by microbial and enzymatic catalysis","volume":"14","author":"Weng","year":"2021","journal-title":"Biotechnol. 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