{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T10:24:39Z","timestamp":1791109479927,"version":"4.1.0"},"reference-count":25,"publisher":"American Chemical Society (ACS)","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chem. Res. Toxicol."],"published-print":{"date-parts":[[2007,10,15]]},"DOI":"10.1021\/tx700231a","type":"journal-article","created":{"date-parts":[[2007,9,14]],"date-time":"2007-09-14T05:00:28Z","timestamp":1189746028000},"page":"1528-1535","source":"Crossref","is-referenced-by-count":34,"title":["Cyclopentenone Prostaglandin, 15-Deoxy-\u0394<sup>12,14<\/sup>-PGJ<sub>2<\/sub>, Is Metabolized by HepG2 Cells via Conjugation with Glutathione"],"prefix":"10.1021","volume":"20","author":[{"given":"Enrico M.","family":"Brunoldi","sequence":"first","affiliation":[{"name":"Departments of Medicine and Pharmacology and Radiation Oncology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, and Department of Organic Chemistry, University of Pavia, Viale Taramelli 10, 27100 Pavia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Zanoni","sequence":"additional","affiliation":[{"name":"Departments of Medicine and Pharmacology and Radiation Oncology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, and Department of Organic Chemistry, University of Pavia, Viale Taramelli 10, 27100 Pavia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Vidari","sequence":"additional","affiliation":[{"name":"Departments of Medicine and Pharmacology and Radiation Oncology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, and Department of Organic Chemistry, University of Pavia, Viale Taramelli 10, 27100 Pavia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soumya","family":"Sasi","sequence":"additional","affiliation":[{"name":"Departments of Medicine and Pharmacology and Radiation Oncology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, and Department of Organic Chemistry, University of Pavia, Viale Taramelli 10, 27100 Pavia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael L.","family":"Freeman","sequence":"additional","affiliation":[{"name":"Departments of Medicine and Pharmacology and Radiation Oncology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, and Department of Organic Chemistry, University of Pavia, Viale Taramelli 10, 27100 Pavia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ginger L.","family":"Milne","sequence":"additional","affiliation":[{"name":"Departments of Medicine and Pharmacology and Radiation Oncology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, and Department of Organic Chemistry, University of Pavia, Viale Taramelli 10, 27100 Pavia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason D.","family":"Morrow","sequence":"additional","affiliation":[{"name":"Departments of Medicine and Pharmacology and Radiation Oncology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, and Department of Organic Chemistry, University of Pavia, Viale Taramelli 10, 27100 Pavia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2007,9,14]]},"reference":[{"key":"ref1\/ref1_1","doi-asserted-by":"crossref","first-page":"11713","DOI":"10.1016\/S0021-9258(17)44287-6","volume":"258","author":"Fitzpatrick F. A.","year":"1983","journal-title":"J. Biol. Chem."},{"key":"ref2\/ref2_1","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1007\/BF00744216","volume":"19","author":"Akimaru K.","year":"1996","journal-title":"Cytotechnology"},{"key":"ref3\/ref3_1","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/0090-6980(96)00047-0","volume":"51","author":"Kim H. S.","year":"1996","journal-title":"Prostaglandins"},{"key":"ref4\/ref4_1","doi-asserted-by":"crossref","first-page":"12076","DOI":"10.1074\/jbc.M009630200","volume":"276","author":"Kondo M.","year":"2001","journal-title":"J. Biol. Chem."},{"key":"ref5\/ref5_1","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1016\/0006-2952(92)90612-M","volume":"43","author":"Parker J.","year":"1992","journal-title":"Biochem. Pharmacol."