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Their Chemistry, Pathogenicity and Other Biological Properties","author":"Bull L. B.","year":"1968"},{"key":"ref5\/cit5","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/S0140-6736(76)90727-3","volume":"2","author":"Tandon B. N.","year":"1976","journal-title":"Lancet"},{"key":"ref6\/cit6","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1136\/gut.17.11.849","volume":"17","author":"Tandon R. K.","year":"1976","journal-title":"Gut"},{"key":"ref7\/cit7","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/S0140-6736(76)90726-1","volume":"308","author":"Mohabbat O.","year":"1976","journal-title":"Lancet"},{"key":"ref8\/cit8","unstructured":"International Programme on Chemical Safety (IPCS) (1988) Pyrrolizidine alkaloids: Environmental Health Criteria 80,WHO,Geneva, Switzerland,www.inchem.org\/documents\/ehc\/ehc\/ehc080.htm."},{"key":"ref9\/cit9","unstructured":"International Programme on Chemical Safety (IPCS) (1989) Pyrrolizidine alkaloids: health and safety guide no. 26;WHO,Geneva, Switzerland,http:\/\/www.inchem.org\/documents\/hsg\/hsg\/hsg026.htm."},{"key":"ref10\/cit10","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1016\/0140-6736(93)90798-L","volume":"341","author":"Chauvin P.","year":"1993","journal-title":"Lancet"},{"key":"ref11\/cit11","first-page":"263","volume":"4","author":"Chauvin P.","year":"1994","journal-title":"Sante"},{"key":"ref12\/cit12","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/0140-6736(93)92341-P","volume":"342","author":"Mayer F.","year":"1993","journal-title":"Lancet"},{"key":"ref13\/cit13","doi-asserted-by":"crossref","first-page":"142","DOI":"10.26719\/1998.4.1.142","volume":"4","author":"Altaee M. Y.","year":"1998","journal-title":"East. Mediterr. Health J."},{"key":"ref14\/cit14","unstructured":"Integrated Regional Information Networks (IRIN) (2008) Afghanistan: \u201cCharmak\u201d disease still killing people, livestock in west,UN Office for the Coordination of Humanitarian Affairs,http:\/\/www.irinnews.org\/Report.aspx?ReportId=81971."},{"key":"ref15\/cit15","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1007\/BF03161201","volume":"4","author":"Kleiman R.","year":"2008","journal-title":"J. Med. Toxicol."},{"key":"ref16\/cit16","doi-asserted-by":"crossref","first-page":"313280","DOI":"10.1155\/2010\/313280","volume":"2010","author":"Kakar F.","year":"2010","journal-title":"J. Toxicol."},{"key":"ref17\/cit17","first-page":"4","volume":"70","author":"Edgar J. A.","year":"2003","journal-title":"Chem. Aust."},{"key":"ref18\/cit18","volume-title":"Pyrrolizidine alkaloids in food. A toxicological review and risk assessment","author":"Food Standards Australia New Zealand (FSANZ)","year":"2001"},{"key":"ref19\/cit19","first-page":"179","volume":"2","author":"Azadbakht M.","year":"2003","journal-title":"Iran. J. Pharm. Res."},{"key":"ref20\/cit20","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1080\/19440049.2010.547520","volume":"28","author":"Edgar J. A.","year":"2011","journal-title":"Food Addit. Contam."},{"key":"ref21\/cit21","doi-asserted-by":"crossref","first-page":"1886","DOI":"10.1080\/19440049.2014.964337","volume":"31","author":"Bodi D.","year":"2014","journal-title":"Food Addit. Contam."},{"key":"ref22\/cit22","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/B978-0-12-403250-7.50025-X","volume-title":"Effects of Poisonous Plants on Livestock","author":"Dickinson J. O.","year":"1978"},{"key":"ref23\/cit23","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1126\/science.835011","volume":"195","author":"Deinzer M. L.","year":"1977","journal-title":"Science"},{"key":"ref24\/cit24","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1021\/jf00107a018","volume":"29","author":"Culvenor C. C. J.","year":"1981","journal-title":"J. Agric. Food Chem."},{"key":"ref25\/cit25","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/0378-4274(83)90239-4","volume":"17","author":"L\u00fcthy J.","year":"1983","journal-title":"Toxicol. Lett."},{"key":"ref26\/cit26","first-page":"94S","volume":"32","author":"Molyneux R. J.","year":"1990","journal-title":"Vet. Hum. Toxicol."},{"key":"ref27\/cit27","first-page":"118","volume-title":"Natural and Selected Synthetic Toxins, Biological Implications","author":"Edgar J. A.","year":"2000"},{"key":"ref28\/cit28","doi-asserted-by":"crossref","first-page":"6664","DOI":"10.1021\/jf049102p","volume":"52","author":"Beales K. A.","year":"2004","journal-title":"J. Agric. Food Chem."},{"key":"ref29\/cit29","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1079\/9781845932732.0094","volume-title":"Poisonous Plants: Global Research and Solutions","author":"Beales K","year":"2007"},{"key":"ref30\/cit30","unstructured":"Bundesamt f\u00fcr Risiokobewertung (BfR) (2007) Salatmischung mit pyrrolizidinalkaloid-haltigem Greiskraut verunreinigt, Stellungnahme Nr.028\/2007 des BfR vom 10,http:\/\/www.bfr.bund.de\/cm\/208\/salatmischung_mit_pyrrolizidinalkaloid_haltigem_geiskraut_verunreinigt.pdf."},{"key":"ref31\/cit31","unstructured":"Bundesamt f\u00fcr Risiokobewertung (BfR) (2011) Chemical analysis and toxicity of pyrrolizidine alkaloids and assessment of the health risk posed by their occurrence in honey, BfR opinion no. 038\/2011 11,http:\/\/www.bfr.bund.de\/cm\/349\/chemical-analysis-and-toxicity-of-pyrrolizidine-alkaloids-and-assessment-of-the-health-risks-posed-by-their-occurence-in-honey.pdf."},{"key":"ref32\/cit32","unstructured":"Bundesamt f\u00fcr Risiokobewertung (BfR) (2013) Pyrrolizidine alkaloids in herbal teas and teas, BfR opinion no. 018\/2013,http:\/\/www.bfr.bund.de\/cm\/349\/pyrrolizidine-alkaloids-in-herbal-teas-and-teas.pdf."},{"key":"ref33\/cit33","first-page":"1","volume":"54","author":"Kempf M.","year":"2010","journal-title":"Mol. Nutr. Food Res."},{"key":"ref34\/cit34","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1080\/19440049.2010.547521","volume":"28","author":"Hoogenboom L. A. P.","year":"2011","journal-title":"Food Addit. Contam."