{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T23:56:34Z","timestamp":1776815794161,"version":"3.51.2"},"reference-count":34,"publisher":"American Chemical Society (ACS)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chem. Res. Toxicol."],"published-print":{"date-parts":[[2003,1,1]]},"DOI":"10.1021\/tx020067v","type":"journal-article","created":{"date-parts":[[2003,1,20]],"date-time":"2003-01-20T05:20:34Z","timestamp":1043040034000},"page":"15-22","source":"Crossref","is-referenced-by-count":13,"title":["Stimulatory Effects of Squamocin, an <i>Annonaceous<\/i> Acetogenin, on Ca<sup>2+<\/sup>-Activated K<sup>+<\/sup> Current in Cultured Smooth Muscle Cells of Human Coronary Artery"],"prefix":"10.1021","volume":"16","author":[{"given":"Sheng-Nan","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Medical Education and Research, Kaohsiung Veterans General Hospital, Kaohsiung City, Taiwan, Institute of Biomedical Sciences, National Sun Yat-Sen University, Kaohsiung City, Taiwan, and Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung City, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hung-Ting","family":"Chiang","sequence":"additional","affiliation":[{"name":"Department of Medical Education and Research, Kaohsiung Veterans General Hospital, Kaohsiung City, Taiwan, Institute of Biomedical Sciences, National Sun Yat-Sen University, Kaohsiung City, Taiwan, and Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung City, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fang-Rong","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Medical Education and Research, Kaohsiung Veterans General Hospital, Kaohsiung City, Taiwan, Institute of Biomedical Sciences, National Sun Yat-Sen University, Kaohsiung City, Taiwan, and Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung City, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chih-Chuang","family":"Liaw","sequence":"additional","affiliation":[{"name":"Department of Medical Education and Research, Kaohsiung Veterans General Hospital, Kaohsiung City, Taiwan, Institute of Biomedical Sciences, National Sun Yat-Sen University, Kaohsiung City, Taiwan, and Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung City, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang-Chang","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Medical Education and Research, Kaohsiung Veterans General Hospital, Kaohsiung City, Taiwan, Institute of Biomedical Sciences, National Sun Yat-Sen University, Kaohsiung City, Taiwan, and Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung City, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"316","published-online":{"date-parts":[[2002,12,5]]},"reference":[{"key":"tx020067vb00001\/tx020067vb00001_1","doi-asserted-by":"crossref","DOI":"10.1021\/np990328+","volume":"63","author":"Guadano A.","year":"2000","journal-title":"J. Nat. Prod."},{"key":"tx020067vb00002\/tx020067vb00002_1","volume-title":"Squamocin and benzyl benzoate, 22 acaricidal components of Uvaria pauci-ovulata bark extracts. Planta Med. 66, 173\u2212175","author":"Raynaud S.","year":"2000"},{"key":"tx020067vb00003\/tx020067vb00003_1","doi-asserted-by":"crossref","DOI":"10.1021\/jm990568m","volume":"43","author":"Queiroz E. F.","year":"2000","journal-title":"J. Med. Chem."},{"key":"tx020067vb00004\/tx020067vb00004_1","volume-title":"Squamocin, a new cytotoxic bis-tetrahydrofuran containing acetogenin from Annona squamosa. Chem. Pharm. Bull. 36, 4802\u22124806","author":"Fujimoto Y.","year":"1988"},{"key":"tx020067vb00005\/tx020067vb00005_1","volume-title":"Acetogenins from seeds of Annona reticulata. Phytochemistry 47, 1057\u22121061","author":"Chang F. R.","year":"1998"},{"key":"tx020067vb00006\/tx020067vb00006_1","volume":"62","author":"Ch\u00e0vez D.","year":"1999","journal-title":"J. Nat. Prod."},{"key":"tx020067vb00007\/tx020067vb00007_1","volume-title":"Semisynthesis and cytotoxicity of amino acetogenins and derivatives. Bioorg. Med. Chem. 7","author":"Duret P.","year":"1999"},{"key":"tx020067vb00008\/tx020067vb00008_1","doi-asserted-by":"crossref","DOI":"10.1021\/np980482g","volume":"62","author":"Queiroz E. F.","year":"1999","journal-title":"J. Nat. Prod."},{"key":"tx020067vb00009\/tx020067vb00009_1","volume-title":"Antitumoral effects of squamocin on parental and multidrug resistant MCF7 (human breast adenocarcinoma) cell lines. Life Sci. 65, 525\u2212533","author":"Raynaud S.","year":"1999"},{"key":"tx020067vb00010\/tx020067vb00010_1","doi-asserted-by":"crossref","DOI":"10.1042\/bj3010161","volume":"301","author":"Degli Esposti M.","year":"1994","journal-title":"Biochem. J."