{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T16:10:46Z","timestamp":1772986246636,"version":"3.50.1"},"reference-count":65,"publisher":"American Chemical Society (ACS)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chem. Res. Toxicol."],"published-print":{"date-parts":[[2010,1,18]]},"DOI":"10.1021\/tx900301r","type":"journal-article","created":{"date-parts":[[2009,12,17]],"date-time":"2009-12-17T15:34:59Z","timestamp":1261064099000},"page":"99-107","source":"Crossref","is-referenced-by-count":59,"title":["Characterization of DNA Damage Induced by a Natural Product Antitumor Antibiotic Leinamycin in Human Cancer Cells"],"prefix":"10.1021","volume":"23","author":[{"given":"Velliyur","family":"Viswesh","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tucson, Arizona 85721, and Departments of Chemistry and Biochemistry, University of Missouri, Columbia, Missouri 65211"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kent","family":"Gates","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tucson, Arizona 85721, and Departments of Chemistry and Biochemistry, University of Missouri, Columbia, Missouri 65211"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daekyu","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tucson, Arizona 85721, and Departments of Chemistry and Biochemistry, University of Missouri, Columbia, Missouri 65211"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"316","published-online":{"date-parts":[[2009,12,17]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"crossref","first-page":"333","DOI":"10.7164\/antibiotics.42.333","volume":"42","author":"Hara M.","year":"1989","journal-title":"J. Antibiot."},{"key":"ref2\/cit2","doi-asserted-by":"crossref","first-page":"1768","DOI":"10.7164\/antibiotics.42.333","volume":"42","author":"Hara M.","year":"1989","journal-title":"J. Antibiot."},{"key":"ref3\/cit3","doi-asserted-by":"crossref","first-page":"1957","DOI":"10.1246\/cl.1993.1957","volume":"11","author":"Hirayama N.","year":"1993","journal-title":"Chem. Lett."},{"key":"ref4\/cit4","doi-asserted-by":"crossref","first-page":"8451","DOI":"10.1021\/ja00071a066","volume":"115","author":"Kanda Y.","year":"1993","journal-title":"J. Am. Chem. Soc."},{"key":"ref5\/cit5","doi-asserted-by":"crossref","first-page":"5676","DOI":"10.1021\/bi00476a005","volume":"29","author":"Hara M.","year":"1990","journal-title":"Biochemistry"},{"key":"ref6\/cit6","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1016\/S0960-894X(98)00133-4","volume":"8","author":"Kanda Y.","year":"1998","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref7\/cit7","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1021\/jm9900366","volume":"42","author":"Kanda Y.","year":"1999","journal-title":"J. Med. Chem."},{"key":"ref8\/cit8","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1097\/00001813-199910000-00006","volume":"10","author":"Ashizawa T.","year":"1999","journal-title":"Anticancer Drugs"},{"key":"ref9\/cit9","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/S0960-894X(02)00949-6","volume":"13","author":"Kanda Y.","year":"2003","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref10\/cit10","doi-asserted-by":"crossref","first-page":"3964","DOI":"10.1021\/jo00118a010","volume":"60","author":"Behroozi S. B.","year":"1995","journal-title":"J. Org. Chem."},{"key":"ref11\/cit11","doi-asserted-by":"crossref","first-page":"9054","DOI":"10.1021\/jo020568l","volume":"67","author":"Breydo L.","year":"2002","journal-title":"J. Org. Chem."},{"key":"ref12\/cit12","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1016\/S0960-894X(01)00196-2","volume":"11","author":"Zang H.","year":"2001","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref13\/cit13","doi-asserted-by":"crossref","first-page":"4996","DOI":"10.1021\/ja029169y","volume":"125","author":"Chatterji T.","year":"2003","journal-title":"J. Am. Chem. Soc."},{"key":"ref14\/cit14","doi-asserted-by":"crossref","first-page":"6802","DOI":"10.1021\/ja960892w","volume":"118","author":"Asai A.","year":"1996","journal-title":"J. Am. Chem. Soc."},{"key":"ref15\/cit15","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1016\/S0968-0896(97)00015-1","volume":"5","author":"Asai A.","year":"1997","journal-title":"Bioorg. Med. Chem."},{"key":"ref16\/cit16","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1039\/b701179b","volume":"5","author":"Keerthi K.","year":"2007","journal-title":"Org. Biomol. Chem."},{"key":"ref17\/cit17","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1021\/tx0341658","volume":"16","author":"Zang H.","year":"2003","journal-title":"Chem. Res. Toxicol."},{"key":"ref18\/cit18","doi-asserted-by":"crossref","first-page":"5711","DOI":"10.1016\/j.tetlet.2004.05.093","volume":"45","author":"Breydo L.","year":"2004","journal-title":"Tetrahedron Lett."