{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T17:46:20Z","timestamp":1774892780679,"version":"3.50.1"},"reference-count":61,"publisher":"American Chemical Society (ACS)","issue":"8","license":[{"start":{"date-parts":[[2019,3,25]],"date-time":"2019-03-25T00:00:00Z","timestamp":1553472000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2019,3,25]],"date-time":"2019-03-25T00:00:00Z","timestamp":1553472000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2019,3,25]],"date-time":"2019-03-25T00:00:00Z","timestamp":1553472000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100007316","name":"Klaus Tschira Stiftung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007316","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011102","name":"Seventh Framework Programme","doi-asserted-by":"publisher","award":["603240"],"award-info":[{"award-number":["603240"]}],"id":[{"id":"10.13039\/100011102","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Heidelberg Biosciences International Graduate School"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Med. Chem."],"published-print":{"date-parts":[[2019,4,25]]},"DOI":"10.1021\/acs.jmedchem.8b02021","type":"journal-article","created":{"date-parts":[[2019,3,25]],"date-time":"2019-03-25T18:52:40Z","timestamp":1553539960000},"page":"3989-4012","source":"Crossref","is-referenced-by-count":35,"title":["Enhancement of Benzothiazoles as Pteridine Reductase-1 Inhibitors for the Treatment of Trypanosomatidic Infections"],"prefix":"10.1021","volume":"62","author":[{"given":"Pasquale","family":"Linciano","sequence":"first","affiliation":[{"name":"Dipartimento di Scienze della Vita, University of Modena and Reggio Emilia, Via Campi 103, 41125 Modena, Italy"}]},{"given":"Cecilia","family":"Pozzi","sequence":"additional","affiliation":[{"name":"Dipartimento di Biotecnologie, Chimica e Farmacia, University of Siena, Via Aldo Moro 2, 53100 Siena, Italy"}]},{"given":"Lucia dello","family":"Iacono","sequence":"additional","affiliation":[{"name":"Dipartimento di Biotecnologie, Chimica e Farmacia, University of Siena, Via Aldo Moro 2, 53100 Siena, Italy"}]},{"given":"Flavio","family":"di Pisa","sequence":"additional","affiliation":[{"name":"Dipartimento di Biotecnologie, Chimica e Farmacia, University of Siena, Via Aldo Moro 2, 53100 Siena, Italy"}]},{"given":"Giacomo","family":"Landi","sequence":"additional","affiliation":[{"name":"Dipartimento di Biotecnologie, Chimica e Farmacia, University of Siena, Via Aldo Moro 2, 53100 Siena, Italy"}]},{"given":"Alessio","family":"Bonucci","sequence":"additional","affiliation":[{"name":"Dipartimento di Biotecnologie, Chimica e Farmacia, University of Siena, Via Aldo Moro 2, 53100 Siena, Italy"}]},{"given":"Sheraz","family":"Gul","sequence":"additional","affiliation":[{"name":"Fraunhofer Institute for Molecular Biology and Applied Ecology Screening Port, 22525 Hamburg, Germany"}]},{"given":"Maria","family":"Kuzikov","sequence":"additional","affiliation":[{"name":"Fraunhofer Institute for Molecular Biology and Applied Ecology Screening Port, 22525 Hamburg, Germany"}]},{"given":"Bernhard","family":"Ellinger","sequence":"additional","affiliation":[{"name":"Fraunhofer Institute for Molecular Biology and Applied Ecology Screening Port, 22525 Hamburg, Germany"}]},{"given":"Gesa","family":"Witt","sequence":"additional","affiliation":[{"name":"Fraunhofer Institute for Molecular Biology and Applied Ecology Screening Port, 22525 Hamburg, Germany"}]},{"given":"Nuno","family":"Santarem","sequence":"additional","affiliation":[{"name":"Institute for Molecular and Cell Biology, 4150-180 Porto, Portugal"},{"name":"Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade, Universidade do Porto and Institute for Molecular and Cell Biology, 4150-180 Porto, Portugal"}]},{"given":"Catarina","family":"Baptista","sequence":"additional","affiliation":[{"name":"Institute for Molecular and Cell Biology, 4150-180 Porto, Portugal"},{"name":"Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade, Universidade do Porto and Institute for Molecular and Cell Biology, 4150-180 Porto, Portugal"}]},{"given":"Caio","family":"Franco","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio Nacional de Bioci\u00eancias (LNBio), Centro Nacional de Pesquisaem Energia e Materiais (CNPEM), 13083-100 Campinas, S\u00e3o Paulo, Brazil"}]},{"given":"Carolina B.","family":"Moraes","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio Nacional de Bioci\u00eancias (LNBio), Centro Nacional de Pesquisaem Energia e Materiais (CNPEM), 13083-100 Campinas, S\u00e3o Paulo, Brazil"}]},{"given":"Wolfgang","family":"M\u00fcller","sequence":"additional","affiliation":[]},{"given":"Ulrike","family":"Wittig","sequence":"additional","affiliation":[]},{"given":"Rosaria","family":"Luciani","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze della Vita, University of Modena and Reggio Emilia, Via Campi 103, 41125 Modena, Italy"}]},{"given":"Antony","family":"Sesenna","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze della Vita, University of Modena and Reggio Emilia, Via Campi 103, 41125 Modena, Italy"}]},{"given":"Antonio","family":"Quotadamo","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze della Vita, University of Modena and Reggio Emilia, Via Campi 103, 41125 Modena, Italy"}]},{"given":"Stefania","family":"Ferrari","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze della Vita, University of Modena and Reggio Emilia, Via Campi 103, 41125 Modena, Italy"}]},{"given":"Ina","family":"P\u00f6hner","sequence":"additional","affiliation":[]},{"given":"Anabela","family":"Cordeiro-da-Silva","sequence":"additional","affiliation":[{"name":"Institute for Molecular and Cell Biology, 4150-180 Porto, Portugal"},{"name":"Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade, Universidade do Porto and Institute for Molecular and Cell Biology, 4150-180 