{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T11:03:22Z","timestamp":1773659002617,"version":"3.50.1"},"reference-count":88,"publisher":"American Chemical Society (ACS)","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chem. Res. Toxicol."],"published-print":{"date-parts":[[2003,10,1]]},"DOI":"10.1021\/tx025641h","type":"journal-article","created":{"date-parts":[[2003,11,19]],"date-time":"2003-11-19T19:32:02Z","timestamp":1069270322000},"page":"1264-1276","source":"Crossref","is-referenced-by-count":15,"title":["Nitrosation, Nitration, and Autoxidation of the Selective Estrogen Receptor Modulator Raloxifene by Nitric Oxide, Peroxynitrite, and Reactive Nitrogen\/Oxygen Species"],"prefix":"10.1021","volume":"16","author":[{"given":"Violeta","family":"Toader","sequence":"first","affiliation":[{"name":"Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, 833 Wood Street, Chicago, Illinois 60612-7231, and Department of Chemistry, Queen's University, Kingston, Ontario, K7L 3N6, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xudong","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, 833 Wood Street, Chicago, Illinois 60612-7231, and Department of Chemistry, Queen's University, Kingston, Ontario, K7L 3N6, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adrian","family":"Nicolescu","sequence":"additional","affiliation":[{"name":"Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, 833 Wood Street, Chicago, Illinois 60612-7231, and Department of Chemistry, Queen's University, Kingston, Ontario, K7L 3N6, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linning","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, 833 Wood Street, Chicago, Illinois 60612-7231, and Department of Chemistry, Queen's University, Kingston, Ontario, K7L 3N6, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Judy L.","family":"Bolton","sequence":"additional","affiliation":[{"name":"Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, 833 Wood Street, Chicago, Illinois 60612-7231, and Department of Chemistry, Queen's University, Kingston, Ontario, K7L 3N6, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregory R. J.","family":"Thatcher","sequence":"additional","affiliation":[{"name":"Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, 833 Wood Street, Chicago, Illinois 60612-7231, and Department of Chemistry, Queen's University, Kingston, Ontario, K7L 3N6, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"316","published-online":{"date-parts":[[2003,9,6]]},"reference":[{"key":"tx025641hb00001\/tx025641hb00001_1","volume-title":"The pharmacology and clinical uses of tamoxifen. Pharmacol. Ther. 25, 127\u2212205","author":"Furr B. J.","year":"1984"},{"key":"tx025641hb00002\/tx025641hb00002_1","volume-title":"The tamoxifen dilemma. Carcinogenesis 20, 1153\u22121160","author":"White I. N.","year":"1999"},{"key":"tx025641hb00003\/tx025641hb00003_1","volume-title":"Selective estrogen receptor modulation:\u2009 the search for an ideal hormonal therapy for breast cancer. Cancer Invest. 19, 649\u2212659","author":"Dhingra K.","year":"2001"},{"key":"tx025641hb00004\/tx025641hb00004_1","volume-title":"Breast cancer prevention trials. Curr. Oncol. Rep. 2, 558\u2212565","author":"Rhodes D. J.","year":"2000"},{"key":"tx025641hb00005\/tx025641hb00005_1","volume":"85","author":"Walsh B. W.","year":"2000","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"tx025641hb00006\/tx025641hb00006_1","volume":"37","author":"Gibaldi M.","year":"1997","journal-title":"J. Clin. Pharmacol."