{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T15:32:48Z","timestamp":1778081568764,"version":"3.51.4"},"reference-count":142,"publisher":"American Chemical Society (ACS)","issue":"6","license":[{"start":{"date-parts":[[2024,5,17]],"date-time":"2024-05-17T00:00:00Z","timestamp":1715904000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda??o para a Ci?ncia e a Tecnologia","doi-asserted-by":"publisher","award":["DSAIPA\/DS\/0118\/2020"],"award-info":[{"award-number":["DSAIPA\/DS\/0118\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda??o para a Ci?ncia e a Tecnologia","doi-asserted-by":"publisher","award":["LA\/P\/0058\/2020"],"award-info":[{"award-number":["LA\/P\/0058\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda??o para a Ci?ncia e a Tecnologia","doi-asserted-by":"publisher","award":["SFRH\/BD\/144966\/2019"],"award-info":[{"award-number":["SFRH\/BD\/144966\/2019"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda??o para a Ci?ncia e a Tecnologia","doi-asserted-by":"publisher","award":["UIDB\/04539\/2020"],"award-info":[{"award-number":["UIDB\/04539\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda??o para a Ci?ncia e a Tecnologia","doi-asserted-by":"publisher","award":["UIDP\/04539\/2020"],"award-info":[{"award-number":["UIDP\/04539\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chem. Res. Toxicol."],"published-print":{"date-parts":[[2024,6,17]]},"DOI":"10.1021\/acs.chemrestox.3c00352","type":"journal-article","created":{"date-parts":[[2024,5,17]],"date-time":"2024-05-17T16:05:57Z","timestamp":1715961957000},"page":"827-849","source":"Crossref","is-referenced-by-count":95,"title":["Advancing Drug Safety in Drug Development: Bridging Computational Predictions for Enhanced Toxicity Prediction"],"prefix":"10.1021","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-2595-6662","authenticated-orcid":true,"given":"Ana M. B.","family":"Amorim","sequence":"first","affiliation":[{"name":"Department of Life Sciences, University of Coimbra, Cal\u00e7ada Martim de Freitas, 3000-456 Coimbra, Portugal"},{"name":"CNC-UC\u2500Center for Neuroscience and Cell Biology, University of Coimbra, Cal\u00e7ada Martim de Freitas, 3000-456 Coimbra, Portugal"},{"name":"CIBB\u2500Centre for Innovative Biomedicine and Biotechnology, University of Coimbra, Cal\u00e7ada Martim de Freitas, 3000-456 Coimbra, Portugal"},{"name":"PhD Programme in Biosciences, Department of Life Sciences, University of Coimbra, Cal\u00e7ada Martim de Freitas, 3000-456 Coimbra, Portugal"},{"name":"PURR.AI, Rua Pedro Nunes, IPN Incubadora, Ed C, 3030-199 Coimbra, Portugal"}]},{"given":"Luiz F.","family":"Piochi","sequence":"additional","affiliation":[{"name":"Department of Life Sciences, University of Coimbra, Cal\u00e7ada Martim de Freitas, 3000-456 Coimbra, Portugal"},{"name":"CNC-UC\u2500Center for Neuroscience and Cell Biology, University of Coimbra, Cal\u00e7ada Martim de Freitas, 3000-456 Coimbra, Portugal"},{"name":"CIBB\u2500Centre for Innovative Biomedicine and Biotechnology, University of Coimbra, Cal\u00e7ada Martim de Freitas, 3000-456 Coimbra, Portugal"}]},{"given":"Ana T.","family":"Gaspar","sequence":"additional","affiliation":[{"name":"Department of Life Sciences, University of Coimbra, Cal\u00e7ada Martim de Freitas, 3000-456 Coimbra, Portugal"},{"name":"CNC-UC\u2500Center for Neuroscience and Cell Biology, University of Coimbra, Cal\u00e7ada Martim de Freitas, 3000-456 Coimbra, Portugal"},{"name":"CIBB\u2500Centre for Innovative Biomedicine and Biotechnology, University of Coimbra, Cal\u00e7ada Martim de Freitas, 3000-456 Coimbra, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4203-2230","authenticated-orcid":true,"given":"Ant\u00f3nio J.","family":"Preto","sequence":"additional","affiliation":[{"name":"CNC-UC\u2500Center for Neuroscience and Cell Biology, University of Coimbra, Cal\u00e7ada Martim de Freitas, 3000-456 Coimbra, Portugal"},{"name":"CIBB\u2500Centre for Innovative Biomedicine and Biotechnology, University of Coimbra, Cal\u00e7ada Martim de Freitas, 3000-456 Coimbra, Portugal"},{"name":"PhD Programme in Experimental Biology and Biomedicine, Institute for Interdisciplinary Research (IIIUC), University of Coimbra, Casa Costa Alem\u00e3o, 3030-789 Coimbra, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7225-9287","authenticated-orcid":true,"given":"N\u00edcia","family":"Ros\u00e1rio-Ferreira","sequence":"additional","affiliation":[{"name":"CNC-UC\u2500Center for Neuroscience and Cell Biology, University of Coimbra, Cal\u00e7ada Martim de Freitas, 3000-456 Coimbra, Portugal"},{"name":"CIBB\u2500Centre