{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T06:14:16Z","timestamp":1790230456963,"version":"4.1.0"},"reference-count":45,"publisher":"American Chemical Society (ACS)","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chem. Res. Toxicol."],"published-print":{"date-parts":[[2013,7,15]]},"DOI":"10.1021\/tx4001013","type":"journal-article","created":{"date-parts":[[2013,5,22]],"date-time":"2013-05-22T22:37:43Z","timestamp":1369262263000},"page":"1088-1096","source":"Crossref","is-referenced-by-count":56,"title":["Disruption of Thioredoxin Reductase 1 Protects Mice from Acute Acetaminophen-Induced Hepatotoxicity through Enhanced NRF2 Activity"],"prefix":"10.1021","volume":"26","author":[{"given":"Andrew D.","family":"Patterson","sequence":"first","affiliation":[{"name":"Laboratory of Metabolism, Center\rfor Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, United\rStates"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bradley A.","family":"Carlson","sequence":"additional","affiliation":[{"name":"Molecular Biology\rof Selenium\rSection, Laboratory of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892,\rUnited States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Li","sequence":"additional","affiliation":[{"name":"Laboratory of Metabolism, Center\rfor Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, United\rStates"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica A.","family":"Bonzo","sequence":"additional","affiliation":[{"name":"Laboratory of Metabolism, Center\rfor Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, United\rStates"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min-Hyuk","family":"Yoo","sequence":"additional","affiliation":[{"name":"Molecular Biology\rof Selenium\rSection, Laboratory of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892,\rUnited States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristopher W.","family":"Krausz","sequence":"additional","affiliation":[{"name":"Laboratory of Metabolism, Center\rfor Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, United\rStates"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcus","family":"Conrad","sequence":"additional","affiliation":[{"name":"Helmholtz Zentrum\rM\u00fcnchen, Institute of Developmental Genetics, Ingolst\u00e4dter\rLandstr. 1, 85764 Neuherberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Food Science and\rNutrition, University of Minnesota, Twin\rCities, St. Paul, Minnesota 55108, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank J.","family":"Gonzalez","sequence":"additional","affiliation":[{"name":"Laboratory of Metabolism, Center\rfor Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, United\rStates"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dolph L.","family":"Hatfield","sequence":"additional","affiliation":[{"name":"Molecular Biology\rof Selenium\rSection, Laboratory of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892,\rUnited States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2013,6,7]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1097\/MCG.0b013e31818a3854","volume":"43","author":"Chun L. J.","year":"2009","journal-title":"J. Clin. Gastroenterol."},{"key":"ref2\/cit2","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1053\/j.gastro.2006.03.045","volume":"131","author":"Gunawan B. K.","year":"2006","journal-title":"Gastroenterology"},{"key":"ref3\/cit3","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1136\/gut.2006.104372","volume":"56","author":"Henderson N. C.","year":"2007","journal-title":"Gut"},{"key":"ref4\/cit4","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1002\/hep.21475","volume":"45","author":"Latchoumycandane C.","year":"2007","journal-title":"Hepatology"},{"key":"ref5\/cit5","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1053\/j.gastro.2008.07.006","volume":"135","author":"Nakagawa H.","year":"2008","journal-title":"Gastroenterology"},{"key":"ref6\/cit6","doi-asserted-by":"crossref","first-page":"35071","DOI":"10.1074\/jbc.M111.276089","volume":"286","author":"Win S.","year":"2011","journal-title":"J. Biol. Chem."