{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T06:01:42Z","timestamp":1778047302841,"version":"3.51.4"},"reference-count":42,"publisher":"American Chemical Society (ACS)","issue":"13","license":[{"start":{"date-parts":[[2022,6,28]],"date-time":"2022-06-28T00:00:00Z","timestamp":1656374400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,6,28]],"date-time":"2022-06-28T00:00:00Z","timestamp":1656374400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,6,28]],"date-time":"2022-06-28T00:00:00Z","timestamp":1656374400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100006111","name":"Minist\u00c3\u00a9rio da Ci\u00c3\u00aancia, Tecnologia e Ensino Superior","doi-asserted-by":"publisher","award":["UIDB\/04462\/2020"],"award-info":[{"award-number":["UIDB\/04462\/2020"]}],"id":[{"id":"10.13039\/501100006111","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006111","name":"Minist\u00c3\u00a9rio da Ci\u00c3\u00aancia, Tecnologia e Ensino Superior","doi-asserted-by":"publisher","award":["UIDP\/04462\/2020"],"award-info":[{"award-number":["UIDP\/04462\/2020"]}],"id":[{"id":"10.13039\/501100006111","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Med. Chem."],"published-print":{"date-parts":[[2022,7,14]]},"DOI":"10.1021\/acs.jmedchem.2c00403","type":"journal-article","created":{"date-parts":[[2022,6,28]],"date-time":"2022-06-28T19:14:24Z","timestamp":1656443664000},"page":"9206-9229","source":"Crossref","is-referenced-by-count":60,"title":["Optimization of TEAD P-Site Binding Fragment Hit into In Vivo Active Lead <b>MSC-4106<\/b>"],"prefix":"10.1021","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9120-8410","authenticated-orcid":true,"given":"Timo","family":"Heinrich","sequence":"first","affiliation":[{"name":"Merck Healthcare KGaA, Frankfurter Str. 250, 64293 Darmstadt, Germany"}]},{"given":"Carl","family":"Peterson","sequence":"additional","affiliation":[{"name":"Merck Healthcare KGaA, Frankfurter Str. 250, 64293 Darmstadt, Germany"}]},{"given":"Richard","family":"Schneider","sequence":"additional","affiliation":[{"name":"Merck Healthcare KGaA, Frankfurter Str. 250, 64293 Darmstadt, Germany"}]},{"given":"Sakshi","family":"Garg","sequence":"additional","affiliation":[{"name":"Merck Healthcare KGaA, Frankfurter Str. 250, 64293 Darmstadt, Germany"}]},{"given":"Daniel","family":"Schwarz","sequence":"additional","affiliation":[{"name":"Merck Healthcare KGaA, Frankfurter Str. 250, 64293 Darmstadt, Germany"}]},{"given":"Jakub","family":"Gunera","sequence":"additional","affiliation":[{"name":"Merck Healthcare KGaA, Frankfurter Str. 250, 64293 Darmstadt, Germany"}]},{"given":"Anita","family":"Seshire","sequence":"additional","affiliation":[{"name":"Merck Healthcare KGaA, Frankfurter Str. 250, 64293 Darmstadt, Germany"}]},{"given":"Lisa","family":"K\u00f6tzner","sequence":"additional","affiliation":[{"name":"Merck Healthcare KGaA, Frankfurter Str. 250, 64293 Darmstadt, Germany"}]},{"given":"Sarah","family":"Schlesiger","sequence":"additional","affiliation":[{"name":"Merck Healthcare KGaA, Frankfurter Str. 250, 64293 Darmstadt, Germany"}]},{"given":"Djordje","family":"Musil","sequence":"additional","affiliation":[{"name":"Merck Healthcare KGaA, Frankfurter Str. 250, 64293 Darmstadt, Germany"}]},{"given":"Heike","family":"Schilke","sequence":"additional","affiliation":[{"name":"Merck Healthcare KGaA, Frankfurter Str. 250, 64293 Darmstadt, Germany"}]},{"given":"Benjamin","family":"Doerfel","sequence":"additional","affiliation":[{"name":"Merck Healthcare KGaA, Frankfurter Str. 250, 64293 Darmstadt, Germany"}]},{"given":"Patrizia","family":"Diehl","sequence":"additional","affiliation":[{"name":"Merck Healthcare KGaA, Frankfurter Str. 250, 64293 Darmstadt, Germany"}]},{"given":"Pia","family":"B\u00f6pple","sequence":"additional","affiliation":[{"name":"Merck Healthcare KGaA, Frankfurter Str. 250, 64293 Darmstadt, Germany"}]},{"given":"Ana R.","family":"Lemos","sequence":"additional","affiliation":[{"name":"iBET, Instituto de Biologia Experimental e