{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T13:42:54Z","timestamp":1770471774762,"version":"3.49.0"},"reference-count":66,"publisher":"American Chemical Society (ACS)","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chem. Res. Toxicol."],"published-print":{"date-parts":[[2000,7,1]]},"DOI":"10.1021\/tx990199x","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T05:54:00Z","timestamp":1027662840000},"page":"585-593","source":"Crossref","is-referenced-by-count":56,"title":["UVA-Induced DNA Single-Strand Cleavage by 1-Hydroxypyrene and Formation of Covalent Adducts between DNA and 1-Hydroxypyrene"],"prefix":"10.1021","volume":"13","author":[{"given":"Shiming","family":"Dong","sequence":"first","affiliation":[{"name":"Departments of Chemistry and Biology, Jackson State University, Jackson, Mississippi 39217"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huey-Min","family":"Hwang","sequence":"additional","affiliation":[{"name":"Departments of Chemistry and Biology, Jackson State University, Jackson, Mississippi 39217"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaochun","family":"Shi","sequence":"additional","affiliation":[{"name":"Departments of Chemistry and Biology, Jackson State University, Jackson, Mississippi 39217"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laketa","family":"Holloway","sequence":"additional","affiliation":[{"name":"Departments of Chemistry and Biology, Jackson State University, Jackson, Mississippi 39217"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongtao","family":"Yu","sequence":"additional","affiliation":[{"name":"Departments of Chemistry and Biology, Jackson State University, Jackson, Mississippi 39217"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"316","published-online":{"date-parts":[[2000,6,17]]},"reference":[{"key":"tx990199xb00001\/tx990199xb00001_1","first-page":"70","volume-title":"Polycyclic Aromatic Hydrocarbons and Cancer","author":"Baum E.","year":"1978"},{"key":"tx990199xb00002\/tx990199xb00002_1","volume-title":"Introduction into Environmental Chemistry","author":"Connell D. W.","year":"1997"},{"key":"tx990199xb00003\/tx990199xb00003_1","first-page":"17","volume-title":"Polycyclic Hydrocarbons and Carcinogenesis","author":"Dipple A.","year":"1985"},{"key":"tx990199xb00004\/tx990199xb00004_1","volume-title":"Induction of microsomal enzymes by foreign chemicals and carcinogenesis by polycyclic aromatic hydrocarbons:\u2009 G. H. A. Clowes memorial lecture. Cancer Res. 42, 4875\u22124910","author":"Conney A. H.","year":"1982"},{"key":"tx990199xb00005\/tx990199xb00005_1","volume-title":"Chemical carcinogenesis:\u2009 benzopyrene system. Methods Enzymol. 105, 539\u2212550","author":"Lesko S. A.","year":"1984"},{"key":"tx990199xb00006\/tx990199xb00006_1","first-page":"181","volume-title":"8th Report on Carcinogens","author":"National Toxicology Program, U.S."},{"key":"tx990199xb00007\/tx990199xb00007_1","volume-title":"Polycyclic aromatic hydrocarbons in carcinogenesis. Environ. Health Perspect. 107, 317\u2212320","author":"Warshawsky D.","year":"1999"},{"key":"tx990199xb00008\/tx990199xb00008_1","volume-title":"Polycyclic aromatic hydrocarbons (PAHs), nitro-PAHs and related environmental compounds:\u2009 biological markers of exposure and effects. Environ. Health Perspect. 