{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T06:56:21Z","timestamp":1740120981871,"version":"3.37.3"},"reference-count":44,"publisher":"American Chemical Society (ACS)","issue":"43","license":[{"start":{"date-parts":[[2019,10,10]],"date-time":"2019-10-10T00:00:00Z","timestamp":1570665600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2019,10,10]],"date-time":"2019-10-10T00:00:00Z","timestamp":1570665600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2019,10,10]],"date-time":"2019-10-10T00:00:00Z","timestamp":1570665600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","award":["NORTE-08-5369-FSE-000042"],"award-info":[{"award-number":["NORTE-08-5369-FSE-000042"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda??o para a Ci?ncia e a Tecnologia","doi-asserted-by":"publisher","award":["UID\/QUI\/50006\/2019","UID\/EQU\/00511\/2019"],"award-info":[{"award-number":["UID\/QUI\/50006\/2019","UID\/EQU\/00511\/2019"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Hovione"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ind. Eng. Chem. Res."],"published-print":{"date-parts":[[2019,10,30]]},"DOI":"10.1021\/acs.iecr.9b04023","type":"journal-article","created":{"date-parts":[[2019,10,11]],"date-time":"2019-10-11T03:18:51Z","timestamp":1570763931000},"page":"20162-20172","source":"Crossref","is-referenced-by-count":2,"title":["Quality by Statistical Control in Crystallization\u2014Assessment of Mixing Conditions and Probability of Obtaining the Desired Particle Size"],"prefix":"10.1021","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5598-337X","authenticated-orcid":true,"given":"Ameessa","family":"Tulcidas","sequence":"first","affiliation":[{"name":"LEPABE\u2014Laboratory for Process Engineering, Environment, Biotechnology and Energy, Faculty of Engineering, University of Porto, Rua Dr. Roberto Frias, 4200-465 Porto, Portugal"},{"name":"Hovione Farmaci\u00eancia SA, 2674-506 Loures, Portugal"}]},{"given":"Bruno","family":"Santos","sequence":"additional","affiliation":[{"name":"Hovione Farmaci\u00eancia SA, 2674-506 Loures, Portugal"}]},{"given":"Sylwin","family":"Pawlowski","sequence":"additional","affiliation":[{"name":"LAQV-REQUIMTE, DQ, FCT, Universidade NOVA de Lisboa, 2829-516 Caparica, Portugal"}]},{"given":"Fernando","family":"Rocha","sequence":"additional","affiliation":[{"name":"LEPABE\u2014Laboratory for Process Engineering, Environment, Biotechnology and Energy, Faculty of Engineering, University of Porto, Rua Dr. Roberto Frias, 4200-465 Porto, Portugal"}]}],"member":"316","published-online":{"date-parts":[[2019,10,10]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1021\/ie050660i"},{"key":"ref2\/cit2","doi-asserted-by":"crossref","DOI":"10.1002\/9783527650323","volume-title":"Crystallization: Basic Concepts and Industrial Applications","author":"Beckmann W.","year":"2013"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1021\/cg0503090"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1021\/cg201269c"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1021\/ie020346d"},{"key":"ref6\/cit6","volume-title":"Handbook of Industrial Crystallization","author":"Myerson A. S.","year":"2001","edition":"2"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1016\/j.reffit.2017.01.002"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1021\/cg800595v"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1021\/acs.cgd.7b01671"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.3303\/CET1757132"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1016\/0022-0248(95)00205-7"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1021\/cg501791q"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1038\/nbt0109-26"},{"key":"ref14\/cit14","unstructured":"Whitcomb, P.; Anderson, M. Using DOE with Tolerance Intervals to Verify Specifications. Presented at the 11th Annual ENBIS Conference, Coimbra, Portugal, September 2011."