Tecnol\u00f3gica, Apartado 12, Oeiras 2781-901, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6672-3610","authenticated-orcid":true,"given":"Pedro M. F.","family":"Sousa","sequence":"additional","affiliation":[{"name":"iBET, Instituto de Biologia Experimental e Tecnol\u00f3gica, Apartado 12, Oeiras 2781-901, Portugal"}]},{"given":"Filipe","family":"Freire","sequence":"additional","affiliation":[{"name":"iBET, Instituto de Biologia Experimental e Tecnol\u00f3gica, Apartado 12, Oeiras 2781-901, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6089-6089","authenticated-orcid":true,"given":"Tiago M.","family":"Bandeiras","sequence":"additional","affiliation":[{"name":"iBET, Instituto de Biologia Experimental e Tecnol\u00f3gica, Apartado 12, Oeiras 2781-901, Portugal"}]},{"given":"Emma","family":"Carswell","sequence":"additional","affiliation":[{"name":"Cancer Research Horizons, Jonas Webb Building, Babraham Research Campus, Cambridge CB22 3AT, U.K."}]},{"given":"Nicholas","family":"Pearson","sequence":"additional","affiliation":[{"name":"Cancer Research Horizons, Jonas Webb Building, Babraham Research Campus, Cambridge CB22 3AT, U.K."}]},{"given":"Sameer","family":"Sirohi","sequence":"additional","affiliation":[{"name":"Cancer Research Horizons, Jonas Webb Building, Babraham Research Campus, Cambridge CB22 3AT, U.K."}]},{"given":"Mollie","family":"Hooker","sequence":"additional","affiliation":[{"name":"Cancer Research Horizons, Jonas Webb Building, Babraham Research Campus, Cambridge CB22 3AT, U.K."},{"name":"MSD, The Francis Crick Institute, 1 Midland Road, London, NW1 1AT, U.K."}]},{"given":"Elisabeth","family":"Trivier","sequence":"additional","affiliation":[{"name":"Cancer Research Horizons, 4NW, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K."}]},{"given":"Rebecca","family":"Broome","sequence":"additional","affiliation":[{"name":"Cancer Research Horizons, 4NW, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K."}]},{"given":"Alexander","family":"Balsiger","sequence":"additional","affiliation":[{"name":"Cancer Research Horizons, 4NW, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K."}]},{"given":"Abigail","family":"Crowden","sequence":"additional","affiliation":[{"name":"Cancer Research Horizons, 4NW, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K."}]},{"given":"Christian","family":"Dillon","sequence":"additional","affiliation":[{"name":"Cancer Research Horizons, 4NW, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K."}]},{"given":"Dirk","family":"Wienke","sequence":"additional","affiliation":[{"name":"Merck Healthcare KGaA, Frankfurter Str. 250, 64293 Darmstadt, Germany"}]}],"member":"316","published-online":{"date-parts":[[2022,6,28]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00005.2014"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-biochem-013118-111829"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.3390\/cells8060600"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.7b00879"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.2036"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1016\/j.str.2015.11.005"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1819400116"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1016\/j.str.2015.09.009"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2019.111767"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2018.11.010"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2020.03.002"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2020.107809"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2021.04.015"},{"key":"ref14\/cit14","unstructured":"Gray, N. S.; Zhang, T.; Che, J.; Kwiatkowski, N. P.; Fan, M.; Lu, W. Transcriptional enhanced associate domain (TEAD) transcription fractor inhibitors and uses thereof. WO 2021133896 A1, 2021."},{"key":"ref15\/cit15","unstructured":"Fett, E.; Venier, O. (1H-Indol-5-yl)acrylamide derivatives as inhibitors of TEAD proteins and the hippo-YAP1\/TAZ signaling cascade for the treamtment of cancer. WO 2021204823 A1, 2021."