{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T20:20:00Z","timestamp":1773001200315,"version":"3.50.1"},"reference-count":46,"publisher":"American Chemical Society (ACS)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chem. Res. Toxicol."],"published-print":{"date-parts":[[2005,4,1]]},"DOI":"10.1021\/tx049672j","type":"journal-article","created":{"date-parts":[[2005,4,18]],"date-time":"2005-04-18T13:52:20Z","timestamp":1113832340000},"page":"747-754","source":"Crossref","is-referenced-by-count":27,"title":["Reaction Kinetics of Biotinylated Organophosphorus Toxicant, FP-biotin, with Human Acetylcholinesterase and Human Butyrylcholinesterase"],"prefix":"10.1021","volume":"18","author":[{"given":"Lawrence M.","family":"Schopfer","sequence":"first","affiliation":[{"name":"Eppley Institute, University of Nebraska Medical Center, Omaha, Nebraska 68198-6805, and Department of Biomedical and Pharmaceutical Sciences, University of Montana, Missoula, Montana 59812"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Troy","family":"Voelker","sequence":"additional","affiliation":[{"name":"Eppley Institute, University of Nebraska Medical Center, Omaha, Nebraska 68198-6805, and Department of Biomedical and Pharmaceutical Sciences, University of Montana, Missoula, Montana 59812"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cynthia F.","family":"Bartels","sequence":"additional","affiliation":[{"name":"Eppley Institute, University of Nebraska Medical Center, Omaha, Nebraska 68198-6805, and Department of Biomedical and Pharmaceutical Sciences, University of Montana, Missoula, Montana 59812"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles M.","family":"Thompson","sequence":"additional","affiliation":[{"name":"Eppley Institute, University of Nebraska Medical Center, Omaha, Nebraska 68198-6805, and Department of Biomedical and Pharmaceutical Sciences, University of Montana, Missoula, Montana 59812"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oksana","family":"Lockridge","sequence":"additional","affiliation":[{"name":"Eppley Institute, University of Nebraska Medical Center, Omaha, Nebraska 68198-6805, and Department of Biomedical and Pharmaceutical Sciences, University of Montana, Missoula, Montana 59812"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"316","published-online":{"date-parts":[[2005,3,22]]},"reference":[{"key":"tx049672jb00001\/tx049672jb00001_1","first-page":"20","volume":"41","author":"Mileson B. E.","year":"1998","journal-title":"Toxicol. Sci."},{"key":"tx049672jb00002\/tx049672jb00002_1","volume":"21","author":"McDonough J. H., Jr.","year":"1997","journal-title":"Neurosci. Biobehav. Rev."},{"key":"tx049672jb00003\/tx049672jb00003_1","first-page":"70","volume":"35","author":"Fillmore C. M.","year":"1993","journal-title":"J. Occup. Med."},{"key":"tx049672jb00004\/tx049672jb00004_1","volume-title":"NTE:\u2009 One target protein for different toxic syndromes with distinct mechanisms? Bioessays 25, 742\u2212745","author":"Glynn P.","year":"2003"},{"key":"tx049672jb00005\/tx049672jb00005_1","volume-title":"Proc. Natl. Acad. Sci. U.S.A. 100","author":"Quistad G. B.","year":"2003"},{"key":"tx049672jb00006\/tx049672jb00006_1","volume-title":"Organophosphate toxicology:\u2009 Safety aspects of nonacetylcholinesterase secondary targets. Chem. Res. Toxicol. 17, 983\u2212998","author":"Casida J. E.","year":"2004"},{"key":"tx049672jb00007\/tx049672jb00007_1","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/0378-4274(87)90254-2","volume":"39","author":"Maxwell D. M.","year":"1987","journal-title":"Toxicol. Lett."},{"key":"tx049672jb00008\/tx049672jb00008_1","volume-title":"Prevention of tolerance to the organophosphorus anticholinesterase paraoxon with carboxylesterase inhibitors. Biochem. Pharmacol. 55, 1419\u22121426","author":"Yang Z. P.","year":"1998"},{"key":"tx049672jb00009\/tx049672jb00009_1","volume-title":"Identification of acylpeptide hydrolase as a sensitive site for reaction with organophosphorus compounds and a potential target for cognitive enhancing drugs. Mol. Pharmacol. 