},{"key":"tx025641hb00007\/tx025641hb00007_1","volume-title":"Arzoxifene, a new selective estrogen receptor modulator for chemoprevention of experimental breast cancer. Cancer Res. 61, 8412\u22128415","author":"Suh N.","year":"2001"},{"key":"tx025641hb00008\/tx025641hb00008_1","volume":"272","author":"Darkow D. J.","year":"1997","journal-title":"Am. J. Physiol."},{"key":"tx025641hb00009\/tx025641hb00009_1","volume":"283","author":"Rahimian R.","year":"1997","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"tx025641hb00010\/tx025641hb00010_1","volume-title":"Raloxifene acutely relaxes rabbit coronary arteries in vitro by an estrogen receptor-dependent and nitric oxide-dependent mechanism. Circulation 100, 1095\u22121101","author":"Figtree G. A.","year":"1999"},{"key":"tx025641hb00011\/tx025641hb00011_1","volume-title":"Nongenomic mechanisms of endothelial nitric oxide synthase activation by the selective estrogen receptor modulator raloxifene. Circulation 105, 1368\u22121373","author":"Simoncini T.","year":"2002"},{"key":"tx025641hb00012\/tx025641hb00012_1","volume-title":"17 Beta-estradiol stimulates expression of endothelial and inducible NO synthase in rat myocardium in-vitro and in-vivo. Cardiovasc. Res. 43, 666\u2212674","author":"Nuedling S.","year":"1999"},{"key":"tx025641hb00013\/tx025641hb00013_1","first-page":"75","volume":"122","author":"Loo S. A.","year":"1998","journal-title":"Cancer Lett."},{"key":"tx025641hb00014\/tx025641hb00014_1","volume":"157","author":"Shao Z. M.","year":"2000","journal-title":"Cancer Lett."},{"key":"tx025641hb00015\/tx025641hb00015_1","doi-asserted-by":"crossref","DOI":"10.1016\/S0014-5793(01)02675-8","volume":"502","author":"Nuedling S.","year":"2001","journal-title":"FEBS Lett."},{"key":"tx025641hb00016\/tx025641hb00016_1","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/bjc.1995.274","volume":"72","author":"Thomsen L. L.","year":"1995","journal-title":"Br. J. Cancer"},{"key":"tx025641hb00017\/tx025641hb00017_1","doi-asserted-by":"crossref","DOI":"10.1038\/bjc.1998.68","volume":"77","author":"Moilanen E.","year":"1998","journal-title":"Br. J. Cancer"},{"key":"tx025641hb00018\/tx025641hb00018_1","volume-title":"Nitric oxide synthase activity in human gynecological cancer. Cancer Res. 54, 1352\u22121354","author":"Thomsen L. L.","year":"1994"},{"key":"tx025641hb00019\/tx025641hb00019_1","volume-title":"Selective inhibition of inducible nitric oxide synthase inhibits tumor growth in vivo:\u2009 studies with 1400W, a novel inhibitor. Cancer Res. 57, 3300\u22123304","author":"Thomsen L. L.","year":"1997"},{"key":"tx025641hb00020\/tx025641hb00020_1","doi-asserted-by":"crossref","DOI":"10.1023\/A:1005912906436","volume":"17","author":"Thomsen L. L.","year":"1998","journal-title":"Cancer Metastasis Rev."},{"key":"tx025641hb00021\/tx025641hb00021_1","volume":"1288","author":"Tamir S.","year":"1996","journal-title":"Biochim. Biophys. Acta"},{"key":"tx025641hb00022\/tx025641hb00022_1","volume-title":"Nitric oxide and peroxynitrite production by human erythrocytes:\u2009 a causative factor of toxic anemia in breast cancer patients. Anticancer Res. 15, 1435\u22121446","author":"Deliconstantinos G.","year":"1995"},{"key":"tx025641hb00023\/tx025641hb00023_1","doi-asserted-by":"crossref","DOI":"10.1093\/jnci\/93.24.1879","volume":"93","author":"Matthews N. E.","year":"2001","journal-title":"J. Natl. Cancer Inst."},{"key":"tx025641hb00024\/tx025641hb00024_1","volume-title":"Chemical biology of nitric oxide:\u2009 regulation and protective and toxic mechanisms. Curr. Top. Cell Regul. 