},{"key":"ref7\/cit7","doi-asserted-by":"crossref","first-page":"2596","DOI":"10.1093\/emboj\/17.9.2596","volume":"17","author":"Saitoh M.","year":"1998","journal-title":"EMBO J."},{"key":"ref8\/cit8","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1124\/jpet.102.038968","volume":"303","author":"Knight T. R.","year":"2002","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref9\/cit9","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1161\/CIRCULATIONAHA.106.625061","volume":"114","author":"Tao L.","year":"2006","journal-title":"Circulation"},{"key":"ref10\/cit10","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1042\/BJ20091378","volume":"430","author":"Turanov A. A.","year":"2010","journal-title":"Biochem. J."},{"key":"ref11\/cit11","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/S0076-6879(10)74014-3","volume":"474","author":"Turanov A. A.","year":"2010","journal-title":"Methods Enzymol."},{"key":"ref12\/cit12","doi-asserted-by":"crossref","first-page":"1980","DOI":"10.1128\/MCB.25.5.1980-1988.2005","volume":"25","author":"Jakupoglu C.","year":"2005","journal-title":"Mol. Cell. Biol."},{"key":"ref13\/cit13","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.semcancer.2006.09.003","volume":"16","author":"Fujino G.","year":"2006","journal-title":"Semin. Cancer Biol."},{"key":"ref14\/cit14","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1089\/152308604771978336","volume":"6","author":"Rundlof A. K.","year":"2004","journal-title":"Antioxid. Redox Signaling"},{"key":"ref15\/cit15","doi-asserted-by":"crossref","first-page":"6","DOI":"10.4161\/cbt.4.1.1434","volume":"4","author":"Biaglow J. E.","year":"2005","journal-title":"Cancer Biol. Ther."},{"key":"ref16\/cit16","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.semcancer.2006.10.001","volume":"16","author":"Arner E. S.","year":"2006","journal-title":"Semin. Cancer Biol."},{"key":"ref17\/cit17","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1016\/j.bbagen.2009.03.001","volume":"1790","author":"Hatfield D. L.","year":"2009","journal-title":"Biochim. Biophys. Acta Gen. Subj."},{"key":"ref18\/cit18","first-page":"325","volume-title":"Selenium: Its Molecular Biology and Role in Human Health","author":"Yoo M. H.","year":"2012"},{"key":"ref19\/cit19","doi-asserted-by":"crossref","first-page":"9505","DOI":"10.1158\/0008-5472.CAN-10-1509","volume":"70","author":"Mandal P. K.","year":"2010","journal-title":"Cancer Res."},{"key":"ref20\/cit20","doi-asserted-by":"crossref","first-page":"10349","DOI":"10.1074\/jbc.274.15.10349","volume":"274","author":"Mirochnitchenko O.","year":"1999","journal-title":"J. Biol. Chem."},{"key":"ref21\/cit21","doi-asserted-by":"crossref","first-page":"1726","DOI":"10.1177\/153537020623101109","volume":"231","author":"Zhu J. H.","year":"2006","journal-title":"Exp. Biol. Med. (Maywood, NJ, U.S.)"},{"key":"ref22\/cit22","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.3181\/0904-RM-142","volume":"234","author":"Zhu J. H.","year":"2009","journal-title":"Exp. Biol. Med. (Maywood, NJ, U.S.)"},{"key":"ref23\/cit23","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1177\/153537020623100508","volume":"231","author":"Zhu J. H.","year":"2006","journal-title":"Exp. Biol. Med. (Maywood, NJ, U.S.)"},{"key":"ref24\/cit24","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1042\/BJ20060784","volume":"399","author":"Lei X. G.","year":"2006","journal-title":"Biochem. J."},{"key":"ref25\/cit25","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1146\/annurev.nutr.27.061406.093716","volume":"27","author":"Lei X. G.","year":"2007","journal-title":"Annu. Rev. Nutr."},{"key":"ref26\/cit26","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.mam.2008.08.003","volume":"30","author":"Yuan L.","year":"2009","journal-title":"Mol. Aspects Med."},{"key":"ref27\/cit27","doi-asserted-by":"crossref","first-page":"19511","DOI":"10.1074\/jbc.M111.221739","volume":"286","author":"Patterson A. D.","year":"2011","journal-title":"J. Biol. Chem."