{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T19:37:11Z","timestamp":1770838631990,"version":"3.50.1"},"reference-count":84,"publisher":"American Chemical Society (ACS)","issue":"9","license":[{"start":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T00:00:00Z","timestamp":1768867200000},"content-version":"vor","delay-in-days":180,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000921","name":"European Cooperation in Science and Technology","doi-asserted-by":"publisher","award":["CA19105"],"award-info":[{"award-number":["CA19105"]}],"id":[{"id":"10.13039\/501100000921","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020655","name":"European Health and Digital Executive Agency","doi-asserted-by":"publisher","award":["101080947"],"award-info":[{"award-number":["101080947"]}],"id":[{"id":"10.13039\/100020655","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007689","name":"Universidade de Aveiro","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007689","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda??o para a Ci?ncia e a Tecnologia","doi-asserted-by":"publisher","award":["2021.04754.BD"],"award-info":[{"award-number":["2021.04754.BD"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda??o para a Ci?ncia e a Tecnologia","doi-asserted-by":"publisher","award":["CEECIND\/01578\/2020"],"award-info":[{"award-number":["CEECIND\/01578\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda??o para a Ci?ncia e a Tecnologia","doi-asserted-by":"publisher","award":["LA\/P\/0094\/2020"],"award-info":[{"award-number":["LA\/P\/0094\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda??o para a Ci?ncia e a Tecnologia","doi-asserted-by":"publisher","award":["UID\/50006"],"award-info":[{"award-number":["UID\/50006"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Proteome Res."],"published-print":{"date-parts":[[2025,9,5]]},"DOI":"10.1021\/acs.jproteome.5c00308","type":"journal-article","created":{"date-parts":[[2025,7,24]],"date-time":"2025-07-24T13:24:58Z","timestamp":1753363498000},"page":"4631-4642","source":"Crossref","is-referenced-by-count":2,"title":["Lipidomic Profiling of Red Blood Cells in the Mitochondrial Fatty Acid \u03b2-oxidation Disorder MCADD Reveals Phospholipid and Sphingolipid Dysregulation"],"prefix":"10.1021","volume":"24","author":[{"given":"In\u00eas M. S.","family":"Guerra","sequence":"first","affiliation":[{"name":"Mass Spectrometry Center, LAQV-REQUIMTE, Department of Chemistry","place":["Aveiro, Portugal"]},{"name":"University of Aveiro","place":["Aveiro, Portugal"]},{"name":"CESAM - Centre for Environmental and Marine Studies, Department of Chemistry","place":["Aveiro, Portugal"]},{"name":"University of Aveiro","place":["Aveiro, Portugal"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6978-6166","authenticated-orcid":true,"given":"Helena B.","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Mass Spectrometry Center, LAQV-REQUIMTE, Department of Chemistry","place":["Aveiro, Portugal"]},{"name":"University of Aveiro","place":["Aveiro, Portugal"]}]},{"given":"Lu\u00edsa","family":"Diogo","sequence":"additional","affiliation":[{"name":"Centro de Refer\u00eancia de Doen\u00e7as Heredit\u00e1rias do Metabolismo","place":["Coimbra, Portugal"]},{"name":"Unidade Local de Sa\u00fade de Coimbra, MetabERN","place":["Coimbra, Portugal"]},{"name":"Servi\u00e7o de Bioqu\u00edmica","place":["Coimbra, Portugal"]},{"name":"Faculdade de Medicina da Universidade de Coimbra","place":["Coimbra, Portugal"]}]},{"given":"S\u00f3nia","family":"Moreira","sequence":"additional","affiliation":[{"name":"Centro de Refer\u00eancia de Doen\u00e7as Heredit\u00e1rias do Metabolismo","place":["Coimbra, Portugal"]},{"name":"Unidade Local de Sa\u00fade de Coimbra, MetabERN","place":["Coimbra, Portugal"]},{"name":"Servi\u00e7o de Bioqu\u00edmica","place":["Coimbra, Portugal"]},{"name":"Faculdade de Medicina da Universidade de Coimbra","place":["Coimbra, Portugal"]}]},{"given":"Stefano","family":"Bonciarelli","sequence":"additional","affiliation":[{"name":"Molecular Discovery Ltd.","place":["Hertfordshire, U.K."]}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9282-9013","authenticated-orcid":true,"given":"Laura","family":"Goracci","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Biology and Biotechnology","place":["Perugia, Italy"]},{"name":"University of Perugia","place":["Perugia, Italy"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0508-4034","authenticated-orcid":true,"given":"T\u00e2nia","family":"Melo","sequence":"additional","affiliation":[{"name":"Mass Spectrometry Center, LAQV-REQUIMTE, Department of Chemistry","place":["Aveiro, Portugal"]},{"name":"University of Aveiro","place":["Aveiro, Portugal"]},{"name":"CESAM - Centre for Environmental and Marine Studies, Department of