{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T09:09:51Z","timestamp":1775812191407,"version":"3.50.1"},"reference-count":76,"publisher":"American Chemical Society (ACS)","issue":"2","license":[{"start":{"date-parts":[[2022,12,29]],"date-time":"2022-12-29T00:00:00Z","timestamp":1672272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,12,29]],"date-time":"2022-12-29T00:00:00Z","timestamp":1672272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,12,29]],"date-time":"2022-12-29T00:00:00Z","timestamp":1672272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","award":["0725_NOR_WATER_1_P"],"award-info":[{"award-number":["0725_NOR_WATER_1_P"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011033","name":"Agencia Estatal de Investigaci?n","doi-asserted-by":"publisher","award":["PID2020117686RB-C32"],"award-info":[{"award-number":["PID2020117686RB-C32"]}],"id":[{"id":"10.13039\/501100011033","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010801","name":"Xunta de Galicia","doi-asserted-by":"publisher","award":["ED431C 2021\/06"],"award-info":[{"award-number":["ED431C 2021\/06"]}],"id":[{"id":"10.13039\/501100010801","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda??o para a Ci?ncia e a Tecnologia","doi-asserted-by":"publisher","award":["2022.02922.PTDC"],"award-info":[{"award-number":["2022.02922.PTDC"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda??o para a Ci?ncia e a Tecnologia","doi-asserted-by":"publisher","award":["2022.02925.CEECIND"],"award-info":[{"award-number":["2022.02925.CEECIND"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda??o para a Ci?ncia e a Tecnologia","doi-asserted-by":"publisher","award":["2022.1276.BD"],"award-info":[{"award-number":["2022.1276.BD"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda??o para a Ci?ncia e a Tecnologia","doi-asserted-by":"publisher","award":["DFA\/BD\/6218\/2020"],"award-info":[{"award-number":["DFA\/BD\/6218\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda??o para a Ci?ncia e a Tecnologia","doi-asserted-by":"publisher","award":["LA\/P\/0126\/2020"],"award-info":[{"award-number":["LA\/P\/0126\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda??o para a Ci?ncia e a Tecnologia","doi-asserted-by":"publisher","award":["PD\/BD\/143090\/2018"],"award-info":[{"award-number":["PD\/BD\/143090\/2018"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda??o para a Ci?ncia e a Tecnologia","doi-asserted-by":"publisher","award":["SFRH\/BD\/139762\/2018"],"award-info":[{"award-number":["SFRH\/BD\/139762\/2018"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda??o para a Ci?ncia e a Tecnologia","doi-asserted-by":"publisher","award":["SFRH\/BD\/147834\/2019"],"award-info":[{"award-number":["SFRH\/BD\/147834\/2019"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda??o para a Ci?ncia e a Tecnologia","doi-asserted-by":"publisher","award":["UIDB\/04033\/2020"],"award-info":[{"award-number":["UIDB\/04033\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda??o para a Ci?ncia e a Tecnologia","doi-asserted-by":"publisher","award":["UIDB\/04423\/2020"],"award-info":[{"award-number":["UIDB\/04423\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda??o para a Ci?ncia e a Tecnologia","doi-asserted-by":"publisher","award":["UIDP\/04423\/2020"],"award-info":[{"award-number":["UIDP\/04423\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Environ. Sci. Technol."],"published-print":{"date-parts":[[2023,1,17]]},"DOI":"10.1021\/acs.est.2c05719","type":"journal-article","created":{"date-parts":[[2022,12,29]],"date-time":"2022-12-29T18:39:48Z","timestamp":1672339188000},"page":"1049-1059","source":"Crossref","is-referenced-by-count":19,"title":["Are Fish Populations at Risk? Metformin Disrupts Zebrafish Development and Reproductive Processes at Chronic Environmentally Relevant Concentrations"],"prefix":"10.1021","volume":"57","author":[{"given":"Susana","family":"Barros","sequence":"first","affiliation":[{"name":"CIIMAR\u2500Interdisciplinary Centre of Marine and Environmental Research, Endocrine Disruptors and Emerging Contaminants Group, University of Porto, Avenida General Norton de Matos, S\/N, 4450-208 Matosinhos, Portugal"},{"name":"CITAB - Centre for the Research and Technology of Agro-Environmental and Biological Sciences, University of Tr\u00e1s-os-Montes and Alto Douro (UTAD), Quinta de Prados, Pavilh\u00e3o 2, 5000-801 Vila Real, Portugal"}]},{"given":"N\u00e9lson","family":"Alves","sequence":"additional","affiliation":[{"name":"CIIMAR\u2500Interdisciplinary Centre of Marine and Environmental Research, Endocrine Disruptors and Emerging Contaminants Group, University of Porto, Avenida General Norton de Matos, S\/N, 4450-208 Matosinhos, Portugal"},{"name":"FCUP - Department of Biology, Faculty of Sciences, University of Porto (U. Porto), Rua do Campo Alegre s\/n, 4169-007 Porto, Portugal"}]},{"given":"Marlene","family":"Pinheiro","sequence":"additional","affiliation":[{"name":"CIIMAR\u2500Interdisciplinary Centre of Marine and Environmental Research, Endocrine Disruptors and Emerging Contaminants Group, University of Porto, Avenida