{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T00:40:24Z","timestamp":1787964024760,"version":"build-2784847793"},"reference-count":48,"publisher":"American Chemical Society (ACS)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chem. Res. Toxicol."],"published-print":{"date-parts":[[2008,6,1]]},"DOI":"10.1021\/tx800008e","type":"journal-article","created":{"date-parts":[[2008,5,23]],"date-time":"2008-05-23T02:00:55Z","timestamp":1211508055000},"page":"1186-1196","source":"Crossref","is-referenced-by-count":21,"title":["Transcriptomic Analysis of Nephrotoxicity Induced by Cephaloridine, a Representative Cephalosporin Antibiotic"],"prefix":"10.1021","volume":"21","author":[{"given":"Masatomo","family":"Rokushima","sequence":"first","affiliation":[{"name":"Discovery Research Laboratories, Shionogi & Co., Ltd., 12-4, Sagisu 5-chome, Fukushima-ku, Osaka 553-0002, Japan, and Developmental Research Laboratories, Shionogi & Co., Ltd., 1-1, Futaba-cho 3-chome, Toyonaka, Osaka 561-0825, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kae","family":"Fujisawa","sequence":"additional","affiliation":[{"name":"Discovery Research Laboratories, Shionogi & Co., Ltd., 12-4, Sagisu 5-chome, Fukushima-ku, Osaka 553-0002, Japan, and Developmental Research Laboratories, Shionogi & Co., Ltd., 1-1, Futaba-cho 3-chome, Toyonaka, Osaka 561-0825, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoko","family":"Furukawa","sequence":"additional","affiliation":[{"name":"Discovery Research Laboratories, Shionogi & Co., Ltd., 12-4, Sagisu 5-chome, Fukushima-ku, Osaka 553-0002, Japan, and Developmental Research Laboratories, Shionogi & Co., Ltd., 1-1, Futaba-cho 3-chome, Toyonaka, Osaka 561-0825, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumio","family":"Itoh","sequence":"additional","affiliation":[{"name":"Discovery Research Laboratories, Shionogi & Co., Ltd., 12-4, Sagisu 5-chome, Fukushima-ku, Osaka 553-0002, Japan, and Developmental Research Laboratories, Shionogi & Co., Ltd., 1-1, Futaba-cho 3-chome, Toyonaka, Osaka 561-0825, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toru","family":"Yanagimoto","sequence":"additional","affiliation":[{"name":"Discovery Research Laboratories, Shionogi & Co., Ltd., 12-4, Sagisu 5-chome, Fukushima-ku, Osaka 553-0002, Japan, and Developmental Research Laboratories, Shionogi & Co., Ltd., 1-1, Futaba-cho 3-chome, Toyonaka, Osaka 561-0825, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryou","family":"Fukushima","sequence":"additional","affiliation":[{"name":"Discovery Research Laboratories, Shionogi & Co., Ltd., 12-4, Sagisu 5-chome, Fukushima-ku, Osaka 553-0002, Japan, and Developmental Research Laboratories, Shionogi & Co., Ltd., 1-1, Futaba-cho 3-chome, Toyonaka, Osaka 561-0825, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akiko","family":"Araki","sequence":"additional","affiliation":[{"name":"Discovery Research Laboratories, Shionogi & Co., Ltd., 12-4, Sagisu 5-chome, Fukushima-ku, Osaka 553-0002, Japan, and Developmental Research Laboratories, Shionogi & Co., Ltd., 1-1, Futaba-cho 3-chome, Toyonaka, Osaka 561-0825, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manabu","family":"Okada","sequence":"additional","affiliation":[{"name":"Discovery Research Laboratories, Shionogi & Co., Ltd., 12-4, Sagisu 5-chome, Fukushima-ku, Osaka 553-0002, Japan, and Developmental Research Laboratories, Shionogi & Co., Ltd., 1-1, Futaba-cho 3-chome, Toyonaka, Osaka 561-0825, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikinori","family":"Torii","sequence":"additional","affiliation":[{"name":"Discovery Research Laboratories, Shionogi & Co., Ltd., 12-4, Sagisu 5-chome, Fukushima-ku, Osaka 553-0002, Japan, and Developmental Research Laboratories, Shionogi & Co., Ltd., 1-1, Futaba-cho 3-chome, Toyonaka, Osaka 561-0825, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ikuo","family":"Kato","sequence":"additional","affiliation":[{"name":"Discovery Research Laboratories, Shionogi & Co., Ltd., 12-4, Sagisu 5-chome, Fukushima-ku, Osaka 553-0002, Japan, and Developmental Research Laboratories, Shionogi & Co., Ltd., 1-1, Futaba-cho 3-chome, Toyonaka, Osaka 561-0825, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Ishizaki","sequence":"additional","affiliation":[{"name":"Discovery Research Laboratories, Shionogi & Co., Ltd., 12-4, Sagisu 5-chome, Fukushima-ku, Osaka 553-0002, Japan, and Developmental Research Laboratories, Shionogi & Co., Ltd., 1-1, Futaba-cho 3-chome, Toyonaka, Osaka 561-0825, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuo","family":"Omi","sequence":"additional","affiliation":[{"name":"Discovery Research Laboratories, Shionogi & Co., Ltd., 12-4, Sagisu 5-chome, Fukushima-ku, Osaka 553-0002, Japan, and Developmental Research Laboratories, Shionogi & Co., Ltd., 1-1, Futaba-cho 3-chome, Toyonaka, Osaka 561-0825, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2008,5,23]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1128\/am.13.2.248-253.1965","volume":"13","author":"Wick W. E.","year":"1965","journal-title":"Appl. Microbiol."