Chemistry","place":["Aveiro, Portugal"]},{"name":"University of Aveiro","place":["Aveiro, Portugal"]}]},{"given":"Pedro","family":"Domingues","sequence":"additional","affiliation":[{"name":"Mass Spectrometry Center, LAQV-REQUIMTE, Department of Chemistry","place":["Aveiro, Portugal"]},{"name":"University of Aveiro","place":["Aveiro, Portugal"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5357-3601","authenticated-orcid":true,"given":"M. Ros\u00e1rio","family":"Domingues","sequence":"additional","affiliation":[{"name":"Mass Spectrometry Center, LAQV-REQUIMTE, Department of Chemistry","place":["Aveiro, Portugal"]},{"name":"University of Aveiro","place":["Aveiro, Portugal"]},{"name":"CESAM - Centre for Environmental and Marine Studies, Department of Chemistry","place":["Aveiro, Portugal"]},{"name":"University of Aveiro","place":["Aveiro, Portugal"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4745-0984","authenticated-orcid":true,"given":"Ana S. P.","family":"Moreira","sequence":"additional","affiliation":[{"name":"Mass Spectrometry Center, LAQV-REQUIMTE, Department of Chemistry","place":["Aveiro, Portugal"]},{"name":"University of Aveiro","place":["Aveiro, Portugal"]},{"name":"CESAM - Centre for Environmental and Marine Studies, Department of Chemistry","place":["Aveiro, Portugal"]},{"name":"University of Aveiro","place":["Aveiro, Portugal"]}]}],"member":"316","published-online":{"date-parts":[[2025,7,24]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1002\/edm2.385"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1007\/s10545-009-1126-8"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.12997\/jla.2020.9.3.313"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.3390\/ijms232213933"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1007\/s11154-020-09568-3"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2020-040303"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1097\/00000433-199212000-00013"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2020.598976"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/44.3.463"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-8981(01)00741-0"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1016\/j.talanta.2015.02.041"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","unstructured":"Sebaa, R.; AlMogren, M.; Alseraty, W.; Abdel Rahman, A. M. Untargeted Metabolomics Identifies Biomarkers for MCADD Neonates in Dried Blood Spots, 2023, 24, 11, 965710.3390\/ijms24119657","DOI":"10.3390\/ijms24119657"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1002\/jimd.12718"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.3390\/ijms221910556"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.3390\/cells10051239"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2004.10.010"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1080\/10715760701687109"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2009.02.009"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijdevneu.2012.03.238"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-011-1119-4"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5849(98)00221-4"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.3390\/metabo13070793"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.3390\/nu16060765"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-60761-322-0_7"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2020.00337"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.3390\/cells12040561"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.3390\/jpm11050337"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2017.01076"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0035102"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/9501826"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.4103\/0975-7406.129171"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.24.11.2001-a"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1080\/09637486.2016.1236076"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdiacomp.2021.107998"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2017.10.020"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1038\/303632a0"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1007\/BF00228075"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1186\/s12944-015-0135-x"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1186\/1476-511X-13-54"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1111\/eci.14121"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1139\/o59-099"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(70)90343-X"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1007\/BF02662211"},{"key":"ref44\/cit44","unstructured":"R:\nThe R Project for\nStatistical Computing\n                      . https:\/\/www.r-project.org\/ (accessed 2024\u201307\u201318)."