{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T07:03:07Z","timestamp":1771484587733,"version":"3.50.1"},"reference-count":51,"publisher":"American Chemical Society (ACS)","issue":"14","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Anal. Chem."],"published-print":{"date-parts":[[2010,7,15]]},"DOI":"10.1021\/ac100516q","type":"journal-article","created":{"date-parts":[[2010,6,17]],"date-time":"2010-06-17T12:41:37Z","timestamp":1276778497000},"page":"6032-6039","source":"Crossref","is-referenced-by-count":111,"title":["First Toxin Profile of Ciguateric Fish in Madeira Arquipelago (Europe)"],"prefix":"10.1021","volume":"82","author":[{"given":"Paz","family":"Otero","sequence":"first","affiliation":[{"name":"Departamento de Farmacolog\u00eda, Facultad de Veterinaria, Universidad de Santiago de Compostela, 27002 Lugo, Spain., Direc\u00e7\u00e3o Regional das Pescas, Estrada da Pontinha, 9000-017 Funchal, Portugal, Instituto Nacional dos Recursos Biol\u00f3gicos, IPIMAR (INRB-IPIMAR), Av. Bras\u00edlia, s\/n, 1449-006, Lisboa, Portugal, Department of Chemistry, Graduate School of Science, Tohoku University, Sendai 980-8578, Japan., CNRS, Institut de Neurobiologie Alfred Fessard, FRC2118, Laboratoire de Neurobiologie Cellulaire et..."}]},{"given":"Sheila","family":"P\u00e9rez","sequence":"additional","affiliation":[{"name":"Departamento de Farmacolog\u00eda, Facultad de Veterinaria, Universidad de Santiago de Compostela, 27002 Lugo, Spain., Direc\u00e7\u00e3o Regional das Pescas, Estrada da Pontinha, 9000-017 Funchal, Portugal, Instituto Nacional dos Recursos Biol\u00f3gicos, IPIMAR (INRB-IPIMAR), Av. Bras\u00edlia, s\/n, 1449-006, Lisboa, Portugal, Department of Chemistry, Graduate School of Science, Tohoku University, Sendai 980-8578, Japan., CNRS, Institut de Neurobiologie Alfred Fessard, FRC2118, Laboratoire de Neurobiologie Cellulaire et..."}]},{"given":"Amparo","family":"Alfonso","sequence":"additional","affiliation":[{"name":"Departamento de Farmacolog\u00eda, Facultad de Veterinaria, Universidad de Santiago de Compostela, 27002 Lugo, Spain., Direc\u00e7\u00e3o Regional das Pescas, Estrada da Pontinha, 9000-017 Funchal, Portugal, Instituto Nacional dos Recursos Biol\u00f3gicos, IPIMAR (INRB-IPIMAR), Av. Bras\u00edlia, s\/n, 1449-006, Lisboa, Portugal, Department of Chemistry, Graduate School of Science, Tohoku University, Sendai 980-8578, Japan., CNRS, Institut de Neurobiologie Alfred Fessard, FRC2118, Laboratoire de Neurobiologie Cellulaire et..."}]},{"given":"Carmen","family":"Vale","sequence":"additional","affiliation":[{"name":"Departamento de Farmacolog\u00eda, Facultad de Veterinaria, Universidad de Santiago de Compostela, 27002 Lugo, Spain., Direc\u00e7\u00e3o Regional das Pescas, Estrada da Pontinha, 9000-017 Funchal, Portugal, Instituto Nacional dos Recursos Biol\u00f3gicos, IPIMAR (INRB-IPIMAR), Av. Bras\u00edlia, s\/n, 1449-006, Lisboa, Portugal, Department of Chemistry, Graduate School of Science, Tohoku University, Sendai 980-8578, Japan., CNRS, Institut de Neurobiologie Alfred Fessard, FRC2118, Laboratoire de Neurobiologie Cellulaire et..."}]},{"given":"Paula","family":"Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Departamento de Farmacolog\u00eda, Facultad de Veterinaria, Universidad de Santiago de Compostela, 27002 Lugo, Spain., Direc\u00e7\u00e3o Regional das Pescas, Estrada da Pontinha, 9000-017 Funchal, Portugal, Instituto Nacional dos Recursos Biol\u00f3gicos, IPIMAR (INRB-IPIMAR), Av. Bras\u00edlia, s\/n, 1449-006, Lisboa, Portugal, Department of Chemistry, Graduate School of Science, Tohoku University, Sendai 980-8578, Japan., CNRS, Institut de Neurobiologie Alfred Fessard, FRC2118, Laboratoire de Neurobiologie Cellulaire et..."