{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T00:46:48Z","timestamp":1789433208664,"version":"build-2803163510"},"reference-count":31,"publisher":"American Chemical Society (ACS)","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chem. Res. Toxicol."],"published-print":{"date-parts":[[2003,9,1]]},"DOI":"10.1021\/tx034064+","type":"journal-article","created":{"date-parts":[[2003,11,19]],"date-time":"2003-11-19T19:30:57Z","timestamp":1069270257000},"page":"1078-1089","source":"Crossref","is-referenced-by-count":72,"title":["Characterization of a Potential Animal Model of an Idiosyncratic Drug Reaction:\u2009 Nevirapine-Induced Skin Rash in the Rat"],"prefix":"10.1021","volume":"16","author":[{"given":"Jacintha M.","family":"Shenton","sequence":"first","affiliation":[{"name":"Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada, Ultrastructural Pathology, National Institutes of Health, Bethesda, Maryland, United States, Department of Pathobiology, Ontario Veterinary College, Guelph University, Guelph, Ontario, Canada, and Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Munehiro","family":"Teranishi","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada, Ultrastructural Pathology, National Institutes of Health, Bethesda, Maryland, United States, Department of Pathobiology, Ontario Veterinary College, Guelph University, Guelph, Ontario, Canada, and Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mones S.","family":"Abu-Asab","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada, Ultrastructural Pathology, National Institutes of Health, Bethesda, Maryland, United States, Department of Pathobiology, Ontario Veterinary College, Guelph University, Guelph, Ontario, Canada, and Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie A.","family":"Yager","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada, Ultrastructural Pathology, National Institutes of Health, Bethesda, Maryland, United States, Department of Pathobiology, Ontario Veterinary College, Guelph University, Guelph, Ontario, Canada, and Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jack P.","family":"Uetrecht","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada, Ultrastructural Pathology, National Institutes of Health, Bethesda, Maryland, United States, Department of Pathobiology, Ontario Veterinary College, Guelph University, Guelph, Ontario, Canada, and Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2003,8,7]]},"reference":[{"key":"tx0340641b00001\/tx0340641b00001_1","volume-title":"Timing of new black box warnings and withdrawals for prescription medications. JAMA 287, 2215\u22122220","author":"Lasser K. E.","year":"2002"},{"key":"tx0340641b00002\/tx0340641b00002_1","volume-title":"Is it possible to more accurately predict which drug candidates will cause idiosyncratic drug reactions? Curr. Drug. Metab. 1, 133\u2212141","author":"Uetrecht J. P.","year":"2000"},{"key":"tx0340641b00003\/tx0340641b00003_1","first-page":"23","volume":"158","author":"Park B. K.","year":"2001","journal-title":"Toxicology"},{"key":"tx0340641b00004\/tx0340641b00004_1","volume-title":"Factors that modify penicillamine-induced autoimmunity in Brown Norway rats:\u2009 failure of the Th1\/Th2 paradigm. Toxicology 163, 195\u2212211","author":"Sayeh E.","year":"2001"},{"key":"tx0340641b00005\/tx0340641b00005_1","volume-title":"Halothane hepatotoxicity in guinea pigs. Anesth. Analg. 66, 222\u2212228","author":"Lind R. C.","year":"1987"},{"key":"tx0340641b00006\/tx0340641b00006_1","volume":"186","author":"Giger U.","year":"1985","journal-title":"J. Am. Vet. Med. Assoc."},{"key":"tx0340641b00007\/tx0340641b00007_1","volume-title":"Antibodies to myeloperoxidase in propylthiouracil-induced autoimmune disease in the cat. Toxicology 114, 155\u2212162","author":"Waldhauser L.","year":"1996"},{"key":"tx0340641b00008\/tx0340641b00008_1","doi-asserted-by":"crossref","DOI":"10.3109\/03602539709037575","volume":"29","author":"Chen M.","year":"1997","journal-title":"Drug Metab. Rev."},{"key":"tx0340641b00009\/tx0340641b00009_1","volume-title":"Safety profile of nevirapine, a nonnucleoside reverse transcriptase inhibitor for the treatment of human immunodeficiency virus infection. Clin. Ther. 20, 1071\u22121092","author":"Pollard R. B.","year":"1998"},{"key":"tx0340641b00010\/tx0340641b00010_1","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/S0140-6736(98)24008-6","volume":"351","author":"Warren K. J.","year":"1998","journal-title":"Lancet"},{"key":"tx0340641b00011\/tx0340641b00011_1","volume-title":"Nevirapine-induced hepatitis:\u2009 a case series and review of the literature. AIDS Read. 11, 379\u2212382","author":"Piliero P. J.","year":"2001"},{"key":"tx0340641b00012\/tx0340641b00012_1","volume-title":"From the