104, 701\u2212908","author":"Talaska G.","year":"1996"},{"key":"tx990199xb00009\/tx990199xb00009_1","volume-title":"Polynuclear Aromatic Compounds. Part I:\u2009 Chemical, Environmental and Experimental Data","author":"International Agency for Research on Cancer","year":"1983"},{"key":"tx990199xb00010\/tx990199xb00010_1","volume-title":"Toxicological Profile for Polycyclic Aromatic Hydrocarbons (PAHs)","author":"U.S. Department of Health and Human Services, P. H. S., ATSDR","year":"1995"},{"key":"tx990199xb00011\/tx990199xb00011_1","volume-title":"Expanded analysis of benzo[a]pyrene-DNA adducts formed in vitro and in mouse skin:\u2009 their significance in tumor initiation. Chem. Res. Toxicol. 9, 897\u2212903","author":"Chen L.","year":"1996"},{"key":"tx990199xb00012\/tx990199xb00012_1","volume-title":"Mechanism of metabolic activation of the potent carcinogen 7,12-dimethylbenz[a]anthracene. Chem. Res. Toxicol. 5, 220\u2212226","author":"RamaKrishna N. V. S.","year":"1992"},{"key":"tx990199xb00013\/tx990199xb00013_1","volume":"60","author":"Gelbroin H. V.","year":"1980","journal-title":"Physiol. Rev."},{"key":"tx990199xb00014\/tx990199xb00014_1","volume-title":"NMR solution structure of stereoisomeric covalent polycyclic aromatic carcinogen-DNA adducts:\u2009 principles, patterns, and diversity. Chem. Res. Toxicol. 10, 111\u2212146","author":"Geacintov N. E.","year":"1997"},{"key":"tx990199xb00015\/tx990199xb00015_1","volume-title":"Polycyclic Aromatic Hydrocarbons:\u2009 Chemistry and Carcinogenicity","author":"Harvey R. G.","year":"1991"},{"key":"tx990199xb00016\/tx990199xb00016_1","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1021\/tx980143n","volume":"12","author":"Penning T. M.","year":"1999","journal-title":"Chem. Res. Toxicol."},{"key":"tx990199xb00017\/tx990199xb00017_1","volume-title":"Proc. Natl. Acad. Sci. U.S.A. 73","author":"Thakker D. R.","year":"1976"},{"key":"tx990199xb00018\/tx990199xb00018_1","volume-title":"Depurinating and stable benzo[a]pyrene-DNA adducts formed in isolated rat liver nuclei. Chem. Res. Toxicol. 9, 1113\u22121116","author":"Devanesan P. D.","year":"1996"},{"key":"tx990199xb00019\/tx990199xb00019_1","doi-asserted-by":"crossref","unstructured":"Rogan, E. G., Devanesan, P. D., RamaKrishna, N. V. S., Higginbotham, S., Padmavathi, N. S., Chapman, K., Cavalieri, E. L., Jeong, H., Jankowiak, R., and Small, G. J. (1993) Identification and quantitation of benzo[a]pyrene-DNA adducts formed in mouse skin.Chem. Res. Toxicol.6, 356\u2212363.","DOI":"10.1021\/tx00033a017"},{"key":"tx990199xb00020\/tx990199xb00020_1","volume-title":"Cu(II)\/Cu(I) redox cycling, and o-semiquinone anion radicals. Biochemistry 36, 8640\u22128648.","author":"Flowers L.","year":"1997"},{"key":"tx990199xb00021\/tx990199xb00021_1","doi-asserted-by":"crossref","unstructured":"Huang, X.D., Krylov, S. N., Ren, L., McKonkey, B. J., Dixon, D. G., and Greenberg, B. M. (1997) Mechanistic quantitative structure\u2212activity relationship model for the photoinduced toxicity of polycyclic aromatic hydrocarbons:\u2009 II. An empirical model for the toxicity of 16 polycyclic aromatic hydrocarbons to the duckweek lemna gibba L. G-3.Environ. Toxicol. Chem.16, 2296\u22122303.","DOI":"10.1897\/1551-5028(1997)016<2296:MQSARM>2.3.CO;2"},{"key":"tx990199xb00022\/tx990199xb00022_1","doi-asserted-by":"crossref","unstructured":"Kagan, J., Tuveson, R. W., and Gong, H.H. (1989) The light-dependent cytotoxicity of benzo[a]pyrene:\u2009 effect on human erythrocytes,Escherichia colicells, andHaemophilus influenzaetransforming DNA.Mutat. Res.216, 231\u2212242.","DOI":"10.1016\/0165-1161(89)90048-4"},{"key":"tx990199xb00023\/tx990199xb00023_1","doi-asserted-by":"crossref","unstructured":"Krylov, S. N., Huang, X.D., Zeiler, L. F., Dixon, D. G., and