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Sci."},{"key":"ref13\/cit13","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1093\/toxsci\/kfj047","volume":"89","author":"Valentine H. L.","year":"2006","journal-title":"Toxicol. Sci."},{"key":"ref14\/cit14","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.taap.2008.01.005","volume":"229","author":"Viquez O. M.","year":"2008","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref15\/cit15","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1039\/p19790000692","author":"Takeshima T.","year":"1979","journal-title":"J. Chem. Soc., Perkin 1"},{"key":"ref16\/cit16","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1021\/tx00028a017","volume":"5","author":"Beaty J. A.","year":"1992","journal-title":"Chem. Res. Toxicol."},{"key":"ref17\/cit17","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1021\/tx00024a015","volume":"4","author":"Jones M. M.","year":"1991","journal-title":"Chem. Res. 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