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Austria Tabakwerke, issue 13, 215\u2212220","author":"Binder H.","year":"1972"},{"key":"tx000260ub00115\/tx000260ub00115_1","volume-title":"Ethylene. IARC Monograph on the Evaluation of Carcinogenic Risks of Chemicals to Humans IARC 60, 45\u221271","author":"International Agency for Research on Cancer","year":"1994"},{"key":"tx000260ub00116\/tx000260ub00116_1","volume-title":"Column elution of humectants from tobacco and determination by vapor chromatography. Tob. Sci. 8, 163\u2212170","author":"Cundiff R. H.","year":"1964"},{"key":"tx000260ub00117\/tx000260ub00117_1","first-page":"51","volume":"11","author":"Lyerly L. A.","year":"1967","journal-title":"Tob. Sci."},{"key":"tx000260ub00118\/tx000260ub00118_1","volume-title":"IARC 60, 181\u2212213.","author":"International Agency for Research on Cancer","year":"1994"},{"key":"tx000260ub00119\/tx000260ub00119_1","volume-title":"Tobacco Flavoring Substances and Methods","author":"Gutcho S.","year":"1972"},{"key":"tx000260ub00120\/tx000260ub00120_1","first-page":"135","volume":"2","author":"Senkus M., Ed.","year":"1976","journal-title":"Recent Adv. Tob. Sci."},{"key":"tx000260ub00121\/tx000260ub00121_1","first-page":"218","volume":"14","author":"Leffingwell J. C., Ed.","year":"1987","journal-title":"Recent Adv. Tob. Sci."},{"key":"tx000260ub00122\/tx000260ub00122_1","volume-title":"2000 CORESTA Congress","author":"Pachinger A.","year":"2000"},{"key":"tx000260ub00123\/tx000260ub00123_1","first-page":"39","volume":"196","author":"Doull J. D.","year":"1994","journal-title":"J. Intl."},{"key":"tx000260ub00124\/tx000260ub00124_1","volume-title":"Toxicological evaluation of flavor ingredients added to cigarette tobacco:\u2009 13-week inhalation exposures in rats. Inhal. Toxicol. 10, 357\u2212381","author":"Gaworski C. L.","year":"1998"},{"key":"tx000260ub00125\/tx000260ub00125_1","volume-title":"New Cigarette Prototypes That Heat Instead of Burn Tobacco. Chemical and Biological Studies, 744 p","author":"Reynolds Tobacco Company","year":"1988"},{"key":"tx000260ub00126\/tx000260ub00126_1","doi-asserted-by":"crossref","DOI":"10.1002\/j.1552-4604.1990.tb03639.x","volume":"30","author":"DeBethizy J. D.","year":"1990","journal-title":"J. Clin. Pharmacol."},{"key":"tx000260ub00127\/tx000260ub00127_1","volume":"73","author":"Borgerding M. F.","year":"1990","journal-title":"J. Assoc. Off. Anal. Chem."},{"key":"tx000260ub00128\/tx000260ub00128_1","volume":"73","author":"Borgerding M. F.","year":"1990","journal-title":"J. Assoc. Off. Anal. Chem."},{"key":"tx000260ub00129\/tx000260ub00129_1","volume-title":"Chemical and biological studies of a new cigarette that primarily heats tobacco. Part 1. Chemical composition of mainstream smoke. Food Chem. Toxicol. 36, 169\u2212182","author":"Borgerding M. F.","year":"1997"},{"key":"tx000260ub00130\/tx000260ub00130_1","volume-title":"Chemical and biological studies of a new cigarette that primarily heats tobacco. Part II. In vitro toxicology of mainstream smoke condensate. Food Chem. Toxicol. 3, 183\u2212190","author":"Bombick B. R.","year":"1998"},{"key":"tx000260ub00131\/tx000260ub00131_1","volume-title":"Chemical and biological studies of a new cigarette that primarily heats tobacco. III. In vitro toxicology of whole smoke. Food Chem. Toxicol. 36, 191\u2212197","author":"Bombick D. W.","year":"1998"},{"key":"tx000260ub00132\/tx000260ub00132_1","first-page":"48","volume":"12","author":"Gardner D. E., Ed.","year":"2000","journal-title":"Inhal. Toxicol."},{"key":"tx000260ub00133\/tx000260ub00133_1","first-page":"30","volume":"414","author":"Brown B. G.","year":"1999","journal-title":"Mutat. Res."