},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1208\/s12248-014-9598-3"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.3390\/s8010211"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1021\/op500169m"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemolab.2007.03.002"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1016\/j.trac.2012.09.007"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1021\/cg2003029"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1016\/j.seppur.2014.05.014"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1080\/10543400802278197"},{"key":"ref23\/cit23","doi-asserted-by":"crossref","DOI":"10.1201\/9781315120034","volume-title":"Statistics for Biotechnology Process Development","author":"Coffey T.","year":"2018","edition":"1"},{"key":"ref24\/cit24","unstructured":"Bohdalov\u00e1, M. \u0160lahor, L. Monte Carlo Simulations of the Multivariate Distributions with Different Marginals. Presented at Matematick\u00fd Workshop, 2007."},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1016\/j.seppur.2018.12.019"},{"volume-title":"The Pilot Plant Real Book: A Unique Handbook for the Chemical Process Industry","year":"2002","author":"McConville F. X.","key":"ref26\/cit26"},{"key":"ref27\/cit27","volume-title":"Polymorphism in Pharmaceutical Solids","volume":"192","author":"Brittain H. G.","year":"2009","edition":"2"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1016\/S0026-0657(13)70090-0"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1016\/j.seppur.2015.06.032"},{"key":"ref30\/cit30","unstructured":"Reis, M. S. Modela\u00e7\u00e3o Matem\u00e1tica de Base Estat\u00edstica\/Emp\u00edrica: Constru\u00e7\u00e3o de Modelos Emp\u00edricos Usando Metodologias de Regress\u00e3o Linear. Presented at Engenharia de Processos e Sistemas, Porto, 2017."},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.15373\/22778160"},{"key":"ref32\/cit32","unstructured":"Babu, G. J. Jackknife and Bootstrap. https:\/\/pdfs.semanticscholar.org\/a180\/ffca3b1f102a911287737de5bbab7ff2d5a5.pdf?_ga=2.36910821.43934980.1570317580-1647050504.1553989771 (accessed May 2019)."},{"key":"ref33\/cit33","volume-title":"Resampling Methods\u2014A Practical Guide to Data Analysis","author":"Good P. I.","year":"2006","edition":"3"},{"issue":"18","key":"ref34\/cit34","first-page":"59","author":"Algamal Z. Y.","year":"2010","journal-title":"Iraqi J. Stat. Sci."},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1109\/87.974338"},{"issue":"1","key":"ref36\/cit36","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1007\/BF02868568","volume":"16","author":"Siotani M.","year":"1964","journal-title":"Ann. Inst. Stat. Math."},{"key":"ref37\/cit37","volume-title":"Mathematical Statistics and Data Analysis","author":"Rice J. A.","year":"2007","edition":"3"},{"volume-title":"Probabilistic Engineering Design","year":"1983","author":"Siddall J. N.","key":"ref38\/cit38"},{"issue":"1","key":"ref39\/cit39","first-page":"89","volume":"4","author":"Bohdalov\u00e1 M.","year":"2008","journal-title":"J. Appl. Math. Stat. Informatics"},{"key":"ref40\/cit40","volume-title":"Operations Research\u2014Applications and Algorithms","author":"Winston W. L.","year":"2004","edition":"4"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1108\/S1474-7979(2009)0000020014"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.14356\/kona.2016021"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1205\/cherd06207"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1021\/op100314g"}],"container-title":["Industrial &amp; Engineering Chemistry Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.iecr.9b04023","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,15]],"date-time":"2023-04-15T02:47:07Z","timestamp":1681526827000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.iecr.9b04023"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10,10]]},"references-count":44,"journal-issue":{"issue":"43","published-print":{"date-parts":[[2019,10,30]]}},"alternative-id":["10.1021\/acs.iecr.9b04023"],"URL":"https:\/\/doi.org\/10.1021\/acs.iecr.9b04023","relation":{},"ISSN":["0888-5885","1520-5045"],"issn-type":[{"type":"print","value":"0888-5885"},{"type":"electronic","value":"1520-5045"}],"subject":[],"published":{"date-parts":[[2019,10,10]]}}}