}]},{"given":"Neide N.","family":"Gouveia","sequence":"additional","affiliation":[{"name":"Departamento de Farmacolog\u00eda, Facultad de Veterinaria, Universidad de Santiago de Compostela, 27002 Lugo, Spain., Direc\u00e7\u00e3o Regional das Pescas, Estrada da Pontinha, 9000-017 Funchal, Portugal, Instituto Nacional dos Recursos Biol\u00f3gicos, IPIMAR (INRB-IPIMAR), Av. Bras\u00edlia, s\/n, 1449-006, Lisboa, Portugal, Department of Chemistry, Graduate School of Science, Tohoku University, Sendai 980-8578, Japan., CNRS, Institut de Neurobiologie Alfred Fessard, FRC2118, Laboratoire de Neurobiologie Cellulaire et..."}]},{"given":"Nuno","family":"Gouveia","sequence":"additional","affiliation":[{"name":"Departamento de Farmacolog\u00eda, Facultad de Veterinaria, Universidad de Santiago de Compostela, 27002 Lugo, Spain., Direc\u00e7\u00e3o Regional das Pescas, Estrada da Pontinha, 9000-017 Funchal, Portugal, Instituto Nacional dos Recursos Biol\u00f3gicos, IPIMAR (INRB-IPIMAR), Av. Bras\u00edlia, s\/n, 1449-006, Lisboa, Portugal, Department of Chemistry, Graduate School of Science, Tohoku University, Sendai 980-8578, Japan., CNRS, Institut de Neurobiologie Alfred Fessard, FRC2118, Laboratoire de Neurobiologie Cellulaire et..."}]},{"given":"Jo\u00e3o","family":"Delgado","sequence":"additional","affiliation":[{"name":"Departamento de Farmacolog\u00eda, Facultad de Veterinaria, Universidad de Santiago de Compostela, 27002 Lugo, Spain., Direc\u00e7\u00e3o Regional das Pescas, Estrada da Pontinha, 9000-017 Funchal, Portugal, Instituto Nacional dos Recursos Biol\u00f3gicos, IPIMAR (INRB-IPIMAR), Av. Bras\u00edlia, s\/n, 1449-006, Lisboa, Portugal, Department of Chemistry, Graduate School of Science, Tohoku University, Sendai 980-8578, Japan., CNRS, Institut de Neurobiologie Alfred Fessard, FRC2118, Laboratoire de Neurobiologie Cellulaire et..."}]},{"given":"Paulo","family":"Vale","sequence":"additional","affiliation":[{"name":"Departamento de Farmacolog\u00eda, Facultad de Veterinaria, Universidad de Santiago de Compostela, 27002 Lugo, Spain., Direc\u00e7\u00e3o Regional das Pescas, Estrada da Pontinha, 9000-017 Funchal, Portugal, Instituto Nacional dos Recursos Biol\u00f3gicos, IPIMAR (INRB-IPIMAR), Av. Bras\u00edlia, s\/n, 1449-006, Lisboa, Portugal, Department of Chemistry, Graduate School of Science, Tohoku University, Sendai 980-8578, Japan., CNRS, Institut de Neurobiologie Alfred Fessard, FRC2118, Laboratoire de Neurobiologie Cellulaire et..."}]},{"given":"Masahiro","family":"Hirama","sequence":"additional","affiliation":[{"name":"Departamento de Farmacolog\u00eda, Facultad de Veterinaria, Universidad de Santiago de Compostela, 27002 Lugo, Spain., Direc\u00e7\u00e3o Regional das Pescas, Estrada da Pontinha, 9000-017 Funchal, Portugal, Instituto Nacional dos Recursos Biol\u00f3gicos, IPIMAR (INRB-IPIMAR), Av. Bras\u00edlia, s\/n, 1449-006, Lisboa, Portugal, Department of Chemistry, Graduate School of Science, Tohoku University, Sendai 980-8578, Japan., CNRS, Institut de Neurobiologie Alfred Fessard, FRC2118, Laboratoire de Neurobiologie Cellulaire et..."}]},{"given":"Yuuki","family":"Ishihara","sequence":"additional","affiliation":[{"name":"Departamento de Farmacolog\u00eda, Facultad de Veterinaria, Universidad de Santiago de Compostela, 27002 Lugo, Spain., Direc\u00e7\u00e3o Regional das Pescas, Estrada da Pontinha, 9000-017 Funchal, Portugal, Instituto Nacional dos Recursos Biol\u00f3gicos, IPIMAR (INRB-IPIMAR), Av. Bras\u00edlia, s\/n, 1449-006, Lisboa, Portugal, Department of Chemistry, Graduate School of Science, Tohoku University, Sendai 980-8578, Japan., CNRS, Institut de Neurobiologie Alfred Fessard, FRC2118, Laboratoire de Neurobiologie Cellulaire et..."