},{"key":"ref28\/cit28","doi-asserted-by":"crossref","first-page":"e6158","DOI":"10.1371\/journal.pone.0006158","volume":"4","author":"Suvorova E. S.","year":"2009","journal-title":"PLoS One"},{"key":"ref29\/cit29","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1124\/dmd.104.002402","volume":"33","author":"Cheung C.","year":"2005","journal-title":"Drug Metab. Dispos."},{"key":"ref30\/cit30","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.taap.2007.08.022","volume":"226","author":"Aleksunes L. M.","year":"2008","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref31\/cit31","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1002\/jbt.20392","volume":"25","author":"Cheng Q.","year":"2011","journal-title":"J. Biochem. Mol. Toxicol."},{"key":"ref32\/cit32","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1093\/toxsci\/kfs133","volume":"127","author":"Ni H. M.","year":"2012","journal-title":"Toxicol. Sci."},{"key":"ref33\/cit33","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1124\/jpet.106.110106","volume":"319","author":"Zamek-Gliszczynski M. J.","year":"2006","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref34\/cit34","doi-asserted-by":"crossref","first-page":"1590","DOI":"10.1124\/mol.105.013680","volume":"68","author":"Dai G.","year":"2005","journal-title":"Mol. Pharmacol."},{"key":"ref35\/cit35","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.taap.2013.03.026","volume":"269","author":"McGill M. R.","year":"2013","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref36\/cit36","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1124\/mi.10.2.7","volume":"10","author":"Jones D. P.","year":"2010","journal-title":"Mol. Interventions"},{"key":"ref37\/cit37","doi-asserted-by":"crossref","first-page":"8244","DOI":"10.1074\/jbc.M109.054999","volume":"285","author":"Shinohara M.","year":"2010","journal-title":"J. Biol. Chem."},{"key":"ref38\/cit38","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1002\/cpt1978243287","volume":"24","author":"Klutch A.","year":"1978","journal-title":"Clin. Pharmacol. Ther."},{"key":"ref39\/cit39","doi-asserted-by":"crossref","first-page":"381","DOI":"10.3109\/00498258209052479","volume":"12","author":"Hart S. J.","year":"1982","journal-title":"Xenobiotica"},{"key":"ref40\/cit40","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1007\/s00726-010-0552-0","volume":"41","author":"Cooper A. J.","year":"2011","journal-title":"Amino Acids"},{"key":"ref41\/cit41","doi-asserted-by":"crossref","first-page":"22244","DOI":"10.1074\/jbc.M110.121327","volume":"285","author":"Mandal P. K.","year":"2010","journal-title":"J. Biol. Chem."},{"key":"ref42\/cit42","doi-asserted-by":"crossref","first-page":"1806","DOI":"10.1093\/carcin\/bgs230","volume":"33","author":"Carlson B. A.","year":"2012","journal-title":"Carcinogenesis"},{"key":"ref43\/cit43","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1038\/cdd.2009.107","volume":"16","author":"Franco R.","year":"2009","journal-title":"Cell Death Differ."},{"key":"ref44\/cit44","first-page":"1169","volume":"30","author":"Corti A.","year":"2010","journal-title":"Anticancer Res."},{"key":"ref45\/cit45","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.2165\/11592590-000000000-00000","volume":"71","author":"Montero A. J.","year":"2011","journal-title":"Drugs"}],"container-title":["Chemical Research in Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/tx4001013","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,14]],"date-time":"2023-04-14T15:14:49Z","timestamp":1681485289000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/tx4001013"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,6,7]]},"references-count":45,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2013,7,15]]}},"alternative-id":["10.1021\/tx4001013"],"URL":"https:\/\/doi.org\/10.1021\/tx4001013","relation":{},"ISSN":["0893-228X","1520-5010"],"issn-type":[{"value":"0893-228X","type":"print"},{"value":"1520-5010","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,6,7]]}}}