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Sci."},{"key":"ref54\/cit54","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1097\/00130832-200208000-00003","volume":"2","author":"Pichler W. J.","year":"2002","journal-title":"Curr. Opin. Allergy Clin. Immunol."},{"key":"ref55\/cit55","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1517\/17425255.2012.658041","volume":"8","author":"Amacher D. E.","year":"2012","journal-title":"Expert Opin. Drug Metab. Toxicol."},{"key":"ref56\/cit56","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1081\/DMR-55227","volume":"37","author":"Tafazoli S.","year":"2005","journal-title":"Drug Metab. Rev."},{"key":"ref57\/cit57","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1002\/hep.22332","volume":"47","author":"Senior J. R.","year":"2008","journal-title":"Hepatology"},{"key":"ref58\/cit58","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1021\/tx034195a","volume":"17","author":"Masson M. J.","year":"2004","journal-title":"Chem. Res. 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