Greenberg, B. M. (1997) Mechanistic quantitative structure\u2212activity relationship model for the photoinduced toxicity of polycyclic aromatic hydrocarbons:\u2009 I. Physical model based on chemical kinetics in a two-compartment system.Environ. Toxicol. Chem.16, 2283\u22122295.","DOI":"10.1002\/etc.5620161113"},{"key":"tx990199xb00024\/tx990199xb00024_1","doi-asserted-by":"crossref","unstructured":"Mezey, P. G., Zimpel, Z., Warburton, P., Walker, P. D., Irvine, D. G., Huang, X.D., Dixon, D. G., and Greenberg, B. M. (1998) Use of quantitative shape-activity relationship to model the photoinduced toxicity of polycyclic aromatic hydrocarbons:\u2009 electron density shape features accurately predict toxicity.Environ. Toxicol. Chem17, 1207\u22121215.","DOI":"10.1002\/etc.5620170703"},{"key":"tx990199xb00025\/tx990199xb00025_1","volume-title":"Phototoxicity of individual polycyclic aromatic hydrocarbons and petroleum to marine invertebrate larvae and juveniles. Environ. Toxicol. Chem. 16, 2190\u22122199","author":"Pelletier M. C.","year":"1997"},{"key":"tx990199xb00026\/tx990199xb00026_1","volume-title":"Photoactivation and toxicity of mixtures of 593 polycyclic aromatic hydrocarbon compounds in marine sediment. Environ. Toxicol. Chem. 16, 2151\u22122157","author":"Swartz R. C.","year":"1997"},{"key":"tx990199xb00027\/tx990199xb00027_1","volume-title":"Effects of light on 3,4-benzopyrene carcinogenesis. Nature 210, 824\u2212825","author":"Santamaria L.","year":"1966"},{"key":"tx990199xb00028\/tx990199xb00028_1","doi-asserted-by":"crossref","unstructured":"Brooks, P., and Lawley, P. D. (1964) Evidence for the binding of polynuclear aromatic hydrocarbons to the nucleic acids of mouse skin:\u2009 relation between carcinogenic power of hydrocarbons and their binding to deoxyribonucleic acid.Nature202, 781\u2212784.","DOI":"10.1038\/202781a0"},{"key":"tx990199xb00029\/tx990199xb00029_1","doi-asserted-by":"crossref","DOI":"10.1042\/bj1490289","volume":"149","author":"Blackburn G. M.","year":"1975","journal-title":"Biochem. J."},{"key":"tx990199xb00030\/tx990199xb00030_1","volume-title":"Photoproducts from DNA pyrimidine bases and polycyclic aromatic hydrocarbons. Nucleic Acids Res. 4, 2487\u22122494","author":"Blackburn G. M.","year":"1977"},{"key":"tx990199xb00031\/tx990199xb00031_1","volume-title":"Photo-induced reactions of benzo[a]pyrene with DNA in vitro. Cancer Res. 40, 245\u2212252","author":"Striste G. F.","year":"1980"},{"key":"tx990199xb00032\/tx990199xb00032_1","volume-title":"Interaction of nucleic acids. V. Chemical linkage of 3,4-benzopyrene to deoxyribonucleic acids in aqueous solution. Biochemistry 8, 2291\u22122298","author":"Lesko S. A.","year":"1969"},{"key":"tx990199xb00033\/tx990199xb00033_1","volume-title":"Proc. Natl. Acad. Sci. U.S.A. 51","author":"Ts'o P. O. P.","year":"1964"},{"key":"tx990199xb00034\/tx990199xb00034_1","volume-title":"Reaction induced in vitro between model DNA and benzo[a]pyrene by near-ultraviolet radiation. Chem.-Biol. Interact. 33, 179\u2212194","author":"Hoard D. E.","year":"1981"},{"key":"tx990199xb00035\/tx990199xb00035_1","volume-title":"Benzo[a]pyrene enhances the formation of 8-hydroxy-2\u2018-deoxyguanosine by ultraviolet A radiation in calf thymus DNA and human epidermoid carcinoma. Biochemistry 37, 10307\u221210312","author":"Liu Z.","year":"1998"},{"key":"tx990199xb00036\/tx990199xb00036_1","volume-title":"Laser pulse-induced photochemical strand cleavage of site-specifically and covalently modified (+)-anti-benzo[a]pyrene diol epoxide-oligonucleotide adducts. Chem. Res. Toxicol. 