},{"key":"ref35\/cit35","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1080\/19440049.2010.541594","volume":"28","author":"D\u00fcbecke A.","year":"2011","journal-title":"Food Addit. Contam."},{"key":"ref36\/cit36","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1079\/9781845938338.0208","volume-title":"Poisonings by Plants, Mycotoxins and Related Toxins","author":"Fletcher M. T.","year":"2011"},{"key":"ref37\/cit37","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1080\/19440049.2010.521771","volume":"28","author":"Kempf M.","year":"2011","journal-title":"Food Addit. Contam."},{"key":"ref38\/cit38","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1080\/19440049.2010.521772","volume":"28","author":"Kempf M.","year":"2011","journal-title":"Food Addit. Contam."},{"key":"ref39\/cit39","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.jfca.2012.11.005","volume":"29","author":"Cao Y.","year":"2013","journal-title":"J. Food Compos. Anal."},{"key":"ref40\/cit40","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1016\/j.foodchem.2012.02.112","volume":"136","author":"Griffin C. T.","year":"2013","journal-title":"Food Chem."},{"key":"ref41\/cit41","doi-asserted-by":"crossref","first-page":"2719","DOI":"10.1021\/jf0114482","volume":"50","author":"Edgar J. A.","year":"2002","journal-title":"J. Agric. Food Chem."},{"key":"ref42\/cit42","unstructured":"Committee on Toxicity of Chemicals in Food, Consumer Products and the Environment (COT) (2008) COT statement on pyrrolizidine alkaloids in food,http:\/\/cot.food.gov.uk\/pdfs\/cotstatementpa200806.pdf."},{"key":"ref43\/cit43","unstructured":"WHO (2011) Discussion paper on pyrrolizidine alkaloids,Joint FAO\/WHO food standards programme, Codex committee on contaminants in foods, 5th session,The Hague, The Netherlands, 21\u201325 March,ftp:\/\/ftp.fao.org\/codex\/meetings\/cccf\/cccf5\/cf05_14e.pdf."},{"key":"ref44\/cit44","first-page":"2406","volume":"9","author":"European Food Safety Authority (EFSA) Panel on Contaminants in the Food Chain (CONTAM)","year":"2011","journal-title":"EFSA J."},{"key":"ref45\/cit45","unstructured":"The U.S. National Toxicology Program (2011) 12th Report on Carcinogens (RoC), ppiii\u2013499,U.S. Department of Health and Human Services,Washington, DC."},{"key":"ref46\/cit46","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1002\/jat.1504","volume":"30","author":"Chen T.","year":"2010","journal-title":"J. Appl. Toxicol."},{"key":"ref47\/cit47","doi-asserted-by":"crossref","first-page":"73","DOI":"10.5694\/mja13.10227","volume":"200","author":"Edgar J. A.","year":"2014","journal-title":"Med. J. Aust."},{"key":"ref48\/cit48","first-page":"369","volume":"42","author":"Green C. R.","year":"1961","journal-title":"Br. J. Exp. Pathol."},{"key":"ref49\/cit49","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1002\/path.1711310406","volume":"131","author":"Peterson J. E.","year":"1980","journal-title":"J. Pathol."},{"key":"ref50\/cit50","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1021\/np50014a001","volume":"44","author":"Smith L. W.","year":"1981","journal-title":"J. Nat. Prod."},{"key":"ref51\/cit51","doi-asserted-by":"crossref","first-page":"2772","DOI":"10.1105\/tpc.104.023176","volume":"16","author":"Reimann A.","year":"2004","journal-title":"Plant Cell"},{"key":"ref52\/cit52","volume-title":"Chemistry and Toxicology of Pyrrolizidine Alkaloids","author":"Mattocks A. R.","year":"1986"},{"key":"ref53\/cit53","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1038\/217723a0","volume":"217","author":"Mattocks A. R.","year":"1968","journal-title":"Nature"},{"key":"ref54\/cit54","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1111\/j.1749-6632.1969.tb24903.x","volume":"163","author":"Culvenor C. C. J.","year":"1969","journal-title":"Ann. N.Y. Acad. Sci."},{"key":"ref55\/cit55","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/S0026-895X(25)15242-5","volume":"6","author":"Jago M. V.","year":"1970","journal-title":"Mol. Pharmacol."},{"key":"ref56\/cit56","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1002\/path.1711000305","volume":"100","author":"Butler W. H.","year":"1970","journal-title":"J. Pathol."},{"key":"ref57\/cit57","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/S0090-9556(25)07643-3","volume":"17","author":"Williams D. E.","year":"1989","journal-title":"Drug Metab. Dispos."},{"key":"ref58\/cit58","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1093\/carcin\/12.3.515","volume":"12","author":"Miranda C. L.","year":"1991","journal-title":"Carcinogenesis"},{"key":"ref59\/cit59","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/0041-008X(91)90137-4","volume":"111","author":"Hincks J. R.","year":"1991","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref60\/cit60","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1006\/taap.1994.1167","volume":"127","author":"Chung W. G.","year":"1994","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref61\/cit61","doi-asserted-by":"crossref","first-page":"929","DOI":"10.3109\/00498259509046664","volume":"25","author":"Chung W. G.","year":"1995","journal-title":"Xenobiotica"},{"key":"ref62\/cit62","doi-asserted-by":"crossref","first-page":"2691","DOI":"10.1093\/carcin\/16.11.2691","volume":"16","author":"Kim H.-Y.","year":"1995","journal-title":"Carcinogenesis"},{"key":"ref63\/cit63","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1097\/00005344-199707000-00018","volume":"30","author":"Kasahara Y.","year":"1997","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"ref64\/cit64","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1002\/(SICI)1099-0461(1998)12:3<157::AID-JBT4>3.0.CO;2-K","volume":"12","author":"Reid M. J.","year":"1998","journal-title":"J. Biochem. Mol. Toxicol."},{"key":"ref65\/cit65","doi-asserted-by":"crossref","first-page":"5441","DOI":"10.1093\/nar\/26.23.5441","volume":"26","author":"Pereira T. N.","year":"1998","journal-title":"Nucl. Acid Res."},{"key":"ref66\/cit66","doi-asserted-by":"crossref","first-page":"2951","DOI":"10.1021\/ja983894k","volume":"121","author":"Tepe J. J.","year":"1999","journal-title":"J. Am. Chem. Soc."