},{"key":"tx000260ub00134\/tx000260ub00134_1","volume-title":"Human smoking behavior study. ECLIPSE cigarette compared to usual brand. Toxicologist 48, 119\u2212120","author":"Stiles M. F.","year":"1999"},{"key":"tx000260ub00135\/tx000260ub00135_1","doi-asserted-by":"crossref","DOI":"10.2105\/AJPH.87.11.1865","volume":"87","author":"Benowitz N. L.","year":"1997","journal-title":"Am. J. Publ. Health"},{"key":"tx000260ub00136\/tx000260ub00136_1","first-page":"9","volume":"361","author":"Smith C. J.","year":"1996","journal-title":"Mutat. Res."},{"key":"tx000260ub00137\/tx000260ub00137_1","doi-asserted-by":"crossref","DOI":"10.1093\/jnci\/53.4.1141","volume":"53","author":"Bernfeld P.","year":"1974","journal-title":"J. Natl. Cancer Inst."},{"key":"tx000260ub00138\/tx000260ub00138_1","volume-title":"Glass fiber contamination of cigarette filters:\u2009 an additional health risk to the smoker? Cancer Epidemiol. Biomarkers Prev. 7, 967\u2212975","author":"Pauly J. L.","year":"2000"},{"key":"tx000260ub00139\/tx000260ub00139_1","volume-title":"Massachusetts disputes claims about Eclipse cigarettes. Tob. Reporter 127 (11), 11\u221213","author":"Anonymous","year":"2000"},{"key":"tx000260ub00140\/tx000260ub00140_1","volume-title":"Policy committee urges regulation on Eclipse. SRNT Newslett. 6 (2\u22123), 21\u221222","author":"Society for Research on Nicotine and Tobacco","year":"2000"},{"key":"tx000260ub00141\/tx000260ub00141_1","volume-title":"1998 Annual Meeting, The Toxicologist. Abst. Issues Toxicol. Sci.","volume":"42","author":"Terpstra P. M.","year":"1998"},{"key":"tx000260ub00142\/tx000260ub00142_1","volume-title":"The changing cigarette. Prev. Med. 20, 427\u2212434","author":"Hoffmann D.","year":"1997"},{"key":"tx000260ub00143\/tx000260ub00143_1","volume-title":"Tob. Alert Spec. Issue, 28 p","author":"World Health Organization","year":"1996"},{"key":"tx000260ub00144\/tx000260ub00144_1","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1002\/cpt197517193","volume":"17","author":"Kozlowski L. T.","year":"1975","journal-title":"Clin. Pharmacol. Ther."},{"key":"tx000260ub00145\/tx000260ub00145_1","volume":"1","author":"Russell M. A. H.","year":"1976","journal-title":"Br. Med. J."},{"key":"tx000260ub00146\/tx000260ub00146_1","first-page":"310","volume-title":"A Safe Cigarette?","author":"Russell M. A. H.","year":"1980"},{"key":"tx000260ub00147\/tx000260ub00147_1","volume":"280","author":"Russell M. A.","year":"1980","journal-title":"Br. Med. J."},{"key":"tx000260ub00148\/tx000260ub00148_1","doi-asserted-by":"crossref","DOI":"10.1111\/j.1360-0443.1982.tb01417.x","volume":"77","author":"Kozlowski L. T.","year":"1982","journal-title":"Br. J. Addict."},{"key":"tx000260ub00149\/tx000260ub00149_1","volume":"309","author":"Benowitz N. T.","year":"1983","journal-title":"N. Engl. J. Med."},{"key":"tx000260ub00150\/tx000260ub00150_1","volume-title":"Cigarette smoking as a risk factor for cardiovascular disease. VI. Compensation with nicotine availability as a single variable. Clin. Pharmacol. Ther. 38, 164\u2212170","author":"Haley N. J.","year":"1985"},{"key":"tx000260ub00151\/tx000260ub00151_1","volume":"283","author":"Herning R. I.","year":"1981","journal-title":"Br. Med. J."},{"key":"tx000260ub00152\/tx000260ub00152_1","doi-asserted-by":"crossref","DOI":"10.2105\/AJPH.77.12.1544","volume":"77","author":"Meyers A. H.","year":"1987","journal-title":"Am. J. Publ. Health"},{"key":"tx000260ub00153\/tx000260ub00153_1","volume":"58","author":"Bross I. D. J.","year":"1968","journal-title":"Am. J. Publ. Health"},{"key":"tx000260ub00154\/tx000260ub00154_1","doi-asserted-by":"crossref","DOI":"10.1001\/jama.1970.03170390013002","volume":"213","author":"Wynder E. L.","year":"1970","journal-title":"J. Am. Med. Assoc."