},{"key":"ref16\/cit16","first-page":"4399","volume":"10","author":"Kaneda A.","year":"2020","journal-title":"Am. J. Cancer Res."},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1021\/acschembio.9b00786"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.0c01275"},{"key":"ref19\/cit19","unstructured":"Castro, A. C. TEAD inhibitors and uses thereof. WO 2020243415 A2, 2020."},{"key":"ref20\/cit20","unstructured":"Wu, X. TEAD transcription factor autopalmitoylation inhibitors. WO 2017053706 A1, 2017."},{"key":"ref21\/cit21","unstructured":"Richalet, F.; Weiler, S.; Reinelt, S.; Groner, A.; Lane, H.; Nuoffer, C. 1,2,4-Oxadiazol-5-one derivatives for the treament of cancer. WO 2021018869 A1, 2021."},{"key":"ref22\/cit22","unstructured":"Crawford, J. J.; Zbieg, J. R. Therapeutic compounds. WO 2021108483 A1, 2021."},{"key":"ref23\/cit23","unstructured":"Konradi, A. W.; Lin, T. T.L. T. Benzocarbonyl compounds. WO 2019113236 A1, 2019."},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.mct-20-0717"},{"key":"ref25\/cit25","unstructured":"Beroza, P. P.; Crawford, J. J.; Lee, W.; Rene, O.; Zbieg, J. R.; Liao, J.; Wang, T.; Yu, C. Carboxamide and sulfonamide derivatives useful as TEAD modulators. WO 2020051099 A1, 2020."},{"key":"ref26\/cit26","unstructured":"Zbieg, J. R.; Villemure, E.; Rudolph, J.; Beroza, P. P.; Crawford, J. J. Heterobifunctional molecules as TEAD inhibitors. WO 2021178339 A1, 2021."},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1080\/13543776.2018.1549226"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1021\/ml500160m"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202006280"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.8b01402"},{"key":"ref31\/cit31","unstructured":"Bordas, V.; Brocklehurst, C.; Ch-Ene, P.; Fei, Z.; Furet, P.; Guagnano, V.; Imbach-Weese, P.; Kallen, J.; Le Douget, M.; Li, J.; Li, W.; Lorthiois, E. L. J.; McKenna, J.; Salem, B.; Schmelzle, T.; Sellner, H.; Soldermann, N.; Voegtle, M.; Wartmann, M. Biaryl derivatives as YAP\/TAZ-TEAD protein-protein interaction inhibitors. WO 2021186324 A1, 2021."},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.9b00591"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1038\/nature10137"},{"key":"ref34\/cit34","first-page":"1227","volume":"55","author":"Sekido Y.","year":"1995","journal-title":"Cancer Res."},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3458"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1007\/s00281-014-0420-1"},{"key":"ref37\/cit37","unstructured":"Heinrich, T.; Schlesiger, S.; Gunera, J.; Carswell, E.; Koetzner, L. Tricyclic heterocycles useful as TEAD binder. WO 2021224291 A1, 2021."},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1016\/j.nima.2009.03.200"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1107\/s0907444909047337"},{"key":"ref40\/cit40","unstructured":"Bricogne, G., Blanc, E., Brandl, M., Flensburg, C., Keller, P., Paciorek, W., Roversi, P., Sharff, A., Smart, O. S., Vonrhein, C.; Womack, T. O. BUSTER version 2.11.1; Global Phasing Ltd: Cambridge, United Kingdom, 2017."},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1088\/1748-0221\/9\/05\/c05032"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1107\/S0907444911007773"}],"container-title":["Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jmedchem.2c00403","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jmedchem.2c00403","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,25]],"date-time":"2023-04-25T18:36:29Z","timestamp":1682447789000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.jmedchem.2c00403"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,28]]},"references-count":42,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2022,7,14]]}},"alternative-id":["10.1021\/acs.jmedchem.2c00403"],"URL":"https:\/\/doi.org\/10.1021\/acs.jmedchem.2c00403","relation":{},"ISSN":["0022-2623","1520-4804"],"issn-type":[{"value":"0022-2623","type":"print"},{"value":"1520-4804","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6,28]]}}}