34, 159\u2212187","author":"Wink D. A.","year":"1996"},{"key":"tx025641hb00025\/tx025641hb00025_1","volume-title":"Proc. Natl. Acad. Sci. U.S.A. 96","author":"Tien M.","year":"1999"},{"key":"tx025641hb00026\/tx025641hb00026_1","volume-title":"Detection and quantitation of nitrotyrosine residues in proteins:\u2009 in vivo marker of peroxynitrite. Methods Enzymol. 269, 185\u2212194","author":"Crow J. P.","year":"1996"},{"key":"tx025641hb00027\/tx025641hb00027_1","doi-asserted-by":"crossref","DOI":"10.1002\/1522-2675(20000906)83:9<2412::AID-HLCA2412>3.0.CO;2-E","volume":"83","author":"Tibi S.","year":"2000","journal-title":"Helv. Chim. Acta"},{"key":"tx025641hb00028\/tx025641hb00028_1","volume-title":"Tyrosine nitration:\u2009 localisation, quantification, consequences for protein function and signal transduction. Free Radical Res. 34, 541\u2212581","author":"Greenacre S. A.","year":"2001"},{"key":"tx025641hb00029\/tx025641hb00029_1","volume-title":"Proc. Natl. Acad. Sci. U.S.A. 99","author":"Thomas D. D.","year":"2002"},{"key":"tx025641hb00030\/tx025641hb00030_1","volume-title":"Myeloperoxidase and horseradish peroxidase catalyze tyrosine nitration in proteins from nitrite and hydrogen peroxide. Arch. Biochem. Biophys. 356, 207\u2212213","author":"Sampson J. B.","year":"1998"},{"key":"tx025641hb00031\/tx025641hb00031_1","volume-title":"Estrogens as a cause of human cancer:\u2009 the Richard and Hinda Rosenthal Foundation award lecture. Cancer Res. 48, 246\u2212253","author":"Henderson B. E.","year":"1988"},{"key":"tx025641hb00032\/tx025641hb00032_1","volume-title":"Synthesis and reactivity of potential toxic metabolites of tamoxifen analogues:\u2009 droloxifene and toremifene o-quinones. Chem. Res. Toxicol. 14, 1643\u22121653","author":"Yao D.","year":"2001"},{"key":"tx025641hb00033\/tx025641hb00033_1","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1021\/tx990145n","volume":"13","author":"Zhang F.","year":"2000","journal-title":"Chem. Res. Toxicol."},{"key":"tx025641hb00034\/tx025641hb00034_1","volume":"9","author":"Schmid C. R.","year":"1999","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"tx025641hb00035\/tx025641hb00035_1","volume":"27","author":"Jones C. D.","year":"1984","journal-title":"J. Med. Chem."},{"key":"tx025641hb00036\/tx025641hb00036_1","doi-asserted-by":"crossref","DOI":"10.1021\/jo01093a611","volume":"24","author":"Patton T. L.","year":"1959","journal-title":"J. Org. Chem."},{"key":"tx025641hb00037\/tx025641hb00037_1","volume-title":"Mesoionic compounds. I. Synthesis of 3-dialkylaminosydnonimines. Chem. Pharm. Bull. 18, 128\u2212132","author":"Masuda K.","year":"1970"},{"key":"tx025641hb00038\/tx025641hb00038_1","author":"Puranik G. S.","year":"1967","journal-title":"J. Chem. Soc. C, 1006\u22121008."},{"key":"tx025641hb00039\/tx025641hb00039_1","volume-title":"Selecting the most appropriate synthesis of peroxynitrite. Methods Enzymol. 269, 285\u2212296","author":"Uppu R. M.","year":"1996"},{"key":"tx025641hb00040\/tx025641hb00040_1","volume-title":"Tyrosine modification by reactive nitrogen species:\u2009 a closer look. Arch. Biochem. Biophys. 