},{"key":"tx000260ub00155\/tx000260ub00155_1","volume-title":"Tar","author":"Hammond E. C.","year":"1976"},{"key":"tx000260ub00156\/tx000260ub00156_1","volume-title":"Res. Paper 14, Part I, 93 p, Tob. Res. Counc.","author":"Dean G.","year":"1977"},{"key":"tx000260ub00157\/tx000260ub00157_1","doi-asserted-by":"crossref","DOI":"10.1136\/jech.32.4.260","volume":"32","author":"Hawthorne V. M.","year":"1978","journal-title":"J. Epidemiol. Commun. Health"},{"key":"tx000260ub00158\/tx000260ub00158_1","doi-asserted-by":"crossref","DOI":"10.1093\/jnci\/62.3.471","volume":"62","author":"Wynder E. L.","year":"1979","journal-title":"J. Natl. Cancer Inst."},{"key":"tx000260ub00159\/tx000260ub00159_1","volume-title":"The effect of filters on the incidence of lung cancer in cigarette smokers. Environ. Res. 24, 162\u2212166","author":"Rimington J.","year":"1981"},{"key":"tx000260ub00160\/tx000260ub00160_1","doi-asserted-by":"crossref","DOI":"10.1056\/NEJM197902223000801","volume":"300","author":"Auerbach O.","year":"1979","journal-title":"N. Engl. J. Med."},{"key":"tx000260ub00161\/tx000260ub00161_1","volume-title":"Pharmacological and physiological determinants of smoking. Ann. Intern Med. 88, 104\u2212114","author":"Schachter S.","year":"1978"},{"key":"tx000260ub00162\/tx000260ub00162_1","volume-title":"Effects of nicotine-enriched cigarette on nicotine titration, daily cigarette consumption, and levels of carbon monoxide, cotinine, and nicotine. Psychopharmacol. 77, 164\u2212167","author":"Fagerstr\u00f6m K. O.","year":"1982"},{"key":"tx000260ub00163\/tx000260ub00163_1","volume-title":"Smoking Behavior, Physiological and Psychological Influences","author":"Schultz F. J.","year":"1978"},{"issue":"5724","key":"tx000260ub00164\/tx000260ub00164_1","doi-asserted-by":"crossref","DOI":"10.1136\/bmj.3.5724.679","volume":"3","author":"Ashton H.","year":"1970","journal-title":"Br. Med. J."},{"key":"tx000260ub00165\/tx000260ub00165_1","doi-asserted-by":"crossref","DOI":"10.2105\/AJPH.70.11.1202","volume":"70","author":"Kozlowski L. T.","year":"1980","journal-title":"Am. J. Publ. Health"},{"key":"tx000260ub00166\/tx000260ub00166_1","volume-title":"Compensation for nicotine by smokers of low-yield cigarettes. NCI Smoking Tob. Control Monogr. 7, 161\u2212172","author":"Kozlowski L. T.","year":"1996"},{"key":"tx000260ub00167\/tx000260ub00167_1","volume":"246","author":"Zacny J. P.","year":"1988","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"tx000260ub00168\/tx000260ub00168_1","volume-title":"Ultralow-yield cigarettes:\u2009 the role of ventilation blocking. Pharmacol. Biochem. Behav. 40, 907\u2212914","author":"Hofer I.","year":"1991"},{"key":"tx000260ub00169\/tx000260ub00169_1","first-page":"90","volume":"18","author":"Porter A.","year":"1998","journal-title":"Beitr. Tabakforsch."},{"key":"tx000260ub00170\/tx000260ub00170_1","first-page":"83","volume":"18","author":"Baker R. P.","year":"1998","journal-title":"Beitr. Tabakforsch."},{"key":"tx000260ub00171\/tx000260ub00171_1","first-page":"111","volume":"7","author":"Benowitz N. L.","year":"1996","journal-title":"Control Monogr."},{"key":"tx000260ub00172\/tx000260ub00172_1","doi-asserted-by":"crossref","DOI":"10.1001\/jama.1986.03380020103032","volume":"256","author":"Benowitz N. L.","year":"1986","journal-title":"J. Am. Med. Assoc."},{"key":"tx000260ub00173\/tx000260ub00173_1","volume-title":"Analytical cigarette yields as predictors of some bioavailability. Reg. Toxicol. Pharmacol. 5, 314\u2212326","author":"Gori G. B.","year":"1985"},{"key":"tx000260ub00174\/tx000260ub00174_1","doi-asserted-by":"crossref","DOI":"10.3109\/00365518709168925","volume":"47","author":"Puustinen D.","year":"1987","journal-title":"Scand. J. Clin. Lab. Invest."