},{"key":"ref2\/cit2","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/0041-008X(66)90050-0","volume":"8","author":"Atkinson R. M.","year":"1966","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref3\/cit3","first-page":"221","volume":"20","author":"Tune B. M.","year":"1994","journal-title":"Miner. Electrolyte Metab."},{"key":"ref4\/cit4","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1093\/jac\/1.suppl_3.119","volume":"1","author":"Foord R. D.","year":"1975","journal-title":"J. Antimicrob. Chemother."},{"key":"ref5\/cit5","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/0005-2760(85)90014-1","volume":"834","author":"Cojocel C.","year":"1985","journal-title":"Biochim. Biophys. Acta"},{"key":"ref6\/cit6","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/0041-008X(82)90052-7","volume":"63","author":"Kuo C. H.","year":"1982","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref7\/cit7","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/S0006-2952(02)01216-9","volume":"64","author":"Kohda Y.","year":"2002","journal-title":"Biochem. Pharmacol."},{"key":"ref8\/cit8","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1254\/jphs.FP0040926","volume":"98","author":"Kohda Y.","year":"2005","journal-title":"J. Pharmacol. Sci."},{"key":"ref9\/cit9","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/S0378-4274(03)00174-7","volume":"143","author":"Kohda Y.","year":"2003","journal-title":"Toxicol. Lett."},{"key":"ref10\/cit10","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1254\/jjp.85.54","volume":"85","author":"Kohda Y.","year":"2001","journal-title":"Jpn. J. Pharmacol."},{"key":"ref11\/cit11","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1021\/tx0496690","volume":"18","author":"Hayes K. R.","year":"2005","journal-title":"Chem. Res. Toxicol."},{"key":"ref12\/cit12","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1021\/tx600260a","volume":"20","author":"Guengerich F. P.","year":"2007","journal-title":"Chem. Res. Toxicol."},{"key":"ref13\/cit13","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1289\/txg.7036","volume":"112","author":"Steiner G.","year":"2004","journal-title":"Environ. Health Perspect."},{"key":"ref14\/cit14","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1289\/ehp.6683","volume":"112","author":"Amin R. P.","year":"2004","journal-title":"Environ. Health Perspect."},{"key":"ref15\/cit15","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1093\/toxsci\/kfh016","volume":"77","author":"Ellinger-Ziegelbauer H.","year":"2004","journal-title":"Toxicol. Sci."},{"key":"ref16\/cit16","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1093\/toxsci\/kfm216","volume":"100","author":"Rokushima M.","year":"2007","journal-title":"Toxicol. Sci."},{"key":"ref17\/cit17","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1080\/01926230590927230","volume":"33","author":"Thukral S. K.","year":"2005","journal-title":"Toxicol. Pathol."},{"key":"ref18\/cit18","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1093\/toxsci\/kfj088","volume":"90","author":"Kharasch E. D.","year":"2006","journal-title":"Toxicol. Sci."},{"key":"ref19\/cit19","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.taap.2004.02.001","volume":"200","author":"Davis J. W.","year":"2004","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref20\/cit20","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1159\/000102086","volume":"156","author":"Bonventre J. V.","year":"2007","journal-title":"Contrib. Nephrol."},{"key":"ref21\/cit21","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1007\/BF01973382","volume":"66","author":"Anthony M. L.","year":"1992","journal-title":"Arch. Toxicol."},{"key":"ref22\/cit22","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1186\/1471-2164-5-87","volume":"5","author":"Wei C.","year":"2004","journal-title":"BMC Genomics"},{"key":"ref23\/cit23","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","volume":"57","author":"Benjamini Y.","year":"1995","journal-title":"J. R. Stat. Soc. Ser. B"},{"key":"ref24\/cit24","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1186\/1471-2105-7-171","volume":"7","author":"Yuryev A.","year":"2006","journal-title":"BMC Bioinformatics"},{"key":"ref25\/cit25","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1289\/ehp.6676","volume":"112","author":"Thompson K. L.","year":"2004","journal-title":"Environ. Health Perspect."},{"key":"ref26\/cit26","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1093\/toxsci\/63.2.196","volume":"63","author":"Huang Q.","year":"2001","journal-title":"Toxicol. Sci."