},{"key":"tx020067vb00011\/tx020067vb00011_1","volume-title":"Quinone-annonaceous acetogenins:\u2009 synthesis and complex I inhibition studies of a new class of natural product hybrids. Chemistry 7, 993\u22121005","author":"Arndt S.","year":"2001"},{"key":"tx020067vb00012\/tx020067vb00012_1","volume-title":"Mode of action of bullatacin, a potent antitumor acetogenin:\u2009 inhibition of NADH oxidase activity of HeLa and HL-60 cells, but not liver, plasma membranes. Life Sci. 56, 343\u2212348","author":"Morr\u00e9 D. J.","year":"1995"},{"key":"tx020067vb00013\/tx020067vb00013_1","volume-title":"Annonaceous acetogenins:\u2009 Naturally occurring inhibitors of ATP synthesis and photosystem II in spinach chloroplasts. Physiol. Plant 111, 262\u2212268","author":"Ch\u00e0vez D.","year":"2001"},{"key":"tx020067vb00014\/tx020067vb00014_1","volume-title":"Membrane conformations and their relation to cytotoxicity of asimicin and its analogues. Biochemistry 37, 854\u2212866","author":"Shimda H.","year":"1998"},{"key":"tx020067vb00015\/tx020067vb00015_1","volume-title":"Involvement of caspase-3 activation in squamocin-induced apoptosis in leukemia cell line HL-60. Life Sci. 70, 1259\u22121269","author":"Zhu X. F.","year":"2002"},{"key":"tx020067vb00016\/tx020067vb00016_1","doi-asserted-by":"crossref","DOI":"10.1152\/ajpcell.1995.268.4.C799","volume":"268","author":"Nelson M. T.","year":"1995","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"tx020067vb00017\/tx020067vb00017_1","volume":"13","author":"Toro L.","year":"1998","journal-title":"News Physiol. Sci."},{"key":"tx020067vb00018\/tx020067vb00018_1","doi-asserted-by":"crossref","DOI":"10.1074\/jbc.274.16.10927","volume":"274","author":"Fukao M.","year":"1999","journal-title":"J. Biol. Chem."},{"key":"tx020067vb00019\/tx020067vb00019_1","volume-title":"C1938\u2212C1945","author":"Nara M.","year":"2000"},{"key":"tx020067vb00020\/tx020067vb00020_1","doi-asserted-by":"crossref","DOI":"10.1046\/j.1365-201X.1998.00462.x","volume":"164","author":"Jaggar J. H.","year":"1998","journal-title":"Acta Physiol. Scand."},{"key":"tx020067vb00021\/tx020067vb00021_1","volume":"514","author":"Bae Y. M.","year":"1999","journal-title":"J. Physiol."},{"key":"tx020067vb00022\/tx020067vb00022_1","volume-title":"Vitro Cell Dev. Biol. 25, 511\u2212520.","author":"Fager G.","year":"1989"},{"key":"tx020067vb00023\/tx020067vb00023_1","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1007\/BF00656997","volume":"391","author":"Hamill O. P.","year":"1981","journal-title":"Pfl\u00fcgers Arch."},{"key":"tx020067vb00024\/tx020067vb00024_1","first-page":"74","volume":"57","author":"Wu S. N.","year":"2002","journal-title":"Thorax"},{"key":"tx020067vb00025\/tx020067vb00025_1","volume-title":"Aromin-A, an Annonaceous acetogenin from Annona cherimola. Phytochemistry 51, 429\u2212433","author":"Chen C. Y.","year":"1999"},{"key":"tx020067vb00026\/tx020067vb00026_1","volume-title":"Inhibition of Ca2+-activated K+ current by clotrimazole in rat anterior pituitary GH3 cells. Neuropharmacology 38, 979\u2212989","author":"Wu S. N.","year":"1999"},{"key":"tx020067vb00027\/tx020067vb00027_1","volume":"44","author":"Wu S. N.","year":"2001","journal-title":"Chin. J. Physiol."},{"key":"tx020067vb00028\/tx020067vb00028_1","volume-title":"YC-1, a novel activator of platelet guanylate cyclase. Blood 84, 4226\u22124233","author":"Ko F. N.","year":"1994"},{"key":"tx020067vb00029\/tx020067vb00029_1","volume-title":"The mechanism of actions of 3-(5\u2018-hydroxymethyl-2\u2018-furyl)-1-benzyl indazole (YC-1) on Ca2+-activated K+ currents in GH3 lactotrophs. Neuropharmacology 39, 1788\u22121799","author":"Wu S. N.","year":"2000"},{"key":"tx020067vb00030\/tx020067vb00030_1","volume":"49","author":"Wu S. N.","year":"2001","journal-title":"J. Invest. Med."},{"key":"tx020067vb00031\/tx020067vb00031_1","first-page":"76","volume":"112","author":"Chen Y.","year":"1995","journal-title":"Atherosclerosis"},{"key":"tx020067vb00032\/tx020067vb00032_1","volume":"36","author":"Peyrat J.-F.","year":"1995","journal-title":"Tetrahedron Lett."},{"key":"tx020067vb00033\/tx020067vb00033_1","volume":"36","author":"Sasaki S.","year":"1995","journal-title":"Tetrahedron Lett."},{"key":"tx020067vb00034\/tx020067vb00034_1","volume":"62","author":"Peyrat J.-F.","year":"1997","journal-title":"J. Org. Chem."}],"container-title":["Chemical Research in Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/tx020067v","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,6]],"date-time":"2023-04-06T17:40:04Z","timestamp":1680802804000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/tx020067v"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,12,5]]},"references-count":34,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2003,1,1]]}},"alternative-id":["10.1021\/tx020067v"],"URL":"https:\/\/doi.org\/10.1021\/tx020067v","relation":{},"ISSN":["0893-228X","1520-5010"],"issn-type":[{"value":"0893-228X","type":"print"},{"value":"1520-5010","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,12,5]]}}}