{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,15]],"date-time":"2026-02-15T03:13:47Z","timestamp":1771125227127,"version":"3.50.1"},"reference-count":60,"publisher":"American Chemical Society (ACS)","issue":"5","funder":[{"DOI":"10.13039\/100004336","name":"Novartis","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004336","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011039","name":"Schweizerisches Zentrum f\u00fcr Angewandte Humantoxikologie","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100011039","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chem. Res. Toxicol."],"published-print":{"date-parts":[[2015,5,18]]},"DOI":"10.1021\/tx5005369","type":"journal-article","created":{"date-parts":[[2015,3,31]],"date-time":"2015-03-31T16:42:54Z","timestamp":1427820174000},"page":"955-966","source":"Crossref","is-referenced-by-count":27,"title":["Steroidomic Footprinting Based on Ultra-High Performance Liquid Chromatography Coupled with Qualitative and Quantitative High-Resolution Mass Spectrometry for the Evaluation of Endocrine Disrupting Chemicals in H295R Cells"],"prefix":"10.1021","volume":"28","author":[{"given":"David","family":"Tonoli","sequence":"first","affiliation":[{"name":"School\rof Pharmaceutical Sciences, University of Geneva and University of Lausanne, Geneva, Switzerland"},{"name":"Department\rof Human Protein Sciences, Faculty of Medicine, University of Geneva, Geneva, Switzerland"},{"name":"Swiss\rCentre for Applied Human Toxicology (SCAHT), Universities of Basel and Geneva, Basel, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cornelia","family":"F\u00fcrstenberger","sequence":"additional","affiliation":[{"name":"Swiss\rCentre for Applied Human Toxicology (SCAHT), Universities of Basel and Geneva, Basel, Switzerland"},{"name":"Division\rof Molecular and Systems Toxicology, Department of Pharmaceutical\rSciences, University of Basel, Basel, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julien","family":"Boccard","sequence":"additional","affiliation":[{"name":"School\rof Pharmaceutical Sciences, University of Geneva and University of Lausanne, Geneva, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Denis","family":"Hochstrasser","sequence":"additional","affiliation":[{"name":"Department\rof Genetic and Laboratory Medicine, Geneva University Hospitals, Geneva, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabienne","family":"Jeanneret","sequence":"additional","affiliation":[{"name":"School\rof Pharmaceutical Sciences, University of Geneva and University of Lausanne, Geneva, Switzerland"},{"name":"Department\rof Human Protein Sciences, Faculty of Medicine, University of Geneva, Geneva, Switzerland"},{"name":"Swiss\rCentre for Applied Human Toxicology (SCAHT), Universities of Basel and Geneva, Basel, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alex","family":"Odermatt","sequence":"additional","affiliation":[{"name":"Swiss\rCentre for Applied Human Toxicology (SCAHT), Universities of Basel and Geneva, Basel, Switzerland"},{"name":"Division\rof Molecular and Systems Toxicology, Department of Pharmaceutical\rSciences, University of Basel, Basel, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Serge","family":"Rudaz","sequence":"additional","affiliation":[{"name":"School\rof Pharmaceutical Sciences, University of Geneva and University of Lausanne, Geneva, Switzerland"},{"name":"Swiss\rCentre for Applied Human Toxicology (SCAHT), Universities of Basel and Geneva, Basel, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"316","published-online":{"date-parts":[[2015,4,17]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1289\/ehp.8875","volume":"114","author":"Harding A. K.","year":"2006","journal-title":"Environ. Health Perspect."},{"key":"ref2\/cit2","volume-title":"Global Assessment of the State-of-the-Science of Endocrine Disruptors","author":"World Health Organization","year":"2002"},{"key":"ref3\/cit3","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.envres.2007.07.002","volume":"105","author":"Belpomme D.","year":"2007","journal-title":"Environ. Res."},{"key":"ref4\/cit4","doi-asserted-by":"crossref","first-page":"713696","DOI":"10.1155\/2012\/713696","volume":"2012","author":"De Coster S.","year":"2012","journal-title":"J. Environ. Public Health"},{"key":"ref5\/cit5","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.jsbmb.2011.04.004","volume":"127","author":"Luccio-Camelo D. C.","year":"2011","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"ref6\/cit6","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1093\/humrep\/16.5.972","volume":"16","author":"Skakkebaek N. E.","year":"2001","journal-title":"Hum. Reprod."},{"key":"ref7\/cit7","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.mce.2011.08.041","volume":"351","author":"Wang T.","year":"2012","journal-title":"Mol. Cell. Endocrinol."},{"key":"ref8\/cit8","first-page":"423","volume":"7","author":"Staels B.","year":"1993","journal-title":"Mol. Endocrinol."