General Norton de Matos, S\/N, 4450-208 Matosinhos, Portugal"},{"name":"FCUP - Department of Biology, Faculty of Sciences, University of Porto (U. Porto), Rua do Campo Alegre s\/n, 4169-007 Porto, Portugal"}]},{"given":"Marta","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"CIIMAR\u2500Interdisciplinary Centre of Marine and Environmental Research, Endocrine Disruptors and Emerging Contaminants Group, University of Porto, Avenida General Norton de Matos, S\/N, 4450-208 Matosinhos, Portugal"},{"name":"FCUP - Department of Biology, Faculty of Sciences, University of Porto (U. Porto), Rua do Campo Alegre s\/n, 4169-007 Porto, Portugal"}]},{"given":"Hugo","family":"Morais","sequence":"additional","affiliation":[{"name":"CIIMAR\u2500Interdisciplinary Centre of Marine and Environmental Research, Endocrine Disruptors and Emerging Contaminants Group, University of Porto, Avenida General Norton de Matos, S\/N, 4450-208 Matosinhos, Portugal"},{"name":"FCUP - Department of Biology, Faculty of Sciences, University of Porto (U. Porto), Rua do Campo Alegre s\/n, 4169-007 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4154-3541","authenticated-orcid":true,"given":"Rosa","family":"Montes","sequence":"additional","affiliation":[{"name":"Department of Analytical Chemistry, Nutrition and Food Sciences, IAQBUS - Institute of Research on Chemical and Biological Analysis, Universidade de Santiago de Compostela, Constantino Candeira S\/N, 15782 Santiago de Compostela, Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7100-723X","authenticated-orcid":true,"given":"Rosario","family":"Rodil","sequence":"additional","affiliation":[{"name":"Department of Analytical Chemistry, Nutrition and Food Sciences, IAQBUS - Institute of Research on Chemical and Biological Analysis, Universidade de Santiago de Compostela, Constantino Candeira S\/N, 15782 Santiago de Compostela, Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2566-8133","authenticated-orcid":true,"given":"Jos\u00e9 Benito","family":"Quintana","sequence":"additional","affiliation":[{"name":"Department of Analytical Chemistry, Nutrition and Food Sciences, IAQBUS - Institute of Research on Chemical and Biological Analysis, Universidade de Santiago de Compostela, Constantino Candeira S\/N, 15782 Santiago de Compostela, Spain"}]},{"given":"Ana M.","family":"Coimbra","sequence":"additional","affiliation":[{"name":"CITAB - Centre for the Research and Technology of Agro-Environmental and Biological Sciences, University of Tr\u00e1s-os-Montes and Alto Douro (UTAD), Quinta de Prados, Pavilh\u00e3o 2, 5000-801 Vila Real, Portugal"},{"name":"Inov4Agro \u2212 Institute for Innovation, Capacity Building and Sustainability of Agri-food Production, University of Tr\u00e1s-os-Montes and Alto Douro (UTAD), Quinta de Prados, Pavilh\u00e3o 2, 5000-801 Vila Real, Portugal"}]},{"given":"Miguel M.","family":"Santos","sequence":"additional","affiliation":[{"name":"CIIMAR\u2500Interdisciplinary Centre of Marine and Environmental Research, Endocrine Disruptors and Emerging Contaminants Group, University of Porto, Avenida General Norton de Matos, S\/N, 4450-208 Matosinhos, Portugal"},{"name":"FCUP - Department of Biology, Faculty of Sciences, University of Porto (U. Porto), Rua do Campo Alegre s\/n, 4169-007 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3314-0184","authenticated-orcid":true,"given":"Teresa","family":"Neuparth","sequence":"additional","affiliation":[{"name":"CIIMAR\u2500Interdisciplinary Centre of Marine and Environmental Research, Endocrine Disruptors and Emerging Contaminants Group, University of Porto, Avenida General Norton de Matos, S\/N, 4450-208 Matosinhos, Portugal"}]}],"member":"316","published-online":{"date-parts":[[2022,12,29]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1038\/s41574-019-0242-2"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-200565030-00005"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2022.157361"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1016\/j.yrtph.2017.12.023"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1016\/J.DIABRES.2019.107843"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1111\/pedi.12473"},{"key":"ref7\/cit7","unstructured":"WHO.  Global Report on Diabetes; 2016; Vol. 978."},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2015.12.022"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2014.05.008"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2017.10.032"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2113947119"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.2760\/01939"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.22438\/jeb\/38\/6(SI)\/06"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2018.09.031"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2015.03.060"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1186\/s12302-018-0179-4"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2018.12.084"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1016\/j.aquatox.2018.10.003"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glaa109"