{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T18:09:23Z","timestamp":1790100563010,"version":"4.0.1"},"reference-count":73,"publisher":"American Chemical Society (ACS)","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chem. Res. Toxicol."],"published-print":{"date-parts":[[2012,9,17]]},"DOI":"10.1021\/tx3001863","type":"journal-article","created":{"date-parts":[[2012,6,1]],"date-time":"2012-06-01T21:06:41Z","timestamp":1338584801000},"page":"1800-1804","source":"Crossref","is-referenced-by-count":16,"title":["A Perspective on the Toxicology of Marine Toxins"],"prefix":"10.1021","volume":"25","author":[{"given":"Luis M.","family":"Botana","sequence":"first","affiliation":[{"name":"Department Farmacolog\u00eda, Fac. Veterinaria-USC, 27002 Lugo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2012,6,12]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.marenvres.2011.10.005","volume":"73","author":"Lopes V. R.","year":"2012","journal-title":"Mar. Environ. Res."},{"key":"ref2\/cit2","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1201\/9781420007541.ch9","volume-title":"Seafood and Freshwater Toxins: Pharmacology, Physiology and Detection","author":"Su\u00e1rez-Isla B.","year":"2008"},{"key":"ref3\/cit3","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1201\/9781420007541.ch24","volume-title":"Seafood and Freshwater Toxins: Pharmacology, Physiology and Detection","author":"Ramsdell J. S.","year":"2008"},{"key":"ref4\/cit4","first-page":"187","volume-title":"Phytotoxins, Chemistry and Biochemistry","author":"Hess P.","year":"2007"},{"key":"ref5\/cit5","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1201\/9781420007541.ch29","volume-title":"Seafood and Freshwater Toxins: Pharmacology, Physiology and Detection","author":"Katikou P.","year":"2008"},{"key":"ref6\/cit6","first-page":"319","volume-title":"Phytotoxins, Chemistry and Biochemistry","author":"Molgo J.","year":"2007"},{"key":"ref7\/cit7","doi-asserted-by":"crossref","first-page":"7182","DOI":"10.1002\/anie.200801696","volume":"47","author":"Nicolaou K. C.","year":"2008","journal-title":"Angew. Chem."},{"key":"ref8\/cit8","doi-asserted-by":"crossref","first-page":"1706","DOI":"10.2903\/j.efsa.2010.1706","volume":"8","author":"EFSA Panel on Contaminants in the Food Chain (CONTAM)","year":"2010","journal-title":"EFSA J."},{"key":"ref9\/cit9","first-page":"1628","volume":"8","author":"EFSA Panel on Contaminants in the Food Chain (CONTAM)","year":"2010","journal-title":"EFSA J."},{"key":"ref10\/cit10","first-page":"1627","volume":"8","author":"EFSA Panel on Contaminants in the Food Chain (CONTAM)","year":"2010","journal-title":"EFSA J."},{"key":"ref11\/cit11","first-page":"1","volume":"1306","author":"EFSA Panel on Contaminants in the Food Chain (CONTAM)","year":"2009","journal-title":"EFSA J."},{"key":"ref12\/cit12","first-page":"1","volume":"1109","author":"EFSA Panel on Contaminants in the Food Chain (CONTAM)","year":"2009","journal-title":"EFSA J."},{"key":"ref13\/cit13","first-page":"1","volume":"1181","author":"EFSA Panel on Contaminants in the Food Chain (CONTAM)","year":"2009","journal-title":"EFSA J."},{"key":"ref14\/cit14","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.2903\/j.efsa.2009.1393","volume":"7","author":"EFSA Panel on Contaminants in the Food Chain (CONTAM)","year":"2009","journal-title":"EFSA J."},{"key":"ref15\/cit15","first-page":"1","volume":"1019","author":"Panel E. C.","year":"2009","journal-title":"EFSA J."},{"key":"ref16\/cit16","first-page":"1","volume":"1306","author":"Panel E. C.","year":"2009","journal-title":"EFSA J."},{"key":"ref17\/cit17","first-page":"1","volume":"1016","author":"Panel E. C.","year":"2008","journal-title":"EFSA J."},{"key":"ref18\/cit18","first-page":"1","volume":"907","author":"EFSA Panel on Contaminants in the Food Chain (CONTAM)","year":"2008","journal-title":"EFSA J."},{"key":"ref19\/cit19","first-page":"1","volume":"723","author":"Panel E. C.","year":"2008","journal-title":"EFSA J."},{"key":"ref20\/cit20","first-page":"1","volume":"589","author":"Panel E. C.","year":"2008","journal-title":"EFSA J."},{"key":"ref21\/cit21","first-page":"3","year":"2011","journal-title":"Off. J. Eur. Commun."},{"key":"ref22\/cit22","first-page":"1745","volume":"28","author":"van den Top H. J.","year":"2011","journal-title":"Food Addit. Contam., Part A"},{"key":"ref23\/cit23","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1007\/s00216-010-4383-3","volume":"399","author":"These A.","year":"2011","journal-title":"Anal. Bioanal. Chem."},{"key":"ref24\/cit24","doi-asserted-by":"crossref","first-page":"5903","DOI":"10.1021\/ac200732m","volume":"83","author":"Otero P.","year":"2011","journal-title":"Anal. Chem."