},{"key":"ref45\/cit45","unstructured":"RStudio|Open source\n&\nprofessional software for data scienceteams\n                      . Posit. https:\/\/rstudio.com\/ (accessed 2024\u201307\u201318)."},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1002\/cpbi.11"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0116221"},{"key":"ref48\/cit48","unstructured":"FactoMineR: Multivariate\nExploratory Data Analysis and Data Mining version 2.11 from CRAN\n                      . https:\/\/rdrr.io\/cran\/FactoMineR\/ (accessed 2024\u201307\u201318)."},{"key":"ref49\/cit49","unstructured":"factoextra: Extract and\nVisualize the Results of Multivariate Data Analyses version 1.0.7\nfrom CRAN\n                      . https:\/\/rdrr.io\/cran\/factoextra\/ (accessed 2024\u201307\u201318)."},{"key":"ref50\/cit50","unstructured":"pheatmap: Pretty Heatmaps\nversion 1.0.12 from CRAN\n                      . https:\/\/rdrr.io\/cran\/pheatmap\/ (accessed 2024\u201307\u201318)."},{"key":"ref51\/cit51","unstructured":"rstatix: Pipe-Friendly\nFramework for Basic Statistical Tests version 0.7.2 from CRAN\n                      . https:\/\/rdrr.io\/cran\/rstatix\/ (accessed 2024\u201307\u201318)."},{"key":"ref52\/cit52","unstructured":"Create Elegant Data Visualisations\nUsing the Grammar of Graphics\n                      . https:\/\/ggplot2.tidyverse.org\/ (accessed 2024\u201307\u201318)."},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.28022.1"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2024.103389"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2008.07.008"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.3390\/metabo11010026"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1016\/j.plipres.2020.101068"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-72176-3"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.1093\/icb\/38.2.280"},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-023-05784-2"},{"key":"ref61\/cit61","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23105330"},{"key":"ref62\/cit62","doi-asserted-by":"publisher","DOI":"10.1186\/s40478-014-0150-6"},{"key":"ref63\/cit63","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2024.1368839"},{"key":"ref64\/cit64","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2017.06.008"},{"key":"ref65\/cit65","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2012.04.019"},{"key":"ref66\/cit66","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2023.1137893"},{"key":"ref67\/cit67","doi-asserted-by":"publisher","DOI":"10.1038\/nrm.2017.107"},{"key":"ref68\/cit68","doi-asserted-by":"publisher","DOI":"10.1016\/j.advms.2023.10.004"},{"key":"ref69\/cit69","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.TR119000427"},{"key":"ref70\/cit70","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2020.00437"},{"key":"ref71\/cit71","doi-asserted-by":"publisher","DOI":"10.1038\/nature13475"},{"key":"ref72\/cit72","doi-asserted-by":"publisher","DOI":"10.1007\/s12017-021-08646-2"},{"key":"ref73\/cit73","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2008.07.002"},{"key":"ref74\/cit74","doi-asserted-by":"publisher","DOI":"10.1155\/2009\/325847"},{"key":"ref75\/cit75","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2011.07.092"},{"key":"ref76\/cit76","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2022.11.032"},{"key":"ref77\/cit77","doi-asserted-by":"publisher","DOI":"10.1007\/978-81-322-2035-0_9"},{"key":"ref78\/cit78","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-75502-x"},{"key":"ref79\/cit79","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2006.03.007"},{"key":"ref80\/cit80","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamem.2017.04.006"},{"key":"ref81\/cit81","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-21519-2"},{"key":"ref82\/cit82","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-18530-4"},{"key":"ref83\/cit83","doi-asserted-by":"publisher","DOI":"10.1007\/s00232-009-9213-1"},{"key":"ref84\/cit84","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glae004"}],"container-title":["Journal of Proteome Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jproteome.5c00308","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jproteome.5c00308","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T18:32:24Z","timestamp":1768933944000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.jproteome.5c00308"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,24]]},"references-count":84,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2025,9,5]]}},"alternative-id":["10.1021\/acs.jproteome.5c00308"],"URL":"https:\/\/doi.org\/10.1021\/acs.jproteome.5c00308","relation":{},"ISSN":["1535-3893","1535-3907"],"issn-type":[{"value":"1535-3893","type":"print"},{"value":"1535-3907","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,24]]}}}