},{"key":"ref19\/cit19","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1021\/tx049964k","volume":"17","author":"Nooner T.","year":"2004","journal-title":"Chem. Res. Toxicol."},{"key":"ref20\/cit20","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1021\/tx049965c","volume":"17","author":"Gates K. S.","year":"2004","journal-title":"Chem. Res. Toxicol."},{"key":"ref21\/cit21","doi-asserted-by":"crossref","first-page":"2111","DOI":"10.1016\/j.bmcl.2005.02.058","volume":"15","author":"Shipova K.","year":"2005","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref22\/cit22","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1146\/annurev.ge.20.120186.001221","volume":"20","author":"Loeb L. A.","year":"1986","journal-title":"Ann. Rev. Genet."},{"key":"ref23\/cit23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.dnarep.2003.10.002","volume":"3","author":"Boiteux S.","year":"2004","journal-title":"DNA Repair"},{"key":"ref24\/cit24","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/S0921-8777(01)00063-5","volume":"485","author":"Wilson D. M.","year":"2001","journal-title":"Mutat. Res."},{"key":"ref25\/cit25","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1089\/15230860152543014","volume":"3","author":"Kelley M. R.","year":"2001","journal-title":"Antioxid. Redox Signaling"},{"key":"ref26\/cit26","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1002\/1097-0282(1999)52:2<65::AID-BIP1>3.0.CO;2-U","volume":"52","author":"Lhomme J.","year":"2000","journal-title":"Biopolymers"},{"key":"ref27\/cit27","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1042\/bj2530553","volume":"253","author":"Bailly V.","year":"1988","journal-title":"Biochem. J."},{"key":"ref28\/cit28","doi-asserted-by":"crossref","first-page":"3618","DOI":"10.1021\/bi00769a019","volume":"11","author":"Lindahl T.","year":"1972","journal-title":"Biochemistry"},{"key":"ref29\/cit29","doi-asserted-by":"crossref","first-page":"1852","DOI":"10.1021\/ja067294u","volume":"129","author":"Dutta S.","year":"2007","journal-title":"J. Am. Chem. Soc."},{"key":"ref30\/cit30","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0921-8777(00)00046-X","volume":"461","author":"Evans A. R.","year":"2000","journal-title":"Mutat. Res."},{"key":"ref31\/cit31","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.jmb.2008.03.053","volume":"379","author":"Berquist B. R.","year":"2008","journal-title":"J. Mol. Biol."},{"key":"ref32\/cit32","doi-asserted-by":"crossref","first-page":"11017","DOI":"10.1021\/bi049560r","volume":"43","author":"Lomax M. E.","year":"2004","journal-title":"Biochemistry"},{"key":"ref33\/cit33","doi-asserted-by":"crossref","first-page":"2859","DOI":"10.1093\/nar\/gki601","volume":"33","author":"Rinne M. L.","year":"2005","journal-title":"Nucleic Acids Res."},{"key":"ref34\/cit34","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1158\/1078-0432.CCR-06-1920","volume":"13","author":"Fishel M. L.","year":"2007","journal-title":"Clin. Cancer Res."},{"key":"ref35\/cit35","first-page":"608","volume":"63","author":"Fishel M. L.","year":"2003","journal-title":"Cancer Res."},{"key":"ref36\/cit36","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1158\/1535-7163.955.3.8","volume":"3","author":"Rinne M. L.","year":"2004","journal-title":"Mol. Cancer Ther."},{"key":"ref37\/cit37","doi-asserted-by":"crossref","first-page":"1768","DOI":"10.1021\/bi952257t","volume":"35","author":"Behroozi S. J.","year":"1996","journal-title":"Biochemistry"},{"key":"ref38\/cit38","doi-asserted-by":"crossref","first-page":"11691","DOI":"10.1021\/ja971359z","volume":"119","author":"Mitra K.","year":"1997","journal-title":"J. Am. Chem. Soc."},{"key":"ref39\/cit39","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/S0960-894X(98)00066-3","volume":"8","author":"Chatterji T.","year":"1998","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref40\/cit40","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1016\/S0960-894X(03)00103-3","volume":"13","author":"Chatterji T.","year":"2003","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref41\/cit41","doi-asserted-by":"crossref","first-page":"3921","DOI":"10.1016\/j.bmcl.2005.05.110","volume":"15","author":"Chatterji T.","year":"2005","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref42\/cit42","doi-asserted-by":"crossref","first-page":"4242","DOI":"10.1016\/S0960-894X(00)00125-6","volume":"10","author":"Breydo L.","year":"2000","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref43\/cit43","doi-asserted-by":"crossref","first-page":"3076","DOI":"10.1016\/j.bmcl.2007.11.092","volume":"18","author":"Sivaramakrishnan S.","year":"2008","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref44\/cit44","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0076-6879(90)86093-B","volume":"186","author":"Halliwell B.","year":"1990","journal-title":"Methods Enzymol."