{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T18:06:11Z","timestamp":1771956371231,"version":"3.50.1"},"reference-count":53,"publisher":"American Chemical Society (ACS)","issue":"46","funder":[{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","award":["NORTE-01-0145-FEDER-000024"],"award-info":[{"award-number":["NORTE-01-0145-FEDER-000024"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","award":["POCI-01-0145-FEDER-007728"],"award-info":[{"award-number":["POCI-01-0145-FEDER-007728"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","award":["POCI-01-0145-FEDER-006980"],"award-info":[{"award-number":["POCI-01-0145-FEDER-006980"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","award":["NORTE-01-0145-FEDER-000028"],"award-info":[{"award-number":["NORTE-01-0145-FEDER-000028"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","award":["POCI-01-0145-FEDER-007274"],"award-info":[{"award-number":["POCI-01-0145-FEDER-007274"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","award":["NORTE-01-0145-FEDER-000012"],"award-info":[{"award-number":["NORTE-01-0145-FEDER-000012"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000921","name":"European Cooperation in Science and Technology","doi-asserted-by":"publisher","award":["CA15135"],"award-info":[{"award-number":["CA15135"]}],"id":[{"id":"10.13039\/501100000921","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda??o para a Ci?ncia e a Tecnologia","doi-asserted-by":"publisher","award":["NORTE-01-0145-FEDER-000012"],"award-info":[{"award-number":["NORTE-01-0145-FEDER-000012"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda??o para a Ci?ncia e a Tecnologia","doi-asserted-by":"publisher","award":["NORTE-01-0145-FEDER-000024"],"award-info":[{"award-number":["NORTE-01-0145-FEDER-000024"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda??o para a Ci?ncia e a Tecnologia","doi-asserted-by":"publisher","award":["NORTE-01-0145-FEDER-000028"],"award-info":[{"award-number":["NORTE-01-0145-FEDER-000028"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda??o para a Ci?ncia e a Tecnologia","doi-asserted-by":"publisher","award":["POCI-01-0145-FEDER-007274"],"award-info":[{"award-number":["POCI-01-0145-FEDER-007274"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda??o para a Ci?ncia e a Tecnologia","doi-asserted-by":"publisher","award":["POCI-01-0145-FEDER-006980"],"award-info":[{"award-number":["POCI-01-0145-FEDER-006980"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda??o para a Ci?ncia e a Tecnologia","doi-asserted-by":"publisher","award":["POCI-01-0145-FEDER-007728"],"award-info":[{"award-number":["POCI-01-0145-FEDER-007728"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008425","name":"Conseller?a de Cultura, Educaci?n e Ordenaci?n Universitaria, Xunta de Galicia","doi-asserted-by":"publisher","award":["ED481B 2018\/007"],"award-info":[{"award-number":["ED481B 2018\/007"]}],"id":[{"id":"10.13039\/501100008425","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008425","name":"Conseller?a de Cultura, Educaci?n e Ordenaci?n Universitaria, Xunta de Galicia","doi-asserted-by":"publisher","award":["GRC2013\/015"],"award-info":[{"award-number":["GRC2013\/015"]}],"id":[{"id":"10.13039\/501100008425","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008425","name":"Conseller?a de Cultura, Educaci?n e Ordenaci?n Universitaria, Xunta de Galicia","doi-asserted-by":"publisher","award":["GPC2017\/015"],"award-info":[{"award-number":["GPC2017\/015"]}],"id":[{"id":"10.13039\/501100008425","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Appl. Mater. Interfaces"],"published-print":{"date-parts":[[2018,11,21]]},"DOI":"10.1021\/acsami.8b17224","type":"journal-article","created":{"date-parts":[[2018,10,24]],"date-time":"2018-10-24T05:15:27Z","timestamp":1540358127000},"page":"39557-39569","source":"Crossref","is-referenced-by-count":53,"title":["PEGylated PLGA Nanoparticles As a Smart Carrier to Increase the Cellular Uptake of a Coumarin-Based Monoamine Oxidase B Inhibitor"],"prefix":"10.1021","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0102-0703","authenticated-orcid":true,"given":"Carlos","family":"Fernandes","sequence":"first","affiliation":[{"name":"CIQUP\/Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, 4169-007 Porto, Portugal"}]},{"given":"Cl\u00e1udia","family":"Martins","sequence":"additional","affiliation":[{"name":"i3S, Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade, Universidade do Porto, 4200-393 Porto, Portugal"},{"name":"INEB, Instituto de Engenharia Biom\u00e9dica, Nanomedicines & Translational Drug Delivery Group, Universidade do Porto, 4200-393 Porto, Portugal"}]},{"given":"Andr\u00e9","family":"Fonseca","sequence":"additional","affiliation":[{"name":"CIQUP\/Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, 4169-007 Porto, Portugal"}]},{"given":"Rute","family":"Nunes","sequence":"additional","affiliation":[{"name":"i3S, Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade, Universidade do Porto, 4200-393 Porto, Portugal"},{"name":"INEB, Instituto de Engenharia Biom\u00e9dica, Nanomedicines & Translational Drug Delivery Group, Universidade do Porto, 4200-393 Porto, Portugal"},{"name":"ICBAS, Instituto de Ci\u00eancias Biom\u00e9dicas Abel Salazar, Universidade do Porto, 4050-313 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3470-8299","authenticated-orcid":true,"given":"Maria Jo\u00e3o","family":"Matos","sequence":"additional","affiliation":[{"name":"CIQUP\/Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, 4169-007 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9962-7548","authenticated-orcid":true,"given":"Renata","family":"Silva","sequence":"additional","affiliation":[{"name":"UCIBIO-REQUIMTE, Laborat\u00f3rio de Toxicologia, Departamento de Ci\u00eancias Biol\u00f3gicas, Faculdade de Farm\u00e1cia, Universidade do Porto, 4050-313 Porto, Portugal"}]},{"given":"Jorge","family":"Garrido","sequence":"additional","affiliation":[{"name":"Departamento de Engenharia Qu\u00edmica, Instituto Superior de Engenharia do Porto (ISEP), Instituto Polit\u00e9cnico do Porto, 4200-072 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5763-7553","authenticated-orcid":true,"given":"Bruno","family":"Sarmento","sequence":"additional","affiliation":[{"name":"i3S, Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade, Universidade