319, 341\u2212350","author":"van der Vliet A.","year":"1995"},{"key":"tx025641hb00041\/tx025641hb00041_1","doi-asserted-by":"crossref","DOI":"10.1097\/00005344-198914110-00004","volume":"14","author":"Feelisch M.","year":"1989","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"tx025641hb00042\/tx025641hb00042_1","doi-asserted-by":"crossref","unstructured":"Crow, J. P. (1997) Dichlorodihydrofluorescein and dihydrorhodamine 123 are sensitive indicators of peroxynitrite in vitro:\u2009 implications for intracellular measurement of reactive nitrogen and oxygen species.Nitric Oxide1, 145\u2212157.","DOI":"10.1006\/niox.1996.0113"},{"key":"tx025641hb00043\/tx025641hb00043_1","volume-title":"NO release from NO donors and nitrovasodilators:\u2009 comparisons between oxyhemoglobin and potentiometric assays. Chem. Res. Toxicol. 11, 1393\u22121397","author":"Artz J. D.","year":"1998"},{"key":"tx025641hb00044\/tx025641hb00044_1","volume-title":"Nitric oxide is consumed, rather than conserved, by reaction with oxyhemoglobin under physiological conditions. Proc. Natl. Acad. Sci. U.S.A. 99, 10341\u221210346","author":"Joshi M. S.","year":"2002"},{"key":"tx025641hb00045\/tx025641hb00045_1","volume-title":"vitro activation of soluble guanylyl cyclase and nitric oxide release:\u2009 a comparison of NO donors and NO mimetics. Biochemistry 40, 9256\u22129264","author":"Artz J. D.","year":"2001"},{"key":"tx025641hb00046\/tx025641hb00046_1","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1006\/abbi.1998.0755","volume":"356","author":"Ischiropoulos H.","year":"1998","journal-title":"Arch. Biochem. Biophys."},{"key":"tx025641hb00047\/tx025641hb00047_1","volume":"278","author":"Whiteman M.","year":"2003","journal-title":"J. Biol. Chem."},{"key":"tx025641hb00048\/tx025641hb00048_1","volume-title":"The quantitative oxidation of methionine to methionine sulfoxide by peroxynitrite. Arch. Biochem. Biophys. 377, 266\u2212272","author":"Perrin D.","year":"2000"},{"key":"tx025641hb00049\/tx025641hb00049_1","volume-title":"Electrode and homogeneous transformations of the NO22- ion. Elektrokhimiya 25, 178\u2212185","author":"Benderskii V. A.","year":"1989"},{"key":"tx025641hb00050\/tx025641hb00050_1","volume-title":"Proc. Natl. Acad. Sci. U.S.A. 99","author":"Bartberger M. D.","year":"2002"},{"key":"tx025641hb00051\/tx025641hb00051_1","volume-title":"Formation of iminoxyl and nitroxide free radicals from nitrosonaphthols:\u2009 an electron spin resonance study. Chem.-Biol. Interact. 57, 129\u2212142","author":"Fischer V.","year":"1986"},{"key":"tx025641hb00052\/tx025641hb00052_1","doi-asserted-by":"crossref","DOI":"10.1046\/j.1460-9568.2002.01930.x","volume":"15","author":"Griffiths C.","year":"2002","journal-title":"Eur. J. Neurosci."},{"key":"tx025641hb00053\/tx025641hb00053_1","volume-title":"A rapid and simple method for the measurement of nitrite and nitrate in plasma by high performance capillary electrophoresis. Biochem. Biophys. Res. Commun. 200, 951\u2212957","author":"Leone A. M.","year":"1994"},{"key":"tx025641hb00054\/tx025641hb00054_1","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/s002960050055","volume":"18","author":"Wanchu A.","year":"1998","journal-title":"Rheumatol. Int."},{"key":"tx025641hb00055\/tx025641hb00055_1","first-page":"140","volume":"28","author":"Funk C.","year":"1913","journal-title":"Proc. Chem. Soc."},{"key":"tx025641hb00056\/tx025641hb00056_1","volume":"37","author":"Johnson T. B.","year":"1915","journal-title":"J. Am. Chem. Soc."