Centers for Disease Control and Prevention. Serious adverse events attributed to nevirapine regimens for postexposure prophylaxis after HIV exposuresworldwide","author":"Anonymous","year":"2001"},{"key":"tx0340641b00013\/tx0340641b00013_1","volume-title":"Adverse effects associated with use of nevirapine in HIV postexposure prophylaxis for 2 health care workers. JAMA 284, 2722\u22122723","author":"Johnson S.","year":"2000"},{"key":"tx0340641b00014\/tx0340641b00014_1","volume-title":"Nevirapine:\u2009 A Review of its Development, Pharmacological Profile and Potential for Clinical Use. Exp. Opin. Invest. Drugs 5, 1183\u22121199","author":"Murphy R. L.","year":"1996"},{"key":"tx0340641b00015\/tx0340641b00015_1","doi-asserted-by":"crossref","DOI":"10.4049\/jimmunol.144.8.2985","volume":"144","author":"Tournade H.","year":"1990","journal-title":"J. Immunol."},{"key":"tx0340641b00016\/tx0340641b00016_1","volume-title":"Dial., Transplant. 6, 621\u2212630.","author":"Tournade H.","year":"1991"},{"key":"tx0340641b00017\/tx0340641b00017_1","doi-asserted-by":"crossref","DOI":"10.1046\/j.1365-3083.2001.00932.x","volume":"54","author":"Abedi-Valugerdi M.","year":"2001","journal-title":"Scand. J. Immunol."},{"key":"tx0340641b00018\/tx0340641b00018_1","volume-title":"Sex differences in nevirapine rash. Clin. Infect. Dis. 32, 124\u2212129","author":"Bersoff-Matcha S. J.","year":"2001"},{"key":"tx0340641b00019\/tx0340641b00019_1","volume-title":"Cutaneous manifestations of human immunodeficiency virus infection. Part II. Arch. Dermatol. 127, 1549\u22121558","author":"Dover J. S.","year":"1991"},{"key":"tx0340641b00020\/tx0340641b00020_1","volume-title":"Prevention of nevirapine-associated exanthema using slow dose escalation and\/or corticosteroids. AIDS 14, 2153\u22122157","author":"Barreiro P.","year":"2000"},{"key":"tx0340641b00021\/tx0340641b00021_1","doi-asserted-by":"crossref","DOI":"10.1111\/1523-1747.ep12388434","volume":"102","author":"Roujeau J. C.","year":"1994","journal-title":"J. Invest. Dermatol."},{"key":"tx0340641b00022\/tx0340641b00022_1","doi-asserted-by":"crossref","DOI":"10.1093\/infdis\/171.3.537","volume":"171","author":"Havlir D.","year":"1995","journal-title":"J. Infect. Dis."},{"key":"tx0340641b00023\/tx0340641b00023_1","volume-title":"T-cell subsets in drug-induced toxic epidermal necrolysis. Possible pathogenic mechanism induced by CD8-positive T cells. Arch. Dermatol. 127, 851\u2212855","author":"Miyauchi H.","year":"1991"},{"key":"tx0340641b00024\/tx0340641b00024_1","first-page":"53","volume":"128","author":"Villada G.","year":"1992","journal-title":"Arch. Dermatol."},{"key":"tx0340641b00025\/tx0340641b00025_1","doi-asserted-by":"crossref","DOI":"10.1111\/j.1365-2133.1985.tb02356.x","volume":"113","author":"Roujeau J. C.","year":"1985","journal-title":"Br. J. Dermatol."},{"key":"tx0340641b00026\/tx0340641b00026_1","volume-title":"Macrophages and tumor necrosis factor alpha in toxic epidermal necrolysis. Arch. Dermatol. 130, 605\u2212608","author":"Paquet P.","year":"1994"},{"key":"tx0340641b00027\/tx0340641b00027_1","volume-title":"Blister fluid T lymphocytes during toxic epidermal necrolysis are functional cytotoxic cells which express human natural killer (NK) inhibitory receptors. Clin. Exp. Immunol. 119, 225\u2212230","author":"Le Cleach L.","year":"2000"},{"key":"tx0340641b00028\/tx0340641b00028_1","volume-title":"T cell involvement in cutaneous drug eruptions. Clin. Exp. Allergy 31, 1398\u22121408","author":"Hari Y.","year":"2001"},{"key":"tx0340641b00029\/tx0340641b00029_1","volume-title":"Infiltration of cytotoxic T cells in drug-induced cutaneous eruptions. Clin. Exp. Allergy 30, 847\u2212855","author":"Yawalkar N.","year":"2000"},{"key":"tx0340641b00030\/tx0340641b00030_1","volume-title":"T-cell-mediated cytotoxicity against keratinocytes in sulfamethoxazole-induced skin reaction. Clin. Exp. Allergy 28, 1412\u22121417","author":"Schnyder B.","year":"1998"},{"key":"tx0340641n00001\/tx0340641n00001_1","volume-title":"toxic epidermal necrolysis","author":"Abbreviations TEN"}],"container-title":["Chemical Research in Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/tx034064%2B","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,11]],"date-time":"2024-01-11T12:34:17Z","timestamp":1704976457000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/tx034064%2B"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,8,7]]},"references-count":31,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2003,9,1]]}},"alternative-id":["10.1021\/tx034064+"],"URL":"https:\/\/doi.org\/10.1021\/tx034064+","relation":{},"ISSN":["0893-228X","1520-5010"],"issn-type":[{"value":"0893-228X","type":"print"},{"value":"1520-5010","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,8,7]]}}}