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Visual Sci."},{"key":"ref16\/cit16","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1093\/emboj\/21.5.857","volume":"21","author":"Farrar G. J.","year":"2002","journal-title":"EMBO J."},{"key":"ref17\/cit17","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S0304-3940(99)00072-5","volume":"262","author":"Schmidt K. F.","year":"1999","journal-title":"Neurosci. Lett."},{"key":"ref18\/cit18","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1080\/10643380490492412","volume":"34","author":"Porter S. K.","year":"2004","journal-title":"Crit. Rev. Environ. Sci. Technol."},{"key":"ref19\/cit19","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1080\/15569520600860215","volume":"25","author":"El-Sherbeeny A. M.","year":"2006","journal-title":"Cutaneous Ocul. Toxicol."},{"key":"ref20\/cit20","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/S0014-4835(87)80035-0","volume":"44","author":"DuVal G.","year":"1987","journal-title":"Exp. Eye Res."},{"key":"ref21\/cit21","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0300-483X(95)03257-G","volume":"107","author":"Warfvinge K.","year":"1996","journal-title":"Toxicology"},{"key":"ref22\/cit22","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1007\/BF02917253","volume":"21","author":"Friberg L.","year":"1989","journal-title":"Biol. Trace Elem. Res."},{"key":"ref23\/cit23","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S0149-7634(05)80217-9","volume":"14","author":"Aschner M.","year":"1990","journal-title":"Neurosci. Biobehav. Rev."},{"key":"ref24\/cit24","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/S0887-2333(00)00057-6","volume":"15","author":"Toimela T. A.","year":"2001","journal-title":"Toxicol. in Vitro"},{"key":"ref25\/cit25","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/j.etap.2004.12.016","volume":"19","author":"Ventura D. F.","year":"2005","journal-title":"Environ. Toxicol. 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