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Chem."},{"key":"ref32\/cit32","doi-asserted-by":"crossref","first-page":"21891","DOI":"10.1016\/S0021-9258(17)31886-0","volume":"269","author":"Lepoivre M.","year":"1994","journal-title":"J. Biol. Chem."},{"key":"ref33\/cit33","first-page":"5448","volume":"15","author":"Loike J. D.","year":"1976","journal-title":"Biochemistry"},{"key":"ref34\/cit34","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1021\/bi00301a024","volume":"23","author":"Long B. H.","year":"1984","journal-title":"Biochemistry"},{"key":"ref35\/cit35","unstructured":"Nemec, J. (1986) Epipodophyllotoxinquinone Glucoside Derivatives, Method of Production and Use, US Patent 4609644."},{"key":"ref36\/cit36","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1006\/jmrb.1994.1062","volume":"104","author":"Duling D. R.","year":"1994","journal-title":"J. Mag. Reson. Ser. 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