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1016\/j.aquatox.2009.07.021"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1787\/9789264203709-en"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1016\/j.aquatox.2015.01.013"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1016\/j.etap.2021.103716"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2021.131213"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1139\/facets-2020-0106"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1002\/etc.5054"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1021\/acs.est.2c01079"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1016\/j.aquatox.2014.07.009"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2020.106020"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1016\/j.aquatox.2022.106095"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1038\/sj.embor.7400222"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1016\/j.marenvres.2004.08.006"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2019.152249"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1897\/07-541.1"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-016-1455-7"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2014.05.015"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2016.391"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.aaf7478"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2016.06.007"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms1859"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.3390\/ijms17081298"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.4161\/cc.10.7.15210"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.1999.9396"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1242\/dev.037879"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1002\/etc.5450"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1002\/etc.2793"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1016\/0016-6480(87)90027-X"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1016\/j.anbehav.2006.03.009"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2013.01.003"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1016\/j.steroids.2015.06.011"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1210\/en.2012-1145"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1016\/j.obmed.2020.100186"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygcen.2015.12.030"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-10-141"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00310.2011"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1080\/13547500110086919"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1897\/05-683R.1"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygcen.2015.12.030"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.1016\/j.etap.2021.103588"},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2013.07.057"},{"key":"ref61\/cit61","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0182868"},{"key":"ref62\/cit62","doi-asserted-by":"publisher","DOI":"10.1021\/es4030035"},{"key":"ref63\/cit63","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2021.148306"},{"key":"ref64\/cit64","doi-asserted-by":"publisher","DOI":"10.1021\/es803103c"},{"key":"ref65\/cit65","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0197259"},{"key":"ref66\/cit66","doi-asserted-by":"publisher","DOI":"10.1021\/acs.est.1c08885"},{"key":"ref67\/cit67","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2009.03.001"},{"key":"ref68\/cit68","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2005.10.011"},{"key":"ref69\/cit69","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpc.2013.03.005"},{"key":"ref70\/cit70","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph15081648"},{"key":"ref71\/cit71","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-11-643"},{"key":"ref72\/cit72","doi-asserted-by":"publisher","DOI":"10.1002\/jez.b.21053"},{"key":"ref73\/cit73","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2020.538701"},{"key":"ref74\/cit74","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2018.10.038"},{"key":"ref75\/cit75","doi-asserted-by":"publisher","DOI":"10.1016\/j.aquatox.2017.12.003"},{"key":"ref76\/cit76","doi-asserted-by":"publisher","DOI":"10.1016\/j.aquatox.2005.09.009"}],"container-title":["Environmental Science &amp; Technology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.est.2c05719","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.est.2c05719","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,26]],"date-time":"2023-04-26T04:56:39Z","timestamp":1682484999000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.est.2c05719"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,29]]},"references-count":76,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,1,17]]}},"alternative-id":["10.1021\/acs.est.2c05719"],"URL":"https:\/\/doi.org\/10.1021\/acs.est.2c05719","relation":{},"ISSN":["0013-936X","1520-5851"],"issn-type":[{"value":"0013-936X","type":"print"},{"value":"1520-5851","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,29]]}}}