for Innovative Biomedicine and Biotechnology, University of Coimbra, Cal\u00e7ada Martim de Freitas, 3000-456 Coimbra, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2970-5250","authenticated-orcid":true,"given":"Irina S.","family":"Moreira","sequence":"additional","affiliation":[{"name":"Department of Life Sciences, University of Coimbra, Cal\u00e7ada Martim de Freitas, 3000-456 Coimbra, Portugal"},{"name":"CNC-UC\u2500Center for Neuroscience and Cell Biology, University of Coimbra, Cal\u00e7ada Martim de Freitas, 3000-456 Coimbra, Portugal"},{"name":"CIBB\u2500Centre for Innovative Biomedicine and Biotechnology, University of Coimbra, Cal\u00e7ada Martim de Freitas, 3000-456 Coimbra, Portugal"}]}],"member":"316","published-online":{"date-parts":[[2024,5,17]]},"reference":[{"key":"ref1\/cit1","volume-title":"Protein Structure, Modelling and Applications","author":"Breda A.","year":"2007"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1080\/02648725.1996.10647923"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.22037\/ijpr.2018.2306"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1002\/prca.201800087"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2003.12.047"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1016\/b978-1-4160-3291-5.50018-4"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1016\/b978-0-12-801076-1.00019-8"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-801076-1.00002-2"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1016\/0273-2300(83)90009-0"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jcim.3c00200"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1258\/jrsm.2008.08k033"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1002\/wcms.1516"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1038\/s41416-020-01033-x"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacbts.2019.10.008"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1007\/s11030-021-10217-3"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2020.10.010"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-0716-1787-8_17"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrestox.9b00227"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1186\/s13321-020-00460-5"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfy152"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2023.108285"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btac192"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btac342"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1016\/j.yrtph.2023.105486"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.3389\/frai.2021.757780"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jcim.2c00256"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2023.e17575"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2019.01.362"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1186\/s13321-019-0383-2"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jcim.0c01164"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jcim.9b00143"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1039\/D1RA07956E"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.3390\/s22218185"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-016-0553-2"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.70.3.782"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrgentox.2019.07.004"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1039\/9781782623656-00001"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkm755"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1002\/jez.a.307"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1016\/j.comtox.2019.100096"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkac956"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.3389\/ftox.2023.1260305"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1016\/j.cotox.2023.100402"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrestox.5b00481"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.3389\/fenvs.2015.00085"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2017.07.175"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-31169-8"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkab255"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1186\/s13321-021-00557-5"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jcim.8b00685"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1186\/s12859-023-05176-5"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.0c03866"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1093\/bib\/bbab503"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2023.04.005"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrestox.3c00098"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrestox.2c00378"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrestox.2c00381"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.1016\/j.slasd.2022.12.003"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jcim.8b00769"},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.1186\/s13321-021-00541-z"},{"key":"ref61\/cit61","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btaa075"},{"key":"ref62\/cit62","doi-asserted-by":"publisher","unstructured":"Chen, T.; Guestrin, C. XGBoost: A Scalable Tree Boosting System. Proceedings of the ACM SIGKDD International Conference on Knowledge Discovery and Data Mining 2016, 13\u201317-August, 785\u201379410.1145\/2939672.2939785.","DOI":"10.1145\/2939672.2939785"},{"key":"ref63\/cit63","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btac266"},{"key":"ref64\/cit64","doi-asserted-by":"publisher","DOI":"10.1109\/ACCESS.2020.3022850"},{"key":"ref65\/cit65","doi-asserted-by":"publisher","DOI":"10.1007\/s11356-021-14028-9"},{"key":"ref66\/cit66","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrestox.2c00372"},{"key":"ref67\/cit67","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrestox.2c00385"},{"key":"ref68\/cit68","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrestox.0c00176"},{"key":"ref69\/cit69","doi-asserted-by":"publisher","DOI":"10.1063\/1.5019779"},{"key":"ref70\/cit70","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrestox.3c00032"},{"key":"ref72\/cit72","doi-asserted-by":"publisher","DOI":"10.22037\/emergency.v3i2.8154"},{"key":"ref73\/cit73","doi-asserted-by":"publisher","DOI":"10.1186\/s13040-023-00322-4"},{"key":"ref74\/cit74","doi-asserted-by":"publisher","DOI":"10.4045\/tidsskr.18.0042"},{"key":"ref75\/cit75","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.12-10598"},{"key":"ref77\/cit77","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bty593"},{"key":"ref78\/cit78","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2020.03.003"},{"key":"ref79\/cit79","doi-asserted-by":"publisher","DOI":"10.3389\/fchem.2019.00782"},{"key":"ref80\/cit80","doi-asserted-by":"publisher","DOI":"10.1093\/bib\/bbab117"},{"key":"ref81\/cit81","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-08787-9"},{"key":"ref82\/cit82","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1007129"},{"key":"ref83\/cit83","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btr500"},{"key":"ref84\/cit84","doi-asserted-by":"publisher","DOI":"10.1186\/s13321-017-0232-0"},{"key":"ref85\/cit85","doi-asserted-by":"publisher","DOI":"10.2133\/dmpk.DMPK-10-RV-062"},{"key":"ref86\/cit86","doi-asserted-by":"publisher","DOI":"10.1177\/0192623312464311"},{"key":"ref87\/cit87","doi-asserted-by":"publisher","DOI":"10.3389\/fdata.2019.00025"},{"key":"ref89\/cit89","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.2c05693"},{"key":"ref90\/cit90","doi-asserted-by":"publisher","DOI":"10.1186\/s13321-017-0209-z"},{"key":"ref91\/cit91","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btz111"},{"key":"ref92\/cit92","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2019.01243"},{"key":"ref93\/cit93","doi-asserted-by":"publisher","DOI":"10.1039\/D0RA02297G"},{"key":"ref94\/cit94","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btaa921"},{"key":"ref95\/cit95","doi-asserted-by":"publisher","DOI":"10.1039\/C8AY01396A"},{"key":"ref96\/cit96","author":"Feng Q.","year":"2018","journal-title":"arXiv [cs.LG]"},{"key":"ref97\/cit97","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20246276"},{"key":"ref98\/cit98","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-8955-3_14"},{"key":"ref99\/cit99","doi-asserted-by":"publisher","DOI":"10.1093\/bib\/bbz157"},{"key":"ref100\/cit100","doi-asserted-by":"publisher","DOI":"10.1101\/2021.09.30.462610"},{"key":"ref101\/cit101","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkx1037"},{"key":"ref102\/cit102","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkp896"},{"key":"ref103\/cit103","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkw1074"},{"key":"ref104\/cit104","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkl999"},{"key":"ref105\/cit105","doi-asserted-by":"publisher","DOI":"10.1002\/prot.20512"},{"key":"ref106\/cit106","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkv1277"},{"key":"ref107\/cit107","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.6b00491"},{"key":"ref108\/cit108","doi-asserted-by":"publisher","DOI