},{"key":"tx025641hb00057\/tx025641hb00057_1","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0300-483X(02)00191-9","volume":"177","author":"Gunther M. R.","year":"2002","journal-title":"Toxicology"},{"key":"tx025641hb00058\/tx025641hb00058_1","volume-title":"Nitric oxide-induced nitration of catecholamine neurotransmitters:\u2009 a key to neuronal degeneration? Bioorg. Med. Chem. 3, 923\u2212927","author":"Ischia M.","year":"1995"},{"key":"tx025641hb00059\/tx025641hb00059_1","doi-asserted-by":"crossref","unstructured":"Alvarez, B., Rubbo, H., Kirk, M., Barnes, S., Freeman, B. A., and Radi, R. (1996) Peroxynitrite-dependent tryptophan nitration.Chem. Res. Toxicol.9, 390\u2212396.","DOI":"10.1021\/tx950133b"},{"key":"tx025641hb00060\/tx025641hb00060_1","doi-asserted-by":"crossref","DOI":"10.1074\/jbc.271.23.13561","volume":"271","author":"Shintani F.","year":"1996","journal-title":"J. Biol. Chem."},{"key":"tx025641hb00061\/tx025641hb00061_1","volume-title":"Oxidation and nitration of catecholamines by nitrogen oxides derived from nitric oxide. Nitric Oxide 1, 234\u2212243","author":"Daveu C.","year":"1997"},{"key":"tx025641hb00062\/tx025641hb00062_1","volume-title":"New aspects in the reaction mechanism of phenol with peroxynitrite:\u2009 the role of phenoxy radicals. Nitric Oxide 2, 259\u2212269","author":"Daiber A.","year":"1998"},{"key":"tx025641hb00063\/tx025641hb00063_1","volume-title":"Transformations of 2,6-diisopropylphenol by NO-derived nitrogen oxides, particularly peroxynitrite. Nitric Oxide 4, 147\u2212156","author":"Cudic M.","year":"2000"},{"key":"tx025641hb00064\/tx025641hb00064_1","doi-asserted-by":"crossref","DOI":"10.1074\/jbc.275.9.6346","volume":"275","author":"Pfeiffer S.","year":"2000","journal-title":"J. Biol. Chem."},{"key":"tx025641hb00065\/tx025641hb00065_1","volume-title":"Oxidation of serotonin by superoxide radical:\u2009 implications to neurodegenerative brain disorders. Chem. Res. Toxicol. 11, 639\u2212650","author":"Wrona M. Z.","year":"1998"},{"key":"tx025641hb00066\/tx025641hb00066_1","volume-title":"Inhibition of peroxynitrite-induced nitration of tyrosine by glutathione in the presence of carbon dioxide through both radical repair and peroxynitrate formation. Chemistry 7, 3313\u22123320","author":"Kirsch M.","year":"2001"},{"key":"tx025641hb00067\/tx025641hb00067_1","volume":"273","author":"Goodwin D. C.","year":"1998","journal-title":"J. Biol. Chem."},{"key":"tx025641hb00068\/tx025641hb00068_1","volume-title":"NO interacts with the tyrosine radical Y(D). of photosystem II to form an iminoxyl radical. Biochemistry 36, 1411\u22121417","author":"Sanakis Y.","year":"1997"},{"key":"tx025641hb00069\/tx025641hb00069_1","doi-asserted-by":"crossref","DOI":"10.1074\/jbc.M106835200","volume":"276","author":"Sturgeon B. E.","year":"2001","journal-title":"J. Biol. Chem."},{"key":"tx025641hb00070\/tx025641hb00070_1","author":"Burawoy A.","year":"1955","journal-title":"J. Chem. Soc. 3727\u22123733."},{"key":"tx025641hb00071\/tx025641hb00071_1","author":"Saarinen H.","year":"1978","journal-title":"Finn. Chem. Lett. 223\u2212226."},{"key":"tx025641hb00072\/tx025641hb00072_1","volume-title":"Does tautomeric equilibrium exist in ortho-nitrosonaphthols? Chem. Phys. 264, 235\u2212244","author":"Ivanova G.","year":"2001"},{"key":"tx025641hb00073\/tx025641hb00073_1","volume-title":"An ab initio molecular orbital study of nitrosophenol\/quinone monooxime equilibria. Theochem 528, 237\u2212244","author":"Krzan A.","year":"2000"},{"key":"tx025641hb00074\/tx025641hb00074_1","doi-asserted-by":"crossref","DOI":"10.1002\/(SICI)1099-1395(199610)9:10<695::AID-POC839>3.0.CO;2-O","volume":"9","author":"Krzan A.","year":"1996","journal-title":"J. Phys. Org. Chem."},{"key":"tx025641hb00075\/tx025641hb00075_1","volume":"90","author":"Wenger N. K.","year":"2002","journal-title":"Am. J. Cardiol."