8, 396\u2212402","author":"Li B.","year":"1995"},{"key":"tx990199xb00037\/tx990199xb00037_1","volume-title":"Effect of visible light on benzo[a]pyrene binding to DNA of cultured human skin epithelial cells. Cancer Res. 41, 1789\u22121793","author":"Camalier R. F.","year":"1981"},{"key":"tx990199xb00038\/tx990199xb00038_1","first-page":"7","volume":"144","author":"White G. L.","year":"1985","journal-title":"Mutat. Res."},{"key":"tx990199xb00039\/tx990199xb00039_1","doi-asserted-by":"crossref","DOI":"10.1016\/0378-4274(94)90030-2","volume":"72","author":"Jongeneelen F. J.","year":"1994","journal-title":"Toxicol. Lett."},{"key":"tx990199xb00040\/tx990199xb00040_1","volume":"29","author":"Dor F.","year":"1999","journal-title":"Crit. Rev. Toxicol."},{"key":"tx990199xb00041\/tx990199xb00041_1","volume-title":"Biomarkers Prev. 7, 147\u2212155.","author":"Merlo F.","year":"1998"},{"key":"tx990199xb00042\/tx990199xb00042_1","volume-title":"Biomarkers Prev. 7, 767\u2212773.","author":"Godschalk R. W. L.","year":"1998"},{"key":"tx990199xb00043\/tx990199xb00043_1","volume-title":"Int. Arch. Occup. Environ. Health 69, 323\u2212331.","author":"Angerer J.","year":"1997"},{"key":"tx990199xb00044\/tx990199xb00044_1","volume-title":"Urinary 1-hydroxypyrene as a marker of exposure to pyrene:\u2009 an epidemiological survey on a general population group. Sci. Total Environ. 199, 247\u2212254","author":"Roggi C.","year":"1997"},{"key":"tx990199xb00045\/tx990199xb00045_1","volume-title":"Evaluation of intra and inter individual variation of urinary 1-hydroxypyrene, a biomarker of exposure to polycyclic aromatic hydrocarbons. Sci. Total Environ. 217, 175\u2212183","author":"Siwinska E.","year":"1998"},{"key":"tx990199xb00046\/tx990199xb00046_1","volume-title":"Polycyclic aromatic hydrocarbon metabolite in urine as biomarkers of exposure and effect. Environ. Health Perspect. 104, 927\u2212935","author":"Strickland P.","year":"1996"},{"key":"tx990199xb00047\/tx990199xb00047_1","doi-asserted-by":"crossref","unstructured":"Lambert, M., Kremer, S., and Anke, H. (1995) Antimicrobial, phytotoxic, nematicidal, cytotoxic, and mutagenic activities of 1-hydroxypyrene, the initial metabolite in pyrene metabolism by the basidiomyceteCrinipellis stipitaria.Bull. Environ. Contam. Toxicol.55, 251\u2212257.","DOI":"10.1007\/BF00203017"},{"key":"tx990199xb00048\/tx990199xb00048_1","volume-title":"Comparison of acute toxicity and genotoxicity concentrations of single compounds and waste elutriate using the Microtox\/Mutatox test system. Ecotoxicol. Environ. Saf. 38, 227\u2212231","author":"Hauser B.","year":"1997"},{"key":"tx990199xb00049\/tx990199xb00049_1","volume-title":"Several synthetic chemicals inhibit progesterone receptor-mediated transactivation in yeast. Biochem. Biophys. Res. Commun. 233, 139\u2212146","author":"Jin L.","year":"1997"},{"key":"tx990199xb00050\/tx990199xb00050_1","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.1021\/es950665e","volume":"30","author":"Nakajima D.","year":"1996","journal-title":"J. Environ. Sci. Technol."},{"key":"tx990199xb00051\/tx990199xb00051_1","volume-title":"UVA light-induced DNA cleavage by selected polycyclic aromatic hydrocarbons. Bull. Environ. Contam. Toxicol. 64 (4), 467\u2212474","author":"Dong S.","year":"2000"},{"key":"tx990199xb00052\/tx990199xb00052_1","volume-title":"Photosensitization of single strand breaks in pBR322 DNA by rose bengal. Photochem. Photobiol. 