{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T04:56:45Z","timestamp":1788929805858,"version":"build-2803163510"},"reference-count":53,"publisher":"American Chemical Society (ACS)","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chem. Res. Toxicol."],"published-print":{"date-parts":[[2007,7,1]]},"DOI":"10.1021\/tx6003562","type":"journal-article","created":{"date-parts":[[2007,6,30]],"date-time":"2007-06-30T11:01:39Z","timestamp":1183201299000},"page":"1038-1045","source":"Crossref","is-referenced-by-count":35,"title":["Aminoglutethimide-Induced Protein Free Radical Formation on Myeloperoxidase:\u2009 A Potential Mechanism of Agranulocytosis"],"prefix":"10.1021","volume":"20","author":[{"given":"Arno G.","family":"Siraki","sequence":"first","affiliation":[{"name":"Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, 111 Alexander Drive, Research Triangle Park, North Carolina 27709"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo G.","family":"Bonini","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, 111 Alexander Drive, Research Triangle Park, North Carolina 27709"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JinJie","family":"Jiang","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, 111 Alexander Drive, Research Triangle Park, North Carolina 27709"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marilyn","family":"Ehrenshaft","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, 111 Alexander Drive, Research Triangle Park, North Carolina 27709"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald P.","family":"Mason","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, 111 Alexander Drive, Research Triangle Park, North Carolina 27709"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2007,6,30]]},"reference":[{"key":"tx6003562b00001\/tx6003562b00001_1","doi-asserted-by":"crossref","DOI":"10.1210\/er.2004-0015","volume":"26","author":"Brueggemeier R. W.","year":"2005","journal-title":"Endocr. Rev."},{"key":"tx6003562b00002\/tx6003562b00002_1","first-page":"34","volume":"175","author":"Lam J. S.","year":"2006","journal-title":"J. Urol."},{"key":"tx6003562b00003\/tx6003562b00003_1","volume-title":"vitro and animal models of drug-induced blood dyscrasias. Environ. Toxicol. Pharmacol. 21, 135\u2212140","author":"Ip J.","year":"2006"},{"key":"tx6003562b00004\/tx6003562b00004_1","first-page":"362","volume-title":"NORD Guide to Rare Disorders","author":"Saito Y.","year":"2003"},{"key":"tx6003562b00005\/tx6003562b00005_1","volume-title":"Wintrobe's Clinical Hematology","author":"Wintrobe M. M.","year":"2003"},{"key":"tx6003562b00006\/tx6003562b00006_1","volume-title":"Aminoglutethimide-induced bone marrow injury. Report of a case and review of the literature. Cancer 54, 1731\u22121733","author":"Young J. A.","year":"1984"},{"key":"tx6003562b00007\/tx6003562b00007_1","doi-asserted-by":"crossref","DOI":"10.1002\/(SICI)1096-8652(199803)57:3<206::AID-AJH4>3.0.CO;2-Z","volume":"57","author":"van der Klauw M. M.","year":"1998","journal-title":"Am. J. Hematol."},{"key":"tx6003562b00008\/tx6003562b00008_1","volume":"275","author":"Liu Z. C.","year":"1995","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"tx6003562b00009\/tx6003562b00009_1","doi-asserted-by":"crossref","DOI":"10.3109\/03602539208996297","volume":"24","author":"Uetrecht J. P.","year":"1992","journal-title":"Drug Metab. Rev."},{"key":"tx6003562b00010\/tx6003562b00010_1","volume":"282","author":"Gill H. J.","year":"1997","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"tx6003562b00011\/tx6003562b00011_1","doi-asserted-by":"crossref","DOI":"10.1016\/S0002-9440(10)63059-3","volume":"159","author":"Brown K. E.","year":"2001","journal-title":"Am. J. Pathol."},{"key":"tx6003562b00012\/tx6003562b00012_1","volume-title":"Heme peroxidases","author":"Dunford H. B.","year":"1999"},{"key":"tx6003562b00013\/tx6003562b00013_1","volume-title":"Peroxidases. Chem.-Biol. Interact. 129, 113\u2212139","author":"O'Brien P. J.","year":"2000"},{"key":"tx6003562b00014\/tx6003562b00014_1","volume-title":"Analysis of the peptide subunits of human neutrophil myeloperoxidase. Blood 67, 1504\u22121507","author":"Nauseef W. M.","year":"1986"},{"key":"tx6003562b00015\/tx6003562b00015_1","volume":"256","author":"Andrews P. C.","year":"1981","journal-title":"J. Biol. Chem."},{"key":"tx6003562b00016\/tx6003562b00016_1","volume-title":"Biosynthesis, processing, and sorting of human myeloperoxidase. Arch. Biochem. Biophys. 445, 214\u2212224","author":"Hansson M.","year":"2006"},{"key":"tx6003562b00017\/tx6003562b00017_1","volume-title":"Mechanism of inhibition of myeloperoxidase by anti-inflammatory drugs. Biochem. Pharmacol. 