}]},{"given":"Jordi","family":"Molg\u00f3","sequence":"additional","affiliation":[{"name":"Departamento de Farmacolog\u00eda, Facultad de Veterinaria, Universidad de Santiago de Compostela, 27002 Lugo, Spain., Direc\u00e7\u00e3o Regional das Pescas, Estrada da Pontinha, 9000-017 Funchal, Portugal, Instituto Nacional dos Recursos Biol\u00f3gicos, IPIMAR (INRB-IPIMAR), Av. Bras\u00edlia, s\/n, 1449-006, Lisboa, Portugal, Department of Chemistry, Graduate School of Science, Tohoku University, Sendai 980-8578, Japan., CNRS, Institut de Neurobiologie Alfred Fessard, FRC2118, Laboratoire de Neurobiologie Cellulaire et..."}]},{"given":"Luis M.","family":"Botana","sequence":"additional","affiliation":[{"name":"Departamento de Farmacolog\u00eda, Facultad de Veterinaria, Universidad de Santiago de Compostela, 27002 Lugo, Spain., Direc\u00e7\u00e3o Regional das Pescas, Estrada da Pontinha, 9000-017 Funchal, Portugal, Instituto Nacional dos Recursos Biol\u00f3gicos, IPIMAR (INRB-IPIMAR), Av. Bras\u00edlia, s\/n, 1449-006, Lisboa, Portugal, Department of Chemistry, Graduate School of Science, Tohoku University, Sendai 980-8578, Japan., CNRS, Institut de Neurobiologie Alfred Fessard, FRC2118, Laboratoire de Neurobiologie Cellulaire et..."}]}],"member":"316","published-online":{"date-parts":[[2010,6,17]]},"reference":[{"key":"ref1\/cit1","author":"Roeder K.","year":"2009","journal-title":"Toxicon"},{"key":"ref2\/cit2","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1021\/ar0301577","volume":"37","author":"Inoue M.","year":"2004","journal-title":"Acc. Chem. Res."},{"key":"ref3\/cit3","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/BF00003882","volume":"1","author":"Legrand A. M.","year":"1989","journal-title":"J.Appl. Phycol."},{"key":"ref4\/cit4","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1016\/S0041-0101(02)00146-0","volume":"40","author":"Hamilton B.","year":"2002","journal-title":"Toxicon"},{"key":"ref5\/cit5","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1080\/02652030210155378","volume":"19","author":"Pottier I.","year":"2002","journal-title":"Food Addit. Contam."},{"key":"ref6\/cit6","doi-asserted-by":"crossref","first-page":"4988","DOI":"10.1021\/ja9944204","volume":"122","author":"Yasumoto T.","year":"2000","journal-title":"J. Am. Chem. Soc."},{"key":"ref7\/cit7","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.niox.2008.03.001","volume":"19","author":"Kumar-Roine S.","year":"2008","journal-title":"Nitric Oxide"},{"key":"ref8\/cit8","unstructured":"Guzm\u00e1n-P\u00e9rez, S. E. and Park, D. L.InSeafood and Freshwater Toxins: Pharmacology, Physiology, and Detection;Botana, L. M., Ed.Marcel and Dekker:New York, 2000, pp401\u2212418."},{"key":"ref9\/cit9","doi-asserted-by":"crossref","first-page":"8929","DOI":"10.1021\/ja00206a032","volume":"111","author":"Murata M.","year":"1989","journal-title":"J. Am. Chem. Soc."},{"key":"ref10\/cit10","doi-asserted-by":"crossref","first-page":"5914","DOI":"10.1021\/ja980389e","volume":"120","author":"Lewis R. J.","year":"1998","journal-title":"J. Am. Chem. Soc."},{"key":"ref11\/cit11","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1038\/sj.bjp.0704980","volume":"137","author":"Hidalgo J.","year":"2002","journal-title":"Br. J. Pharmacol."