{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T15:28:45Z","timestamp":1788535725928,"version":"build-2803163510"},"reference-count":50,"publisher":"American Chemical Society (ACS)","issue":"9","license":[{"start":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T00:00:00Z","timestamp":1787184000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100006975","name":"Indiana Clinical and Translational Sciences Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006975","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007069","name":"Oklahoma State University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006377","name":"Purdue University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006377","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The liver is a metabolically active organ vital for carbohydrate, protein, and lipid metabolism as well as detoxification of harmful substances. Here, we integrated multiple reaction monitoring (MRM) profiling, untargeted lipidomics, and desorption electrospray ionization-mass spectrometry imaging (DESI-MSI) to identify age-associated changes in lipid profiles in the liver of adult mice across three age groups: adult (3\u20134 months), midaged (10 months), and old (19\u201321 months). Comparative lipidomic analysis revealed age-dependent remodeling of membrane phospholipids and sphingolipids. Aging was associated with significant alterations of phosphatidylcholines (PC), lysophosphatidylcholines (LPC), phosphatidylserines (PS), phosphatidylethanolamines (PE), and phosphatidylinositols (PI), characterized by reduced levels of unsaturated PC species (PC 36:5, PC 36:4) and saturated PC 32:0 alongside increased LPCs and highly unsaturated PC 40:7. In parallel, sphingolipids were also altered, with increased ceramides (Cer 34:1; O2, CerP 36:1; O2, ACer 59:1; O2) and sphingomyelins (SM 34:1; O2, SM 34:0; O2), and decreased levels of longer-chain sphingomyelins (SM 40:1; O2, SM 42:1; O2, SM 40:2; O2) compared with adult and midaged mice. Additionally, DESI-MSI revealed age-associated changes in monounsaturated (palmitoleic, oleic, eicosenoic) and polyunsaturated (linoleic, docosahexaenoic) fatty acids. These lipid alterations were consistently observed across multiple mass spectrometry platforms, including spatially resolved lipid distributions obtained by DESI-MSI, and are linked to membrane structure, signaling, and metabolism, providing new insights into age-related liver dysfunction.<\/jats:p>","DOI":"10.1021\/acs.jproteome.6c00254","type":"journal-article","created":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T13:01:47Z","timestamp":1787230907000},"page":"4782-4795","source":"Crossref","is-referenced-by-count":0,"title":["Integrated\nHepatic Lipidome Analysis in Aging Mice"],"prefix":"10.1021","volume":"25","author":[{"given":"Punyatoya","family":"Panda","sequence":"first","affiliation":[{"name":"Purdue University , , , ,","place":["West Lafayette, Indiana, United States, 47907"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3988-6454","authenticated-orcid":true,"given":"Christina R.","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Purdue University , , , ,","place":["West Lafayette, Indiana, United States, 47907"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4999-0565","authenticated-orcid":true,"given":"Allison J.","family":"Schaser","sequence":"additional","affiliation":[{"name":"Purdue University , , , ,","place":["West Lafayette, Indiana, United States, 47907"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4543-1536","authenticated-orcid":true,"given":"Uma K.","family":"Aryal","sequence":"additional","affiliation":[{"name":"Purdue University , , , ,","place":["West Lafayette, Indiana, United States, 47907"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,8,20]]},"reference":[{"issue":"21","key":"2026090409142288900_cit1","doi-asserted-by":"publisher","first-page":"R1147","DOI":"10.1016\/j.cub.2017.09.019","article-title":"The Liver","volume":"27","author":"Trefts","year":"2017","journal-title":"Curr. Biol."},{"issue":"2","key":"2026090409142288900_cit2","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.cld.2019.02.001","article-title":"The Liver\nin Systemic Disease","volume":"23","author":"Herrera","year":"2019","journal-title":"Clin. Liver Dis."