},{"key":"ref25\/cit25","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1016\/j.trac.2010.09.004","volume":"29","author":"Botana L. M.","year":"2010","journal-title":"Trends Anal. Chem."},{"key":"ref26\/cit26","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1021\/ac203054y","volume":"84","author":"Otero P.","year":"2012","journal-title":"Anal. Chem."},{"key":"ref27\/cit27","doi-asserted-by":"crossref","first-page":"5622","DOI":"10.1021\/ac800769e","volume":"80","author":"Rodriguez P.","year":"2008","journal-title":"Anal. Chem."},{"key":"ref28\/cit28","doi-asserted-by":"crossref","first-page":"6032","DOI":"10.1021\/ac100516q","volume":"82","author":"Otero P.","year":"2010","journal-title":"Anal. Chem."},{"key":"ref29\/cit29","doi-asserted-by":"crossref","first-page":"10499","DOI":"10.1021\/ja201254c","volume":"133","author":"Araoz R.","year":"2011","journal-title":"J. Am. Chem. Soc."},{"key":"ref30\/cit30","doi-asserted-by":"crossref","first-page":"6076","DOI":"10.1073\/pnas.0912372107","volume":"107","author":"Bourne Y.","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"ref31\/cit31","doi-asserted-by":"crossref","first-page":"1753","DOI":"10.1021\/tx100210a","volume":"23","author":"Wandscheer C. B.","year":"2010","journal-title":"Chem. Res. Toxicol."},{"key":"ref32\/cit32","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1016\/j.toxicon.2007.02.002","volume":"49","author":"Villar-Gonzalez A.","year":"2007","journal-title":"Toxicon"},{"key":"ref33\/cit33","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1016\/j.toxicon.2011.08.008","volume":"58","author":"Rundberget T.","year":"2011","journal-title":"Toxicon"},{"key":"ref34\/cit34","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/j.toxicon.2007.10.016","volume":"51","author":"Aligizaki K.","year":"2008","journal-title":"Toxicon"},{"key":"ref35\/cit35","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1021\/ac980598h","volume":"71","author":"Lewis R. J.","year":"1999","journal-title":"Anal. Chem."},{"key":"ref36\/cit36","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/S0041-0101(01)00259-8","volume":"40","author":"Hamilton B.","year":"2002","journal-title":"Toxicon"},{"key":"ref37\/cit37","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1038\/sj.bjp.0704980","volume":"137","author":"Hidalgo J.","year":"2002","journal-title":"Br. J. Pharmacol."},{"key":"ref38\/cit38","first-page":"419","volume-title":"Seafood and Freshwater Toxins: Pharmacology, Physiology and Detection","author":"Lewis R. J.","year":"2000"},{"key":"ref39\/cit39","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/S0021-9258(17)42455-0","volume":"261","author":"Messner D. J.","year":"1986","journal-title":"J. Biol. Chem."},{"key":"ref40\/cit40","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1016\/j.jmb.2007.05.056","volume":"371","author":"Allingham J. S.","year":"2007","journal-title":"J. Mol. Biol."},{"key":"ref41\/cit41","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/j.toxicon.2011.09.012","volume":"58","author":"Nzoughet J. K.","year":"2011","journal-title":"Toxicon"},{"key":"ref42\/cit42","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1016\/j.toxicon.2008.02.016","volume":"51","author":"Nzoughet K. J.","year":"2008","journal-title":"Toxicon"},{"key":"ref43\/cit43","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.ygeno.2007.10.015","volume":"91","author":"Twiner M.","year":"2008","journal-title":"Genomics"},{"key":"ref44\/cit44","doi-asserted-by":"crossref","first-page":"2952","DOI":"10.1002\/jnr.21731","volume":"86","author":"Vale C.","year":"2008","journal-title":"J. Neurosci. Res."},{"key":"ref45\/cit45","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1093\/toxsci\/kfp246","volume":"113","author":"Vale C.","year":"2010","journal-title":"Toxicol. Sci."},{"key":"ref46\/cit46","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/S0006-2952(02)01454-5","volume":"65","author":"Alfonso A.","year":"2003","journal-title":"Biochem. Pharmacol."},{"key":"ref47\/cit47","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.tox.2007.11.007","volume":"244","author":"Callegari F.","year":"2008","journal-title":"Toxicology"},{"key":"ref48\/cit48","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/j.trac.2009.02.014","volume":"28","author":"Botana L. M.","year":"2009","journal-title":"Trends Anal. Chem."},{"key":"ref49\/cit49","doi-asserted-by":"crossref","first-page":"2865","DOI":"10.1007\/s00216-011-5019-y","volume":"400","author":"Yakes B. J.","year":"2011","journal-title":"Anal. Bioanal. Chem."},{"key":"ref50\/cit50","doi-asserted-by":"crossref","first-page":"2977","DOI":"10.1021\/ac1000338","volume":"82","author":"Campbell K.","year":"2010","journal-title":"Anal. Chem."},{"key":"ref51\/cit51","doi-asserted-by":"crossref","first-page":"10208","DOI":"10.1021\/ac902084a","volume":"81","author":"Stewart L. D.","year":"2009","journal-title":"Anal. Chem."