},{"key":"ref6\/ref6_1","doi-asserted-by":"crossref","first-page":"5429","DOI":"10.1021\/bi027347u","volume":"42","author":"Paumi C. M.","year":"2003","journal-title":"Biochemistry"},{"key":"ref7\/ref7_1","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1002\/med.1006","volume":"21","author":"Straus D. S.","year":"2001","journal-title":"Med. Res. Rev."},{"key":"ref8\/ref8_1","doi-asserted-by":"crossref","first-page":"10459","DOI":"10.1074\/jbc.M110314200","volume":"277","author":"Shibata T.","year":"2002","journal-title":"J. Biol. Chem."},{"key":"ref9\/ref9_1","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1073\/pnas.81.5.1317","volume":"81","author":"Kikawa Y.","year":"1984","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"ref10\/ref10_1","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1172\/JCI200318012","volume":"112","author":"Bell-Parikh L. C.","year":"2003","journal-title":"J. Clin. Invest."},{"key":"ref11\/ref11_1","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1021\/tx034213o","volume":"17","author":"Milne G. L.","year":"2004","journal-title":"Chem. Res. Toxicol."},{"key":"ref12\/ref12_1","first-page":"306","volume":"242","author":"Narumiya S.","year":"1987","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref13\/ref13_1","doi-asserted-by":"crossref","first-page":"2226","DOI":"10.1021\/ja00475a040","volume":"100","author":"Luche J.","year":"1978","journal-title":"J. Am. Chem. Soc."},{"key":"ref14\/ref14_1","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1080\/009841098159097","volume":"53","author":"Rebbeor J. F.","year":"1998","journal-title":"J. Toxicol. Environ. Health, Part A"},{"key":"ref15\/ref15_1","doi-asserted-by":"crossref","first-page":"10863","DOI":"10.1074\/jbc.274.16.10863","volume":"274","author":"Chen Y.","year":"1999","journal-title":"J. Biol. Chem."},{"key":"ref16\/ref16_1","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/0092-8674(95)90193-0","volume":"83","author":"Forman B. M.","year":"1995","journal-title":"Cell"},{"key":"ref17\/ref17_1","doi-asserted-by":"crossref","first-page":"14440","DOI":"10.1074\/jbc.M600260200","volume":"281","author":"Chen Z. H.","year":"2006","journal-title":"J. Biol. Chem."},{"key":"ref18\/ref18_1","doi-asserted-by":"crossref","first-page":"4844","DOI":"10.1073\/pnas.97.9.4844","volume":"97","author":"Straus D. S.","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"ref19\/ref19_1","doi-asserted-by":"crossref","first-page":"2376","DOI":"10.1021\/ja9628359","volume":"119","author":"Suzuki M. M.","year":"1997","journal-title":"J. Am. Chem. Soc."},{"key":"ref20\/ref20_1","first-page":"1879","volume":"50","author":"Atsmon J.","year":"1990","journal-title":"Cancer Res."},{"key":"ref21\/ref21_1","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S1388-1981(02)00267-6","volume":"1584","author":"Cox B.","year":"2002","journal-title":"Biochim. Biophys. Acta"},{"key":"ref22\/ref22_1","doi-asserted-by":"crossref","first-page":"3221","DOI":"10.1016\/j.bmc.2004.03.061","volume":"12","author":"Bickley J. F.","year":"2004","journal-title":"Bioorg. Med. Chem."},{"key":"ref23\/ref23_1","first-page":"1879","volume":"50","author":"Atsmon J.","year":"1990","journal-title":"Cancer Research"},{"key":"ref24\/ref24_1","first-page":"233","volume":"1","author":"Roberts L. J.","year":"1987","journal-title":"Handbook of Eicosanoids: Prostaglandins and Related Lipids"},{"key":"ref25\/ref25_1","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1128\/MCB.24.1.36-45.2004","volume":"24","author":"Itoh K.","year":"2004","journal-title":"Mol. Cell. Biol."}],"container-title":["Chemical Research in Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/tx700231a","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,15]],"date-time":"2023-03-15T12:41:16Z","timestamp":1678884076000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/tx700231a"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,9,14]]},"references-count":25,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2007,10,15]]}},"alternative-id":["10.1021\/tx700231a"],"URL":"https:\/\/doi.org\/10.1021\/tx700231a","relation":{},"ISSN":["0893-228X","1520-5010"],"issn-type":[{"value":"0893-228X","type":"print"},{"value":"1520-5010","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,9,14]]}}}