},{"issue":"1","key":"2026090409142288900_cit3","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1002\/cphy.c130024","article-title":"Energy Metabolism\nin the Liver","volume":"4","author":"Rui","year":"2014","journal-title":"Compr. Physiol."},{"issue":"12","key":"2026090409142288900_cit4","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1038\/s41574-019-0256-9","article-title":"The Regulation of\nHepatic Fatty Acid Synthesis and\nPartitioning: The Effect of Nutritional State","volume":"15","author":"Hodson","year":"2019","journal-title":"Nat. Rev. Endocrinol."},{"issue":"3","key":"2026090409142288900_cit5","doi-asserted-by":"publisher","first-page":"829","DOI":"10.1172\/JCI34275","article-title":"Contribution of de Novo Fatty Acid\nSynthesis to Hepatic\nSteatosis and Insulin Resistance: Lessons from Genetically Engineered\nMice","volume":"118","author":"Postic","year":"2008","journal-title":"J. Clin. Invest."},{"issue":"1","key":"2026090409142288900_cit6","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/j.pharmthera.2012.12.007","article-title":"Cytochrome P450 Enzymes in Drug Metabolism: Regulation\nof Gene Expression, Enzyme Activities, and Impact of Genetic Variation","volume":"138","author":"Zanger","year":"2013","journal-title":"Pharmacol. Ther."},{"issue":"10","key":"2026090409142288900_cit7","doi-asserted-by":"publisher","DOI":"10.1097\/HC9.0000000000000808","article-title":"The Impact of Aging\non Liver Health and the Development\nof Liver Diseases","volume":"9","author":"Williams","year":"2025","journal-title":"Hepatol. Commun."},{"key":"2026090409142288900_cit8","doi-asserted-by":"publisher","first-page":"1151","DOI":"10.1016\/j.csbj.2019.07.021","article-title":"Hallmarks of Aging in the Liver","volume":"17","author":"Hunt","year":"2019","journal-title":"Comput. Struct. Biotechnol. J."},{"issue":"4","key":"2026090409142288900_cit9","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2014.162","article-title":"Impaired Autophagic Flux Is Associated\nwith Increased Endoplasmic Reticulum Stress during the Development\nof NAFLD","volume":"5","author":"Gonza\u0301lez-Rodri\u0301guez","year":"2014","journal-title":"Cell Death Dis."},{"issue":"9","key":"2026090409142288900_cit10","doi-asserted-by":"publisher","first-page":"1578","DOI":"10.1038\/s42255-023-00880-1","article-title":"Dynamic Lipidome\nAlterations Associated with Human Health, Disease and Ageing","volume":"5","author":"Hornburg","year":"2023","journal-title":"Nat. Metab."},{"issue":"1","key":"2026090409142288900_cit11","doi-asserted-by":"publisher","first-page":"lnae004","DOI":"10.1093\/lifemedi\/lnae004","article-title":"A Biomarker Framework for Liver Aging: The Aging Biomarker\nConsortium Consensus Statement","volume":"3","author":"Jiang","year":"2024","journal-title":"Life Med."},{"issue":"8","key":"2026090409142288900_cit12","doi-asserted-by":"publisher","first-page":"766","DOI":"10.1016\/j.bbalip.2017.02.016","article-title":"Common\nCases of Improper Lipid Annotation Using High-Resolution Tandem Mass\nSpectrometry Data and Corresponding Limitations in Biological Interpretation","volume":"1862","author":"Koelmel","year":"2017","journal-title":"Biochim. Biophys. Acta Mol. Cell Biol. Lipids"},{"issue":"12","key":"2026090409142288900_cit13","doi-asserted-by":"publisher","first-page":"1247","DOI":"10.1002\/jms.4301","article-title":"Comprehensive Lipid\nProfiling of Early Stage Oocytes and Embryos by MRM Profiling","volume":"53","author":"de Lima","year":"2018","journal-title":"J. Mass Spectrom."},{"key":"2026090409142288900_cit14","doi-asserted-by":"publisher","first-page":"105048","DOI":"10.1016\/j.chemphyslip.2021.105048","article-title":"Multiple Reaction\nMonitoring Profiling (MRM Profiling): Small Molecule Exploratory Analysis\nGuided by Chemical Functionality","volume":"235","author":"Xie","year":"2021","journal-title":"Chem. Phys.\nLipids"},{"issue":"2","key":"2026090409142288900_cit15","doi-asserted-by":"publisher","first-page":"3fc1f5fe.1972c438","DOI":"10.7171\/3fc1f5fe.1972c438","article-title":"Step-by-Step\nApproach to Build Multiple Reaction Monitoring (MRM) Profiling Instrument\nAcquisition Methods for Class-Based Lipid Exploratory Analysis by\nMass Spectrometry","volume":"34","author":"Reis","year":"2023","journal-title":"J. Biomol. Tech."