{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T03:35:55Z","timestamp":1793072155954,"version":"4.5.0"},"reference-count":22,"publisher":"American Chemical Society (ACS)","license":[{"start":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T00:00:00Z","timestamp":1792800000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T00:00:00Z","timestamp":1792800000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T00:00:00Z","timestamp":1792800000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100004387","name":"Ningbo University","doi-asserted-by":"publisher","award":["215432000282"],"award-info":[{"award-number":["215432000282"]}],"id":[{"id":"10.13039\/501100004387","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22174080"],"award-info":[{"award-number":["22174080"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Public Welfare Science and Technology Project of Ningbo","award":["2021S087"],"award-info":[{"award-number":["2021S087"]}]},{"name":"Ningbo Top Talent Project","award":["215432094250"],"award-info":[{"award-number":["215432094250"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Resolving spectral crowding in complex biological matrices remains a formidable challenge in 19F NMR spectroscopy. Herein, we propose a \u201cchemical dimensionality extension\u201d strategy designed to overcome the inherent trade-off between data acquisition speed and spectral resolution. Through the rational design of a multiplex probe containing three chemically nonequivalent fluorine nuclei, we project the identity of a single analyte into a unique set of spatial coordinates within a pseudo-three-dimensional chemical shift space (\u03b4F1, \u03b4F2, \u03b4F3). Remarkably, this high-dimensional fingerprinting is fully realized through a rapid, standard, one-dimensional 19F NMR experiment. This chemical multiplex encoding approach exponentially increases peak capacity and effectively deconvolutes severely overlapping signals, circumventing the need for time-consuming multidimensional pulse sequences. The probe exhibits an exceptionally broad chemical shift window and high quantitative sensitivity, with a limit of detection of 0.8 \u03bcM of dopamine. To demonstrate its practical utility, we achieved the accurate quantification of dopamine (R2 = 0.999) and directly confirmed 17 endogenous amino acids from a highly congested crude extract of Ophiopogon japonicus. Ultimately, this study delivers a robust, high-throughput chemical tool for the high-resolution profiling of amine-containing metabolites, signifying a paradigm shift in NMR resolution enhancement from physical instrumentation to rational chemical design.<\/jats:p>","DOI":"10.1021\/acs.analchem.6c05927","type":"journal-article","created":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T13:02:22Z","timestamp":1792846942000},"source":"Crossref","is-referenced-by-count":0,"title":["Achieving Three-Dimensional Resolution in One-Dimensional Time: Multiplex 19F Chemical Shift Encoding for Profiling Amines in Complex Mixtures"],"prefix":"10.1021","author":[{"given":"Zijie","family":"Su","sequence":"first","affiliation":[{"name":"Ningbo University , ,","place":["Ningbo, China, 315211"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang","family":"Li","sequence":"additional","affiliation":[{"name":"Ningbo University , ,","place":["Ningbo, China, 315211"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xijian","family":"Wu","sequence":"additional","affiliation":[{"name":"Ningbo University , ,","place":["Ningbo, China, 315211"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2407-949X","authenticated-orcid":true,"given":"Shaohua","family":"Huang","sequence":"additional","affiliation":[{"name":"Ningbo University , ,","place":["Ningbo, China, 315211"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,10,24]]},"reference":[{"issue":"1","key":"2026102409021683600_cit1","doi-asserted-by":"publisher","first-page":"6832","DOI":"10.1038\/s41467-025-62110-4","article-title":"Multivariate metal-organic frameworks enable chemical shift-encoded MRI with femtomolar sensitivity for biological systems","volume":"16","author":"Zeng","year":"2025","journal-title":"Nat. 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