},{"key":"ref67\/cit67","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1016\/S0090-9556(24)13677-X","volume":"28","author":"Lin G.","year":"2000","journal-title":"Drug Metab. Dispos."},{"key":"ref68\/cit68","first-page":"1","volume":"36","author":"Fu P. P.","year":"2004","journal-title":"Drug Metab. Rev."},{"key":"ref69\/cit69","doi-asserted-by":"crossref","first-page":"948","DOI":"10.3390\/i3090948","volume":"3","author":"Fu P. P.","year":"2002","journal-title":"Int. J. Mol. Sci."},{"key":"ref70\/cit70","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1021\/tx000150n","volume":"14","author":"Yang Y.-C.","year":"2001","journal-title":"Chem. Res. Toxicol."},{"key":"ref71\/cit71","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1021\/tx000149o","volume":"14","author":"Yang Y.-C.","year":"2001","journal-title":"Chem. Res. Toxicol."},{"key":"ref72\/cit72","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1021\/tx025605i","volume":"16","author":"Xia Q.","year":"2003","journal-title":"Chem. Res. Toxicol."},{"key":"ref73\/cit73","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/S0304-3835(03)00045-4","volume":"193","author":"Chou M. W.","year":"2003","journal-title":"Cancer Lett."},{"key":"ref74\/cit74","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1021\/tx030030q","volume":"17","author":"Xia Q.","year":"2004","journal-title":"Chem. Res. Toxicol."},{"key":"ref75\/cit75","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.canlet.2005.01.023","volume":"231","author":"Xia Q.","year":"2006","journal-title":"Cancer Lett."},{"key":"ref76\/cit76","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/0009-2797(83)90096-0","volume":"43","author":"Mattocks A. R.","year":"1983","journal-title":"Chem.\u2013Biol. Interact."},{"key":"ref77\/cit77","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1002\/path.1700780215","volume":"78","author":"Bull L. B.","year":"1959","journal-title":"J. Pathol. Bacteriol."},{"key":"ref78\/cit78","doi-asserted-by":"crossref","first-page":"563","DOI":"10.3109\/00498257109041530","volume":"1","author":"Mattocks A. R.","year":"1971","journal-title":"Xenobiotica"},{"key":"ref79\/cit79","doi-asserted-by":"crossref","first-page":"146","DOI":"10.2460\/ajvr.1991.52.01.146","volume":"52","author":"Molyneux R. J.","year":"1991","journal-title":"Am. J. Vet. Res."},{"key":"ref80\/cit80","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/S0378-4274(03)00293-5","volume":"145","author":"Chou M. W.","year":"2003","journal-title":"Toxicol. Lett."},{"key":"ref81\/cit81","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/j.toxlet.2004.11.010","volume":"155","author":"Wang Y.-P.","year":"2005","journal-title":"Toxicol. Lett."},{"key":"ref82\/cit82","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1177\/0748233708093727","volume":"24","author":"Yan J.","year":"2008","journal-title":"Toxicol. Ind. Health"},{"key":"ref83\/cit83","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1002\/pca.1079","volume":"19","author":"Cao Y.","year":"2008","journal-title":"Phytochem. Anal."},{"key":"ref84\/cit84","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1038\/219480a0","volume":"219","author":"Mattocks A. R.","year":"1968","journal-title":"Nature"},{"key":"ref85\/cit85","first-page":"3599","volume":"41","author":"Culvenor C. C. J.","year":"1969","journal-title":"Aust. J. Chem."},{"key":"ref86\/cit86","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1039\/j39690001155","author":"Mattocks A. R.","year":"1969","journal-title":"J. Chem. Soc. C"},{"key":"ref87\/cit87","doi-asserted-by":"crossref","first-page":"1853","DOI":"10.1071\/CH9701853","volume":"23","author":"Culvenor C. C. J.","year":"1970","journal-title":"Aust. J. Chem."},{"key":"ref88\/cit88","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/0009-2797(90)90031-H","volume":"76","author":"Mattocks A. R.","year":"1990","journal-title":"Chem.\u2013Biol. Interact."},{"key":"ref89\/cit89","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S0009-2797(86)80089-8","volume":"58","author":"Mattocks A. R.","year":"1986","journal-title":"Chem.\u2013Biol. Interact."},{"key":"ref90\/cit90","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/S0090-9556(25)07870-5","volume":"10","author":"Eastman D. F.","year":"1982","journal-title":"Drug Metab. Dispos."},{"key":"ref91\/cit91","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1177\/0748233706071765","volume":"22","author":"Chou M. W.","year":"2006","journal-title":"Toxicol. Ind. Health"},{"key":"ref92\/cit92","doi-asserted-by":"crossref","first-page":"834","DOI":"10.3181\/00379727-144-37693","volume":"144","author":"Hsu I. C.","year":"1973","journal-title":"Proc. Soc. Exp. Biol. Med."},{"key":"ref93\/cit93","first-page":"99","volume":"11","author":"Hsu I. C.","year":"1975","journal-title":"Res. Commun. Chem. Pathol. Pharmacol."},{"key":"ref94\/cit94","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/0009-2797(76)90078-8","volume":"13","author":"Curtain C. C.","year":"1976","journal-title":"Chem.\u2013Biol. Interact."},{"key":"ref95\/cit95","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/S0015-6264(77)80006-0","volume":"15","author":"Sun P. S.","year":"1977","journal-title":"Food Cosmet. Toxicol."},{"key":"ref96\/cit96","first-page":"20","volume":"17","author":"Seawright A. A.","year":"1992","journal-title":"Proc. Nutr. Soc. Aust."},{"key":"ref97\/cit97","first-page":"77","volume-title":"Plant-Associated Toxins; Agricultural, Phytochemical and Ecological Aspects","author":"Seawright A. A.","year":"1994"},{"key":"ref98\/cit98","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/0009-2797(74)90038-6","volume":"8","author":"Hsu I. C.","year":"1974","journal-title":"Chem.\u2013Biol. Interact."},{"key":"ref99\/cit99","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/0009-2797(76)90063-6","volume":"12","author":"Hsu I. C.","year":"1976","journal-title":"Chem.\u2013Biol. Interact."