{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T22:05:42Z","timestamp":1747173942626,"version":"3.40.5"},"reference-count":46,"publisher":"American Chemical Society (ACS)","issue":"5","license":[{"start":{"date-parts":[[2023,4,19]],"date-time":"2023-04-19T00:00:00Z","timestamp":1681862400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,4,19]],"date-time":"2023-04-19T00:00:00Z","timestamp":1681862400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,4,19]],"date-time":"2023-04-19T00:00:00Z","timestamp":1681862400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"name":"Northern Portugal Regional Operational Programme","award":["NORTE-01-0145-FEDER-000039","NORTE-08-5369-FSE-000012","UMINHO\/BD\/33\/2016"],"award-info":[{"award-number":["NORTE-01-0145-FEDER-000039","NORTE-08-5369-FSE-000012","UMINHO\/BD\/33\/2016"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Biomater. Sci. Eng."],"published-print":{"date-parts":[[2023,5,8]]},"DOI":"10.1021\/acsbiomaterials.3c00148","type":"journal-article","created":{"date-parts":[[2023,4,19]],"date-time":"2023-04-19T14:47:09Z","timestamp":1681915629000},"page":"2514-2523","source":"Crossref","is-referenced-by-count":3,"title":["The Influence of Feeder Cell-Derived Extracellular Matrix Density on Thymic Epithelial Cell Culture"],"prefix":"10.1021","volume":"9","author":[{"given":"Catarina S.","family":"Silva","sequence":"first","affiliation":[{"name":"3B\u2019s Research Group, I3Bs \u2212 Research Institute on Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, AvePark - Parque de Ci\u00eancia e Tecnologia, Zona Industrial da Gandra, Barco, Guimar\u00e3es 4805-017, Portugal"},{"name":"ICVS\/3B\u2019s\u2212PT Government Associate Laboratory, Braga 4710-057, Portugal"},{"name":"ICVS\/3B\u2019s\u2212PT Government Associate Laboratory, Guimar\u00e3es 4805-017, Portugal"}]},{"given":"Rute D.","family":"Pinto","sequence":"additional","affiliation":[{"name":"i3S \u2212 Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade, IBMC - Instituto de Biologia Molecular e Celular, Universidade do Porto, Rua Alfredo Allen, 208, 4200-135 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9197-0138","authenticated-orcid":true,"given":"Ricardo A.","family":"Pires","sequence":"additional","affiliation":[{"name":"3B\u2019s Research Group, I3Bs \u2212 Research Institute on Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, AvePark - Parque de Ci\u00eancia e Tecnologia, Zona Industrial da Gandra, Barco, Guimar\u00e3es 4805-017, Portugal"},{"name":"ICVS\/3B\u2019s\u2212PT Government Associate Laboratory, Braga 4710-057, Portugal"},{"name":"ICVS\/3B\u2019s\u2212PT Government Associate Laboratory, Guimar\u00e3es 4805-017, Portugal"}]},{"given":"Margarida","family":"Correia-Neves","sequence":"additional","affiliation":[{"name":"ICVS\/3B\u2019s\u2212PT Government Associate Laboratory, Braga 4710-057, Portugal"},{"name":"ICVS\/3B\u2019s\u2212PT Government Associate Laboratory, Guimar\u00e3es 4805-017, Portugal"},{"name":"Life and Health Sciences Research Institute (ICVS), School of Medicine, Campus de Gualtar, Universidade do Minho, Braga 4710-057, Portugal"}]},{"given":"Rui L.","family":"Reis","sequence":"additional","affiliation":[{"name":"3B\u2019s Research Group, I3Bs \u2212 Research Institute on Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, AvePark - Parque de Ci\u00eancia e Tecnologia, Zona Industrial da Gandra, Barco, Guimar\u00e3es 4805-017, Portugal"},{"name":"ICVS\/3B\u2019s\u2212PT Government Associate Laboratory, Braga 4710-057, Portugal"},{"name":"ICVS\/3B\u2019s\u2212PT Government Associate Laboratory, Guimar\u00e3es 4805-017, Portugal"}]},{"given":"Nuno L.","family":"Alves","sequence":"additional","affiliation":[{"name":"i3S \u2212 Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade, IBMC - Instituto de Biologia Molecular e Celular, Universidade do Porto, Rua Alfredo Allen, 208, 4200-135 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3868-0251","authenticated-orcid":true,"given":"Albino","family":"Martins","sequence":"additional","affiliation":[{"name":"3B\u2019s Research Group, I3Bs \u2212 Research Institute on Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, AvePark - Parque de Ci\u00eancia e Tecnologia, Zona Industrial da Gandra, Barco, Guimar\u00e3es 4805-017, Portugal"},{"name":"ICVS\/3B\u2019s\u2212PT Government Associate Laboratory, Braga 4710-057, Portugal"},{"name":"ICVS\/3B\u2019s\u2212PT Government Associate Laboratory, Guimar\u00e3es 4805-017, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3041-0687","authenticated-orcid":true,"given":"Nuno M.","family":"Neves","sequence":"additional","affiliation":[{"name":"3B\u2019s Research Group, I3Bs \u2212 Research Institute on Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, AvePark - Parque de Ci\u00eancia e Tecnologia, Zona Industrial da Gandra, Barco, Guimar\u00e3es 4805-017, Portugal"},{"name":"ICVS\/3B\u2019s\u2212PT Government Associate Laboratory, Braga 4710-057, Portugal"},{"name":"ICVS\/3B\u2019s\u2212PT Government Associate Laboratory, Guimar\u00e3es 4805-017, Portugal"}]}],"member":"316","published-online":{"date-parts":[[2023,4,19]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-021-00927-z"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2012.03.005"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.03099"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1080\/01926230600865549"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.176.2.730"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1006\/smim.1998.0158"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(02)00474-0"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2018.12.011"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2020.108320"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.4237"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201344110"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202100773"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1089\/ten.teb.2014.0547"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1002\/stem.1731"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201746922"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2014.07.029"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1021\/acsbiomaterials.9b01610"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202010747"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-20082-7"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1038\/mt.2015.77"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2016.11.054"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2011.01.057"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1186\/s12896-020-00658-3"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1002\/cpcb.2"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0171488"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1038\/s41536-021-00133-3"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2021.112585"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1002\/smll.200801648"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biomac.0c00599"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biomac.0c00933"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1084\/jem.175.6.1601"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1097\/IJG.0000000000000108"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1089\/ten.teb.2008.0619"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-49575-2"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.3390\/biom10091208"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1177\/33.7.3891843"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1155\/2000\/60247"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2010.12.002"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiomech.2014.09.035"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1089\/ten.tec.2014.0092"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1039\/C6RA03840A"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1002\/term.2529"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0085178"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1021\/am506951c"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1080\/09205063.2019.1669313"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/9703609"}],"container-title":["ACS Biomaterials Science &amp; Engineering"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsbiomaterials.3c00148","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsbiomaterials.3c00148","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,8]],"date-time":"2023-05-08T08:23:22Z","timestamp":1683534202000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acsbiomaterials.3c00148"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,19]]},"references-count":46,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2023,5,8]]}},"alternative-id":["10.1021\/acsbiomaterials.3c00148"],"URL":"https:\/\/doi.org\/10.1021\/acsbiomaterials.3c00148","relation":{},"ISSN":["2373-9878","2373-9878"],"issn-type":[{"type":"print","value":"2373-9878"},{"type":"electronic","value":"2373-9878"}],"subject":[],"published":{"date-parts":[[2023,4,19]]}}}