},{"key":"ref52\/cit52","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1007\/s00216-007-1444-3","volume":"389","author":"Llamas N. M.","year":"2007","journal-title":"Anal. Bioanal. Chem."},{"key":"ref53\/cit53","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1007\/s00216-010-3533-y","volume":"397","author":"Araoz R.","year":"2010","journal-title":"Anal. Bioanal. Chem."},{"key":"ref54\/cit54","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1006\/abio.1997.2127","volume":"248","author":"Vieytes M. R.","year":"1997","journal-title":"Anal. Biochem."},{"key":"ref55\/cit55","doi-asserted-by":"crossref","first-page":"2708","DOI":"10.1021\/ac900144r","volume":"81","author":"Vilarino N.","year":"2009","journal-title":"Anal. Chem."},{"key":"ref56\/cit56","doi-asserted-by":"crossref","first-page":"4350","DOI":"10.1021\/ac203449f","volume":"84","author":"Fraga M.","year":"2012","journal-title":"Anal. Chem."},{"key":"ref57\/cit57","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.trac.2010.10.010","volume":"30","author":"Campbell A.","year":"2011","journal-title":"Trends Anal. Chem."},{"key":"ref58\/cit58","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1201\/9781420007541.ch18","volume-title":"Seafood and Freshwater Toxins: Pharmacology, Physiology and Detection","author":"Munday R.","year":"2008"},{"key":"ref59\/cit59","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.toxicon.2003.10.003","volume":"43","author":"Miles C. O.","year":"2004","journal-title":"Toxicon"},{"key":"ref60\/cit60","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1201\/9781420007541.pt6","volume-title":"Seafood and Freshwater Toxins: Pharmacology, Physiology and Detection","author":"Reguera B.","year":"2008"},{"key":"ref61\/cit61","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1042\/bj2560283","volume":"256","author":"Bialojan C.","year":"1988","journal-title":"Biochem. J."},{"key":"ref62\/cit62","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.fct.2011.10.062","volume":"50","author":"Otero P.","year":"2012","journal-title":"Food Chem. Toxicol."},{"key":"ref63\/cit63","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/toxins4010001","volume":"4","author":"Munday R.","year":"2012","journal-title":"Toxins (Basel)"},{"key":"ref64\/cit64","doi-asserted-by":"crossref","first-page":"9672","DOI":"10.1021\/ac801506d","volume":"80","author":"Alfonso C.","year":"2008","journal-title":"Anal. Chem."},{"key":"ref65\/cit65","unstructured":"CODEX, A. (2004) Joint FAO\/IOC\/WHO ad hoc Expert Consultation on Biotoxins in Bivalve Molluscs.CODEX Report Background Document, Oslo, Norway, Sept."},{"key":"ref66\/cit66","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/S0041-0101(03)00032-1","volume":"41","author":"Tubaro A.","year":"2003","journal-title":"Toxicon"},{"key":"ref67\/cit67","unstructured":"CODEX, A. (2006) Report of the working group meeting to assess the advice from the joint FAO\/WHO\/IOC ad hoc expert consultation on biotoxins in bivalve molluscs;ftp:\/\/ftp.fao.org\/codex\/Meetings\/CCFFP\/ccffp28\/fp2806ae.pdf."},{"key":"ref68\/cit68","volume-title":"Acute Oral Toxicity-Up and Down Procedure","author":"OECD","year":"2001"},{"key":"ref69\/cit69","first-page":"53","volume":"31","author":"Wheatley J. L.","year":"2002","journal-title":"Lab. Anim. (NY)"},{"key":"ref70\/cit70","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.toxicon.2004.05.017","volume":"44","author":"Munday R.","year":"2004","journal-title":"Toxicon"},{"key":"ref71\/cit71","doi-asserted-by":"crossref","first-page":"447","DOI":"10.2989\/18142320609504195","volume":"28","author":"Munday R.","year":"2006","journal-title":"Afr. J. Mar. Sci."},{"key":"ref72\/cit72","doi-asserted-by":"crossref","DOI":"10.2807\/ese.16.46.20020-en","volume":"16","author":"Hossen V.","year":"2011","journal-title":"Euro Surveill."},{"key":"ref73\/cit73","doi-asserted-by":"crossref","first-page":"7467","DOI":"10.1021\/ja300565t","volume":"134","author":"Alonso E.","year":"2012","journal-title":"J. Am. Chem. Soc."}],"container-title":["Chemical Research in Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/tx3001863","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,22]],"date-time":"2023-04-22T20:02:08Z","timestamp":1682193728000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/tx3001863"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,6,12]]},"references-count":73,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2012,9,17]]}},"alternative-id":["10.1021\/tx3001863"],"URL":"https:\/\/doi.org\/10.1021\/tx3001863","relation":{},"ISSN":["0893-228X","1520-5010"],"issn-type":[{"value":"0893-228X","type":"print"},{"value":"1520-5010","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,6,12]]}}}