{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T22:34:41Z","timestamp":1774305281913,"version":"3.50.1"},"reference-count":22,"publisher":"American Chemical Society (ACS)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chem. Res. Toxicol."],"published-print":{"date-parts":[[2009,2,16]]},"DOI":"10.1021\/tx8004828","type":"journal-article","created":{"date-parts":[[2009,1,26]],"date-time":"2009-01-26T18:07:01Z","timestamp":1232993221000},"page":"369-373","source":"Crossref","is-referenced-by-count":91,"title":["Metabolic Oxidative Cleavage of Thioesters: Evidence for the Formation of Sulfenic Acid Intermediates in the Bioactivation of the Antithrombotic Prodrugs Ticlopidine and Clopidogrel"],"prefix":"10.1021","volume":"22","author":[{"given":"Patrick M.","family":"Dansette","sequence":"first","affiliation":[{"name":"Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques, UMR 8601 CNRS, Universit\u00e9 Paris Descartes, 45 rue des Saints-P\u00e8res, 75270 Paris Cedex 06, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie","family":"Libraire","sequence":"additional","affiliation":[{"name":"Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques, UMR 8601 CNRS, Universit\u00e9 Paris Descartes, 45 rue des Saints-P\u00e8res, 75270 Paris Cedex 06, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gildas","family":"Bertho","sequence":"additional","affiliation":[{"name":"Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques, UMR 8601 CNRS, Universit\u00e9 Paris Descartes, 45 rue des Saints-P\u00e8res, 75270 Paris Cedex 06, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Mansuy","sequence":"additional","affiliation":[{"name":"Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques, UMR 8601 CNRS, Universit\u00e9 Paris Descartes, 45 rue des Saints-P\u00e8res, 75270 Paris Cedex 06, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"316","published-online":{"date-parts":[[2009,1,26]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1002\/cbdv.200790032","volume":"4","author":"Testa B.","year":"2007","journal-title":"Chem. Biodiverity"},{"key":"ref2\/cit2","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1021\/tx00040a008","volume":"7","author":"Jin L.","year":"1994","journal-title":"Chem. Res. Toxicol."},{"key":"ref3\/cit3","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1124\/dmd.105.009043","volume":"34","author":"Pearce R. E.","year":"2006","journal-title":"Drug Metab. Dispos."},{"key":"ref4\/cit4","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.3109\/00498259109043201","volume":"21","author":"Feng P. C.","year":"1991","journal-title":"Xenobiotica"},{"key":"ref5\/cit5","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1038\/sj.bjp.0705808","volume":"142","author":"Yoneda K.","year":"2004","journal-title":"Br. J. Pharmacol."},{"key":"ref6\/cit6","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1124\/dmd.30.11.1288","volume":"30","author":"Pereillo J. M.","year":"2002","journal-title":"Drug Metab. Dispos."},{"key":"ref7\/cit7","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1080\/00498250701485542","volume":"37","author":"Smith R. L.","year":"2007","journal-title":"Xenobiotica"},{"key":"ref8\/cit8","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1160\/TH07-11-0673","volume":"99","author":"Gachet C.","year":"2008","journal-title":"Thromb. Haemostasis"},{"key":"ref9\/cit9","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1055\/s-0037-1617006","volume":"27","author":"Schror K.","year":"2007","journal-title":"Haemostaseologie"},{"key":"ref10\/cit10","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1007\/BF03189474","volume":"6","author":"Tuong A.","year":"1981","journal-title":"Eur. J. Drug Metab. Pharmacokinet."},{"key":"ref11\/cit11","doi-asserted-by":"crossref","first-page":"12112","DOI":"10.1021\/bi010254c","volume":"40","author":"Ha-Duong N. T.","year":"2001","journal-title":"Biochemistry"},{"key":"ref12\/cit12","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1021\/tx015574b","volume":"15","author":"Dalvie D. K.","year":"2002","journal-title":"Chem. Res. Toxicol."},{"key":"ref13\/cit13","doi-asserted-by":"crossref","first-page":"6234","DOI":"10.1016\/S0021-9258(19)42244-8","volume":"249","author":"Benitez L. V.","year":"1974","journal-title":"J. Biol. Chem."},{"key":"ref14\/cit14","doi-asserted-by":"crossref","first-page":"1624","DOI":"10.1021\/bc050257s","volume":"16","author":"Poole L. B.","year":"2005","journal-title":"Bioconjugate Chem."},{"key":"ref15\/cit15","unstructured":"Boigegrain, R., Maffrand, J. P., Suzuki, N., Matsubayachi, K., and Ashida, S.(1985) Preparation of 5,6,7,7a-terahydro-4H-thieno(3,2-C)pyridin-2-one compounds, 8p. U.S. Patent US4515951, Sanofi, France."},{"key":"ref16\/cit16","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1111\/j.1432-1033.1981.tb05561.x","volume":"118","author":"Kremers P.","year":"1981","journal-title":"Eur. J. Biochem."},{"key":"ref17\/cit17","unstructured":"Asai, F., Sugidachi, K., Ikeda, T., Koike, H., Inoue, T., Katsumoti, T., Iwamura, K., and Kita, J. I.(2000) Cyclic amines derivatives, 81p. U.S. Patent US0687379, Sankyo Co. Ltd., Japan."},{"key":"ref18\/cit18","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1007\/0-387-27447-2_7","volume-title":"Cytochrome P450: Structure, Mechanism, and Biochemistry","author":"Correia M. A.","year":"2005"},{"key":"ref19\/cit19","first-page":"337","volume-title":"Cytochrome P450: Structure, Mechanism, and Biochemistry","author":"Guengerich F. P.","year":"2005"},{"key":"ref20\/cit20","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1021\/tx0500373","volume":"18","author":"Reddy V. B.","year":"2005","journal-title":"Chem. Res. Toxicol."},{"key":"ref21\/cit21","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/0006-2952(92)90555-W","volume":"43","author":"Hart B. W.","year":"1992","journal-title":"Biochem. Pharmacol."},{"key":"ref22\/cit22","doi-asserted-by":"crossref","first-page":"13732","DOI":"10.1021\/bi00212a044","volume":"32","author":"Shirane N.","year":"1993","journal-title":"Biochemistry"}],"container-title":["Chemical Research in Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/tx8004828","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,23]],"date-time":"2023-03-23T03:47:52Z","timestamp":1679543272000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/tx8004828"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,1,26]]},"references-count":22,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2009,2,16]]}},"alternative-id":["10.1021\/tx8004828"],"URL":"https:\/\/doi.org\/10.1021\/tx8004828","relation":{},"ISSN":["0893-228X","1520-5010"],"issn-type":[{"value":"0893-228X","type":"print"},{"value":"1520-5010","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,1,26]]}}}