},{"key":"ref100\/cit100","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1002\/path.1711190105","volume":"119","author":"Shumaker R. C.","year":"1976","journal-title":"J. Pathol."},{"key":"ref101\/cit101","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/0009-2797(76)90162-9","volume":"15","author":"Mattocks A. R.","year":"1976","journal-title":"Chem.\u2013Biol. Interact."},{"key":"ref102\/cit102","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0009-2797(85)80152-6","volume":"54","author":"Candrian U.","year":"1985","journal-title":"Chem.\u2013Biol. Interact."},{"key":"ref103\/cit103","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/0009-2797(90)90120-C","volume":"75","author":"Mattocks A. R.","year":"1990","journal-title":"Chem.\u2013Biol. Interact."},{"key":"ref104\/cit104","first-page":"997","volume":"35","author":"Allen J. R.","year":"1975","journal-title":"Cancer Res."},{"key":"ref105\/cit105","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1093\/jnci\/56.4.787","volume":"56","author":"Shumaker R. C.","year":"1976","journal-title":"J. Natl. Cancer Inst."},{"key":"ref106\/cit106","first-page":"381","volume":"70","author":"Peterson J. E.","year":"1983","journal-title":"J. Natl. Cancer Inst."},{"key":"ref107\/cit107","first-page":"273","volume":"21","author":"Percy J.","year":"1971","journal-title":"Immunology"},{"key":"ref108\/cit108","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1002\/path.1711070305","volume":"107","author":"Peterson J. E.","year":"1972","journal-title":"J. Pathol."},{"key":"ref109\/cit109","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0378-4274(83)90002-4","volume":"16","author":"Mattocks A. R.","year":"1983","journal-title":"Toxicol. Lett."},{"key":"ref110\/cit110","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S1383-5742(99)00010-1","volume":"443","author":"Prakash A. S.","year":"1999","journal-title":"Mutat. Res."},{"key":"ref111\/cit111","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/0021-9975(75)90020-1","volume":"85","author":"Hooper P. T.","year":"1975","journal-title":"J. Comp. Pathol."},{"key":"ref112\/cit112","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.1021\/tx1002436","volume":"23","author":"Wong L. S.N.","year":"2010","journal-title":"Chem. Res. Toxicol."},{"key":"ref113\/cit113","first-page":"201","volume":"30","author":"Molyneux R. J.","year":"1988","journal-title":"Vet. Hum. Toxicol."},{"key":"ref114\/cit114","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1002\/hep.510230326","volume":"23","author":"DeLeve L. D.","year":"1996","journal-title":"Hepatology"},{"key":"ref115\/cit115","doi-asserted-by":"crossref","first-page":"1779","DOI":"10.1002\/hep.510290615","volume":"29","author":"DeLeve L. D.","year":"1999","journal-title":"Hepatology"},{"key":"ref116\/cit116","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1055\/s-2002-23204","volume":"22","author":"DeLeve L. D.","year":"2002","journal-title":"Semin. Liver Dis."},{"key":"ref117\/cit117","first-page":"G1045","volume":"284","author":"DeLeve L. D.","year":"2003","journal-title":"Am. J. Physiol.: Gastrointest. Liver Physiol."},{"key":"ref118\/cit118","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.1002\/hep.22772","volume":"49","author":"DeLeve L. D.","year":"2009","journal-title":"Hepatology"},{"key":"ref119\/cit119","first-page":"42","volume-title":"Toxicants of Plant Origin","volume":"1","author":"Huxtable R. J.","year":"1989"},{"key":"ref120\/cit120","first-page":"129","volume":"49","author":"Nolan J. P.","year":"1966","journal-title":"Am. J. Pathol."},{"key":"ref121\/cit121","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1016\/S0002-9440(10)64591-9","volume":"157","author":"Gordon G. J.","year":"2000","journal-title":"Am. J. Pathol."},{"key":"ref122\/cit122","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1093\/toxsci\/kfg222","volume":"76","author":"Hanumegowda U. M.","year":"2003","journal-title":"Toxicol. Sci."},{"key":"ref123\/cit123","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1002\/hep.510310224","volume":"31","author":"Wang X.","year":"2000","journal-title":"Hepatology"},{"key":"ref124\/cit124","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1016\/S0016-5085(85)80027-5","volume":"88","author":"Ridker P. M.","year":"1985","journal-title":"Gastroenterology"},{"key":"ref125\/cit125","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1159\/000070799","volume":"18","author":"Rasenack R.","year":"2003","journal-title":"Fetal Diagn. Ther."},{"key":"ref126\/cit126","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1002\/path.1700920216","volume":"92","author":"Kay J. M.","year":"1966","journal-title":"J. Pathol. Bacteriol."},{"key":"ref127\/cit127","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1093\/cvr\/1.1.74","volume":"1","author":"Heath D.","year":"1967","journal-title":"Cardiovasc. Res."},{"key":"ref128\/cit128","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1136\/thx.22.2.176","volume":"22","author":"Kay J. M.","year":"1967","journal-title":"Thorax"},{"key":"ref129\/cit129","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1002\/path.1711060306","volume":"106","author":"Burns J.","year":"1972","journal-title":"J. Pathol."},{"key":"ref130\/cit130","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/0014-4800(72)90071-8","volume":"17","author":"Allen J. R.","year":"1972","journal-title":"Exp. Mol. Pathol."},{"key":"ref131\/cit131","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.2460\/ajvr.1973.34.12.1577","volume":"34","author":"Chesney C. F.","year":"1973","journal-title":"Am. J. Vet. Res."},{"key":"ref132\/cit132","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1093\/cvr\/7.4.508","volume":"7","author":"Chesney C. F.","year":"1973","journal-title":"Cardiovasc. Res."},{"key":"ref133\/cit133","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1161\/01.RES.35.5.657","volume":"35","author":"Fishman A. P.","year":"1974","journal-title":"Circ. Res."