{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T15:15:43Z","timestamp":1759936543523,"version":"3.37.3"},"reference-count":58,"publisher":"American Chemical Society (ACS)","issue":"8","funder":[{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["SFRH\/BD\/74174\/2010","UID\/EQU\/00511\/2013"],"award-info":[{"award-number":["SFRH\/BD\/74174\/2010","UID\/EQU\/00511\/2013"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"crossref","award":["UID\/EQU\/00511\/2013"],"award-info":[{"award-number":["UID\/EQU\/00511\/2013"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Crystal Growth & Design"],"published-print":{"date-parts":[[2016,8,3]]},"DOI":"10.1021\/acs.cgd.6b00334","type":"journal-article","created":{"date-parts":[[2016,7,5]],"date-time":"2016-07-05T15:45:40Z","timestamp":1467733540000},"page":"4285-4291","source":"Crossref","is-referenced-by-count":4,"title":["The Finding of Nondissolving Lysozyme Crystals and Its Significance for the Study of Hard-to-Crystallize Biological Macromolecules"],"prefix":"10.1021","volume":"16","author":[{"given":"Cec\u00edlia","family":"Ferreira","sequence":"first","affiliation":[{"name":"LEPABE,\rLaborat\u00f3rio de Engenharia de Processos, Ambiente, Biotecnologia\re Energia, Departamento de Engenharia Qu\u00edmica, Faculdade de Engenharia da Universidade do Porto, Rua Dr. Roberto Frias, 4200-465 Porto, Portugal"}]},{"given":"Fernando A.","family":"Rocha","sequence":"additional","affiliation":[{"name":"LEPABE,\rLaborat\u00f3rio de Engenharia de Processos, Ambiente, Biotecnologia\re Energia, Departamento de Engenharia Qu\u00edmica, Faculdade de Engenharia da Universidade do Porto, Rua Dr. Roberto Frias, 4200-465 Porto, Portugal"}]},{"given":"Ana M.","family":"Damas","sequence":"additional","affiliation":[{"name":"ICBAS\r\u2212 Instituto de Ci\u00eancias Biom\u00e9dicas Abel Salazar, Universidade do Porto, Porto, Portugal"}]},{"given":"Pedro M.","family":"Martins","sequence":"additional","affiliation":[{"name":"LEPABE,\rLaborat\u00f3rio de Engenharia de Processos, Ambiente, Biotecnologia\re Energia, Departamento de Engenharia Qu\u00edmica, Faculdade de Engenharia da Universidade do Porto, Rua Dr. Roberto Frias, 4200-465 Porto, Portugal"},{"name":"ICBAS\r\u2212 Instituto de Ci\u00eancias Biom\u00e9dicas Abel Salazar, Universidade do Porto, Porto, Portugal"}]}],"member":"316","published-online":{"date-parts":[[2016,7,21]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1111\/febs.12580"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1107\/S2053230X1401262X"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1107\/S2053230X13033141"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1002\/pro.2423"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1016\/j.sbi.2013.03.003"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1016\/j.sbi.2011.07.005"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1021\/cg3017003"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1107\/S2053230X14011601"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1016\/j.aca.2013.04.064"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1021\/cg1013768"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2014.109"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1107\/S2053230X14015507"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1021\/cg401668z"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1107\/S0021889810040951"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1039\/c0ce00550a"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1021\/cg8006958"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1126\/science.1150609"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1016\/j.str.2004.03.008"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1016\/S1047-8477(03)00041-8"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1107\/S2053230X15024619"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbiomolbio.2009.12.006"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1021\/je980316a"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-0248(01)01052-1"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1021\/cg900113e"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1021\/cg900919w"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1021\/acs.cgd.5b00821"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1517\/14712598.4.3.301"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1002\/crat.201500057"},{"key":"ref29\/cit29","doi-asserted-by":"crossref","DOI":"10.1142\/5172","volume-title":"Crystal Growth for Beginners: Fundamentals of Nucleation, Crystal Growth and Epitaxy","author":"Markov I. V.","year":"2003"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2006.07.011"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1016\/S0968-0004(01)01938-7"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M115.699348"},{"key":"ref33\/cit33","unstructured":"Crespo, R.; Villar-Alvarez, E.; Taboada, P.; Rocha, F. A.; Damas, A. M.; Martins, P. M.The availability of soluble amyloidogenic protein is decreased in the presence of insoluble off-pathway aggregates, 2016."},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrysgro.2013.01.016"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1021\/cg201354s"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2744(69)90397-0"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1016\/0022-0248(86)90175-2"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1016\/j.susc.2006.01.042"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1039\/C0CE00390E"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2004.02.009"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfa.2007.12.031"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1107\/S2053230X16000030"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1021\/la102960m"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.375345"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymeth.2004.03.021"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1016\/j.ab.2006.07.027"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1107\/S2053230X15012662"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1107\/S1744309112051858"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1107\/S0907444902014610"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1107\/S0021889802013973"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1021\/cg301531f"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1021\/cg101364m"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1021\/cg060696t"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbiomolbio.2009.12.002"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1021\/cg400231g"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1107\/S2053230X14019670"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1107\/S2059798315024687"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.1039\/b819362b"}],"container-title":["Crystal Growth & Design"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.cgd.6b00334","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,22]],"date-time":"2023-04-22T19:51:11Z","timestamp":1682193071000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.cgd.6b00334"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7,21]]},"references-count":58,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2016,8,3]]}},"alternative-id":["10.1021\/acs.cgd.6b00334"],"URL":"https:\/\/doi.org\/10.1021\/acs.cgd.6b00334","relation":{},"ISSN":["1528-7483","1528-7505"],"issn-type":[{"type":"print","value":"1528-7483"},{"type":"electronic","value":"1528-7505"}],"subject":[],"published":{"date-parts":[[2016,7,21]]}}}