},{"key":"ref27\/cit27","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/S0014-2999(02)01749-1","volume":"450","author":"Cuzzocrea S.","year":"2002","journal-title":"Eur. J. Pharmacol."},{"key":"ref28\/cit28","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1002\/jat.941","volume":"24","author":"Ozen S.","year":"2004","journal-title":"J. Appl. Toxicol."},{"key":"ref29\/cit29","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1002\/cbf.1264","volume":"24","author":"Parlakpinar H.","year":"2006","journal-title":"Cell Biochem. Funct."},{"key":"ref30\/cit30","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1042\/BJ20051518","volume":"395","author":"Vollrath V.","year":"2006","journal-title":"Biochem. J."},{"key":"ref31\/cit31","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1042\/bj20031948","volume":"380","author":"Ikeda H.","year":"2004","journal-title":"Biochem. J."},{"key":"ref32\/cit32","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1042\/bj20020320","volume":"365","author":"Chanas S. A.","year":"2002","journal-title":"Biochem. J."},{"key":"ref33\/cit33","doi-asserted-by":"crossref","first-page":"16891","DOI":"10.1074\/jbc.M500166200","volume":"280","author":"Dhakshinamoorthy S.","year":"2005","journal-title":"J. Biol. Chem."},{"key":"ref34\/cit34","doi-asserted-by":"crossref","first-page":"4914","DOI":"10.1128\/MCB.25.12.4914-4923.2005","volume":"25","author":"Banning A.","year":"2005","journal-title":"Mol. Cell. Biol."},{"key":"ref35\/cit35","doi-asserted-by":"crossref","first-page":"8135","DOI":"10.1074\/jbc.M211898200","volume":"278","author":"Kwak M. K.","year":"2003","journal-title":"J. Biol. Chem."},{"key":"ref36\/cit36","first-page":"5196","volume":"62","author":"Thimmulappa R. K.","year":"2002","journal-title":"Cancer Res."},{"key":"ref37\/cit37","doi-asserted-by":"crossref","first-page":"1824","DOI":"10.1101\/gad.1223504","volume":"18","author":"Li B.","year":"2004","journal-title":"Genes Dev."},{"key":"ref38\/cit38","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.tibs.2004.06.006","volume":"29","author":"Bracken A. P.","year":"2004","journal-title":"Trends Biochem. Sci."},{"key":"ref39\/cit39","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1159\/000186253","volume":"57","author":"Nonclercq D.","year":"1991","journal-title":"Nephron"},{"key":"ref40\/cit40","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1146\/annurev.pharmtox.39.1.67","volume":"39","author":"Dalton T. P.","year":"1999","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"ref41\/cit41","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-2172-8-1","volume":"8","author":"Sharif O.","year":"2007","journal-title":"BMC Immunol."},{"key":"ref42\/cit42","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.tox.2006.10.025","volume":"230","author":"Francescato H. D.","year":"2007","journal-title":"Toxicology"},{"key":"ref43\/cit43","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.1016\/S0022-5347(05)67772-5","volume":"163","author":"Donnahoo K. K.","year":"2000","journal-title":"J. Urol."},{"key":"ref44\/cit44","doi-asserted-by":"crossref","first-page":"4135","DOI":"10.1074\/jbc.273.7.4135","volume":"273","author":"Ichimura T.","year":"1998","journal-title":"J. Biol. Chem."},{"key":"ref45\/cit45","doi-asserted-by":"crossref","first-page":"F552","DOI":"10.1152\/ajprenal.00285.2002","volume":"286","author":"Ichimura T.","year":"2004","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"ref46\/cit46","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1093\/toxsci\/kfm260","volume":"101","author":"Zhou Y.","year":"2008","journal-title":"Toxicol. Sci."},{"key":"ref47\/cit47","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1203\/01.PDR.0000180557.68222.5A","volume":"58","author":"Shimizu M.","year":"2005","journal-title":"Pediatr. Res."},{"key":"ref48\/cit48","doi-asserted-by":"crossref","first-page":"F203","DOI":"10.1152\/ajprenal.2000.279.2.F203","volume":"279","author":"Beck F. X.","year":"2000","journal-title":"Am. J. Physiol. Renal Physiol."}],"container-title":["Chemical Research in Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/tx800008e","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,30]],"date-time":"2025-01-30T06:24:55Z","timestamp":1738218295000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/tx800008e"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,5,23]]},"references-count":48,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2008,6,1]]}},"alternative-id":["10.1021\/tx800008e"],"URL":"https:\/\/doi.org\/10.1021\/tx800008e","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1116515.572547","asserted-by":"object"}]},"ISSN":["0893-228X","1520-5010"],"issn-type":[{"value":"0893-228X","type":"print"},{"value":"1520-5010","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,5,23]]}}}