},{"key":"ref134\/cit134","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1006\/taap.1993.1013","volume":"118","author":"Pan L. C.","year":"1993","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref135\/cit135","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1165\/rcmb.2007-0066TR","volume":"37","author":"Sehgal P. B.","year":"2007","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"ref136\/cit136","first-page":"L1013","volume":"297","author":"Stenmark K. R.","year":"2009","journal-title":"Am. J. Physiol.: Lung Cell. Mol. Physiol."},{"key":"ref137\/cit137","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.jcyt.2012.09.002","volume":"15","author":"Yen C. H.","year":"2013","journal-title":"Cytotherapy"},{"key":"ref138\/cit138","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1021\/mp300426u","volume":"10","author":"Gupta V.","year":"2013","journal-title":"Mol. Pharmaceutics"},{"key":"ref139\/cit139","first-page":"L363","volume":"302","author":"Gomez-Arroyo J. G.","year":"2012","journal-title":"Am. J. Physiol.: Lung Cell. Mol. Physiol."},{"key":"ref140\/cit140","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1136\/thx.26.3.249","volume":"26","author":"Kay J. M.","year":"1971","journal-title":"Thorax"},{"key":"ref141\/cit141","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1136\/thx.30.4.399","volume":"30","author":"Heath D.","year":"1975","journal-title":"Thorax"},{"key":"ref142\/cit142","first-page":"210","volume":"139","author":"Gy\u00f6rika S.","year":"2009","journal-title":"Swiss Med. Wkly."},{"key":"ref143\/cit143","first-page":"426","volume-title":"Food and Cancer Prevention","author":"Couet C. E.","year":"1993"},{"key":"ref144\/cit144","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.tiv.2004.06.003","volume":"19","author":"Ji L.","year":"2005","journal-title":"Toxicol. In Vitro"},{"key":"ref145\/cit145","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1111\/j.1349-7006.1993.tb02791.x","volume":"84","author":"Hirono I.","year":"1993","journal-title":"Jpn. J. Cancer Res."},{"key":"ref146\/cit146","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/S0378-4274(03)00240-6","volume":"144","author":"Chan P. C.","year":"2003","journal-title":"Toxicol. Lett."},{"key":"ref147\/cit147","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1177\/1947601911413466","volume":"2","author":"Malkin D.","year":"2011","journal-title":"Genes Cancer"},{"key":"ref148\/cit148","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1002\/1097-0142(19841001)54:7<1256::AID-CNCR2820540704>3.0.CO;2-S","volume":"54","author":"LeTendre L.","year":"1984","journal-title":"Cancer"},{"key":"ref149\/cit149","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1007\/BF00183576","volume":"9","author":"Miser J. S.","year":"1991","journal-title":"Invest. New Drugs"},{"key":"ref150\/cit150","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1164\/rccm.200709-1369PP","volume":"178","author":"Rai P. R.","year":"2008","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref151\/cit151","first-page":"2237","volume":"28","author":"Schoental R.","year":"1968","journal-title":"Cancer Res."},{"key":"ref152\/cit152","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/S0031-6997(25)06884-X","volume":"22","author":"McLean E. K.","year":"1970","journal-title":"Pharmacol. Rev."},{"key":"ref153\/cit153","first-page":"908","volume":"32","author":"Svoboda D. J.","year":"1972","journal-title":"Cancer Res."},{"key":"ref154\/cit154","first-page":"527","volume":"64","author":"Hirono I.","year":"1973","journal-title":"Gann Monogr. Cancer Res."},{"key":"ref155\/cit155","first-page":"865","volume":"61","author":"Hirono I.","year":"1978","journal-title":"J. Natl. Cancer Inst."},{"key":"ref156\/cit156","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1002\/mpo.2950240513","volume":"24","author":"Kanwar V. S.","year":"1995","journal-title":"Med. Pediatr. Oncol."},{"key":"ref157\/cit157","doi-asserted-by":"crossref","first-page":"2435","DOI":"10.1002\/(SICI)1097-0142(19970615)79:12<2435::AID-CNCR21>3.0.CO;2-R","volume":"79","author":"Ortega J. A.","year":"1997","journal-title":"Cancer"},{"key":"ref158\/cit158","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1002\/(SICI)1096-911X(199710)29:4<245::AID-MPO2>3.0.CO;2-M","volume":"29","author":"Bisogno G.","year":"1997","journal-title":"Med. Pediatr. Oncol."},{"key":"ref159\/cit159","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1002\/(SICI)1096-911X(199911)33:5<462::AID-MPO5>3.0.CO;2-8","volume":"33","author":"Ludwig R.","year":"1999","journal-title":"Med. Pediatr. Oncol."},{"key":"ref160\/cit160","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1007\/BF01102990","volume":"375","author":"Burkhardt A.","year":"1977","journal-title":"Virchows Arch. A: Pathol. Anat. Histol."},{"key":"ref161\/cit161","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1093\/annonc\/mdh095","volume":"15","author":"Rubbia-Brandt L.","year":"2004","journal-title":"Ann. Oncol."},{"key":"ref162\/cit162","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1002\/ajh.20338","volume":"79","author":"Boula A. M.","year":"2005","journal-title":"Am. J. Hematol."},{"key":"ref163\/cit163","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1002\/pbc.20338","volume":"46","author":"Elli M.","year":"2006","journal-title":"Pediatr. Blood Cancer"},{"key":"ref164\/cit164","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1038\/sj.bmt.1701225","volume":"21","author":"Matute-Bello G.","year":"1998","journal-title":"Bone Marrow Transplant."},{"key":"ref165\/cit165","doi-asserted-by":"crossref","first-page":"255","DOI":"10.7326\/0003-4819-118-4-199302150-00003","volume":"118","author":"McDonald G. B.","year":"1993","journal-title":"Ann. Int. Med."},{"key":"ref166\/cit166","doi-asserted-by":"crossref","first-page":"3259","DOI":"10.1182\/blood.V93.10.3259.410k13_3259_3266","volume":"93","author":"Strasser S. I.","year":"1999","journal-title":"Blood"},{"key":"ref167\/cit167","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1038\/sj.bmt.1702432","volume":"25","author":"Copelan E. A.","year":"2000","journal-title":"Bone Marrow Transplant."