},{"key":"tx000260ub00175\/tx000260ub00175_1","volume-title":"Self-regulation of smoking intensity. Smoke yields of the low-nicotine, low-\u201ctar","author":"Djordjevic M. V.","year":"1995"},{"key":"tx000260ub00176\/tx000260ub00176_1","doi-asserted-by":"crossref","DOI":"10.1093\/jnci\/92.2.106","volume":"92","author":"Djordjevic M. V.","year":"2000","journal-title":"J. Natl. Cancer Inst."},{"key":"tx000260ub00177\/tx000260ub00177_1","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1093\/jnci\/92.2.90","volume":"92","author":"Wilkenfeld J.","year":"2000","journal-title":"J. Natl. Cancer Inst."},{"key":"tx000260ub00178\/tx000260ub00178_1","doi-asserted-by":"crossref","DOI":"10.1093\/jnci\/92.2.90","volume":"92","author":"Wilkenfeld J.","year":"2000","journal-title":"J. Natl. Cancer Inst."},{"key":"tx000260ub00179\/tx000260ub00179_1","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1093\/jnci\/92.10.842","volume":"92","author":"Peeler C. L.","year":"2000","journal-title":"J. Natl. Cancer Inst."},{"key":"tx000260ub00180\/tx000260ub00180_1","volume-title":"Nicotine, and Carbon Monoxide of the Smoke of 1254 Varieties of Domestic Cigarettes for the Year","author":"Federal Trade Commission","year":"2000"},{"key":"tx000260ub00181\/tx000260ub00181_1","doi-asserted-by":"crossref","DOI":"10.1093\/oxfordjournals.epirev.a036258","volume":"5","author":"Wynder E. L.","year":"1983","journal-title":"Epidemiol. Rev."},{"key":"tx000260ub00182\/tx000260ub00182_1","volume-title":"Smoking and lung cancer:\u2009 risk as a function of cigarette tar content. Prev. Med. 17, 263\u2212272","author":"Wilcox H. B.","year":"1988"},{"key":"tx000260ub00183\/tx000260ub00183_1","volume-title":"The effect of the low-yield cigarette smoking and lung cancer risk. Cancer 62, 1223\u22121230","author":"Wynder E. L.","year":"1988"},{"key":"tx000260ub00184\/tx000260ub00184_1","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1007\/BF00051707","volume":"4","author":"Sidney S.","year":"1993","journal-title":"Cancer Causes Control"},{"key":"tx000260ub00185\/tx000260ub00185_1","volume-title":"Risk of squamous cell carcinoma and adenocarcinoma of the lung in relation to lifetime filter cigarette smoking. Cancer 80, 362\u2212368","author":"Stellman S. D.","year":"1997"},{"key":"tx000260ub00186\/tx000260ub00186_1","first-page":"563","volume":"8","author":"National Institute of Health, National Cancer Institute","year":"1997","journal-title":"Smoking Tob. Control"},{"key":"tx000260ub00187\/tx000260ub00187_1","volume-title":"Changes in mortality from smoking in two American Cancer Society prospective studies since","author":"Thun M. J.","year":"1997"},{"key":"tx000260ub00188\/tx000260ub00188_1","doi-asserted-by":"crossref","first-page":"1486","DOI":"10.1093\/jnci\/90.19.1486","volume":"90","author":"Wynder E. L.","year":"1998","journal-title":"J. Natl. Cancer Inst."},{"key":"tx000260ub00189\/tx000260ub00189_1","volume-title":"The past, present, and future of the prevention of lung cancer. Cancer Epidemiol. Biomarkers Prev. 7, 735\u2212748","author":"Wynder E. L.","year":"1998"},{"key":"tx000260ub00190\/tx000260ub00190_1","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S0169-5002(00)00170-7","volume":"31","author":"Mannino D. M.","year":"2001","journal-title":"Lung Cancer"},{"key":"tx000260ub00191\/tx000260ub00191_1","first-page":"1082","volume":"57","author":"Young J. L.","year":"1981","journal-title":"NCI Monogr."