{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T21:16:42Z","timestamp":1787001402078,"version":"build-2736575974"},"reference-count":62,"publisher":"American Chemical Society (ACS)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chem. Res. Toxicol."],"published-print":{"date-parts":[[2008,2,1]]},"DOI":"10.1021\/tx700176r","type":"journal-article","created":{"date-parts":[[2007,12,29]],"date-time":"2007-12-29T01:00:46Z","timestamp":1198890046000},"page":"330-340","source":"Crossref","is-referenced-by-count":25,"title":["Essential Role of the AH Receptor in the Dysfunction of Heme Metabolism Induced by 2,3,7,8-Tetrachlorodibenzo-\n                    <i>p<\/i>\n                    -dioxin"],"prefix":"10.1021","volume":"21","author":[{"given":"Reginald","family":"Davies","sequence":"first","affiliation":[{"name":"MRC Toxicology Unit, Hodgkin Building, University of Leicester, P.O. Box 138, Lancaster Road, Leicester LE1 9HN, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce","family":"Clothier","sequence":"additional","affiliation":[{"name":"MRC Toxicology Unit, Hodgkin Building, University of Leicester, P.O. Box 138, Lancaster Road, Leicester LE1 9HN, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan W.","family":"Robinson","sequence":"additional","affiliation":[{"name":"MRC Toxicology Unit, Hodgkin Building, University of Leicester, P.O. Box 138, Lancaster Road, Leicester LE1 9HN, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard E.","family":"Edwards","sequence":"additional","affiliation":[{"name":"MRC Toxicology Unit, Hodgkin Building, University of Leicester, P.O. Box 138, Lancaster Road, Leicester LE1 9HN, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Greaves","sequence":"additional","affiliation":[{"name":"MRC Toxicology Unit, Hodgkin Building, University of Leicester, P.O. Box 138, Lancaster Road, Leicester LE1 9HN, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JinLi","family":"Luo","sequence":"additional","affiliation":[{"name":"MRC Toxicology Unit, Hodgkin Building, University of Leicester, P.O. Box 138, Lancaster Road, Leicester LE1 9HN, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy W.","family":"Gant","sequence":"additional","affiliation":[{"name":"MRC Toxicology Unit, Hodgkin Building, University of Leicester, P.O. Box 138, Lancaster Road, Leicester LE1 9HN, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatyana","family":"Chernova","sequence":"additional","affiliation":[{"name":"MRC Toxicology Unit, Hodgkin Building, University of Leicester, P.O. Box 138, Lancaster Road, Leicester LE1 9HN, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew G.","family":"Smith","sequence":"additional","affiliation":[{"name":"MRC Toxicology Unit, Hodgkin Building, University of Leicester, P.O. Box 138, Lancaster Road, Leicester LE1 9HN, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2007,12,29]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1080\/026520300283351","volume":"17","author":"Birnbaum L. S.","year":"2000","journal-title":"Food Addit. Contam."},{"key":"ref2\/cit2","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1001\/archderm.1964.01590300021006","volume":"89","author":"Bleiberg J.","year":"1964","journal-title":"Arch. Dermatol. (Chic.)"},{"key":"ref3\/cit3","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1080\/00039896.1981.10667598","volume":"36","author":"Pazderova-Vejlupkova J.","year":"1981","journal-title":"Arch. Environ. Health"},{"key":"ref4\/cit4","first-page":"919","volume":"6","author":"Goldstein J. A.","year":"1973","journal-title":"Res. Commun. Chem. Pathol. Pharmacol."},{"key":"ref5\/cit5","first-page":"631","volume":"17","author":"Jones K. G.","year":"1977","journal-title":"Res. Commun. Chem. Pathol. Pharmacol."},{"key":"ref6\/cit6","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/0041-008X(81)90275-1","volume":"57","author":"Cantoni L.","year":"1981","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref7\/cit7","doi-asserted-by":"crossref","first-page":"2825","DOI":"10.1016\/0006-2952(81)90421-4","volume":"30","author":"Smith A. G.","year":"1981","journal-title":"Biochem. Pharmacol."},{"key":"ref8\/cit8","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1016\/0006-2952(82)90388-4","volume":"31","author":"Goldstein J. A.","year":"1982","journal-title":"Biochem. Pharmacol."},{"key":"ref9\/cit9","first-page":"67","volume-title":"The Porphyrin Handbook, Volume 14\/Medical Aspects of Porphyrins","author":"Elder G. H.","year":"2003"},{"key":"ref10\/cit10","doi-asserted-by":"crossref","first-page":"865","DOI":"10.3109\/00498259009046902","volume":"20","author":"Smith A. G.","year":"1990","journal-title":"Xenobiotica"},{"key":"ref11\/cit11","doi-asserted-by":"crossref","first-page":"5079","DOI":"10.1073\/pnas.0700547104","volume":"104","author":"Phillips J. D.","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"ref12\/cit12","doi-asserted-by":"crossref","first-page":"1660","DOI":"10.1021\/tx060212v","volume":"19","author":"Lim C. K.","year":"2006","journal-title":"Chem. Res. Toxicol."