},{"key":"ref168\/cit168","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1038\/sj.bmt.1703393","volume":"29","author":"Horn B.","year":"2002","journal-title":"Bone Marrow Transplant."},{"key":"ref169\/cit169","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1002\/ajh.10072","volume":"69","author":"Bairey O.","year":"2002","journal-title":"Am. J. Hematol."},{"key":"ref170\/cit170","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1038\/sj.bmt.1704069","volume":"32","author":"Barker C. C.","year":"2003","journal-title":"Bone Marrow Transplant."},{"key":"ref171\/cit171","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1007\/s00277-003-0669-2","volume":"82","author":"Kraemer D. M.","year":"2003","journal-title":"Ann. Hematol."},{"key":"ref172\/cit172","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1038\/sj.bmt.1703881","volume":"31","author":"Bajwa R. P. S.","year":"2003","journal-title":"Bone Marrow Transplant."},{"key":"ref173\/cit173","doi-asserted-by":"crossref","first-page":"2285","DOI":"10.1016\/j.transproceed.2005.03.025","volume":"37","author":"Kalayoglu-Besisik S.","year":"2005","journal-title":"Transplant. Proc."},{"key":"ref174\/cit174","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1007\/s12185-008-0172-6","volume":"88","author":"Papadopoulos A.","year":"2008","journal-title":"Int. J. Hematol."},{"key":"ref175\/cit175","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1097\/00007890-198706000-00020","volume":"43","author":"Dulley F. L.","year":"1987","journal-title":"Transplantation"},{"key":"ref176\/cit176","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1034\/j.1600-0609.2000.9r200.x","volume":"64","author":"Carreras E.","year":"2000","journal-title":"Eur. J. Haematol."},{"key":"ref177\/cit177","doi-asserted-by":"crossref","first-page":"589","DOI":"10.4065\/78.5.589","volume":"78","author":"Kumar S.","year":"2003","journal-title":"Mayo Clin. Proc."},{"key":"ref178\/cit178","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.thromres.2005.02.015","volume":"118","author":"Gharib M. I.","year":"2006","journal-title":"Thromb. Res."},{"key":"ref179\/cit179","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1158\/1535-7163.MCT-10-1072","volume":"10","author":"Rubbia-Brandt L.","year":"2011","journal-title":"Mol. Cancer Ther."},{"key":"ref180\/cit180","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1038\/sj.bjc.6603097","volume":"94","author":"De Jonge M. E.","year":"2006","journal-title":"Br. J. Cancer"},{"key":"ref181\/cit181","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1007\/BF00499045","volume":"272","author":"Plapp F. V.","year":"1972","journal-title":"Arch. Pharmacol"},{"key":"ref182\/cit182","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/0006-2952(95)02189-2","volume":"51","author":"Yan C. C.","year":"1996","journal-title":"Biochem. Pharmacol."},{"key":"ref183\/cit183","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1038\/nm0210-171","volume":"16","author":"Hettmer S.","year":"2010","journal-title":"Nat. Med."},{"key":"ref184\/cit184","doi-asserted-by":"crossref","first-page":"A224","DOI":"10.1289\/ehp.113-a224","volume":"113","author":"Daughton C. G.","year":"2005","journal-title":"Environ. Health Perspect."},{"key":"ref185\/cit185","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1161\/ATVBAHA.107.141200","volume":"27","author":"Morty R. E.","year":"2007","journal-title":"Arterioscler., Thromb., Vasc. Biol."},{"key":"ref186\/cit186","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1258\/ebm.2010.009383","volume":"235","author":"Murakami K.","year":"2010","journal-title":"Exp. Biol. Med."},{"key":"ref187\/cit187","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.vph.2007.01.005","volume":"46","author":"Ramos M.","year":"2007","journal-title":"Vasc. Pharmacol."},{"key":"ref188\/cit188","doi-asserted-by":"crossref","first-page":"7759","DOI":"10.1073\/pnas.78.12.7759","volume":"78","author":"Owens G. K.","year":"1981","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"ref189\/cit189","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/S0008-6363(99)00230-8","volume":"44","author":"Veyssier-Belot C.","year":"1999","journal-title":"Cardiovasc. Res."},{"key":"ref190\/cit190","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1002\/j.2040-4603.2011.tb00329.x","volume":"1","author":"Tajsic T.","year":"2011","journal-title":"Comp. Physiol."},{"key":"ref191\/cit191","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1177\/019262339702500405","volume":"25","author":"Lappin P. B.","year":"1997","journal-title":"Toxicol. Pathol."},{"key":"ref192\/cit192","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1006\/taap.1998.8398","volume":"150","author":"Lappin P. B.","year":"1998","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref193\/cit193","doi-asserted-by":"crossref","first-page":"L715","DOI":"10.1152\/ajpcell.00507.2008","volume":"297","author":"Lee J.","year":"2009","journal-title":"Am. J. Physiol.: Lung Cell. Mol. Physiol."},{"key":"ref194\/cit194","first-page":"L449","volume":"249","author":"Mukhopadhyay S.","year":"2008","journal-title":"Am. J. Physiol.: Lung Cell Mol. Physiol."},{"key":"ref195\/cit195","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1111\/j.1751-0813.1955.tb05488.x","volume":"31","author":"Bull L. B.","year":"1955","journal-title":"Aust. Vet. J."},{"key":"ref196\/cit196","first-page":"405","volume":"56","author":"Jago M. V.","year":"1969","journal-title":"Am. J. Pathol."},{"key":"ref197\/cit197","first-page":"399","volume":"65","author":"Svoboda D.","year":"1971","journal-title":"Am. J. Pathol."},{"key":"ref198\/cit198","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/0009-2797(75)90112-X","volume":"10","author":"Samuel A.","year":"1975","journal-title":"Chem.\u2013Biol. Interact."