},{"key":"tx000260ub00192\/tx000260ub00192_1","volume-title":"Comparative epidemiology of tobacco-related caners. Cancer Res. 37, 4608\u22124622","author":"Wynder E. L.","year":"1977"},{"key":"tx000260ub00193\/tx000260ub00193_1","volume-title":"No. 1","author":"Kreyberg L.","year":"1967"},{"key":"tx000260ub00194\/tx000260ub00194_1","volume-title":"The changing histopathology of lung cancer. Cancer 39, 1647\u22121655","author":"Vincent R. G.","year":"1977"},{"key":"tx000260ub00195\/tx000260ub00195_1","volume-title":"Significant changes in the distribution of histologic types of lung cancer. A review of 4,928 cases. Cancer 65, 2361\u22122367","author":"El-Torkey M.","year":"1990"},{"key":"tx000260ub00196\/tx000260ub00196_1","volume-title":"Cigarette smoking among adults in the United States","author":"U.S. Department of Health and Human Services","year":"1997"},{"key":"tx000260ub00197\/tx000260ub00197_1","volume-title":"Bronchiogenic carcinoma in Olmsted County","author":"Beard M. C.","year":"1985"},{"key":"tx000260ub00198\/tx000260ub00198_1","first-page":"454","volume":"41","author":"Cutler S. J.","year":"1975","journal-title":"NCI Monogr."},{"key":"tx000260ub00199\/tx000260ub00199_1","first-page":"34","volume":"1","author":"Devesa S. S.","year":"1991","journal-title":"Cancer Epidemiol. Biomarkers Prev."},{"key":"tx000260ub00200\/tx000260ub00200_1","volume":"54","author":"Wynder E. L.","year":"1994","journal-title":"J. Natl. Cancer Inst."},{"key":"tx000260ub00201\/tx000260ub00201_1","volume-title":"Cancer 68","author":"Auerbach O.","year":"1991"},{"key":"tx000260ub00202\/tx000260ub00202_1","volume-title":"Biochemistry, biology, and carcinogenicity of tobacco-specific N-nitrosamines. Chem. Res. Toxicol. 11, 559\u2212603","author":"Hecht S. S.","year":"1998"},{"key":"tx000260ub00203\/tx000260ub00203_1","volume-title":"Reducing Tobacco Use. A Report of the Surgeon General, 462 p","author":"U.S. Department Health and Human Services","year":"2000"},{"key":"tx000260ub00204\/tx000260ub00204_1","volume-title":"Tar, Nicotine, and Carbon Monoxide of the Smoke of 1206 Varieties of Domestic Cigarettes for the year","author":"Federal Trade Commission","year":"1995"},{"key":"tx000260ub00205\/tx000260ub00205_1","doi-asserted-by":"crossref","DOI":"10.1056\/NEJM199407143310212","volume":"331","author":"Benowitz N. L.","year":"1994","journal-title":"N. Engl. J. Med."},{"key":"tx000260ub00206\/tx000260ub00206_1","volume-title":"Zur Entstehung Carcinogener Nitrosamine am Beispiel des Tabakrauches (On the formation of nitrosamines with tobacco smoke as one example). Naturwissenschaften 49, 498\u2212499","author":"Druckrey H.","year":"1962"},{"key":"tx000260ub00207\/tx000260ub00207_1","unstructured":"Klus, H., and Kuhn, H. (1975) Zur Bestimmung des Nornikotins im Rauchkondensat von Nornikotin reichen Zigaretten (N\u2018-nitrosonornicotine in the smoke condensate of cigarettes rich in nornicotine).Fachl. Mitt. Oester. Tabakregie.14, 251\u2212257."},{"key":"tx000260ub00208\/tx000260ub00208_1","volume":"73","author":"Caldwell W. S.","year":"1990","journal-title":"J. Assoc. Offic. Anal. Chem."},{"key":"tx000260ub00209\/tx000260ub00209_1","volume-title":"The nitrosation of nicotine:\u2009 a kinetic study. Chem. Res. Toxicol. 4, 513\u2212516","author":"Caldwell W. S.","year":"1991"},{"key":"tx000260ub00210\/tx000260ub00210_1","volume-title":"53rd Tobacco Scientists' Res. Conf. Montreal","author":"Peele D. M.","year":"1999"},{"key":"tx000260ub00211\/tx000260ub00211_1","doi-asserted-by":"crossref","DOI":"10.3109\/10408449109017915","volume":"21","author":"Preston-Martin S.","year":"1991","journal-title":"Crit. Rev. Toxicol."},{"key":"tx000260ub00212\/tx000260ub00212_1","volume-title":"Chemical composition and carcinogenicity of smokeless tobacco. Adv. Dent. Res. 11, 322\u2212329","author":"Hoffmann D.","year":"1997"},{"key":"tx000260ub00213\/tx000260ub00213_1","volume-title":"Effect of storage conditions on nitrosated, acylated, and oxidized pyridine alkaloid derivatives in smokeless tobacco products. Cancer Res. 49, 5895\u22125900","author":"Anderson R. A.","year":"1989"},{"key":"tx000260ub00214\/tx000260ub00214_1","doi-asserted-by":"crossref","DOI":"10.1021\/jf00034a051","volume":"41","author":"Djordjevic M. V.","year":"1993","journal-title":"J. Agric. Food Chem."