58, 577\u2212583","author":"Richards P. G.","year":"2000"},{"key":"tx049672jb00010\/tx049672jb00010_1","volume-title":"Albumin, a new biomarker of organophosphorus toxicant exposure, identified by mass spectrometry. Toxicol. Sci. 83, 303\u2212312","author":"Peeples E. S.","year":"2005"},{"key":"tx049672jb00011\/tx049672jb00011_1","volume-title":"Correlation of the anticholinesterase activity of a series of organophosphates with their ability to compete with agonist binding to muscarinic receptors. Toxicol. Appl. Pharmacol. 122, 300\u2212307","author":"Ward T. R.","year":"1993"},{"key":"tx049672jb00012\/tx049672jb00012_1","doi-asserted-by":"crossref","DOI":"10.1074\/jbc.270.43.25481","volume":"270","author":"Tjoelker L. W.","year":"1995","journal-title":"J. Biol. Chem."},{"key":"tx049672jb00013\/tx049672jb00013_1","doi-asserted-by":"crossref","DOI":"10.1124\/jpet.102.043109","volume":"304","author":"Santos M. D.","year":"2003","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"tx049672jb00014\/tx049672jb00014_1","volume-title":"Comparisons of the acute effects of cholinesterase inhibitors using a neurobehavioral screening battery in rats. Neurotoxicol. Teratol. 17, 617\u2212625","author":"Moser V. C.","year":"1995"},{"key":"tx049672jb00015\/tx049672jb00015_1","volume":"2","author":"Pope C. N.","year":"1999","journal-title":"J. Toxicol. Environ. Health B Crit. Rev."},{"key":"tx049672jb00016\/tx049672jb00016_1","volume":"120","author":"Ray D. E.","year":"2001","journal-title":"Toxicol. Lett."},{"key":"tx049672jb00017\/tx049672jb00017_1","volume-title":"The use of zebrafish mutants to identify secondary target effects of acetylcholine esterase inhibitors. Toxicol. Sci. 77, 325\u2212333","author":"Behra M.","year":"2004"},{"key":"tx049672jb00018\/tx049672jb00018_1","volume-title":"Life without acetylcholinesterase:\u2009 The implications of cholinesterase inhibitor toxicity in AChE-knockout mice. Environ. Toxicol. Pharmacol. Published online","author":"Lockridge O.","year":"2005"},{"key":"tx049672jb00019\/tx049672jb00019_1","volume-title":"Proc. Natl. Acad. Sci. U.S.A. 96","author":"Liu Y.","year":"1999"},{"key":"tx049672jb00020\/tx049672jb00020_1","volume-title":"Profiling serine hydrolase activities in complex proteomes. Biochemistry 40, 4005\u22124015","author":"Kidd D.","year":"2001"},{"key":"tx049672jb00021\/tx049672jb00021_1","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/0163-7258(90)90044-3","volume":"47","author":"Lockridge O.","year":"1990","journal-title":"Pharmacol. Ther."},{"key":"tx049672jb00022\/tx049672jb00022_1","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/0006-2952(61)90145-9","volume":"7","author":"Ellman G. L.","year":"1961","journal-title":"Biochem. Pharmacol."},{"key":"tx049672jb00023\/tx049672jb00023_1","doi-asserted-by":"crossref","DOI":"10.1042\/bj1150147","volume":"115","author":"Aldridge W. N.","year":"1969","journal-title":"Biochem. J."},{"key":"tx049672jb00024\/tx049672jb00024_1","volume-title":"Affinity and phosphorylation constants for the inhibition of esterases by organophosphates. Science 144, 992\u2212993","author":"Main A. R.","year":"1964"},{"key":"tx049672jb00025\/tx049672jb00025_1","doi-asserted-by":"crossref","DOI":"10.1042\/bj0940023C","volume":"94","author":"Green N. M.","year":"1965","journal-title":"Biochem. J."},{"key":"tx049672jb00026\/tx049672jb00026_1","volume-title":"Atomic structure of acetylcholinesterase from Torpedo californica:\u2009 A prototypic acetylcholine-binding protein. Science 253, 872\u2212879","author":"Sussman J. L.","year":"1991"},{"key":"tx049672jb00027\/tx049672jb00027_1","volume-title":"Butyrylcholinesterase-mediated enhancement of the enzymatic activity of trypsin. Cell Mol. Neurobiol. 21, 285\u2212296","author":"Darvesh S.","year":"2001"},{"key":"tx049672jb00028\/tx049672jb00028_1","doi-asserted-by":"crossref","DOI":"10.1074\/jbc.M210241200","volume":"278","author":"Nicolet Y.","year":"2003","journal-title":"J. Biol. Chem."