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Rev."},{"key":"ref12\/cit12","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/S0022-3565(24)36867-3","volume":"282","author":"Gill H. J.","year":"1997","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref13\/cit13","doi-asserted-by":"crossref","first-page":"2081","DOI":"10.1016\/S0002-9440(10)63059-3","volume":"159","author":"Brown K. E.","year":"2001","journal-title":"Am. J. Pathol."},{"key":"ref14\/cit14","volume-title":"Heme peroxidases","author":"Dunford H. B.","year":"1999"},{"key":"ref15\/cit15","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/S0009-2797(00)00201-5","volume":"129","author":"O\u2019Brien P. J.","year":"2000","journal-title":"Chem. Biol. Interact."},{"key":"ref16\/cit16","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1182\/blood.V67.4.865.865","volume":"67","author":"Nauseef W. M.","year":"1986","journal-title":"Blood"},{"key":"ref17\/cit17","doi-asserted-by":"crossref","first-page":"4211","DOI":"10.1016\/S0021-9258(19)69420-2","volume":"256","author":"Andrews P. C.","year":"1981","journal-title":"J. Biol. Chem."},{"key":"ref18\/cit18","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.abb.2005.08.009","volume":"445","author":"Hansson M.","year":"2006","journal-title":"Arch. Biochem. Biophys."},{"key":"ref19\/cit19","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1016\/0006-2952(91)90565-M","volume":"41","author":"Kettle A. J.","year":"1991","journal-title":"Biochem. Pharmacol."},{"key":"ref20\/cit20","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0009-2797(02)00052-2","volume":"142","author":"Galati G.","year":"2002","journal-title":"Chem. Biol. Interact."},{"key":"ref21\/cit21","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1021\/tx6003562","volume":"20","author":"Siraki A. 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