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W.","year":"1986"},{"key":"tx0200313b00046\/tx0200313b00046_1","doi-asserted-by":"crossref","DOI":"10.1111\/1523-1747.ep12478534","volume":"97","author":"Nishi J.","year":"1991","journal-title":"J. Invest. Dermatol."},{"key":"tx0200313b00047\/tx0200313b00047_1","unstructured":"Yagi, K. (1988) Lipid peroxides in the skin.The biological role of reactive oxygen species in skin, pp 109\u2212116, University of Tokyo Press, Tokyo."},{"key":"tx0200313b00048\/tx0200313b00048_1","doi-asserted-by":"crossref","unstructured":"Iwahashi, H., Albro, P., McCown, S. R., Tomer, K. B., and Mason, R. P. (1991) Isolation and identification of \u03b1-(4-pyridyl-1-oxide)-N-tert-butylnitrone radical adducts formed by the decomposition of the hydroperoxides of linoleic acid, linolenic acid, and arachidonic acid by soybean lipoxigenase.Arch. Biochem. Biophys.285, 172\u2212180.","DOI":"10.1016\/0003-9861(91)90346-K"},{"key":"tx0200313b00049\/tx0200313b00049_1","volume-title":"NADPH and ferric chloride. 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