},{"key":"ref13\/cit13","first-page":"389","volume":"11","author":"Poland A.","year":"1975","journal-title":"Mol. Pharmacol."},{"key":"ref14\/cit14","first-page":"86","volume":"17","author":"Poland A.","year":"1980","journal-title":"Mol. Pharmacol."},{"key":"ref15\/cit15","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1006\/taap.1999.8720","volume":"159","author":"Diliberto J. J.","year":"1999","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref16\/cit16","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/0041-008X(80)90379-8","volume":"53","author":"Jones K. G.","year":"1980","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref17\/cit17","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1124\/mol.53.1.52","volume":"53","author":"Smith A. G.","year":"1998","journal-title":"Mol. Pharmacol."},{"key":"ref18\/cit18","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1124\/mol.61.3.674","volume":"61","author":"Robinson S. W.","year":"2002","journal-title":"Mol. Pharmacol."},{"key":"ref19\/cit19","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1042\/bj2540245","volume":"254","author":"Hahn M. E.","year":"1988","journal-title":"Biochem. J."},{"key":"ref20\/cit20","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1042\/bj3300149","volume":"330","author":"Sinclair P. R.","year":"1998","journal-title":"Biochem. J."},{"key":"ref21\/cit21","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1006\/taap.2001.9167","volume":"173","author":"Smith A. G.","year":"2001","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref22\/cit22","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1053\/jhep.2002.32487","volume":"35","author":"Gorman N.","year":"2002","journal-title":"Hepatology"},{"key":"ref23\/cit23","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/0041-008X(84)90265-5","volume":"74","author":"Greig J. B.","year":"1984","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref24\/cit24","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1007\/BF00295754","volume":"60","author":"Greig J. B.","year":"1987","journal-title":"Arch. Toxicol."},{"key":"ref25\/cit25","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1126\/science.432648","volume":"204","author":"Sweeney G. D.","year":"1979","journal-title":"Science"},{"key":"ref26\/cit26","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1007\/BF01701169","volume":"45","author":"Wahba Z. Z.","year":"1990","journal-title":"Bull. Environ. Contam. Toxicol."},{"key":"ref27\/cit27","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1042\/bj2910029","volume":"291","author":"Smith A. G.","year":"1993","journal-title":"Biochem. J."},{"key":"ref28\/cit28","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/0891-5849(90)90052-K","volume":"9","author":"Stohs S. J.","year":"1990","journal-title":"Free Radical Biol. Med."},{"key":"ref29\/cit29","doi-asserted-by":"crossref","first-page":"2322","DOI":"10.1073\/pnas.93.6.2322","volume":"93","author":"Park J.-Y. K.","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"ref30\/cit30","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1006\/bbrc.1998.9753","volume":"253","author":"Shertzer H. G.","year":"1998","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref31\/cit31","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1093\/toxsci\/54.2.390","volume":"54","author":"Slezak B. P.","year":"2000","journal-title":"Toxicol. Sci."},{"key":"ref32\/cit32","doi-asserted-by":"crossref","first-page":"2019","DOI":"10.1016\/0006-2952(91)90144-T","volume":"41","author":"Deam S.","year":"1991","journal-title":"Biochem. Pharmacol."},{"key":"ref33\/cit33","doi-asserted-by":"crossref","first-page":"6731","DOI":"10.1073\/pnas.93.13.6731","volume":"93","author":"Schmidt J. V.","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"ref34\/cit34","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1016\/S0006-2952(98)00241-X","volume":"56","author":"Hamm J. T.","year":"1998","journal-title":"Biochem. Pharmacol."},{"key":"ref35\/cit35","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1002\/(SICI)1099-0801(199609)10:5<213::AID-BMC592>3.0.CO;2-D","volume":"10","author":"Guo R.","year":"1996","journal-title":"Biomed. Chromatogr."},{"key":"ref36\/cit36","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1289\/ehp.111-1241506","volume":"111","author":"Gant T. W.","year":"2003","journal-title":"Environ. Health Perspect."},{"key":"ref37\/cit37","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1289\/ehp.111-1241507","volume":"111","author":"Smith A. G.","year":"2003","journal-title":"Environ. Health Perspect."},{"key":"ref38\/cit38","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1016\/S0002-9440(10)62325-5","volume":"166","author":"Davies R.","year":"2005","journal-title":"Am. J. Pathol."