},{"key":"tx025641hb00076\/tx025641hb00076_1","doi-asserted-by":"crossref","DOI":"10.1023\/A:1021219212638","volume":"21","author":"Pappas S. G.","year":"2002","journal-title":"Cancer Metastasis Rev."},{"key":"tx025641hb00077\/tx025641hb00077_1","volume-title":"A-ring nitro- and amino-substituted estradiol analogues produce a negative cooperative or noncooperative [3H]estradiol-estrogen receptor binding mechanism. Biochemistry 33, 13267\u221213273","author":"Schwartz J. A.","year":"1994"},{"key":"tx025641hb00078\/tx025641hb00078_1","doi-asserted-by":"crossref","DOI":"10.1021\/jm9703294","volume":"40","author":"Wiese T. E.","year":"1997","journal-title":"J. Med. Chem."},{"key":"tx025641hb00079\/tx025641hb00079_1","volume-title":"Crystal structure, receptor binding, and gene regulation of 2- and 4-nitroestradiols. Steroids 61, 670\u2212676","author":"Palomino E.","year":"1996"},{"key":"tx025641hb00080\/tx025641hb00080_1","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S0300-483X(02)00195-6","volume":"177","author":"Bolton J. L.","year":"2002","journal-title":"Toxicology"},{"key":"tx025641hb00081\/tx025641hb00081_1","doi-asserted-by":"crossref","DOI":"10.1016\/S0891-5849(97)00269-4","volume-title":"Synergistic induction of DNA strand breakage by catechol-estrogen and nitric oxide:\u2009 implications for hormonal carcinogenesis. Free Radical Biol. Med. 24, 341\u2212348","author":"Yoshie Y.","year":"1998"},{"key":"tx025641hb00082\/tx025641hb00082_1","volume-title":"vitro generation of peroxynitrite by 2- and 4-hydroxyestrogens in the presence of nitric oxide. Chem. Res. Toxicol. 14, 547\u2212554","author":"Paquette B.","year":"2001"},{"key":"tx025641hb00083\/tx025641hb00083_1","doi-asserted-by":"crossref","DOI":"10.1046\/j.1471-4159.2002.00900.x","volume":"81","author":"Laranjinha J.","year":"2002","journal-title":"J. Neurochem."},{"key":"tx025641hb00084\/tx025641hb00084_1","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1006\/abbi.1997.0100","volume":"342","author":"Yoshie Y.","year":"1997","journal-title":"Arch. Biochem. Biophys."},{"key":"tx025641hb00085\/tx025641hb00085_1","volume":"338","author":"Oge A.","year":"2003","journal-title":"Neurosci. Lett."},{"key":"tx025641hb00086\/tx025641hb00086_1","volume-title":"Raloxifene improves endothelial dysfunction in hypertension by reduced oxidative stress and enhanced nitric oxide production. Circulation 105","author":"Wassmann S.","year":"2002"},{"key":"tx025641hb00087\/tx025641hb00087_1","first-page":"52","volume":"13","author":"Fan P. W.","year":"2000","journal-title":"Chem. Res. Toxicol."},{"key":"tx025641hb00088\/tx025641hb00088_1","volume-title":"Cytochrome P450 3A4-Mediated Bioactivation of Raloxifene:\u2009 Irreversible Enzyme Inhibition and Thiol Adduct Formation. Chem. Res. Toxicol. 15, 907\u2212914","author":"Chen Q.","year":"2002"}],"container-title":["Chemical Research in Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/tx025641h","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,14]],"date-time":"2023-03-14T13:41:09Z","timestamp":1678801269000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/tx025641h"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,9,6]]},"references-count":88,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2003,10,1]]}},"alternative-id":["10.1021\/tx025641h"],"URL":"https:\/\/doi.org\/10.1021\/tx025641h","relation":{},"ISSN":["0893-228X","1520-5010"],"issn-type":[{"value":"0893-228X","type":"print"},{"value":"1520-5010","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,9,6]]}}}