},{"key":"ref12\/cit12","author":"Schlumberger S.","year":"2009","journal-title":"Toxicon"},{"key":"ref13\/cit13","volume-title":"X Reunion Ib\u00e9rica sobre Fitoplancton T\u00f3xico e Biotoxinas","author":"Gouveia N.","year":"2009"},{"key":"ref14\/cit14","doi-asserted-by":"crossref","first-page":"1904","DOI":"10.1126\/science.1065757","volume":"294","author":"Hirama M.","year":"2001","journal-title":"Science"},{"key":"ref15\/cit15","doi-asserted-by":"crossref","first-page":"4380","DOI":"10.1021\/ja00167a040","volume":"112","author":"Murata M.","year":"1990","journal-title":"J. Am. Chem. Soc."},{"key":"ref16\/cit16","unstructured":"Legrand, A. M., Aibara, K, Kumagai, S, and Ohtsubo, K, T, Y., Eds.The Japanese Association of Mycotoxicology:Tokyo, Japan, 1988, pp17\u221218."},{"key":"ref17\/cit17","unstructured":"Smith-Vaniz, W. F.InUnesco;Whitehead, P. J. P., Bauchot, M. L., Hureau, J. C., and Nielsen, J., E., T., Eds. 1986; Vol.II, pp815\u2212844."},{"key":"ref18\/cit18","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.toxicon.2009.03.013","volume":"54","author":"Lewis R. J.","year":"2009","journal-title":"Toxicon"},{"key":"ref19\/cit19","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/0736-5748(89)90050-6","volume":"7","author":"Schousboe I.","year":"1989","journal-title":"Int. J. Dev. Neurosci."},{"key":"ref20\/cit20","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1046\/j.1475-1313.1998.00360.x","volume":"18","author":"Vale J.","year":"1998","journal-title":"Ophthalmic Physiol. Opt."},{"key":"ref21\/cit21","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/S0041-0101(02)00276-3","volume":"41","author":"Vale P.","year":"2003","journal-title":"Toxicon"},{"key":"ref22\/cit22","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1038\/sj.bjp.0707389","volume":"152","author":"Vale C.","year":"2007","journal-title":"Br. J. Pharmacol."},{"key":"ref23\/cit23","doi-asserted-by":"crossref","first-page":"1912","DOI":"10.1523\/JNEUROSCI.20-05-01912.2000","volume":"20","author":"Vale C.","year":"2000","journal-title":"Eur J Neurosc"},{"key":"ref24\/cit24","doi-asserted-by":"crossref","first-page":"2394","DOI":"10.1046\/j.1460-9568.2002.02302.x","volume":"16","author":"Vale C.","year":"2002","journal-title":"Eur J Neurosci."},{"key":"ref25\/cit25","doi-asserted-by":"crossref","first-page":"2831","DOI":"10.1152\/jn.00261.2004","volume":"92","author":"Afshari F. S.","year":"2004","journal-title":"J. Neurophysiol."},{"key":"ref26\/cit26","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1113\/jphysiol.2005.097022","volume":"569","author":"Osorio N.","year":"2005","journal-title":"J. Physiol."},{"key":"ref27\/cit27","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1016\/S0041-0101(02)00088-0","volume":"40","author":"Pottier I.","year":"2002","journal-title":"Toxicon"},{"key":"ref28\/cit28","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S0041-0101(96)00132-8","volume":"35","author":"Lewis R. J.","year":"1997","journal-title":"Toxicon"},{"key":"ref29\/cit29","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.taap.2004.08.020","volume":"204","author":"Birinyi-Strachan L. C.","year":"2005","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref30\/cit30","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1093\/chemse\/bjl008","volume":"31","author":"Ghiaroni V.","year":"2006","journal-title":"Chem. Senses"},{"key":"ref31\/cit31","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1038\/sj.bjp.0705852","volume":"142","author":"Yamaoka K.","year":"2004","journal-title":"Br. J. Pharmacol."},{"key":"ref32\/cit32","doi-asserted-by":"crossref","first-page":"5622","DOI":"10.1021\/ac800769e","volume":"80","author":"Rodriguez P.","year":"2008","journal-title":"Anal. Chem."},{"key":"ref33\/cit33","doi-asserted-by":"crossref","first-page":"6153","DOI":"10.1021\/ac060250j","volume":"78","author":"Ciminiello P.","year":"2006","journal-title":"Anal. Chem."