},{"key":"ref39\/cit39","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1002\/hep.21233","volume":"44","author":"Grant G. R.","year":"2006","journal-title":"Hepatology"},{"key":"ref40\/cit40","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1006\/taap.1996.0103","volume":"138","author":"van Birgelen A. P.","year":"1996","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref41\/cit41","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/j.bcp.2006.04.017","volume":"72","author":"Kohle C.","year":"2006","journal-title":"Biochem. Pharmacol."},{"key":"ref42\/cit42","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1093\/toxsci\/kfi162","volume":"85","author":"Boverhof D. R.","year":"2005","journal-title":"Toxicol. Sci."},{"key":"ref43\/cit43","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1248\/bpb.28.1087","volume":"28","author":"Ishii Y.","year":"2005","journal-title":"Biol. Pharm. Bull."},{"key":"ref44\/cit44","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/S0006-2952(99)00088-X","volume":"58","author":"Gorman N.","year":"1999","journal-title":"Biochem. Pharmacol."},{"key":"ref45\/cit45","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1016\/S0006-2952(96)00475-3","volume":"52","author":"Constantin D.","year":"1996","journal-title":"Biochem. Pharmacol."},{"key":"ref46\/cit46","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1038\/nrc2015","volume":"6","author":"Nebert D. W.","year":"2006","journal-title":"Nat. Rev. Cancer"},{"key":"ref47\/cit47","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1016\/j.bbrc.2006.02.121","volume":"342","author":"Genter M. B.","year":"2006","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref48\/cit48","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1093\/toxsci\/kfl100","volume":"94","author":"Boverhof D. R.","year":"2006","journal-title":"Toxicol. Sci."},{"key":"ref49\/cit49","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1124\/mol.105.018705","volume":"69","author":"Tijet N.","year":"2006","journal-title":"Mol. Pharmacol."},{"key":"ref50\/cit50","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1038\/182313a0","volume":"182","author":"Heikel T.","year":"1958","journal-title":"Nature (London)"},{"key":"ref51\/cit51","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1006\/taap.2001.9314","volume":"178","author":"Senft A. P.","year":"2002","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref52\/cit52","doi-asserted-by":"crossref","first-page":"25305","DOI":"10.1074\/jbc.M500095200","volume":"280","author":"Shen D.","year":"2005","journal-title":"J. Biol. Chem."},{"key":"ref53\/cit53","doi-asserted-by":"crossref","first-page":"2191","DOI":"10.1271\/bbb.60135","volume":"70","author":"Ito Y.","year":"2006","journal-title":"Biosci., Biotechnol., Biochem."},{"key":"ref54\/cit54","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1016\/S0891-5849(02)01014-6","volume":"33","author":"Senft A. P.","year":"2002","journal-title":"Free Radical Biol. Med."},{"key":"ref55\/cit55","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.taap.2006.09.014","volume":"217","author":"Shertzer H. G.","year":"2006","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref56\/cit56","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1146\/annurev.physiol.69.031905.164337","volume":"69","author":"Andrews N. C.","year":"2007","journal-title":"Annu. Rev. Physiol."},{"key":"ref57\/cit57","first-page":"736","volume":"9","author":"Poland A.","year":"1973","journal-title":"Mol. Pharmacol."},{"key":"ref58\/cit58","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1016\/S0024-3205(01)01212-7","volume":"69","author":"Nishimura N.","year":"2001","journal-title":"Life Sci."},{"key":"ref59\/cit59","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1006\/taap.1996.0210","volume":"140","author":"Fernandez-Salguero P. M.","year":"1996","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref60\/cit60","doi-asserted-by":"crossref","first-page":"10442","DOI":"10.1073\/pnas.190256997","volume":"97","author":"Lahvis G. P.","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"ref61\/cit61","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1097\/01.fpc.0000204994.99429.46","volume":"16","author":"Jiang Z.","year":"2006","journal-title":"Pharmacogenet. Genomics"},{"key":"ref62\/cit62","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1067\/mlc.2000.111024","volume":"136","author":"Bulaj Z. J.","year":"2000","journal-title":"J. Lab. Clin. Med."}],"container-title":["Chemical Research in Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/tx700176r","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,16]],"date-time":"2023-03-16T02:11:00Z","timestamp":1678932660000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/tx700176r"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,12,29]]},"references-count":62,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2008,2,1]]}},"alternative-id":["10.1021\/tx700176r"],"URL":"https:\/\/doi.org\/10.1021\/tx700176r","relation":{},"ISSN":["0893-228X","1520-5010"],"issn-type":[{"value":"0893-228X","type":"print"},{"value":"1520-5010","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,12,29]]}}}