49, 293\u2212298","author":"Ciulla T. A.","year":"1989"},{"key":"tx990199xb00053\/tx990199xb00053_1","doi-asserted-by":"crossref","DOI":"10.1016\/0022-2836(74)90031-X","volume":"86","author":"McGhee J. D.","year":"1974","journal-title":"J. Mol. Biol."},{"key":"tx990199xb00054\/tx990199xb00054_1","doi-asserted-by":"crossref","DOI":"10.1021\/ja00066a002","volume":"115","author":"Chaires J. B.","year":"1993","journal-title":"J. Am. Chem. Soc."},{"key":"tx990199xb00055\/tx990199xb00055_1","volume-title":"Thermodynamics of the interaction of m-AMSA and o-AMSA with nucleic acids:\u2009 influence of ionic strength and DNA base composition. Nucleic Acids Res. 17, 9933\u22129946","author":"Wadkins R. M.","year":"1989"},{"key":"tx990199xb00056\/tx990199xb00056_1","volume-title":"Evidence for nonintercalative complexes formed from the reversible binding of benzo[a]pyrene metabolites to closed-circular, single-stranded M13mp19 DNA. Biomed. Biophys. Res. Commun. 168, 1095\u22121102","author":"Price H. L.","year":"1990"},{"key":"tx990199xb00057\/tx990199xb00057_1","volume":"257","author":"Meehan T.","year":"1982","journal-title":"J. Biol. Chem."},{"key":"tx990199xb00058\/tx990199xb00058_1","volume-title":"Properties of covalent benzo[a]pyrene diol epoxide-DNA adducts investigated by fluorescence technique. Carcinogenesis 8, 925\u2212935","author":"Geacintov N. E.","year":"1987"},{"key":"tx990199xb00059\/tx990199xb00059_1","volume-title":"Solution properties and computational analysis of an oligodeoxynucleotide containing N-(deoxyguanosin-8-yl)-1-aminopyrene. Carcinogenesis 17, 133\u2212144","author":"Nolan S. J.","year":"1996"},{"key":"tx990199xb00060\/tx990199xb00060_1","doi-asserted-by":"crossref","DOI":"10.1021\/ja9542606","volume":"118","author":"Leng F.","year":"1996","journal-title":"J. Am. Chem. Soc."},{"key":"tx990199xb00061\/tx990199xb00061_1","first-page":"81","volume":"1442","author":"Leng F.","year":"1998","journal-title":"Biochim. Biophys. Acta"},{"key":"tx990199xb00062\/tx990199xb00062_1","volume-title":"Biochemical and Clinical Aspects of Oxygen","author":"Foote C. S.","year":"1979"},{"key":"tx990199xb00063\/tx990199xb00063_1","volume":"114","author":"Williams R. M.","year":"1992","journal-title":"J. Am. Chem. Soc."},{"key":"tx990199xb00064\/tx990199xb00064_1","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1021\/ja00080a008","volume":"116","author":"Shafirovich V. Y.","year":"1994","journal-title":"J. Am. Chem. Soc."},{"key":"tx990199xb00065\/tx990199xb00065_1","volume":"99","author":"Miller J. C.","year":"1977","journal-title":"J. Am. Chem. Soc."},{"key":"tx990199xn00001\/tx990199xn00001_1","volume-title":"covalent adduct with DNA and HOP (exact structure not yet determined)","author":"Abbreviations HOP"}],"container-title":["Chemical Research in Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/tx990199x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,15]],"date-time":"2021-10-15T21:48:01Z","timestamp":1634334481000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/tx990199x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,6,17]]},"references-count":66,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2000,7,1]]}},"alternative-id":["10.1021\/tx990199x"],"URL":"https:\/\/doi.org\/10.1021\/tx990199x","relation":{},"ISSN":["0893-228X","1520-5010"],"issn-type":[{"value":"0893-228X","type":"print"},{"value":"1520-5010","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,6,17]]}}}