},{"key":"ref45\/cit45","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/S0955-0674(03)00002-4","volume":"15","author":"Finkel T.","year":"2003","journal-title":"Curr. Opin. Cell Biol."},{"key":"ref46\/cit46","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/35041687","volume":"408","author":"Finkel T.","year":"2000","journal-title":"Nature"},{"key":"ref47\/cit47","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1038\/nchembio.85","volume":"4","author":"Winterbourn C. C.","year":"2008","journal-title":"Nat. Chem. Biol."},{"key":"ref48\/cit48","doi-asserted-by":"crossref","first-page":"2181","DOI":"10.1002\/jps.20874","volume":"96","author":"Ozben T.","year":"2007","journal-title":"J. Pharm. Sci."},{"key":"ref49\/cit49","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1097\/01.cad.0000136886.72917.6f","volume":"15","author":"Bassett S.","year":"2004","journal-title":"Anti-Cancer Drugs"},{"key":"ref50\/cit50","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1007\/s12013-007-0032-7","volume":"47","author":"Barkley L. R.","year":"2007","journal-title":"Cell Biochem. Biophys."},{"key":"ref51\/cit51","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/B978-0-08-091283-7.00074-6","volume-title":"Comprehensive Natural Products Chemistry","author":"Gates K. S.","year":"1999"},{"key":"ref52\/cit52","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1021\/tx000089m","volume":"13","author":"Gates K. S.","year":"2000","journal-title":"Chem. Res. Toxicol."},{"key":"ref53\/cit53","doi-asserted-by":"crossref","first-page":"3703","DOI":"10.1021\/bi00129a020","volume":"31","author":"Kubo K.","year":"1992","journal-title":"Biochemistry"},{"key":"ref54\/cit54","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1073\/pnas.97.2.686","volume":"97","author":"Atamna H.","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"ref55\/cit55","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1385\/MB:26:3:249","volume":"26","author":"Collins A. R.","year":"2004","journal-title":"Mol. Biotechnol."},{"key":"ref56\/cit56","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/S0921-8777(98)00053-6","volume":"409","author":"Horvathova E.","year":"1998","journal-title":"Mutat. Res."},{"key":"ref57\/cit57","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/S0076-6879(99)00133-0","volume":"300","author":"Buxser S. E.","year":"1999","journal-title":"Methods Enzymol."},{"key":"ref58\/cit58","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1002\/9780470120828.ch8","volume-title":"Reviews of Reactive Intermediates","author":"Gates K. S.","year":"2007"},{"key":"ref59\/cit59","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1021\/tx980174i","volume":"11","author":"Greenberg M. M.","year":"1998","journal-title":"Chem. Res. Toxicol."},{"key":"ref60\/cit60","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1016\/0891-5849(94)00209-3","volume":"18","author":"Breen A. P.","year":"1995","journal-title":"Free Radical Biol. Med."},{"key":"ref61\/cit61","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1039\/B612729K","volume":"5","author":"Greenberg M. M.","year":"2007","journal-title":"Org. Biomol. Chem."},{"key":"ref62\/cit62","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1002\/anie.199507461","volume":"34","author":"Pratviel G.","year":"1995","journal-title":"Angew. Chem., Int. Ed. Engl."},{"key":"ref63\/cit63","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1080\/07328319808005194","volume":"17","author":"Asaeda A.","year":"1998","journal-title":"Nucleosides Nucleotides"},{"key":"ref64\/cit64","doi-asserted-by":"crossref","first-page":"6305","DOI":"10.1093\/nar\/10.20.6305","volume":"10","author":"Male R.","year":"1982","journal-title":"Nucleic Acid Res."},{"key":"ref65\/cit65","first-page":"2522","volume":"59","author":"Nakamura J.","year":"1999","journal-title":"Cancer Res."}],"container-title":["Chemical Research in Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/tx900301r","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,5]],"date-time":"2023-03-05T22:35:38Z","timestamp":1678055738000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/tx900301r"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,12,17]]},"references-count":65,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2010,1,18]]}},"alternative-id":["10.1021\/tx900301r"],"URL":"https:\/\/doi.org\/10.1021\/tx900301r","relation":{},"ISSN":["0893-228X","1520-5010"],"issn-type":[{"value":"0893-228X","type":"print"},{"value":"1520-5010","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,12,17]]}}}