{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T20:29:25Z","timestamp":1760646565873,"version":"3.37.3"},"reference-count":64,"publisher":"American Chemical Society (ACS)","issue":"51","funder":[{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["UID\/DTP\/04138\/2013"],"award-info":[{"award-number":["UID\/DTP\/04138\/2013"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biochemistry"],"published-print":{"date-parts":[[2016,12,27]]},"DOI":"10.1021\/acs.biochem.6b00759","type":"journal-article","created":{"date-parts":[[2016,11,30]],"date-time":"2016-11-30T18:02:41Z","timestamp":1480528961000},"page":"7086-7098","source":"Crossref","is-referenced-by-count":5,"title":["Unveiling the Pathogenic Molecular Mechanisms of the Most Common Variant (p.K329E) in Medium-Chain Acyl-CoA Dehydrogenase Deficiency by <i>in Vitro<\/i> and <i>in Silico<\/i> Approaches"],"prefix":"10.1021","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3863-3033","authenticated-orcid":true,"given":"C\u00e1tia A.","family":"Bonito","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Human Biology, \u00a7Medicinal Chemistry,\rResearch Institute\rfor Medicines, iMed.ULisboa, \u2021Metabolism and Genetics Group, Research Institute\rfor Medicines, iMed.ULisboa,  and \u2225Department of Pharmaceutical Chemistry and\rTherapeutics, Faculty of Pharmacy, Universidade de Lisboa, Av. Prof.\rGama Pinto, 1649-003 Lisboa, Portugal"}]},{"given":"Joana","family":"Nunes","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Human Biology, \u00a7Medicinal Chemistry,\rResearch Institute\rfor Medicines, iMed.ULisboa, \u2021Metabolism and Genetics Group, Research Institute\rfor Medicines, iMed.ULisboa,  and \u2225Department of Pharmaceutical Chemistry and\rTherapeutics, Faculty of Pharmacy, Universidade de Lisboa, Av. Prof.\rGama Pinto, 1649-003 Lisboa, Portugal"}]},{"given":"Jo\u00e3o","family":"Leandro","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Human Biology, \u00a7Medicinal Chemistry,\rResearch Institute\rfor Medicines, iMed.ULisboa, \u2021Metabolism and Genetics Group, Research Institute\rfor Medicines, iMed.ULisboa,  and \u2225Department of Pharmaceutical Chemistry and\rTherapeutics, Faculty of Pharmacy, Universidade de Lisboa, Av. Prof.\rGama Pinto, 1649-003 Lisboa, Portugal"}]},{"given":"Filipa","family":"Louro","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Human Biology, \u00a7Medicinal Chemistry,\rResearch Institute\rfor Medicines, iMed.ULisboa, \u2021Metabolism and Genetics Group, Research Institute\rfor Medicines, iMed.ULisboa,  and \u2225Department of Pharmaceutical Chemistry and\rTherapeutics, Faculty of Pharmacy, Universidade de Lisboa, Av. Prof.\rGama Pinto, 1649-003 Lisboa, Portugal"}]},{"given":"Paula","family":"Leandro","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Human Biology, \u00a7Medicinal Chemistry,\rResearch Institute\rfor Medicines, iMed.ULisboa, \u2021Metabolism and Genetics Group, Research Institute\rfor Medicines, iMed.ULisboa,  and \u2225Department of Pharmaceutical Chemistry and\rTherapeutics, Faculty of Pharmacy, Universidade de Lisboa, Av. Prof.\rGama Pinto, 1649-003 Lisboa, Portugal"}]},{"given":"F\u00e1tima V.","family":"Ventura","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Human Biology, \u00a7Medicinal Chemistry,\rResearch Institute\rfor Medicines, iMed.ULisboa, \u2021Metabolism and Genetics Group, Research Institute\rfor Medicines, iMed.ULisboa,  and \u2225Department of Pharmaceutical Chemistry and\rTherapeutics, Faculty of Pharmacy, Universidade de Lisboa, Av. Prof.\rGama Pinto, 1649-003 Lisboa, Portugal"}]},{"given":"Rita C.","family":"Guedes","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Human Biology, \u00a7Medicinal Chemistry,\rResearch Institute\rfor Medicines, iMed.ULisboa, \u2021Metabolism and Genetics Group, Research Institute\rfor Medicines, iMed.ULisboa,  and \u2225Department of Pharmaceutical Chemistry and\rTherapeutics, Faculty of Pharmacy, Universidade de Lisboa, Av. Prof.\rGama Pinto, 1649-003 Lisboa, Portugal"}]}],"member":"316","published-online":{"date-parts":[[2016,12,15]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1007\/s10545-008-0990-y"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.16.7523"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1046\/j.1432-1033.2003.03948.x"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1093\/jb\/mvg143"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymgme.2005.09.020"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1007\/s10545-010-9115-5"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1111\/cge.12227"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-physiol-021115-105045"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1007\/s10545-006-0292-1"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymgme.2012.03.018"},{"volume-title":"Gene