},{"key":"ref9\/cit9","first-page":"731","volume":"77","author":"Rainey W. E.","year":"1993","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref10\/cit10","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1007\/s00216-007-1657-5","volume":"390","author":"Hecker M.","year":"2008","journal-title":"Anal. Bioanal. Chem."},{"key":"ref11\/cit11","first-page":"5488","volume":"50","author":"Gazdar A. F.","year":"1990","journal-title":"Cancer Res."},{"issue":"1","key":"ref12\/cit12","first-page":"23","volume":"14","author":"Hollert H.","year":"2007","journal-title":"Environ. Sci. Pollut. Res."},{"key":"ref13\/cit13","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1007\/s11356-010-0396-x","volume":"18","author":"Hecker M.","year":"2011","journal-title":"Environ. Sci. Pollut. Res."},{"key":"ref14\/cit14","volume-title":"Multi-Laboratory Validation Report of the H295R Steroidogenesis Assay to Identify Modulators of Testosterone and Estradiol Production","author":"Organisation for Economic Co-operation and Development - OECD","year":"2010"},{"key":"ref15\/cit15","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1677\/joe.0.1760069","volume":"176","author":"Liakos P.","year":"2003","journal-title":"J. Endocrinol."},{"key":"ref16\/cit16","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1373\/49.8.1381","volume":"49","author":"Taieb J.","year":"2003","journal-title":"Clin. Chem."},{"key":"ref17\/cit17","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.ecoenv.2006.06.012","volume":"65","author":"Gracia T.","year":"2006","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref18\/cit18","doi-asserted-by":"crossref","first-page":"2549","DOI":"10.4155\/bio.11.254","volume":"3","author":"Couchman L.","year":"2011","journal-title":"Bioanalysis"},{"key":"ref19\/cit19","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.aca.2008.02.053","volume":"613","author":"Strahm E.","year":"2008","journal-title":"Anal. Chim. Acta"},{"key":"ref20\/cit20","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.jchromb.2013.07.013","volume":"935","author":"Abdel-Khalik J.","year":"2013","journal-title":"J. Chromatogr., B"},{"key":"ref21\/cit21","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.taap.2011.11.017","volume":"258","author":"Cheng L. C.","year":"2012","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref22\/cit22","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1016\/j.lfs.2010.04.009","volume":"86","author":"Iwaoka Y.","year":"2010","journal-title":"Life Sci."},{"key":"ref23\/cit23","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1002\/jcp.24262","volume":"228","author":"Komarnytsky S.","year":"2013","journal-title":"J. Cell. Physiol."},{"key":"ref24\/cit24","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.bcp.2014.05.013","volume":"90","author":"Lin C. J.","year":"2014","journal-title":"Biochem. Pharmacol."},{"key":"ref25\/cit25","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.taap.2012.10.022","volume":"266","author":"Rosenmai A. K.","year":"2013","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref26\/cit26","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.jsbmb.2011.11.003","volume":"128","author":"Schloms L.","year":"2012","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"ref27\/cit27","doi-asserted-by":"crossref","first-page":"3681","DOI":"10.3390\/molecules19033681","volume":"19","author":"Schloms L.","year":"2014","journal-title":"Molecules"},{"key":"ref28\/cit28","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1530\/JOE-12-0310","volume":"215","author":"van der Pas R.","year":"2012","journal-title":"J. Endocrinol."},{"key":"ref29\/cit29","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1530\/JOE-10-0493","volume":"209","author":"Xing Y.","year":"2011","journal-title":"J. Endocrinol."},{"key":"ref30\/cit30","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.ab.2014.06.011","volume":"462","author":"Yurek D.","year":"2014","journal-title":"Anal. Biochem."},{"key":"ref31\/cit31","doi-asserted-by":"crossref","first-page":"3123","DOI":"10.1002\/rcm.5208","volume":"25","author":"Zhang F.","year":"2011","journal-title":"Rapid Commun. Mass Spectrom."},{"key":"ref32\/cit32","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1093\/toxsci\/kfr061","volume":"121","author":"Zhang X.","year":"2011","journal-title":"Toxicol. Sci."},{"key":"ref33\/cit33","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1038\/nrmicro1177","volume":"3","author":"Kell D. B.","year":"2005","journal-title":"Nat. Rev. Microbiol."},{"key":"ref34\/cit34","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1007\/s00216-011-4779-8","volume":"400","author":"Badoud F.","year":"2011","journal-title":"Anal. Bioanal. Chem."},{"key":"ref35\/cit35","doi-asserted-by":"crossref","first-page":"4423","DOI":"10.1016\/j.chroma.2009.03.033","volume":"1216","author":"Badoud F.","year":"2009","journal-title":"J. Chromatogr., A"},{"key":"ref36\/cit36","doi-asserted-by":"crossref","first-page":"4109","DOI":"10.1016\/j.chroma.2009.11.001","volume":"1217","author":"Badoud F.","year":"2010","journal-title":"J. Chromatogr., A"},{"key":"ref37\/cit37","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.forsciint.2011.07.023","volume":"213","author":"Boccard J.","year":"2011","journal-title":"Forensic Sci. Int."