41, 1485\u22121492","author":"Kettle A. J.","year":"1991"},{"key":"tx6003562b00018\/tx6003562b00018_1","volume-title":"Vasculitis and antineutrophil cytoplasmic autoantibodies associated with propylthiouracil therapy. Lancet 342, 651\u2212652","author":"Dolman K. M.","year":"1993"},{"key":"tx6003562b00019\/tx6003562b00019_1","volume-title":"Antibodies to myeloperoxidase in propylthiouracil-induced autoimmune disease in the cat. Toxicology 114, 155\u2212162","author":"Waldhauser L.","year":"1996"},{"key":"tx6003562b00020\/tx6003562b00020_1","volume-title":"Immunological identification of the heart myoglobin radical formed by hydrogen peroxide. Free Radical Biol. Med. 33, 364\u2212349","author":"Detweiler C. D.","year":"2002"},{"key":"tx6003562b00021\/tx6003562b00021_1","volume-title":"Immunochemical detection of hemoglobin-derived radicals formed by reaction with hydrogen peroxide:\u2009 involvement of a protein-tyrosyl radical. Free Radical Biol. Med. 34, 830\u2212839","author":"Ramirez D. C.","year":"2003"},{"key":"tx6003562b00022\/tx6003562b00022_1","volume-title":"Glutathione-induced radical formation on lactoperoxidase does not correlate with the enzyme's peroxidase activity. Free Radical Biol. Med. 42, 985\u2212992","author":"Bonini M. G.","year":"2007"},{"key":"tx6003562b00023\/tx6003562b00023_1","volume-title":"Protein radical formation on thyroid peroxidase during turnover as detected by immuno-spin trapping. Free Radical Biol. Med. 41, 422\u2212430","author":"Ehrenshaft M.","year":"2006"},{"key":"tx6003562b00024\/tx6003562b00024_1","volume-title":"Immunolocalization of hypochlorite-induced, catalase-bound free radical formation in mouse hepatocytes. Free Radical Biol. Med. 42, 530\u2212540","author":"Bonini M. G.","year":"2007"},{"key":"tx6003562b00025\/tx6003562b00025_1","volume-title":"Using anti-5,5-dimethyl-1-pyrroline N-oxide (anti-DMPO) to detect protein radicals in time and space with immuno-spin trapping. Free Radical Biol. Med. 36, 1214\u22121223","author":"Mason R. P.","year":"2004"},{"key":"tx6003562b00026\/tx6003562b00026_1","volume-title":"Oxidation of clozapine and ascorbate by myeloperoxidase. Arch. Biochem. Biophys. 368, 413\u2212420","author":"Hsuanyu Y.","year":"1999"},{"key":"tx6003562b00027\/tx6003562b00027_1","volume":"195","author":"Beers R. F., Jr.","year":"1952","journal-title":"J. Biol. Chem."},{"key":"tx6003562b00028\/tx6003562b00028_1","doi-asserted-by":"crossref","DOI":"10.1021\/j100691a009","volume":"75","author":"Lagercrantz C.","year":"1971","journal-title":"J. Phys. Chem."},{"key":"tx6003562b00029\/tx6003562b00029_1","doi-asserted-by":"crossref","unstructured":"Ramirez, D. C., Gomez Mejiba, S. E., and Mason, R. P. (2005) Mechanism of hydrogen peroxide-induced Cu,Zn-superoxide dismutase-centered radical formation as explored by immuno-spin trapping:\u2009 the role of copper- and carbonate radical anion-mediated oxidations.Free Radical Biol. Med. 38, 201\u2212214.","DOI":"10.1016\/j.freeradbiomed.2004.10.008"},{"key":"tx6003562b00030\/tx6003562b00030_1","volume-title":"Large-scale purification of myeloperoxidase from HL60 promyelocytic cells:\u2009 characterization and comparison to human neutrophil myeloperoxidase. Protein Expression Purif. 18, 269\u2212276","author":"Hope H. R.","year":"2000"},{"key":"tx6003562b00031\/tx6003562b00031_1","volume-title":"Spectral and kinetic studies on the formation of myeloperoxidase compounds I and II:\u2009 roles of hydrogen peroxide and superoxide. Biochemistry 33, 1447\u22121454","author":"Marquez L. A.","year":"1994"},{"key":"tx6003562b00032\/tx6003562b00032_1","doi-asserted-by":"crossref","DOI":"10.1016\/S0040-4039(01)85414-9","volume":"19","author":"Pfab J.","year":"1978","journal-title":"Tetrahedron Lett."},{"key":"tx6003562b00033\/tx6003562b00033_1","doi-asserted-by":"crossref","DOI":"10.1016\/S0040-4020(01)92851-0","volume-title":"Investigation of radical intermediates in organic reactions by use of nitroso compounds as scavengers:\u2009 the nitroxide method. Tetrahedron 26, 2759\u22122773","author":"Torssell K.","year":"1970"},{"key":"tx6003562b00034\/tx6003562b00034_1","volume-title":"Spectroscopic studies of cutaneous photosensitizing agents-I. Spin trapping of photolysis products from sulfanilamide, 4-aminobenzoic acid and related compounds. Photochem. Photobiol. 