},{"key":"tx049672jb00029\/tx049672jb00029_1","volume-title":"Open \u201cback door","author":"Gilson M. K.","year":"1994"},{"key":"tx049672jb00030\/tx049672jb00030_1","volume-title":"Organophosphorus acid anhydride hydrolase activity in human butyrylcholinesterase:\u2009 Synergy results in a somanase. Biochemistry 37, 237\u2212247","author":"Millard C. B.","year":"1998"},{"key":"tx049672jb00031\/tx049672jb00031_1","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1006\/taap.2001.9279","volume":"176","author":"Doorn J. A.","year":"2001","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"tx049672jb00032\/tx049672jb00032_1","volume-title":"Inhibition of various cholinesterases with the enantiomers of malaoxon. Bull. Environ. Contam. Toxicol. 58, 171\u2212176","author":"Rodriguez O. P.","year":"1997"},{"key":"tx049672jb00033\/tx049672jb00033_1","volume-title":"Specificity and orientation of trigonal carboxyl esters and tetrahedral alkylphosphonyl esters in cholinesterases. Biochemistry 34, 11528\u221211536","author":"Hosea N. A.","year":"1995"},{"key":"tx049672jb00034\/tx049672jb00034_1","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/0041-008X(84)90249-7","volume":"72","author":"Benschop H. P.","year":"1984","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"tx049672jb00035\/tx049672jb00035_1","volume-title":"Exploring the active center of human acetylcholinesterase with stereomers of an organophosphorus inhibitor with two chiral centers. Biochemistry 38, 3055\u22123066","author":"Ordentlich A.","year":"1999"},{"key":"tx049672jb00036\/tx049672jb00036_1","volume-title":"Crystal structures of aged phosphonylated acetylcholinesterase:\u2009 Nerve agent reaction products at the atomic level. Biochemistry 38, 7032\u22127039","author":"Millard C. B.","year":"1999"},{"key":"tx049672jb00037\/tx049672jb00037_1","volume-title":"Albumin, a new biomarker of organophosphorus toxicant exposure, identified by mass spectrometry. Toxicol. Sci. 83, 303\u2212312","author":"Peeples E. S.","year":"2005"},{"key":"tx049672jb00038\/tx049672jb00038_1","volume-title":"Inhibition of acetylcholinesterase and butyrylcholinesterase by chlorpyrifos-oxon. Biochem. Pharmacol. 56, 293\u2212299","author":"Amitai G.","year":"1998"},{"key":"tx049672jb00039\/tx049672jb00039_1","volume-title":"Human butyrylcholinesterase as a general prophylactic antidote for nerve agent toxicity. In vitro and in vivo quantitative characterization. Biochem. Pharmacol. 45, 2465\u22122474","author":"Raveh L.","year":"1993"},{"key":"tx049672jb00040\/tx049672jb00040_1","volume-title":"Inhibition, reactivation and aging kinetics of cyclohexylmethylphosphonofluoridate-inhibited human cholinesterases. Arch. Toxicol. 72, 580\u2212587","author":"Worek F.","year":"1998"},{"key":"tx049672jb00041\/tx049672jb00041_1","volume":"7","author":"Skrinjaric-Spoljar M.","year":"1993","journal-title":"J. Enzymol. Inhib."},{"key":"tx049672jb00042\/tx049672jb00042_1","doi-asserted-by":"crossref","DOI":"10.1074\/jbc.271.20.11953","volume":"271","author":"Ordentlich A.","year":"1996","journal-title":"J. Biol. Chem."},{"key":"tx049672jb00043\/tx049672jb00043_1","volume":"315","author":"Skrinjaric-Spoljar M.","year":"1973","journal-title":"Biochim. Biophys. Acta"},{"key":"tx049672jb00044\/tx049672jb00044_1","volume":"101","author":"Main A. R.","year":"1966","journal-title":"Biochem. J."},{"key":"tx049672jb00045\/tx049672jb00045_1","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1007\/s002040050580","volume":"73","author":"Worek F.","year":"1999","journal-title":"Arch. Toxicol."},{"key":"tx049672jn00001\/tx049672jn00001_1","volume-title":"butyrylcholinesterase","author":"Abbreviations E"}],"container-title":["Chemical Research in Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/tx049672j","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,15]],"date-time":"2023-03-15T11:43:04Z","timestamp":1678880584000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/tx049672j"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,3,22]]},"references-count":46,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2005,4,1]]}},"alternative-id":["10.1021\/tx049672j"],"URL":"https:\/\/doi.org\/10.1021\/tx049672j","relation":{},"ISSN":["0893-228X","1520-5010"],"issn-type":[{"value":"0893-228X","type":"print"},{"value":"1520-5010","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,3,22]]}}}