Reviews","year":"2015","author":"Matern D.","key":"ref11\/cit11"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.17.10284"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1016\/0925-4439(93)90068-C"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddp079"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1097\/01.gim.0000204472.25153.8d"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1006\/bmmb.1994.1031"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1007\/s10545-014-9732-5"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1997.00548.x"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0093852"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1111\/cbdd.12755"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1016\/j.pep.2004.06.021"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(76)90527-3"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1016\/0307-4412(91)90060-L"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1021\/bi048135v"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2007.321"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1007\/s00249-009-0403-7"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1021\/bi9607867"},{"volume-title":"Molecular Operating Environment (MOE)","year":"2016","key":"ref28\/cit28"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1016\/S0010-4655(99)00540-8"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1021\/jp984217f"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.20090"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1016\/0010-4655(95)00042-E"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1007\/s008940100045"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1021\/ct700301q"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.20291"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1021\/ct200196m"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1007\/s10822-014-9713-7"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1107\/S0907444904011679"},{"key":"ref39\/cit39","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1007\/978-94-015-7658-1_21","volume-title":"Intermolecular Forces","author":"Berendsen H. J. C.","year":"1981"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1063\/1.2408420"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1103\/PhysRevA.31.1695"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1080\/00268978300102851"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1063\/1.328693"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-987X(199709)18:12<1463::AID-JCC4>3.3.CO;2-L"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1021\/ct700200b"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.540130805"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1063\/1.464397"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1063\/1.470117"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gku1028"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1002\/bip.360221211"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btr168"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1021\/cr900095e"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1107\/S0907444993011333"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpc.2013.07.018"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1021\/ci500020m"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.181342398"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1021\/jp0572535"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.1016\/0263-7855(96)00018-5"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.3390\/ijms17010077"},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.1002\/humu.21310"},{"key":"ref61\/cit61","doi-asserted-by":"publisher","DOI":"10.1063\/1.1320826"},{"key":"ref62\/cit62","doi-asserted-by":"publisher","DOI":"10.1038\/379055a0"},{"key":"ref63\/cit63","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2011.09.009"},{"key":"ref64\/cit64","doi-asserted-by":"publisher","DOI":"10.1110\/ps.03504104"}],"container-title":["Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.biochem.6b00759","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,23]],"date-time":"2023-04-23T19:06:32Z","timestamp":1682276792000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.biochem.6b00759"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12,15]]},"references-count":64,"journal-issue":{"issue":"51","published-print":{"date-parts":[[2016,12,27]]}},"alternative-id":["10.1021\/acs.biochem.6b00759"],"URL":"https:\/\/doi.org\/10.1021\/acs.biochem.6b00759","relation":{},"ISSN":["0006-2960","1520-4995"],"issn-type":[{"type":"print","value":"0006-2960"},{"type":"electronic","value":"1520-4995"}],"subject":[],"published":{"date-parts":[[2016,12,15]]}}}