},{"key":"ref34\/cit34","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/j.toxicon.2007.10.016","volume":"51","author":"Aligizaki K.","year":"2008","journal-title":"Toxicon"},{"key":"ref35\/cit35","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1080\/15563650701502865","volume":"45","author":"Bentur Y.","year":"2007","journal-title":"Clin. Toxicol."},{"key":"ref36\/cit36","first-page":"75","volume":"9","author":"Aligizaki K.","year":"2008","journal-title":"J. Biol. Res. (Thessaloniki, Greece)"},{"key":"ref37\/cit37","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1515\/BOT.2003.048","volume":"46","author":"Maclean C.","year":"2003","journal-title":"Bot. Mar."},{"key":"ref38\/cit38","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1080\/09541449710001719325","volume":"32","author":"Jensen M.","year":"1997","journal-title":"Eur. J. Phycol."},{"key":"ref39\/cit39","doi-asserted-by":"crossref","first-page":"1981","DOI":"10.3201\/eid1112.050393","volume":"11","author":"P\u00e9rez-Arellano J. L.","year":"2005","journal-title":"Emerging Infect. Dis."},{"key":"ref40\/cit40","author":"Stewart I.","year":"2009","journal-title":"Toxicon"},{"key":"ref41\/cit41","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.toxicon.2005.04.006","volume":"46","author":"Dechraoui M. Y.","year":"2005","journal-title":"Toxicon"},{"key":"ref42\/cit42","first-page":"333","volume":"37","author":"Rhodes L. L.","year":"2009","journal-title":"Toxicon"},{"key":"ref43\/cit43","author":"Dickey R. W.","year":"2009","journal-title":"Toxicon"},{"key":"ref44\/cit44","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/S0168-1605(00)00382-2","volume":"61","author":"Lehane L.","year":"2000","journal-title":"Int. J. Food Microbiol."},{"key":"ref45\/cit45","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1080\/20026491051695","volume":"10","author":"Landsberg J. H.","year":"2002","journal-title":"Rev. Fish. Sci."},{"key":"ref46\/cit46","unstructured":"Lewis, R. J., Molg\u00f3, J., and Adams, D. J.InSeafood and Freshwater Toxins: Pharmacology, Physiology, and Detection;Botana, L. M., Ed.Marcel Dekker:New York, 2000; pp419\u2212447."},{"key":"ref47\/cit47","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.jchromb.2008.02.020","volume":"865","author":"Alfonso C","year":"2008","journal-title":"J Chromatogr B"},{"key":"ref48\/cit48","author":"Otero P.","year":"2010","journal-title":"Biomed. Chromatogr."},{"key":"ref49\/cit49","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1016\/j.toxicon.2007.02.002","volume":"49","author":"Villar-Gonz\u00e1lez A.","year":"2007","journal-title":"Toxicon"},{"key":"ref50\/cit50","author":"Hamilton B.","year":"2009","journal-title":"Toxicon"},{"key":"ref51\/cit51","doi-asserted-by":"crossref","unstructured":"Dickey, R. W.InSeafood and Freshwater Toxins;LM, B., Ed.New York, 2008; pp479\u2212500.","DOI":"10.1201\/9781420007541.ch22"}],"container-title":["Analytical Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/ac100516q","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,21]],"date-time":"2023-03-21T06:27:21Z","timestamp":1679380041000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/ac100516q"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,6,17]]},"references-count":51,"journal-issue":{"issue":"14","published-print":{"date-parts":[[2010,7,15]]}},"alternative-id":["10.1021\/ac100516q"],"URL":"https:\/\/doi.org\/10.1021\/ac100516q","relation":{},"ISSN":["0003-2700","1520-6882"],"issn-type":[{"value":"0003-2700","type":"print"},{"value":"1520-6882","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,6,17]]}}}