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4824-7478","authenticated-orcid":true,"given":"Stefano","family":"Mangani","sequence":"additional","affiliation":[{"name":"Dipartimento di Biotecnologie, Chimica e Farmacia, University of Siena, Via Aldo Moro 2, 53100 Siena, Italy"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5334-8084","authenticated-orcid":true,"given":"Luca","family":"Costantino","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze della Vita, University of Modena and Reggio Emilia, Via Campi 103, 41125 Modena, Italy"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0443-5402","authenticated-orcid":true,"given":"Maria Paola","family":"Costi","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze della Vita, University of Modena and Reggio Emilia, Via Campi 103, 41125 Modena, Italy"}]}],"member":"316","published-online":{"date-parts":[[2019,3,25]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(03)14694-6"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(09)60829-1"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2005.08.026"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.2217\/fmb.11.88"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1038\/nature.2017.22856"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0000923"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2005.10.052"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1021\/jm2005018"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.21.13883"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1016\/s0925-4439(02)00088-1"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.91.24.11442"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.m110.209593"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2006.05332.x"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1002\/cmdc.201000450"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1021\/jm1010572"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0704384105"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.7b00473"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1021\/jm400362b"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1021\/jm900414x"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1021\/jm300563f"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1107\/s0907444910040886"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.3390\/molecules22030426"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1021\/jm901059x"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.6b00698"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1038\/nrd4683"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.2174\/156802611795429185"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2006.05332.x"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1021\/jm901059x"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.21256"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jcim.7b00313"},{"key":"ref31\/cit31","unstructured":"Lagorce, D.; Sperandio, O.; Baell, J.; Miteva, M.; Villoutreix, B. FAFDrugs4 http:\/\/fafdrugs4.mti.univ-paris-diderot.fr (accessed Sept 10, 2017)."},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1177\/1087057114556236"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1202885109"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1038\/srep04703"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejps.2007.12.002"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1016\/s1056-8719(00)00107-6"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.15406\/mojbb.2017.03.00044"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2018.01.043"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1016\/0263-7855(96)00018-5"},{"key":"ref40\/cit40","unstructured":"ChemBio3D Ultra; PerkinElmer, 2014."},{"key":"ref41\/cit41","unstructured":"BIOVIA; D. S. Discovery Studio, 2014."},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2007.198"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1107\/s0907444910048675"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1107\/s0907444912048524"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1107\/s0907444909047337"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1107\/s0907444905036693"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1107\/s090744491003982x"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1107\/s0907444994003112"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1107\/s0907444909042589"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1107\/s0907444911001314"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1107\/s0907444904019158"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1107\/s0907444910007493"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2008.91"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1016\/s0959-440x(98)80156-5"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1107\/s0907444904023716"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1016\/j.ab.2009.09.003"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpddr.2012.02.002"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2016.12.017"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.6b00698"},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2007.10.014"},{"key":"ref61\/cit61","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0002571"}],"container-title":["Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jmedchem.8b02021","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,27]],"date-time":"2023-04-27T11:17:10Z","timestamp":1682594230000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.jmedchem.8b02021"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3,25]]},"references-count":61,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2019,4,25]]}},"alternative-id":["10.1021\/acs.jmedchem.8b02021"],"URL":"https:\/\/doi.org\/10.1021\/acs.jmedchem.8b02021","relation":{},"ISSN":["0022-2623","1520-4804"],"issn-type":[{"value":"0022-2623","type":"print"},{"value":"1520-4804","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,3,25]]}}}