},{"key":"ref38\/cit38","doi-asserted-by":"crossref","first-page":"2523","DOI":"10.4155\/bio.14.200","volume":"6","author":"Boccard J.","year":"2014","journal-title":"Bioanalysis"},{"key":"ref39\/cit39","doi-asserted-by":"crossref","first-page":"2587","DOI":"10.1007\/s00216-011-5641-8","volume":"402","author":"Hopfgartner G.","year":"2012","journal-title":"Anal. Bioanal. Chem."},{"key":"ref40\/cit40","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.4155\/bio.11.98","volume":"3","author":"Korfmacher W.","year":"2011","journal-title":"Bioanalysis"},{"key":"ref41\/cit41","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.jchromb.2012.07.009","volume":"904","author":"Tonoli D.","year":"2012","journal-title":"J. Chromatogr., B"},{"key":"ref42\/cit42","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1289\/ehp.11200","volume":"116","author":"Ahn K. C.","year":"2008","journal-title":"Environ. Health Perspect."},{"key":"ref43\/cit43","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1210\/en.2007-1057","volume":"149","author":"Chen J.","year":"2008","journal-title":"Endocrinology"},{"key":"ref44\/cit44","unstructured":"U.S. Food and Drug Administration - FDA (2013) FDA Taking Closer Look at \u2018Antibacterial\u2019 Soap. (FDA, Ed., Washington D.C., U.S.A.)."},{"key":"ref45\/cit45","doi-asserted-by":"crossref","first-page":"2207","DOI":"10.1039\/b914324f","volume":"11","author":"Heidler J.","year":"2009","journal-title":"J. Environ. Monit."},{"key":"ref46\/cit46","doi-asserted-by":"crossref","first-page":"3109","DOI":"10.1021\/es103650m","volume":"45","author":"Schebb N. H.","year":"2011","journal-title":"Environ. Sci. Technol."},{"key":"ref47\/cit47","doi-asserted-by":"crossref","first-page":"e46958","DOI":"10.1371\/journal.pone.0046958","volume":"7","author":"Nashev L. G.","year":"2012","journal-title":"PLoS One"},{"key":"ref48\/cit48","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1002\/cem.1187","volume":"22","author":"Eriksson L.","year":"2008","journal-title":"J. Chemom."},{"key":"ref49\/cit49","doi-asserted-by":"crossref","first-page":"4009","DOI":"10.1002\/rcm.3823","volume":"22","author":"Pozo O. J.","year":"2008","journal-title":"Rapid Commun. Mass Spectrom."},{"key":"ref50\/cit50","doi-asserted-by":"crossref","first-page":"3291","DOI":"10.1021\/pr070183p","volume":"6","author":"Gika H. G.","year":"2007","journal-title":"J. Proteome Res."},{"key":"ref51\/cit51","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.aca.2011.09.042","volume":"711","author":"Theodoridis G. A.","year":"2012","journal-title":"Anal. Chim. Acta"},{"key":"ref52\/cit52","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.toxlet.2013.10.031","volume":"230","author":"Jeanneret F.","year":"2014","journal-title":"Toxicol. Lett."},{"key":"ref53\/cit53","doi-asserted-by":"crossref","first-page":"D801","DOI":"10.1093\/nar\/gks1065","volume":"41","author":"Wishart D. S.","year":"2013","journal-title":"Nucleic Acids Res."},{"key":"ref54\/cit54","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1194\/jlr.E400004-JLR200","volume":"46","author":"Fahy E.","year":"2005","journal-title":"J. Lipid Res."},{"key":"ref55\/cit55","doi-asserted-by":"crossref","first-page":"S9","DOI":"10.1194\/jlr.R800095-JLR200","volume":"50","author":"Fahy E.","year":"2009","journal-title":"J. Lipid Res."},{"key":"ref56\/cit56","first-page":"846","volume":"25","author":"Sansone S. A.","year":"2007","journal-title":"Nat. Biotechnol."},{"key":"ref57\/cit57","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1007\/s11306-007-0082-2","volume":"3","author":"Sumner L. W.","year":"2007","journal-title":"Metabolomics"},{"key":"ref58\/cit58","unstructured":"U.S. Food and Drug Administration - FDA (2013) Guidance for Industry - Bioanalytical Method Validation. (FDA, Ed., Washington D.C., U.S.A.)"},{"key":"ref59\/cit59","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.taap.2006.07.007","volume":"217","author":"Hecker M.","year":"2006","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref60\/cit60","doi-asserted-by":"crossref","first-page":"1720","DOI":"10.1021\/tx3001779","volume":"25","author":"Rijk J. C. W.","year":"2012","journal-title":"Chem. Res. Toxicol."}],"container-title":["Chemical Research in Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/tx5005369","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,14]],"date-time":"2023-04-14T09:39:13Z","timestamp":1681465153000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/tx5005369"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,4,17]]},"references-count":60,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2015,5,18]]}},"alternative-id":["10.1021\/tx5005369"],"URL":"https:\/\/doi.org\/10.1021\/tx5005369","relation":{},"ISSN":["0893-228X","1520-5010"],"issn-type":[{"value":"0893-228X","type":"print"},{"value":"1520-5010","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,4,17]]}}}