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Commun."},{"key":"ref52\/cit52","doi-asserted-by":"crossref","first-page":"6305","DOI":"10.1093\/nar\/10.20.6305","volume":"20","author":"Male R.","year":"1982","journal-title":"Nucleic Acids Res."},{"key":"ref53\/cit53","doi-asserted-by":"crossref","first-page":"3610","DOI":"10.1021\/bi00769a018","volume":"11","author":"Lindahl T.","year":"1972","journal-title":"Biochemistry"},{"key":"ref54\/cit54","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1016\/S0022-2836(02)01452-3","volume":"326","author":"Kaul M.","year":"2003","journal-title":"J. Mol. Biol."},{"key":"ref55\/cit55","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1023\/A:1016604828024","volume":"12","author":"Sutrisno B., Y.","year":"2001","journal-title":"Struct. Chem."},{"key":"ref56\/cit56","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.bioorg.2010.10.002","volume":"39","author":"Andac C. A.","year":"2011","journal-title":"Bioorg. 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Genet."},{"key":"ref67\/cit67","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1021\/cr040461t","volume":"106","author":"Berti P. J.","year":"2006","journal-title":"Chem. Rev."},{"key":"ref68\/cit68","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1038\/292858a0","volume":"292","author":"Behmoaras T.","year":"1981","journal-title":"Nature"},{"key":"ref69\/cit69","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1016\/S0021-9258(19)68603-5","volume":"256","author":"Pierre J.","year":"1981","journal-title":"J. Biol. Chem."},{"key":"ref70\/cit70","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/0009-2797(86)90047-5","volume":"57","author":"Malvy C.","year":"1986","journal-title":"Chem. Biol. Interact."},{"key":"ref71\/cit71","doi-asserted-by":"crossref","first-page":"4994","DOI":"10.1021\/jo00231a028","volume":"52","author":"Vasseur J. J.","year":"1987","journal-title":"J. Org. 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