32, 563\u2212571","author":"Chignell C. F.","year":"1980"},{"key":"tx6003562b00035\/tx6003562b00035_1","volume-title":"ESR study of the interaction of mononuclear and binuclear metal carbonyls with silicon hydrides and the use of these systems to generate \u03b1-chlorine-containing radicals. Russ. Chem. Bull. 30, 980\u2212984","author":"Gasanov R. G.","year":"1981"},{"key":"tx6003562b00036\/tx6003562b00036_1","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1111\/j.1751-1097.1983.tb04428.x","volume":"37","author":"Motten A. G.","year":"1983","journal-title":"Photochem. Photobiol."},{"key":"tx6003562b00037\/tx6003562b00037_1","volume-title":"EPR spin trapping of protein radicals. Free Radical Biol. Med. 36, 1072\u22121086","author":"Davies M. J.","year":"2004"},{"key":"tx6003562b00038\/tx6003562b00038_1","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1126\/science.91.2369.509.a","volume":"91","author":"Rosenthal S. M.","year":"1940","journal-title":"Science"},{"key":"tx6003562b00039\/tx6003562b00039_1","volume":"90","author":"Huie R. E.","year":"1986","journal-title":"J. Phys. Chem."},{"key":"tx6003562b00040\/tx6003562b00040_1","volume":"264","author":"Ator M. A.","year":"1989","journal-title":"J. Biol. Chem."},{"key":"tx6003562b00041\/tx6003562b00041_1","volume":"126","author":"Huang L.","year":"2004","journal-title":"J. Am. Chem. Soc."},{"key":"tx6003562b00042\/tx6003562b00042_1","doi-asserted-by":"crossref","DOI":"10.1042\/bj3210503","volume":"321","author":"Kettle A. J.","year":"1997","journal-title":"Biochem. J."},{"key":"tx6003562b00043\/tx6003562b00043_1","volume-title":"Mechanism-based inactivation of horseradish peroxidase by sodium azide. Formation of meso-azidoprotoporphyrin IX. Biochemistry 27, 5470\u22125476","author":"Ortiz de Montellano P. R.","year":"1988"},{"key":"tx6003562b00044\/tx6003562b00044_1","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/S0300-483X(02)00197-X","volume":"177","author":"Siraki A. G.","year":"2002","journal-title":"Toxicology"},{"key":"tx6003562b00045\/tx6003562b00045_1","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1146\/annurev.nu.16.070196.000341","volume":"16","author":"Halliwell B.","year":"1996","journal-title":"Annu. Rev. Nutr."},{"key":"tx6003562b00046\/tx6003562b00046_1","volume-title":"Dietary polyphenols:\u2009 good, bad, or indifferent for your health? Cardiovasc. Res. 73, 341\u2212347","author":"Halliwell B.","year":"2007"},{"key":"tx6003562b00047\/tx6003562b00047_1","volume-title":"Myeloperoxidase biosynthesis by a human promyelocytic leukemia cell line:\u2009 insight into myeloperoxidase deficiency. Blood 67, 865\u2212872","author":"Nauseef W. M.","year":"1986"},{"key":"tx6003562b00048\/tx6003562b00048_1","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1089\/152308602753625870","volume":"4","author":"Swain S. D.","year":"2002","journal-title":"Antioxid. Redox Signaling"},{"key":"tx6003562b00049\/tx6003562b00049_1","doi-asserted-by":"crossref","DOI":"10.1016\/S0021-9258(18)60977-9","volume":"262","author":"Arnljots K.","year":"1987","journal-title":"J. Biol. Chem."},{"key":"tx6003562b00050\/tx6003562b00050_1","volume-title":"Myeloperoxidase:\u2009 its structure and expression during myeloid differentiation. Blood 65, 484\u2212491","author":"Koeffler H. P.","year":"1985"},{"key":"tx6003562b00051\/tx6003562b00051_1","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.etap.2003.08.003","volume":"15","author":"Coleman M. D.","year":"2003","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"tx6003562b00052\/tx6003562b00052_1","doi-asserted-by":"crossref","unstructured":"van Zyl, J. M., Kriegler, A., and van der Walt, B. J. (1993) Anti-oxidant properties of H2-receptor antagonists. Effects on myeloperoxidase-catalysed reactions and hydroxyl radical generation in a ferrous-hydrogen peroxide system.Biochem. Pharmacol. 45, 2389\u22122397.","DOI":"10.1016\/0006-2952(93)90218-L"},{"key":"tx6003562n00001\/tx6003562n00001_1","volume-title":"aminoglutethimide","author":"Abbreviations AG"}],"container-title":["Chemical Research in Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/tx6003562","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,15]],"date-time":"2023-03-15T16:19:26Z","timestamp":1678897166000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/tx6003562"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,6,30]]},"references-count":53,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2007,7,1]]}},"alternative-id":["10.1021\/tx6003562"],"URL":"https:\/\/doi.org\/10.1021\/tx6003562","relation":{},"ISSN":["0893-228X","1520-5010"],"issn-type":[{"value":"0893-228X","type":"print"},{"value":"1520-5010","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,6,30]]}}}