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Soc."},{"key":"ref11\/cit11","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1021\/tx0502948","volume":"19","author":"Wang M.","year":"2006","journal-title":"Chem. Res. Toxicol."},{"key":"ref12\/cit12","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1021\/tx000118t","volume":"13","author":"Wang M.","year":"2000","journal-title":"Chem. Res. Toxicol."},{"key":"ref13\/cit13","doi-asserted-by":"crossref","first-page":"2177","DOI":"10.1093\/carcin\/16.9.2177","volume":"16","author":"Fang J. L.","year":"1995","journal-title":"Carcinogenesis"},{"key":"ref14\/cit14","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1093\/carcin\/18.4.627","volume":"18","author":"Fang J. L.","year":"1997","journal-title":"Carcinogenesis"},{"key":"ref15\/cit15","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1021\/tx060113h","volume":"19","author":"Matsuda T.","year":"2006","journal-title":"Chem. Res. 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Toxicol."},{"key":"ref30\/cit30","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1007\/BF01940790","volume":"32","author":"Novotny M.","year":"1976","journal-title":"Experientia"},{"key":"ref31\/cit31","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/0378-4274(92)90094-Z","volume":"63","author":"Talaska G.","year":"1992","journal-title":"Toxicol. Lett."},{"key":"ref32\/cit32","doi-asserted-by":"crossref","first-page":"5719","DOI":"10.1021\/jo990500e","volume":"64","author":"Sako M.","year":"1999","journal-title":"J. Org. Chem."},{"key":"ref33\/cit33","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1021\/tx7001146","volume":"20","author":"Matter B.","year":"2007","journal-title":"Chem. Res. Toxicol."},{"key":"ref34\/cit34","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1021\/tx0100385","volume":"14","author":"Wang M.","year":"2001","journal-title":"Chem. Res. 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