},{"key":"ref199\/cit199","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1016\/S0140-6736(03)13167-4","volume":"361","author":"Runo J. R.","year":"2003","journal-title":"Lancet"},{"key":"ref200\/cit200","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1164\/rccm.201003-0491OC","volume":"182","author":"Aldred M. A.","year":"2010","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref201\/cit201","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1164\/rccm.201007-1147ED","volume":"182","author":"Austin E. D.","year":"2010","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref202\/cit202","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1213\/00000539-199610000-00003","volume":"83","author":"Taura P.","year":"1996","journal-title":"Anesth. Analg."},{"key":"ref203\/cit203","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1016\/S0140-6736(04)16107-2","volume":"363","author":"Hoeper M. M.","year":"2004","journal-title":"Lancet"},{"key":"ref204\/cit204","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.bpg.2006.07.011","volume":"21","author":"Herve P.","year":"2007","journal-title":"Best Pract. Res., Clin. Gastroenterol."},{"key":"ref205\/cit205","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1007\/s11894-010-0164-6","volume":"13","author":"Kochar R.","year":"2011","journal-title":"Curr. Gastroenterol. Rep."},{"key":"ref206\/cit206","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1164\/arrd.1983.127.4.437","volume":"127","author":"McDonnell P. J.","year":"1983","journal-title":"Am. Rev. Respir. Dis."},{"key":"ref207\/cit207","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1007\/BF01213304","volume":"32","author":"Murata K.","year":"1997","journal-title":"J. Gastroenterol."},{"key":"ref208\/cit208","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/j.cellsig.2010.10.003","volume":"23","author":"Bragdon B.","year":"2011","journal-title":"Cell. Signalling"},{"key":"ref209\/cit209","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1359\/jbmr.060411","volume":"21","author":"Okamoto M.","year":"2006","journal-title":"J. Bone Miner. Res."},{"key":"ref210\/cit210","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1046\/j.1365-2141.2003.04739.x","volume":"124","author":"Steward C. G.","year":"2004","journal-title":"Br. J. Hamaetol."},{"key":"ref211\/cit211","doi-asserted-by":"crossref","first-page":"4367","DOI":"10.1182\/blood-2010-10-312082","volume":"117","author":"Slatter M. A.","year":"2011","journal-title":"Blood"},{"key":"ref212\/cit212","doi-asserted-by":"crossref","first-page":"686","DOI":"10.2106\/JBJS.I.00705","volume":"92","author":"Kaplan F. S.","year":"2010","journal-title":"J. Bone Jt. Surg., Am. Vol."},{"key":"ref213\/cit213","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1034\/j.1399-0004.2000.580407.x","volume":"58","author":"Xu M.-Q.","year":"2000","journal-title":"Clin. Genet."},{"key":"ref214\/cit214","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/S0046-8177(97)90133-7","volume":"28","author":"Gannon F. H.","year":"1997","journal-title":"Human Pathol."},{"key":"ref215\/cit215","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1017\/S1462399406000020","volume":"8","author":"Enklaar T.","year":"2006","journal-title":"Expert Rev. Mol. Med."},{"key":"ref216\/cit216","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.bbrc.2007.06.049","volume":"360","author":"Sun J.","year":"2007","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref217\/cit217","first-page":"255","volume":"3","author":"Sotelo-Avila C.","year":"1976","journal-title":"Perspect. Pediatr. Pathol."},{"key":"ref218\/cit218","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1002\/ajmg.a.30729","volume":"136","author":"Rump P.","year":"2005","journal-title":"Am. J. Med. Gen."},{"key":"ref219\/cit219","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1002\/pbc.24215","volume":"59","author":"Spector L. G.","year":"2012","journal-title":"Pediatr. Blood Cancer"},{"key":"ref220\/cit220","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1038\/ng0594-91","volume":"7","author":"Bardeesy N.","year":"1994","journal-title":"Nat. Genet."},{"key":"ref221\/cit221","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1002\/mpo.10077","volume":"39","author":"Muwakkit S.","year":"2002","journal-title":"Med. Pediatr. Oncol."},{"key":"ref222\/cit222","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1007\/BF00713384","volume":"411","author":"M\u00fcller-H\u00f6cker J.","year":"1987","journal-title":"Virchows Arch. A: Pathol. Anat. Histopathol."},{"key":"ref223\/cit223","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1080\/00313029600169264","volume":"28","author":"Price L. A.","year":"1996","journal-title":"Pathology"},{"key":"ref224\/cit224","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1055\/s-2007-994108","volume":"14","author":"Seibold-Weiger K.","year":"1997","journal-title":"Am. J. Perinatol."},{"key":"ref225\/cit225","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1016\/S0344-0338(99)80108-3","volume":"195","author":"Sergi C.","year":"1999","journal-title":"Pathol., Res. Pract."},{"key":"ref226\/cit226","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1007\/s004310051095","volume":"158","author":"Trollmann R.","year":"1999","journal-title":"Eur. J. Pediatr."},{"key":"ref227\/cit227","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1071\/AR9560281","volume":"7","author":"Bull L. B.","year":"1956","journal-title":"Aust. J. Agric. Res."},{"key":"ref228\/cit228","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1111\/j.1751-0813.1962.tb04033.x","volume":"38","author":"St George-Grambauer T. D.","year":"1962","journal-title":"Aust. Vet. J."},{"key":"ref229\/cit229","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/0041-008X(81)90326-4","volume":"60","author":"Miranda C. L.","year":"1981","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref230\/cit230","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/S0021-9975(08)80061-8","volume":"105","author":"Howell J. M.","year":"1991","journal-title":"J. Comp. Pathol."},{"key":"ref231\/cit231","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1136\/adc.48.6.476","volume":"48","author":"Walker-Smith J.","year":"1973","journal-title":"Arch. Dis. Child."