},{"issue":"18","key":"2026090409142288900_cit16","doi-asserted-by":"publisher","first-page":"12085","DOI":"10.1021\/acs.analchem.9b03270","article-title":"Quantitative\nFragmentation Model for Bottom-Up Shotgun\nLipidomics","volume":"91","author":"Schuhmann","year":"2019","journal-title":"Anal. Chem."},{"issue":"9","key":"2026090409142288900_cit17","doi-asserted-by":"publisher","DOI":"10.1002\/rcm.9266","article-title":"Resolving Isobaric\nInterferences in Direct Infusion\nTandem Mass Spectrometry","volume":"36","author":"Kaeslin","year":"2022","journal-title":"Rapid Commun. Mass\nSpectrom."},{"issue":"25","key":"2026090409142288900_cit18","doi-asserted-by":"publisher","first-page":"4087","DOI":"10.1016\/j.chroma.2010.02.039","article-title":"Comprehensive\nBlood Plasma Lipidomics by Liquid Chromatography\/Quadrupole Time-of-Flight\nMass Spectrometry","volume":"1217","author":"Sandra","year":"2010","journal-title":"J. Chromatogr. A"},{"issue":"1","key":"2026090409142288900_cit19","doi-asserted-by":"publisher","DOI":"10.1002\/jms.4681","article-title":"Multiple Reaction\nMonitoring Profiling as an Analytical Strategy to Investigate Lipids\nin Extracellular Vesicles","volume":"56","author":"Edwards","year":"2021","journal-title":"J. Mass Spectrom."},{"issue":"5695","key":"2026090409142288900_cit20","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1126\/science.1104404","article-title":"Mass Spectrometry\nSampling under Ambient Conditions with Desorption Electrospray Ionization","volume":"306","author":"Taka\u0301ts","year":"2004","journal-title":"Science"},{"issue":"3","key":"2026090409142288900_cit21","doi-asserted-by":"publisher","first-page":"1077","DOI":"10.1021\/acs.jproteome.4c00688","article-title":"Multiplatform\nLipid Analysis of the Brain of Aging Mice by Mass Spectrometry","volume":"24","author":"Panda","year":"2025","journal-title":"J. Proteome Res."},{"issue":"3","key":"2026090409142288900_cit22","doi-asserted-by":"publisher","first-page":"5205","DOI":"10.1007\/s11357-025-01601-0","article-title":"Proteomic and Phosphoproteomic\nSignatures\nof Aging Mouse Liver","volume":"47","author":"Mohallem","year":"2025","journal-title":"GeroScience"},{"key":"2026090409142288900_cit23","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1186\/s40478-020-01026-0","article-title":"Trans-Synaptic and Retrograde Axonal\nSpread of Lewy Pathology Following Pre-Formed Fibril Injection in\nan in Vivo A53T Alpha-Synuclein Mouse Model of Synucleinopathy","volume":"8","author":"Schaser","year":"2020","journal-title":"Acta Neuropathol. Commun."},{"issue":"9","key":"2026090409142288900_cit24","doi-asserted-by":"publisher","first-page":"100819","DOI":"10.1016\/j.mcpro.2024.100819","article-title":"Molecular\nSignatures of Neurodegenerative\nDiseases Identified by Proteomic and Phosphoproteomic Analyses in\nAging Mouse Brain","volume":"23","author":"Mohallem","year":"2024","journal-title":"Mol. Cell. Proteomics"},{"issue":"8","key":"2026090409142288900_cit25","doi-asserted-by":"publisher","first-page":"911","DOI":"10.1139\/o59-099","article-title":"A Rapid Method of\nTotal Lipid Extraction and Purification","volume":"37","author":"Bligh","year":"1959","journal-title":"Can.\nJ. Biochem. Physiol."},{"issue":"9","key":"2026090409142288900_cit27","doi-asserted-by":"publisher","first-page":"100599","DOI":"10.1016\/j.jlr.2024.100599","article-title":"Spatial Lipidomics\nReveals Zone-Specific Hepatic Lipid Alteration and Remodeling in Metabolic\nDysfunction-Associated Steatohepatitis","volume":"65","author":"Seubnooch","year":"2024","journal-title":"J. Lipid\nRes."