},{"key":"tx000260ub00215\/tx000260ub00215_1","volume-title":"Curing the TSNA problem. Tob. Reporter 127 (No. 8), 51\u221256","author":"Fisher B.","year":"2000"},{"key":"tx000260ub00216\/tx000260ub00216_1","doi-asserted-by":"crossref","DOI":"10.1093\/jnci\/58.6.1841","volume":"58","author":"Hoffmann D.","year":"1977","journal-title":"J. Natl. Cancer Inst."},{"key":"tx000260ub00217\/tx000260ub00217_1","doi-asserted-by":"crossref","DOI":"10.1016\/0304-3835(83)90173-8","volume":"17","author":"Adams J. D.","year":"1983","journal-title":"Cancer Lett."},{"key":"tx000260ub00218\/tx000260ub00218_1","volume-title":"Endogenous formation of N-nitrosoproline in cigarette smokers. Cancer Res. 43, 5570\u22125574","author":"Hoffmann D.","year":"1983"},{"key":"tx000260ub00219\/tx000260ub00219_1","doi-asserted-by":"crossref","DOI":"10.1016\/0304-3835(86)90079-0","volume":"30","author":"Tsuda M.","year":"1986","journal-title":"Cancer Lett."},{"key":"tx000260ub00220\/tx000260ub00220_1","volume-title":"The occurrence of tobacco-specific nitrosamines in oral tobacco products and their potential formation under simulated gastric conditions. Food Chem. Toxicol. 26, 861\u2212865","author":"Tricker A. R.","year":"1988"},{"key":"tx000260ub00221\/tx000260ub00221_1","volume-title":"Tobacco-specific N-nitrosamines in the saliva of habitual male snuff dippers. Food Addit. Contam. 5, 581\u2212586","author":"\u00d6sterdahl B.-G.","year":"1988"},{"key":"tx000260ub00222\/tx000260ub00222_1","volume-title":"Chronic infection and inflammatory process as cancer risk factors. Possible role of nitric oxide in carcinogenesis. Mutat. Res. 305, 253\u2212264","author":"Ohshima H.","year":"1994"},{"key":"tx000260ub00223\/tx000260ub00223_1","volume-title":"The Health Consequences of Smoking. Nicotine Addiction. A Report of the Surgeon General, 639 p","author":"U.S. Department of Health and Human Services","year":"1988"},{"key":"tx000260ub00224\/tx000260ub00224_1","volume-title":"Structure and activity of acetylcholine. Nature 228, 917\u2212922","author":"Beers W. H.","year":"1970"},{"key":"tx000260ub00225\/tx000260ub00225_1","doi-asserted-by":"crossref","DOI":"10.1021\/jo00871a022","volume":"41","author":"Whidby J. F.","year":"1976","journal-title":"J. Org. Chem."},{"key":"tx000260ub00226\/tx000260ub00226_1","volume-title":"Gorod","author":"Domino E. F.","year":"1999"},{"key":"tx000260ub00227\/tx000260ub00227_1","first-page":"41","volume":"27","author":"Peavill C.","year":"1998","journal-title":"Neuropharmacology"},{"key":"tx000260un00001\/tx000260un00001_1","volume-title":"adenocarcinoma","author":"Abbreviations AC"},{"key":"tx000260un00002\/tx000260un00002_1","volume-title":"tar","author":"The"}],"container-title":["Chemical Research in Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/tx000260u","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,6]],"date-time":"2023-04-06T17:27:25Z","timestamp":1680802045000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/tx000260u"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,6,28]]},"references-count":229,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2001,7,1]]}},"alternative-id":["10.1021\/tx000260u"],"URL":"https:\/\/doi.org\/10.1021\/tx000260u","relation":{},"ISSN":["0893-228X","1520-5010"],"issn-type":[{"value":"0893-228X","type":"print"},{"value":"1520-5010","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,6,28]]}}}