},{"key":"ref232\/cit232","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/S0344-0338(88)80157-2","volume":"183","author":"M\u00fcller-H\u00f6cker J.","year":"1988","journal-title":"Pathol., Res. Pract."},{"key":"ref233\/cit233","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/S0344-0338(98)80027-7","volume":"194","author":"M\u00fcller-H\u00f6cker J.","year":"1998","journal-title":"Pathol., Res. Pract."},{"key":"ref234\/cit234","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1016\/S0140-6736(94)90337-9","volume":"344","author":"Von M\u00fchlendahl K. E.","year":"1994","journal-title":"Lancet"},{"key":"ref235\/cit235","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1016\/S0140-6736(94)91649-7","volume":"344","author":"Scheinberg I. H.","year":"1994","journal-title":"Lancet"},{"key":"ref236\/cit236","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1016\/0168-8278(95)80059-X","volume":"23","author":"Baker A.","year":"1995","journal-title":"J. Hepatol."},{"key":"ref237\/cit237","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1016\/S0140-6736(96)91351-3","volume":"347","author":"M\u00fcller T.","year":"1996","journal-title":"Lancet"},{"key":"ref238\/cit238","doi-asserted-by":"crossref","first-page":"1082S","DOI":"10.1093\/ajcn\/67.5.1082S","volume":"67","author":"M\u00fcller T.","year":"1998","journal-title":"Am. J. Clin. Nutr."},{"key":"ref239\/cit239","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1038\/sj.ejhg.5200235","volume":"6","author":"Wijmenga C.","year":"1998","journal-title":"Eur. J. Hum. Genet."},{"key":"ref240\/cit240","doi-asserted-by":"crossref","first-page":"1074S","DOI":"10.1093\/ajcn\/67.5.1074S","volume":"67","author":"Tanner M. S.","year":"1998","journal-title":"Am. J. Clin. Nutr."},{"key":"ref241\/cit241","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1002\/(SICI)1096-9896(1998100)186:2<215::AID-PATH145>3.0.CO;2-C","volume":"186","author":"Aston N. S.","year":"1998","journal-title":"J. Pathol."},{"key":"ref242\/cit242","first-page":"233","volume":"28","author":"Dieter H. H.","year":"1999","journal-title":"Eur. J. Med. Res."},{"key":"ref243\/cit243","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S0013-9351(03)00037-9","volume":"92","author":"Zietz B. P.","year":"2003","journal-title":"Environ. Res."},{"key":"ref244\/cit244","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S0048-9697(02)00399-6","volume":"302","author":"Zietz B. P.","year":"2003","journal-title":"Sci. Total Environ."},{"key":"ref245\/cit245","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/S0022-3476(76)80988-2","volume":"88","author":"Mellis C.","year":"1976","journal-title":"J. Pediatr."},{"key":"ref246\/cit246","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/S0022-3476(87)80546-2","volume":"110","author":"Etzioni A.","year":"1987","journal-title":"J. Pediatr."},{"key":"ref247\/cit247","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1038\/ng1780","volume":"38","author":"Roscioli T.","year":"2006","journal-title":"Nat. Genet."},{"key":"ref248\/cit248","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1002\/pd.1759","volume":"27","author":"Cliffe S. T.","year":"2007","journal-title":"Prenatal Diagn."},{"key":"ref249\/cit249","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/j.jaci.2012.02.054","volume":"130","author":"Cliffe S. T.","year":"2012","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref250\/cit250","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.clim.2012.07.016","volume":"145","author":"Wang T.","year":"2012","journal-title":"Clin. Immunol."},{"key":"ref251\/cit251","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1111\/pai.12051","volume":"24","author":"Ganaiem H.","year":"2013","journal-title":"Pediatr. Allergy Immunol."},{"key":"ref252\/cit252","unstructured":"(2009) Genetics Home Reference,US National Library of Medicine,http:\/\/ghr.nlm.nih.gov\/gene\/SP110."},{"key":"ref253\/cit253","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1016\/0272-0590(90)90308-7","volume":"14","author":"Deyo J. A.","year":"1990","journal-title":"Fundam. Appl. Toxicol."},{"key":"ref254\/cit254","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1080\/19440049.2010.547519","volume":"28","author":"Molyneux R. J.","year":"2011","journal-title":"Food Addit. Contam., Part A"},{"key":"ref255\/cit255","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1080\/03062686.1973.11904153","volume":"1","author":"Newberne P. M.","year":"1973","journal-title":"Plant Foods Man"},{"key":"ref256\/cit256","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1006\/taap.2000.8968","volume":"166","author":"Yee S. B.","year":"2000","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref257\/cit257","first-page":"1406","volume":"132","year":"1992","journal-title":"Dtsch. Apoth. Ztg."},{"key":"ref258\/cit258","unstructured":"European Medicines Agency (2013) Public statement on the use of herbal medicinal products containing toxic, unsaturated pyrrolizidine alkaloids (PAs), EMA\/HMPC\/893108\/2011, 2nd draft, 6 Nov,EMA,London,http:\/\/www.ema.europa.eu\/docs\/en_GB\/document_library\/Public_statement\/2013\/11\/WC500154224.pdf."},{"key":"ref259\/cit259","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1055\/s-2008-1072380","volume":"10","author":"Czauderna P.","year":"2000","journal-title":"Eur. J. Pediatr. Surg."},{"key":"ref260\/cit260","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1080\/08880010701640390","volume":"24","author":"Cecen E.","year":"2007","journal-title":"Pediatr. Hematol. Oncol."},{"key":"ref261\/cit261","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1021\/tx400241c","volume":"26","author":"Xia Q.","year":"2013","journal-title":"Chem. Res. Toxicol."},{"key":"ref262\/cit262","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1111\/j.1751-2980.2011.00552.x","volume":"13","author":"Gao H.","year":"2012","journal-title":"J. Dig. 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