":"10.1007\/s10822-015-9860-5"},{"key":"ref109\/cit109","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2019.05.024"},{"key":"ref110\/cit110","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkaa971"},{"key":"ref111\/cit111","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btn162"},{"key":"ref112\/cit112","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.1990"},{"key":"ref113\/cit113","doi-asserted-by":"publisher","DOI":"10.1021\/ci400709d"},{"key":"ref114\/cit114","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.530"},{"key":"ref115\/cit115","doi-asserted-by":"publisher","DOI":"10.3390\/cimb44050155"},{"key":"ref116\/cit116","doi-asserted-by":"publisher","DOI":"10.1093\/bib\/bbu010"},{"key":"ref117\/cit117","doi-asserted-by":"publisher","DOI":"10.48550\/ARXIV.1902.04166"},{"key":"ref118\/cit118","doi-asserted-by":"publisher","DOI":"10.48550\/arXiv.1908.06760"},{"key":"ref119\/cit119","doi-asserted-by":"publisher","unstructured":"Agyemang, B.; Wu, W.P.; Kpiebaareh, M. Y.; Nanor, E. Drug-Target Indication Prediction by Integrating End-to-End Learning and Fingerprints. In  2019 16th International Computer Conference on Wavelet Active Media Technology and Information Processing; IEEE, 201910.1109\/iccwamtip47768.2019.9067510.","DOI":"10.1109\/iccwamtip47768.2019.9067510"},{"key":"ref120\/cit120","doi-asserted-by":"publisher","DOI":"10.1016\/j.cels.2020.03.002"},{"key":"ref121\/cit121","doi-asserted-by":"publisher","DOI":"10.1186\/s12864-022-08648-9"},{"key":"ref122\/cit122","doi-asserted-by":"publisher","DOI":"10.26508\/lsa.201800098"},{"key":"ref123\/cit123","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymeth.2017.05.015"},{"key":"ref124\/cit124","doi-asserted-by":"publisher","DOI":"10.1080\/15287394.2021.1994492"},{"key":"ref125\/cit125","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-023-03471-x"},{"key":"ref126\/cit126","doi-asserted-by":"publisher","DOI":"10.1016\/j.drup.2022.100811"},{"key":"ref127\/cit127","doi-asserted-by":"publisher","DOI":"10.1093\/gigascience\/giac087"},{"key":"ref128\/cit128","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btad645"},{"key":"ref129\/cit129","doi-asserted-by":"publisher","DOI":"10.1186\/s13321-022-00649-w"},{"key":"ref130\/cit130","doi-asserted-by":"publisher","DOI":"10.1002\/qsar.200710043"},{"key":"ref131\/cit131","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbi.2020.103496"},{"key":"ref132\/cit132","doi-asserted-by":"publisher","DOI":"10.1016\/j.sbi.2023.102546"},{"key":"ref133\/cit133","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics11040168"},{"key":"ref134\/cit134","doi-asserted-by":"publisher","DOI":"10.1002\/psp4.12895"},{"key":"ref135\/cit135","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2021.09.013"},{"key":"ref136\/cit136","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfu246"},{"key":"ref137\/cit137","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2020.105581"},{"key":"ref138\/cit138","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24032239"},{"key":"ref139\/cit139","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfac101"},{"key":"ref140\/cit140","doi-asserted-by":"publisher","DOI":"10.3389\/fsysb.2023.1180948"},{"key":"ref141\/cit141","doi-asserted-by":"publisher","DOI":"10.1101\/2023.07.17.549292"},{"key":"ref142\/cit142","doi-asserted-by":"publisher","DOI":"10.3904\/kjim.2009.24.1.1"},{"key":"ref143\/cit143","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.115.065920"},{"key":"ref144\/cit144","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-015-1832-0"},{"key":"ref145\/cit145","unstructured":"Canadian society of pharmacology and therapeutics\n(CSPT)\u2500therapeutic\nindex. https:\/\/pharmacologycanada.org\/Therapeutic-Index (accessed 2024\u201303\u201319)."}],"container-title":["Chemical Research in Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.chemrestox.3c00352","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.chemrestox.3c00352","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,17]],"date-time":"2024-06-17T08:09:39Z","timestamp":1718611779000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.chemrestox.3c00352"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,17]]},"references-count":142,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,6,17]]}},"alternative-id":["10.1021\/acs.chemrestox.3c00352"],"URL":"https:\/\/doi.org\/10.1021\/acs.chemrestox.3c00352","relation":{},"ISSN":["0893-228X","1520-5010"],"issn-type":[{"value":"0893-228X","type":"print"},{"value":"1520-5010","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,17]]}}}