do Porto, 4200-393 Porto, Portugal"},{"name":"INEB, Instituto de Engenharia Biom\u00e9dica, Nanomedicines & Translational Drug Delivery Group, Universidade do Porto, 4200-393 Porto, Portugal"},{"name":"CESPU, Instituto de Investiga\u00e7\u00e3o e Forma\u00e7\u00e3o Avan\u00e7ada em Ci\u00eancias e Tecnologias da Sa\u00fade, 4585-116 Gandra, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1382-5119","authenticated-orcid":true,"given":"Fernando","family":"Remi\u00e3o","sequence":"additional","affiliation":[{"name":"UCIBIO-REQUIMTE, Laborat\u00f3rio de Toxicologia, Departamento de Ci\u00eancias Biol\u00f3gicas, Faculdade de Farm\u00e1cia, Universidade do Porto, 4050-313 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9030-2253","authenticated-orcid":true,"given":"Francisco J.","family":"Otero-Espinar","sequence":"additional","affiliation":[{"name":"Departamento de Farmacologia, Farmacia y Tecnologia Farmaceutica, Universidad of Santiago de Compostela, 15782 Santiago de Compostela, Spain"}]},{"given":"Eugenio","family":"Uriarte","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica Org\u00e1nica, Facultad de Farmacia, 15782 Santiago de Compostela, Espa\u00f1a"},{"name":"Instituto de Ciencias Qu\u00edmicas Aplicadas, Universidad Aut\u00f3noma de Chile, 7500912 Santiago, Chile"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1050-2402","authenticated-orcid":true,"given":"Fernanda","family":"Borges","sequence":"additional","affiliation":[{"name":"CIQUP\/Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, 4169-007 Porto, Portugal"}]}],"member":"316","published-online":{"date-parts":[[2018,10,23]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.2174\/187221112799219125"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1007\/s11302-008-9100-8"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a008870"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.6b00527"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1517\/13543776.2012.698613"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2011.05.062"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2011.11.010"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2017.09.001"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.201701035"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1023\/A:1010931127745"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3003594"},{"issue":"6","key":"ref12\/cit12","first-page":"2425","volume":"33","author":"Vangara K. K.","year":"2013","journal-title":"Anticancer Res."},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2016.05.044"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2012.09.024"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2011.01.015"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1021\/jm2004267"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1021\/mp300452g"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1039\/C4AY01203H"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2015.06.002"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1098\/rsif.2013.0931"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1039\/C5RA04096E"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1021\/bm400161g"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1007\/s11671-009-9431-6"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1021\/jf202135j"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S36684"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2016.04.054"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1021\/mp400342f"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2013.08.049"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpb.2008.03.009"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejps.2014.06.024"},{"key":"ref31\/cit31","volume-title":"Fundamentals and Applications of Controlled Release Drug Delivery","author":"Siegel R. A.","year":"2012","edition":"1"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1016\/j.jscs.2011.11.004"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1016\/S0032-3861(00)00646-7"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2013.03.019"},{"key":"ref35\/cit35","unstructured":"Molinspiration\nCheminformatics. http:\/\/www.molinspiration.com (accessed Mar 2, 2017)."},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1038\/nrd3187"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.108.143339"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1211\/jpp.60.5.0002"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S32188"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2004.07.050"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S75615"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1038\/nmat2202"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1039\/C5TB01425E"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics8020012"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1007\/s11481-016-9685-6"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2008.05720.x"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.2217\/nnm.10.53"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1002\/cmdc.201300533"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1002\/smll.201403799"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1021\/cm300301c"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-013-1120-7"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1186\/s40064-016-3267-1"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1517\/17425255.1.2.175"}],"container-title":["ACS Applied Materials & Interfaces"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsami.8b17224","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,27]],"date-time":"2023-04-27T21:43:36Z","timestamp":1682631816000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acsami.8b17224"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10,23]]},"references-count":53,"journal-issue":{"issue":"46","published-print":{"date-parts":[[2018,11,21]]}},"alternative-id":["10.1021\/acsami.8b17224"],"URL":"https:\/\/doi.org\/10.1021\/acsami.8b17224","relation":{},"ISSN":["1944-8244","1944-8252"],"issn-type":[{"value":"1944-8244","type":"print"},{"value":"1944-8252","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,10,23]]}}}