},{"key":"2026090409142288900_cit28","doi-asserted-by":"publisher","first-page":"033894","DOI":"10.1101\/2020.04.09.033894","article-title":"LipidLynxX: A Data\nTransfer Hub to Support Integration\nof Large Scale Lipidomics Datasets","author":"Ni","year":"2020","journal-title":"bioRxiv"},{"issue":"6","key":"2026090409142288900_cit29","doi-asserted-by":"publisher","first-page":"giz061","DOI":"10.1093\/gigascience\/giz061","article-title":"LION\/Web: A Web-Based Ontology Enrichment\nTool for Lipidomic Data Analysis","volume":"8","author":"Molenaar","year":"2019","journal-title":"GigaScience"},{"issue":"11","key":"2026090409142288900_cit30","doi-asserted-by":"publisher","first-page":"986","DOI":"10.1016\/S1044-0305(00)00172-0","article-title":"Characterization of\nPhosphatidylinositol, Phosphatidylinositol-4-Phosphate,\nand Phosphatidylinositol-4,5-Bisphosphate by Electrospray Ionization\nTandem Mass Spectrometry: A Mechanistic Study","volume":"11","author":"Hsu","year":"2000","journal-title":"J. Am. Soc. Mass Spectrom."},{"issue":"10","key":"2026090409142288900_cit31","doi-asserted-by":"publisher","first-page":"892","DOI":"10.1016\/S1044-0305(00)00159-8","article-title":"Charge-Remote and Charge-Driven Fragmentation\nProcesses in Diacyl\nGlycerophosphoethanolamine upon Low-Energy Collisional Activation:\nA Mechanistic Proposal","volume":"11","author":"Hsu","year":"2000","journal-title":"J. Am. Soc. Mass Spectrom."},{"issue":"5","key":"2026090409142288900_cit32","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1016\/S1044-0305(99)00150-6","article-title":"Structural Determination\nof Sphingomyelin by Tandem Mass Spectrometry\nwith Electrospray Ionization","volume":"11","author":"Hsu","year":"2000","journal-title":"J. Am. Soc. Mass\nSpectrom."},{"issue":"6","key":"2026090409142288900_cit33","doi-asserted-by":"publisher","first-page":"680","DOI":"10.1016\/S1044-0305(02)00362-8","article-title":"Structural Studies\non Ceramides as Lithiated Adducts by Low Energy Collisional-Activated\nDissociation Tandem Mass Spectrometry with Electrospray Ionization","volume":"13","author":"Hsu","year":"2002","journal-title":"J. Am. Soc. Mass Spectrom."},{"issue":"11","key":"2026090409142288900_cit34","doi-asserted-by":"publisher","first-page":"1619","DOI":"10.1038\/s43587-024-00692-2","article-title":"Nonlinear Dynamics\nof Multi-Omics Profiles during Human\nAging","volume":"4","author":"Shen","year":"2024","journal-title":"Nat. Aging"},{"issue":"5","key":"2026090409142288900_cit35","doi-asserted-by":"publisher","first-page":"1149","DOI":"10.3390\/ijms20051149","article-title":"An Updated Review\nof Lysophosphatidylcholine Metabolism in Human\nDiseases","volume":"20","author":"Law","year":"2019","journal-title":"Int. J. Mol. Sci."},{"issue":"8","key":"2026090409142288900_cit36","doi-asserted-by":"publisher","first-page":"436","DOI":"10.4254\/wjh.v12.i8.436","article-title":"Lipidomics in Non-Alcoholic Fatty Liver Disease","volume":"12","author":"Kartsoli","year":"2020","journal-title":"World J. Hepatol."},{"key":"2026090409142288900_cit37","doi-asserted-by":"publisher","first-page":"652960","DOI":"10.1101\/2025.05.08.652960","article-title":"Longitudinal Study of Liver Disease Progression in the PEX1-Gly844Asp\nMouse Model of Mild Zellweger Spectrum Disorder","author":"Chen","year":"2025","journal-title":"bioRxiv"},{"issue":"5","key":"2026090409142288900_cit38","doi-asserted-by":"publisher","first-page":"1565","DOI":"10.1002\/hep.27695","article-title":"Altered Hepatic\nGene Expression in\nNonalcoholic Fatty Liver Disease Is Associated with Lower Hepatic\nN-3 and n-6 Polyunsaturated Fatty Acids","volume":"61","author":"Arendt","year":"2015","journal-title":"Hepatology"},{"issue":"10","key":"2026090409142288900_cit39","doi-asserted-by":"publisher","first-page":"2803","DOI":"10.1007\/s00216-021-03179-w","article-title":"Spatially\nAware Clustering\nof Ion Images in Mass Spectrometry Imaging Data Using Deep Learning","volume":"413","author":"Zhang","year":"2021","journal-title":"Anal. Bioanal. Chem."},{"issue":"7","key":"2026090409142288900_cit40","doi-asserted-by":"publisher","first-page":"5240","DOI":"10.1021\/acs.analchem.9b05764","article-title":"Prioritization of m\/z-Values\nin Mass\nSpectrometry Imaging Profiles Obtained Using Uniform Manifold Approximation\nand Projection for Dimensionality Reduction","volume":"92","author":"Smets","year":"2020","journal-title":"Anal. Chem."},{"key":"2026090409142288900_cit41","doi-asserted-by":"publisher","first-page":"1137893","DOI":"10.3389\/fnins.2023.1137893","article-title":"Sphingolipids in\nNeurodegenerative Diseases","volume":"17","author":"Pan","year":"2023","journal-title":"Front. Neurosci."