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Alternative cell sources and suitable scaffolds for salivary gland regeneration remain lacking. A functionalized scaffold system is fabricated by three-dimensional printing combined with freeze-drying to prepare a collagen-silk fibroin-Matrigel scaffold. The scaffold exhibits high porosity and strong water absorption capacity. Its internal surface is coated with a basement membrane extract-rich layer that enhances hydrophilicity and creates a physiologically relevant cell niche. In vitro, a synergistic co-culture system incorporating urine-derived induced pluripotent stem cells (iPSCs), parotid mesenchymal stem cells, and parotid epithelial cells directs the differentiation of iPSCs into KRT18+\/VIM+\/AQP5+ iPSC-derived cells. These cells readily adhere to the scaffold, proliferate, and form acinar-like aggregates within its porous architecture. In a rat model of parotid gland trauma, implantation of the scaffold progressively promotes tissue regeneration and attenuates trauma-induced atrophy. Histological analysis reveals that the scaffold recruits host cells to organize within its pores, forming amylase-secreting acinar-like structures. This study provides a reliable seed cell source and a suitable scaffold for structural and functional parotid restoration, offering a potential strategy for salivary gland tissue engineering.<\/jats:p>","DOI":"10.1021\/acsami.6c11219","type":"journal-article","created":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T23:01:24Z","timestamp":1789081284000},"page":"51578-51591","source":"Crossref","is-referenced-by-count":0,"title":["3D-Printed Collagen\/Silk Fibroin\/Matrigel Scaffold Combined with iPSC-Derived Cells for Tissue Regeneration of Salivary Glands"],"prefix":"10.1021","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2675-8744","authenticated-orcid":true,"given":"Han","family":"Liu","sequence":"first","affiliation":[{"name":"Beijing Stomatological Hospital, Capital Medical University , , ,","place":["Beijing, China, 100070"]},{"name":"Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction , ,","place":["Beijing, China, 100070"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyan","family":"Sun","sequence":"additional","affiliation":[{"name":"Capital Medical University , , ,","place":["Beijing, China, 100070"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yizhou","family":"Jin","sequence":"additional","affiliation":[{"name":"Beijing Stomatological Hospital, Capital Medical University , , ,","place":["Beijing, China, 100070"]},{"name":"Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction , ,","place":["Beijing, China, 100070"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0614-0314","authenticated-orcid":true,"given":"Ruixin","family":"Li","sequence":"additional","affiliation":[{"name":"Nankai University , , ,","place":["Tianjin, China, 300041"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaochen","family":"Shan","sequence":"additional","affiliation":[{"name":"Beijing Stomatological Hospital, Capital Medical University , , ,","place":["Beijing, China, 100070"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,9,10]]},"reference":[{"key":"2026092606061320800_cit1","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1146\/annurev-food-030212-182700","article-title":"The secretion, components, and properties of saliva","volume":"4","author":"Carpenter","year":"2013","journal-title":"Annu. 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