{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T13:53:22Z","timestamp":1791381202358,"version":"4.3.3"},"reference-count":39,"publisher":"American Chemical Society (ACS)","issue":"9","license":[{"start":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T00:00:00Z","timestamp":1773360000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100011393","name":"State Key Laboratory of Solid Lubrication","doi-asserted-by":"publisher","award":["LSL-2401"],"award-info":[{"award-number":["LSL-2401"]}],"id":[{"id":"10.13039\/501100011393","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52475216"],"award-info":[{"award-number":["52475216"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2025MS951"],"award-info":[{"award-number":["ZR2025MS951"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007128","name":"Natural Science Foundation of Shaanxi Province","doi-asserted-by":"publisher","award":["2024RS-CXTD-62"],"award-info":[{"award-number":["2024RS-CXTD-62"]}],"id":[{"id":"10.13039\/501100007128","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Metal\u2013organic frameworks (MOFs) demonstrate considerable potential for biomedical applications. Due to their high porosity and photoactive porphyrin ligands, PCN-224 is considered an ideal drug delivery nanocarrier. However, the synthesis strategy for tailoring the application of PCN-224 in complex pathological diseases remains unclear. In this study, we investigated the structure\u2013activity relationship of PCN-224 nanoparticles as bifunctional nanocarriers for osteoarthritis (OA) treatment under a precisely controlled temperature gradient. By tuning the temperatures, a series of PCN-224 nanoparticles with adjustable sizes were synthesized and their morphologies transitioned from a spindle-shaped to a spherical-shaped structure. The photoluminescence intensity of PCN-224 nanoparticles decreased as the synthesis temperatures increased. Using PCN-224 nanoparticles as aqueous lubricating additives, both the friction coefficient and wear volume were significantly reduced. Among the MOFs, PCN-224 (synthesized at 105 \u00b0C) exhibited excellent antifriction performances and acid-responsive drug release properties, demonstrating their promise as bifunctional OA treatment nanocarriers. Our work enhanced the understanding of the relationships between PCN-224 synthesis conditions and its physicochemical properties relationships, expanding their potential for multifunctional biomedical applications.<\/jats:p>","DOI":"10.1021\/prechem.5c00448","type":"journal-article","created":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T15:09:19Z","timestamp":1773414559000},"page":"1405-1413","source":"Crossref","is-referenced-by-count":3,"title":["Precise Temperature-Gradient\nRegulated Structure\u2013Activity\nRelationship of PCN-224 as Bifunctional Nanocarriers"],"prefix":"10.1021","volume":"4","author":[{"given":"Lejie","family":"Tian","sequence":"first","affiliation":[{"name":"Northwestern Polytechnical University , , ,","place":["Xi\u2019an, China, 710072"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5429-7477","authenticated-orcid":true,"given":"Huidan","family":"Xue","sequence":"additional","affiliation":[{"name":"Shaanxi University of Science and Technology , , ,","place":["Xi\u2019an, China, 710021"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7262-7115","authenticated-orcid":true,"given":"Michael","family":"Gradzielski","sequence":"additional","affiliation":[{"name":"Technische University Berlin , , ,","place":["Berlin, Germany, 10623"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1575-1934","authenticated-orcid":true,"given":"Li","family":"Shang","sequence":"additional","affiliation":[{"name":"Northwestern Polytechnical University , , ,","place":["Xi\u2019an, China, 710072"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2144-4378","authenticated-orcid":true,"given":"Shuanhong","family":"Ma","sequence":"additional","affiliation":[{"name":"Chinese Academy of Sciences , , ,","place":["Lanzhou, China, 730000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peiwei","family":"Gong","sequence":"additional","affiliation":[{"name":"Qufu Normal University , , , ,","place":["Qufu, Shandong, China, 273165"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Long","family":"Wang","sequence":"additional","affiliation":[{"name":"Northwestern Polytechnical University , , ,","place":["Xi\u2019an, China, 710072"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6394-600X","authenticated-orcid":true,"given":"Jianxi","family":"Liu","sequence":"additional","affiliation":[{"name":"Northwestern Polytechnical University , , ,","place":["Xi\u2019an, China, 710072"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weimin","family":"Liu","sequence":"additional","affiliation":[{"name":"Northwestern Polytechnical University , , ,","place":["Xi\u2019an, China, 710072"]},{"name":"Chinese Academy of Sciences , , ,","place":["Lanzhou, China, 730000"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,3,13]]},"reference":[{"issue":"6149","key":"2026092808080262100_cit1","doi-asserted-by":"publisher","first-page":"1230444","DOI":"10.1126\/science.1230444","article-title":"The Chemistry and\nApplications of Metal-Organic Frameworks","volume":"341","author":"Furukawa","year":"2013","journal-title":"Science"},{"issue":"4","key":"2026092808080262100_cit2","doi-asserted-by":"publisher","DOI":"10.1016\/j.surfrep.2025.100669","article-title":"Surface-anchored,\nOriented, Monolithic Metal-Organic\nFramework Thin Films: Surface and Interface Phenomena in Crystalline\nMOF Architectures","volume":"80","author":"Tian","year":"2025","journal-title":"Surf. 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