},{"issue":"3","key":"2026090409142288900_cit42","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1016\/j.jgg.2023.06.006","article-title":"Emerging Roles and Therapeutic Potentials\nof Sphingolipids in Pathophysiology: Emphasis on Fatty Acyl Heterogeneity","volume":"51","author":"Mu","year":"2024","journal-title":"J. Genet. Genomics"},{"issue":"1","key":"2026090409142288900_cit43","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1038\/s42003-023-05657-6","article-title":"Curvature Sensing\nLipid Dynamics\nin a Mitochondrial Inner Membrane Model","volume":"7","author":"Golla","year":"2024","journal-title":"Commun.\nBiol."},{"issue":"9","key":"2026090409142288900_cit44","doi-asserted-by":"publisher","first-page":"2028","DOI":"10.1194\/jlr.M600177-JLR200","article-title":"Regulation of Hepatic\nFatty Acid Elongase and Desaturase Expression in Diabetes and Obesity","volume":"47","author":"Wang","year":"2006","journal-title":"J. Lipid Res."},{"issue":"4","key":"2026090409142288900_cit45","doi-asserted-by":"publisher","first-page":"706","DOI":"10.1194\/jlr.M400335-JLR200","article-title":"Tissue-Specific,\nNutritional, and Developmental Regulation\nof Rat Fatty Acid Elongases","volume":"46","author":"Wang","year":"2005","journal-title":"J. Lipid Res."},{"issue":"02","key":"2026090409142288900_cit46","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1042\/BST20253042","article-title":"Ceramide Homeostasis\nin Hepatic Lipid Droplets","volume":"53","author":"Robles-Martinez","year":"2025","journal-title":"Biochem. Soc. Trans."},{"issue":"7","key":"2026090409142288900_cit47","doi-asserted-by":"publisher","first-page":"726","DOI":"10.1016\/j.bbalip.2018.04.005","article-title":"Cholesterol\nand Bile Acid-Mediated\nRegulation of Autophagy in Fatty Liver Diseases and Atherosclerosis","volume":"1863","author":"Wang","year":"2018","journal-title":"Biochim. Biophys. Acta Mol. Cell Biol. Lipids"},{"issue":"3","key":"2026090409142288900_cit48","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1002\/hep4.1629","article-title":"Fatty Acid Desaturase\n1 Influences Hepatic Lipid Homeostasis by Modulating the PPAR\u03b1-FGF21\nAxis","volume":"5","author":"Athinarayanan","year":"2021","journal-title":"Hepatol. Commun."},{"key":"2026090409142288900_cit50","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1016\/B978-0-12-821618-7.00144-9","article-title":"Cholesterol\nand Other Steroids","volume-title":"Encyclopedia of Cell\nBiology","author":"Burris","year":"2023","edition":"2"},{"issue":"8","key":"2026090409142288900_cit51","doi-asserted-by":"publisher","first-page":"1133","DOI":"10.3390\/biom10081133","article-title":"Arachidonic Acid as\nan Early Indicator\nof Inflammation during Non-Alcoholic Fatty Liver Disease Development","volume":"10","author":"Sztolsztener","year":"2020","journal-title":"Biomolecules"},{"key":"2026090409142288900_cit52","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/j.jare.2018.02.004","article-title":"Ageing:\nIs There a Role for Arachidonic Acid and Other Bioactive Lipids? A\nReview","volume":"11","author":"Das","year":"2018","journal-title":"J. Adv. Res."}],"container-title":["Journal of Proteome Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jproteome.6c00254","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/jprobs\/article-pdf\/25\/9\/4782\/66902995\/acs.jproteome.6c00254.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/jprobs\/article-pdf\/25\/9\/4782\/66902995\/acs.jproteome.6c00254.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T15:09:19Z","timestamp":1788534559000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/jprobs\/article\/25\/9\/4782\/5278065\/Integrated-Hepatic-Lipidome-Analysis-in-Aging-Mice"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,20]]},"references-count":50,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2026,8,20]]},"published-print":{"date-parts":[[2026,9,4]]}},"URL":"https:\/\/doi.org\/10.1021\/acs.jproteome.6c00254","relation":{},"ISSN":["1535-3893","1535-3907"],"issn-type":[{"value":"1535-3893","type":"print"},{"value":"1535-3907","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,20]]}}}